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Gene: Ccdc8 (coiled-coil domain containing 8 subunit of 3M complex) Rattus norvegicus
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Symbol:
Ccdc8
Name:
coiled-coil domain containing 8 subunit of 3M complex (Ensembl:coiled-coil domain containing 8)
RGD ID:
1359717
Description:
Predicted to be involved in microtubule cytoskeleton organization and regulation of mitotic nuclear division. Predicted to be located in centrosome and cytoplasm. Predicted to be part of 3M complex. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human CCDC8 (coiled-coil domain containing 8); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
coiled-coil domain containing 8; coiled-coil domain-containing protein 8; MGC72567; probable Coiled-coil domain-containing protein 8; similar to coiled-coil domain containing 8
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 86,807,607 - 86,810,935 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 1 86,806,942 - 86,814,204 (+) Ensembl GRCr8 mRatBN7.2 1 77,679,521 - 77,682,849 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 77,679,218 - 77,683,090 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 1 83,059,619 - 83,062,971 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 1 91,623,686 - 91,627,038 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 1 84,814,724 - 84,818,076 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 1 78,933,372 - 78,936,700 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 78,933,372 - 78,936,700 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 1 80,180,875 - 80,184,203 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 1 77,334,504 - 77,337,832 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 1 72,164,565 - 72,167,893 (+) NCBI Celera RGSC_v3.1 1 77,412,614 - 77,415,946 (+) NCBI Cytogenetic Map 1 q21 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Imported Disease Annotations - OMIM
Only show annotations with direct experimental evidence (0 objects hidden)
Ccdc8 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Ccdc8 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ccdc8 Rat 1,2-dichloroethane decreases expression ISO Ccdc8 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of CCDC8 mRNA CTD PMID:28960355 Ccdc8 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Ccdc8 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ccdc8 Rat 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CCDC8 mRNA CTD PMID:27291303 Ccdc8 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Ccdc8 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ccdc8 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CCDC8 mRNA CTD PMID:33387578 Ccdc8 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Ccdc8 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ccdc8 Rat acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of CCDC8 mRNA CTD PMID:28959563 Ccdc8 Rat acrylamide decreases expression ISO CCDC8 (Homo sapiens) 6480464 Acrylamide results in decreased expression of CCDC8 mRNA CTD PMID:32763439 Ccdc8 Rat antirheumatic drug increases expression ISO CCDC8 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of CCDC8 mRNA CTD PMID:24449571 Ccdc8 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CCDC8 mRNA CTD PMID:25181051 Ccdc8 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CCDC8 mRNA CTD PMID:34947998|PMID:41034487 Ccdc8 Rat bisphenol F increases expression ISO Ccdc8 (Mus musculus) 6480464 bisphenol F results in increased expression of CCDC8 mRNA CTD PMID:38685157 Ccdc8 Rat cadmium dichloride increases expression ISO CCDC8 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of CCDC8 mRNA CTD PMID:38568856 Ccdc8 Rat cadmium dichloride decreases expression ISO CCDC8 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of CCDC8 mRNA CTD PMID:38174414 Ccdc8 Rat cannabidiol decreases expression ISO CCDC8 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of CCDC8 mRNA CTD PMID:33244087 Ccdc8 Rat cantharidin decreases expression ISO Ccdc8 (Mus musculus) 6480464 Cantharidin results in decreased expression of CCDC8 mRNA CTD PMID:36907384 Ccdc8 Rat clothianidin increases expression ISO CCDC8 (Homo sapiens) 6480464 clothianidin results in increased expression of CCDC8 mRNA CTD PMID:31626844 Ccdc8 Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of CCDC8 mRNA CTD PMID:26577399 Ccdc8 Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of CCDC8 mRNA CTD PMID:23640034 Ccdc8 Rat dicrotophos increases expression ISO CCDC8 (Homo sapiens) 6480464 dicrotophos results in increased expression of CCDC8 mRNA CTD PMID:28302478 Ccdc8 Rat doxorubicin decreases expression ISO CCDC8 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of CCDC8 mRNA CTD PMID:29803840 Ccdc8 Rat formaldehyde decreases expression ISO CCDC8 (Homo sapiens) 6480464 Formaldehyde results in decreased expression of CCDC8 mRNA CTD PMID:20655997 Ccdc8 Rat FR900359 decreases phosphorylation ISO CCDC8 (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of CCDC8 protein CTD PMID:37730182 Ccdc8 Rat furan increases expression EXP 6480464 furan results in increased expression of CCDC8 mRNA CTD PMID:27387713 Ccdc8 Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of CCDC8 mRNA CTD PMID:33387578 Ccdc8 Rat hydroquinone decreases expression ISO CCDC8 (Homo sapiens) 6480464 hydroquinone results in decreased expression of CCDC8 mRNA CTD PMID:31256213 Ccdc8 Rat inulin multiple interactions ISO Ccdc8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CCDC8 mRNA CTD PMID:36331819 Ccdc8 Rat iron dichloride decreases expression ISO CCDC8 (Homo sapiens) 6480464 ferrous chloride results in decreased expression of CCDC8 mRNA CTD PMID:35984750 Ccdc8 Rat isoflurane decreases methylation ISO Ccdc8 (Mus musculus) 6480464 Isoflurane results in decreased methylation of CCDC8 mRNA CTD PMID:35249202 Ccdc8 Rat ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of CCDC8 mRNA CTD PMID:36653537 Ccdc8 Rat N-methyl-4-phenylpyridinium increases expression ISO CCDC8 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of CCDC8 mRNA CTD PMID:24810058 Ccdc8 Rat nickel atom decreases expression ISO CCDC8 (Homo sapiens) 6480464 Nickel results in decreased expression of CCDC8 mRNA CTD PMID:24768652|PMID:25583101 Ccdc8 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of CCDC8 mRNA CTD PMID:33387578 Ccdc8 Rat PCB138 multiple interactions ISO Ccdc8 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ccdc8 Rat perfluorohexanesulfonic acid increases expression ISO Ccdc8 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of CCDC8 mRNA CTD PMID:37995155 Ccdc8 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Ccdc8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CCDC8 mRNA CTD PMID:36331819 Ccdc8 Rat potassium chromate increases expression ISO CCDC8 (Homo sapiens) 6480464 potassium chromate(VI) results in increased expression of CCDC8 mRNA CTD PMID:22714537 Ccdc8 Rat sevoflurane decreases methylation ISO Ccdc8 (Mus musculus) 6480464 Sevoflurane results in decreased methylation of CCDC8 mRNA CTD PMID:35249202 Ccdc8 Rat silicon dioxide decreases expression ISO CCDC8 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of CCDC8 mRNA CTD PMID:25895662 Ccdc8 Rat sodium arsenite decreases expression ISO CCDC8 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of CCDC8 mRNA CTD PMID:29301061 Ccdc8 Rat sodium arsenite increases expression ISO Ccdc8 (Mus musculus) 6480464 sodium arsenite results in increased expression of CCDC8 mRNA CTD PMID:39515575 Ccdc8 Rat sodium dodecyl sulfate decreases expression ISO CCDC8 (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in decreased expression of CCDC8 mRNA CTD PMID:31734321 Ccdc8 Rat Soman increases expression EXP 6480464 Soman results in increased expression of CCDC8 mRNA CTD PMID:19281266 Ccdc8 Rat tamoxifen increases expression ISO Ccdc8 (Mus musculus) 6480464 Tamoxifen results in increased expression of CCDC8 mRNA CTD PMID:25123088 Ccdc8 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of CCDC8 mRNA CTD PMID:33387578 Ccdc8 Rat valproic acid increases expression ISO CCDC8 (Homo sapiens) 6480464 Valproic Acid results in increased expression of CCDC8 mRNA CTD PMID:23179753
QTLs in Region (GRCr8)
1331732 Srn4 Serum renin concentration QTL 4 4.467 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) 1 43457837 87558729 Rat 1578649 Bmd8 Bone mineral density QTL 8 4.9 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 1 51940904 101229020 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 51941022 208479811 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 39728272 132889942 Rat 4889929 Bss87 Bone structure and strength QTL 87 6.7 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) 1 46302615 91302615 Rat 1331792 Rf29 Renal function QTL 29 4.589 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) 1 43457837 87558729 Rat 2313062 Bmd73 Bone mineral density QTL 73 3.9 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 1 46302615 91302615 Rat 1578654 Bss10 Bone structure and strength QTL 10 4 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 1 51940904 168768703 Rat 8552900 Pigfal1 Plasma insulin-like growth factor 1 level QTL 1 7.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 43509952 88509952 Rat 1354643 Foco2 Food consumption QTL 2 7.17 0.0001 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) 1 42122968 87122968 Rat 2313065 Bss67 Bone structure and strength QTL 67 3.1 0.0001 tibia area (VT:1000281) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 7421628 Bp361 Blood pressure QTL 361 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 83019780 128019780 Rat 631495 Bp96 Blood pressure QTL 96 4.52 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 66404680 111404680 Rat 2313069 Bss68 Bone structure and strength QTL 68 2.9 0.0001 tibia size trait (VT:0100001) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 70225 Bp58 Blood pressure QTL 58 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34184556 172281316 Rat 2313075 Bss66 Bone structure and strength QTL 66 3.4 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 46302615 91302615 Rat 631512 Scl6 Serum cholesterol level QTL 6 9.6 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 1 81269860 99645535 Rat 2298545 Neuinf8 Neuroinflammation QTL 8 4.6 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 1 66009857 160501508 Rat 10059597 Bp377 Blood pressure QTL 377 3.42 0.025 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34565911 208798288 Rat 1331778 Rf28 Renal function QTL 28 4.66 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) 1 43457837 87558729 Rat 2313077 Bss69 Bone structure and strength QTL 69 3.5 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 1 46302615 91302615 Rat 1302788 Scl19 Serum cholesterol QTL 19 4.6 0.001 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 66400974 132889942 Rat 1549903 Bp267 Blood pressure QTL 267 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 84107164 115183752 Rat 2313402 Anxrr24 Anxiety related response QTL 24 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 1 51511344 153680016 Rat 1331785 Rf27 Renal function QTL 27 4.643 urine sodium amount (VT:0006274) urine sodium level (CMO:0000129) 1 30708375 87558729 Rat 61342 Bp27 Blood pressure QTL 27 3.4 0.0006 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 65405637 96805205 Rat 4889962 Bss94 Bone structure and strength QTL 94 3.8 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) 1 51909206 91302615 Rat 1358192 Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 3.4 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) 1 86622262 131622262 Rat 6903308 Scl36 Serum cholesterol QTL 36 2 0.0125 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 58769992 103769992 Rat 2300164 Bmd44 Bone mineral density QTL 44 5.4 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 1 66077886 111077886 Rat 2313092 Bmd72 Bone mineral density QTL 72 2.5 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 1 46302615 91302615 Rat 2313097 Bss70 Bone structure and strength QTL 70 3.5 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 9589820 Insglur3 Insulin/glucose ratio QTL 3 10.75 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 1 43509952 88509952 Rat 152025249 Scl82 Serum cholesterol level QTL 82 4.77 blood cholesterol amount (VT:0000180) 1 52891222 109116986 Rat 1354599 Bw29 Body weight QTL 29 3.46 0.001 body mass (VT:0001259) body weight (CMO:0000012) 1 42122968 87122968 Rat 4889919 Bss86 Bone structure and strength QTL 86 4.1 tibia area (VT:1000281) tibia midshaft total cross-sectional area (CMO:0001715) 1 46302615 91302615 Rat 8552948 Pigfal11 Plasma insulin-like growth factor 1 level QTL 11 4.7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 43509952 88509952 Rat
