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Gene: Serpinb3 (serpin family B member 3) Rattus norvegicus

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Symbol:

Serpinb3 (Ensembl: Serpinb3a)

Name:

serpin family B member 3 (Ensembl:serpin family B member 3A)

RGD ID:

1549766

Description:

Predicted to enable cysteine-type endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Predicted to be involved in several processes, including autocrine signaling; paracrine signaling; and positive regulation of epithelial to mesenchymal transition. Predicted to be located in cytoplasmic vesicle; extracellular exosome; and nucleus. Orthologous to human SERPINB3 (serpin family B member 3); INTERACTS WITH bisphenol A; fenvalerate; vinclozolin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

serine protease inhibitor B3; serpin peptidase inhibitor, clade B (ovalbumin), member 3

RGD Orthologs

Human

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINB3 (serpin family B member 3)	HGNC	Ensembl, Inparanoid, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Serpinb3d (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SERPINB4 (serpin family B member 4)	HGNC	Ensembl, OrthoDB, Panther, PhylomeDB, Treefam
Alliance orthologs ³
Homo sapiens (human):	SERPINB3 (serpin family B member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SERPINB3 (serpin family B member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Serpinb3a (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Serpinb3a (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Serpinb3c (serine (or cysteine) peptidase inhibitor, clade B, member 3C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Serpinb3c (serine (or cysteine) peptidase inhibitor, clade B, member 3C)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Serpinb3d (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Serpinb3d (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Mus musculus (house mouse):	Serpinb3b (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Serpinb3b (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn27A	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28Da	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28Db	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn28F	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn38F	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn42Dc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn42Dd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn43Aa	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn47C	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn53F	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn88Ea	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn88Eb	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nec	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn31A	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	serpinb4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	serpinb4	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cd9	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	23,788,758 - 23,795,298 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	23,788,758 - 23,795,298 (-)	Ensembl				GRCr8
mRatBN7.2	13	23,274,120 - 23,280,660 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	23,274,484 - 23,313,682 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	23,637,345 - 23,643,886 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	24,921,816 - 24,928,357 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,607,534 - 23,614,075 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	27,186,701 - 27,193,211 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	27,187,130 - 27,192,592 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	32,336,215 - 32,341,680 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	13,339,447 - 13,344,912 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	23,119,963 - 23,125,428 (-)	NCBI		Celera
Cytogenetic Map	13	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

contact dermatitis (ISO)

Esophageal Neoplasms (ISO)

esophagus squamous cell carcinoma (ISO)

Mouth Neoplasms (ISO)

pre-malignant neoplasm (ISO)

Spontaneous Abortions (ISO)

squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dimethoxyphenol (ISO)

3-phenylprop-2-enal (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

cyclosporin A (ISO)

deguelin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

eugenol (ISO)

farnesol (ISO)

fenvalerate (EXP)

furfural (ISO)

geraniol (ISO)

ketoconazole (ISO)

lead diacetate (ISO)

lead(0) (ISO)

levonorgestrel (ISO)

melatonin (ISO)

methylisothiazolinone (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

Ortho-topolin riboside (ISO)

propanal (ISO)

quercetin (ISO)

resorcinol (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium dodecyl sulfate (ISO)

testosterone undecanoate (ISO)

thiram (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (EXP)

zinc(0) (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (ISO)

cytoplasmic vesicle (ISO)

cytosol (ISO)

extracellular exosome (ISO)

extracellular space (IEA)

nucleus (ISO)

Molecular Function

cysteine-type endopeptidase inhibitor activity (ISO)

protease binding (ISO)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A genomic analysis of rat proteases and protease inhibitors.	Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10956412	PMID:12949073	PMID:12975381	PMID:19056867	PMID:19190083	PMID:20527027	PMID:21383048	PMID:21557262	PMID:21630459	PMID:23376485

Genomics

Comparative Map Data

Serpinb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	23,788,758 - 23,795,298 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	23,788,758 - 23,795,298 (-)	Ensembl				GRCr8
mRatBN7.2	13	23,274,120 - 23,280,660 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	23,274,484 - 23,313,682 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	23,637,345 - 23,643,886 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	24,921,816 - 24,928,357 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,607,534 - 23,614,075 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	27,186,701 - 27,193,211 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	27,187,130 - 27,192,592 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	32,336,215 - 32,341,680 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	13,339,447 - 13,344,912 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	23,119,963 - 23,125,428 (-)	NCBI		Celera
Cytogenetic Map	13	p11	NCBI

SERPINB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	63,655,197 - 63,661,893 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	63,653,686 - 63,661,893 (-)	Ensembl			hg38	GRCh38
GRCh37	18	61,322,431 - 61,329,127 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	59,473,411 - 59,480,094 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	59,473,410 - 59,480,094	NCBI
Celera	18	58,042,926 - 58,049,692 (-)	NCBI		Celera
Cytogenetic Map	18	q21.33	NCBI
HuRef	18	58,022,262 - 58,029,029 (-)	NCBI		HuRef
CHM1_1	18	61,318,618 - 61,325,385 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	63,860,279 - 63,866,975 (-)	NCBI		T2T-CHM13v2.0

Serpinb3d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	107,005,893 - 107,011,210 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	107,005,897 - 107,011,236 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	107,078,163 - 107,083,480 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	107,078,167 - 107,083,506 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	108,974,770 - 108,980,057 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	108,905,740 - 108,911,027 (-)	NCBI		MGSCv36	mm8
Celera	1	109,926,247 - 109,931,536 (-)	NCBI		Celera
Cytogenetic Map	1	E2.1	NCBI
cM Map	1	50.34	NCBI

Variants

Variants in Serpinb3
21 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	66
Count of miRNA genes:	60
Interacting mature miRNAs:	62
Transcripts:	ENSRNOT00000040021
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34785618	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12285517	34884386	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	6002008	37088115	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	12285517	34884386	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	34785618	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
3	1	1	29	8	19	1	6	1	6	18	8	23	5	43	18

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001395733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BN000349	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003475 ⟹ ENSRNOP00000003475

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	23,274,484 - 23,313,682 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000040021 ⟹ ENSRNOP00000046632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	23,756,118 - 23,766,341 (-)	Ensembl
mRatBN7.2 Ensembl	13	23,274,484 - 23,280,011 (-)	Ensembl
Rnor_6.0 Ensembl	13	27,187,130 - 27,192,592 (-)	Ensembl

RefSeq Acc Id:

NM_001395733 ⟹ NP_001382662

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	23,788,758 - 23,795,298 (-)	NCBI
mRatBN7.2	13	23,274,120 - 23,280,660 (-)	NCBI

RefSeq Acc Id:

XM_006249631 ⟹ XP_006249693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	23,788,758 - 23,794,720 (-)	NCBI
mRatBN7.2	13	23,274,120 - 23,280,082 (-)	NCBI
Rnor_6.0	13	27,186,701 - 27,193,211 (-)	NCBI
Rnor_5.0	13	32,336,215 - 32,341,680 (-)	NCBI

Sequence:

show sequence

CCTTCAGAAAGACAAGACTTTAAGGTCACACAAAGCCATCATGCATTTGTTTGCTAAAGCGACT
ACTCAATTCACACTTGAGCTGTACAGGCAGCTCAGAGACTCAGAGGACAACATCTTCTATTCCC
CTCTCAGCATAATGACAGCATTAGCAATGCTCCAGCTCGGAGCCAAGGGAAACACTGAAAAACA
AATTGAGAAGGCTCTACAACTCAGTGAAACCACAAAAAAGCCAAAAGAAAAATCTGCGGACTCT
CATGATGAAGAAAATGTCCATGAACAATTTCGAAAGATTATGAATCAATTAAACAAATCCAATG
GTGCTTATGACCTGAAGTCTCCCAACAGTATCTATGGAGCAAAGGGTTTCCCATTTCTCCAGAC
GTTTATGGAAGACATTAAGAAATATTACCAAGCTAATGTGGAATCCCTTGATTTTGCACATGCT
GCAGAAGAAAGCCAAAAGAAGATTAATTCCTGGGTAGAAAACAAAACAAATGGAAAAATCAAAG
ACTTGTTTCCTAGGGGGAGCCTGAACAGTAGCACTATCCTGGTTCTGGTGAATGCAGTGTATTT
CAAAGGACAATGGAATCACAAATTTGATGAACAGCGTACCAGAGAAGACAAGTTTTGGCTGAAC
AAGAATACAAGTAAACCTGTCCAGATGATGAGGCAAACAAACGAGTTTAACTTCATCTTTCTGG
AGGATGTGCAGGCCAAGATGGTGGAAATACCATACAAAGGCAAGGAGCTAAGTATGTTCATCCT
GCTGCCAATGGAAATTGATGGTCTGAAGAAGCTTGAAGAAAAACTAAGTGCTGACACGTTGCTA
GCGTGGACAAGCCCAAAGAACATGCGGATGACGCAGTTGAATTTATCTTTGCCTCGGTTCAAAG
TGCAAGAGAAGTATGACCTCCCAGGTCCATTGGAGCACATGGGGATGGTCGATGCTTTCAATCC
ACAGAAGGCTGATTTCTCTGGCATGAGCAGCACTAAAGGTCTAGTGGTGTCTAAAGTTTTACAC
AAATCCTTTTTGGAGGTAAATGAAGAGGGAGCTGAAGCTGCTGCTGCCACAGGGGTGGAAACCC
GCATACTATCTGCACCAAGGACCACAGAATTTACTTGTAATCGCCCTTTCATAGTCTTCATAAA
GCCAAACAACACCAACAGCATCCTCTTCTTTGGAAGAGTATCTTCCCCTTAAGGGTGGTGGCTC
TGCCACGTATCCAGAAAAGTTAACAACCTTGCTGTAGGTAATTGAGGCTGGGAACAGTTTTGCT
TGCCTCCTTTCCTGTCCCATCTCAGACTGCATTAGTTGAGGCAGGATAGCTCTACTATCTCTAT
TTTCTCCTTTCTTCTCTATATGTATATACAAACCTGGTTTCTGTCTGTAACCCTTCTCTGGGAA
AAAATGGTCAACAAAAATTGGGATATTTTAATATAGTTTCTTTTAATCTAACATGTATCTGTCA
ACTGCGTTAAGTGAAGTAGAGTAAACCATACCCTCTTTTTAAATTGATTAGCATAAAAATATAC
ATTCCTTTAGGAGAAACCTGGAAACTGCATAAGCTTTTACATGTTGTGATGTTACAAAATACAT
TTTCAATAAAATGATAATCTTTCCAACTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001382662	(Get FASTA)	NCBI Sequence Viewer
	XP_006249693	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAE51401	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003475
	ENSRNOP00000003475.4
	ENSRNOP00000046632.4

RefSeq Acc Id:	XP_006249693 ⟸ XM_006249631
- Peptide Label:	isoform X1
- UniProtKB:	F1MAA9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHLFAKATTQFTLELYRQLRDSEDNIFYSPLSIMTALAMLQLGAKGNTEKQIEKALQLSETTKK PKEKSADSHDEENVHEQFRKIMNQLNKSNGAYDLKSPNSIYGAKGFPFLQTFMEDIKKYYQANV ESLDFAHAAEESQKKINSWVENKTNGKIKDLFPRGSLNSSTILVLVNAVYFKGQWNHKFDEQRT REDKFWLNKNTSKPVQMMRQTNEFNFIFLEDVQAKMVEIPYKGKELSMFILLPMEIDGLKKLEE KLSADTLLAWTSPKNMRMTQLNLSLPRFKVQEKYDLPGPLEHMGMVDAFNPQKADFSGMSSTKG LVVSKVLHKSFLEVNEEGAEAAAATGVETRILSAPRTTEFTCNRPFIVFIKPNNTNSILFFGRV SSP hide sequence

Ensembl Acc Id:

ENSRNOP00000046632 ⟸ ENSRNOT00000040021

Ensembl Acc Id:

ENSRNOP00000003475 ⟸ ENSRNOT00000003475

RefSeq Acc Id:	NP_001382662 ⟸ NM_001395733
- UniProtKB:	F1MAA9 (UniProtKB/TrEMBL)

Protein Domains

SERPIN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1MAA9-F1-model_v2	AlphaFold	F1MAA9	1-326	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549766	AgrOrtholog
BioCyc Gene	G2FUF-18595	BioCyc
Ensembl Genes	ENSRNOG00000031134	Ensembl
	ENSRNOG00000066913	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000070387	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003475	ENTREZGENE
	ENSRNOT00000003475.6	UniProtKB/TrEMBL
	ENSRNOT00000040021.4	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/TrEMBL
InterPro	Protease_inhib_I4_serpin	UniProtKB/TrEMBL
	Protease_inhib_I4_serpin_CS	UniProtKB/TrEMBL
	Sepin_dom	UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/TrEMBL
NCBI Gene	304688	ENTREZGENE
PANTHER	Prot_inh_serpin	UniProtKB/TrEMBL
	SERPIN B4	UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/TrEMBL
PhenoGen	Serpinb3	PhenoGen
PROSITE	SERPIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000031134	RatGTEx
	ENSRNOG00000066913	RatGTEx
	ENSRNOG00000070387	RatGTEx
SMART	SERPIN	UniProtKB/TrEMBL
Superfamily-SCOP	Prot_inh_serpin	UniProtKB/TrEMBL
UniProt	D3ZJK2_RAT	UniProtKB/TrEMBL
	F1MAA9	ENTREZGENE, UniProtKB/TrEMBL
	Q6IE44_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Serpinb3	serpin family B member 3	Serpinb3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-07	Serpinb3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	Serpinb3	serine protease inhibitor B3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-15	Serpinb3	serine protease inhibitor B3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD