Pth2 (parathyroid hormone 2) - Rat Genome Database

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Gene: Pth2 (parathyroid hormone 2) Rattus norvegicus
Analyze
Symbol: Pth2
Name: parathyroid hormone 2
RGD ID: 1559447
Description: Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in extracellular region. Orthologous to human PTH2 (parathyroid hormone 2); INTERACTS WITH bisphenol A; Cuprizon; trichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC499149; RGD1559447; similar to tuberoinfundibular 39 residue protein precursor; Tifp39; TIP39; tuberoinfundibular peptide of 39 amino acids; tuberoinfundibular peptide of 39 residues; tuberoinfundibular peptide of 39 residues (TIP39) preprohormone
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,802,983 - 104,803,632 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,802,983 - 104,803,632 (+)EnsemblGRCr8
mRatBN7.2195,666,525 - 95,667,174 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1101,051,926 - 101,052,575 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,524,589 - 109,525,238 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,814,990 - 102,815,639 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,175,499 - 101,179,001 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,178,104 - 101,178,753 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,240,446 - 102,243,707 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,657,750 - 95,658,399 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,924,894 - 89,925,543 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11818570   PMID:12508326   PMID:12559132   PMID:14643775   PMID:15677763   PMID:16458435   PMID:18495420   PMID:19936783   PMID:20861230   PMID:21873635  


Genomics

Comparative Map Data
Pth2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,802,983 - 104,803,632 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,802,983 - 104,803,632 (+)EnsemblGRCr8
mRatBN7.2195,666,525 - 95,667,174 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1101,051,926 - 101,052,575 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,524,589 - 109,525,238 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,814,990 - 102,815,639 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,175,499 - 101,179,001 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,178,104 - 101,178,753 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,240,446 - 102,243,707 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,657,750 - 95,658,399 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,924,894 - 89,925,543 (+)NCBICelera
Cytogenetic Map1q22NCBI
PTH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,422,419 - 49,423,441 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,422,419 - 49,423,660 (-)Ensemblhg38GRCh38
GRCh371949,925,676 - 49,926,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,617,483 - 54,618,510 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1946,793,291 - 46,794,318 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,302,281 - 46,303,308 (-)NCBIHuRef
CHM1_11949,927,609 - 49,928,636 (-)NCBICHM1_1
T2T-CHM13v2.01952,419,850 - 52,420,872 (-)NCBIT2T-CHM13v2.0
Pth2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,829,447 - 44,831,262 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,830,419 - 44,831,262 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,179,701 - 45,181,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,180,995 - 45,181,838 (+)Ensemblmm10GRCm38
MGSCv37752,436,365 - 52,437,208 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,049,224 - 45,049,880 (+)NCBIMGSCv36mm8
Celera740,636,888 - 40,637,731 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.17NCBI
Pth2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,412,489 - 1,414,881 (+)Ensembl
ChiLan1.0NW_0049555591,409,966 - 1,414,881 (+)NCBIChiLan1.0ChiLan1.0
PTH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,538,395 - 55,540,194 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,458,703 - 57,460,502 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,435,293 - 46,437,104 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PTH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,069,586 - 107,070,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,069,395 - 107,070,530 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1106,651,873 - 106,653,743 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01107,588,672 - 107,590,554 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,589,121 - 107,590,611 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,261,665 - 107,263,538 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,904,233 - 106,906,111 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,744,889 - 107,746,765 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pth2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,683,204 - 21,684,157 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,301,401 - 3,302,616 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,301,370 - 3,302,185 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,504,868 - 54,510,723 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,504,871 - 54,506,149 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,233,848 - 50,238,254 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,602,564 - 42,603,859 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,602,613 - 42,603,474 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607322,530,389 - 22,531,542 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pth2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,779,506 - 4,781,270 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248324,780,150 - 4,781,340 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pth2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,360,226 - 154,360,868 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pth2
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:87
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000028072
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
PMC122245P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,666,638 - 95,667,099 (+)MAPPERmRatBN7.2
Rnor_6.01101,178,218 - 101,178,678NCBIRnor6.0
Rnor_5.01102,243,091 - 102,243,551UniSTSRnor5.0
RGSC_v3.4195,657,864 - 95,658,324UniSTSRGSC3.4
Celera189,925,008 - 89,925,468UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
1 3 57 4 5 12 8 56 1 26 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000028072   ⟹   ENSRNOP00000028072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,178,104 - 101,178,753 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151846   ⟹   ENSRNOP00000112668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,802,983 - 104,803,632 (+)Ensembl
RefSeq Acc Id: NM_001109144   ⟹   NP_001102614
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,802,983 - 104,803,632 (+)NCBI
mRatBN7.2195,666,525 - 95,667,174 (+)NCBI
Rnor_6.01101,178,104 - 101,178,753 (+)NCBI
Rnor_5.01102,240,446 - 102,243,707 (+)NCBI
RGSC_v3.4195,657,750 - 95,658,399 (+)RGD
Celera189,924,894 - 89,925,543 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102614 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07393 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000112668
GenBank Protein P0C172 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102614   ⟸   NM_001109144
- Peptide Label: precursor
- UniProtKB: A6JAZ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028072   ⟸   ENSRNOT00000028072
Ensembl Acc Id: ENSRNOP00000112668   ⟸   ENSRNOT00000151846

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C172-F1-model_v2 AlphaFold P0C172 1-100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559447 AgrOrtholog
BioCyc Gene G2FUF-59705 BioCyc
Ensembl Genes ENSRNOG00000020681 Ensembl
  ENSRNOG00000072882 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000151846 ENTREZGENE
InterPro TIP39 UniProtKB/Swiss-Prot
NCBI Gene 499149 ENTREZGENE
PANTHER PTHR28585 UniProtKB/Swiss-Prot
  TUBEROINFUNDIBULAR PEPTIDE OF 39 RESIDUES UniProtKB/Swiss-Prot
Pfam TIP39 UniProtKB/Swiss-Prot
PhenoGen Pth2 PhenoGen
RatGTEx ENSRNOG00000020681 RatGTEx
  ENSRNOG00000072882 RatGTEx
UniProt A0ABK0LNW6_RAT UniProtKB/TrEMBL
  A6JAZ1 ENTREZGENE, UniProtKB/TrEMBL
  P0C172 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Pth2  parathyroid hormone 2  Tifp39  tuberoinfundibular peptide of 39 residues (TIP39) preprohormone  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Tifp39  tuberoinfundibular peptide of 39 residues (TIP39) preprohormone  RGD1559447_predicted  similar to tuberoinfundibular 39 residue protein precursor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559447_predicted  similar to tuberoinfundibular 39 residue protein precursor (predicted)  LOC499149  similar to tuberoinfundibular 39 residue protein precursor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499149  similar to tuberoinfundibular 39 residue protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL