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Gene: Oas2 (2'-5' oligoadenylate synthetase 2) Rattus norvegicus

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Symbol:

Oas2

Name:

2'-5' oligoadenylate synthetase 2

RGD ID:

1359697

Description:

Predicted to enable 2'-5'-oligoadenylate synthetase activity; ATP binding activity; and double-stranded RNA binding activity. Predicted to be involved in several processes, including innate immune response; interleukin-27-mediated signaling pathway; and positive regulation of cytokine production. Predicted to act upstream of or within RNA catabolic process and response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OAS2 (2'-5'-oligoadenylate synthetase 2); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

(2-5')oligo(A) synthase 2; 2 ' -5 ' oligoadenylate synthetase 2; 2' -5' oligoadenylate synthetase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,464,568 - 41,492,036 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,467,315 - 41,495,881 (+)	Ensembl				GRCr8
mRatBN7.2	12	35,802,824 - 35,830,778 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,806,759 - 35,829,371 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	36,986,622 - 37,009,090 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,597,840 - 37,620,309 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,650,302 - 36,672,772 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,341,417 - 41,363,124 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,340,815 - 41,363,161 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,198,845 - 43,220,552 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	37,468,525 - 37,491,086 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Human Influenza (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dimethoxyphenol (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amantadine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chenodeoxycholic acid (ISO)

chlorophyllin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

deoxycholic acid (ISO)

deoxynivalenol (ISO)

Dibutyl phosphate (ISO)

dichloroacetic acid (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

ferric oxide (ISO)

folic acid (ISO)

formaldehyde (ISO)

fructose (ISO)

furfural (ISO)

Genipin (ISO)

genistein (ISO)

glucose (ISO)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

GW 4064 (ISO)

hydroquinone (ISO)

lipopolysaccharide (ISO)

methamphetamine (ISO)

methyl methanesulfonate (ISO)

methylarsonic acid (ISO)

N-Acetyl-S-(1,2-dichlorovinyl)-cysteine (ISO)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (EXP)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

poly(I:C) (ISO)

propanal (ISO)

rac-lactic acid (ISO)

Ro 41-5253 (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

succimer (ISO)

tamibarotene (ISO)

temozolomide (ISO)

testosterone (EXP)

testosterone enanthate (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tofacitinib (ISO)

trichloroethene (EXP)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

trovafloxacin (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (IBA)

defense response to bacterium (IEA)

defense response to virus (IEA,ISO,ISS)

immune system process (IEA)

innate immune response (IEA)

interleukin-27-mediated signaling pathway (IBA,IEA,ISO)

negative regulation of viral genome replication (IBA)

positive regulation of interferon-beta production (IEA,ISO)

positive regulation of tumor necrosis factor production (IEA,ISO)

regulation of lactation (ISO,ISS)

response to bacterium (ISO)

response to virus (TAS)

RNA catabolic process (ISO)

type I interferon-mediated signaling pathway (IBA,ISO,ISS)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IBA)

membrane (IBA)

nucleoplasm (IBA)

perinuclear region of cytoplasm (IEA,ISO,ISS)

Molecular Function

2'-5'-oligoadenylate synthetase activity (IBA,IEA,ISO,ISS)

ATP binding (IEA,ISO,ISS)

double-stranded RNA binding (IBA,IEA,ISO,ISS)

metal ion binding (IEA)

nucleotide binding (IEA)

nucleotidyltransferase activity (IEA)

protein binding (ISO)

RNA binding (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.	Kakuta S, etal., J Interferon Cytokine Res 2002 Sep;22(9):981-93.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.	Perelygin AA, etal., J Mol Evol. 2006 Oct;63(4):562-76. Epub 2006 Oct 5.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9880569	PMID:10464285	PMID:11682059	PMID:15865429	PMID:19923450	PMID:19946888	PMID:23012479	PMID:29117179

Genomics

Comparative Map Data

Oas2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,464,568 - 41,492,036 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,467,315 - 41,495,881 (+)	Ensembl				GRCr8
mRatBN7.2	12	35,802,824 - 35,830,778 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,806,759 - 35,829,371 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	36,986,622 - 37,009,090 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,597,840 - 37,620,309 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,650,302 - 36,672,772 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,341,417 - 41,363,124 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,340,815 - 41,363,161 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,198,845 - 43,220,552 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	37,468,525 - 37,491,086 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

OAS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	112,978,519 - 113,011,723 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	112,978,395 - 113,011,723 (+)	Ensembl			hg38	GRCh38
GRCh37	12	113,416,324 - 113,449,528 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	111,900,657 - 111,933,911 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	111,879,114 - 111,911,741	NCBI
Celera	12	113,043,310 - 113,076,547 (+)	NCBI		Celera
Cytogenetic Map	12	q24.13	NCBI
HuRef	12	110,428,832 - 110,462,054 (+)	NCBI		HuRef
CHM1_1	12	113,384,631 - 113,417,877 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	112,955,143 - 112,988,347 (+)	NCBI		T2T-CHM13v2.0

Oas2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	120,868,398 - 120,887,949 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	120,868,398 - 120,887,918 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	120,730,333 - 120,749,886 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	120,730,333 - 120,749,853 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	121,180,342 - 121,199,857 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	120,990,951 - 121,010,405 (-)	NCBI		MGSCv36	mm8
Celera	5	117,816,435 - 117,836,109 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	60.64	NCBI

Oas2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	9,364,516 - 9,386,852 (+)	Ensembl
ChiLan1.0	NW_004955482	9,365,400 - 9,386,314 (+)	NCBI	ChiLan1.0	ChiLan1.0

OAS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	121,067,822 - 121,100,920 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	121,064,213 - 121,097,316 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1 Ensembl	12	113,968,061 - 114,001,209 (+)	Ensembl			panPan2	panpan1.1

OAS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	10,431,881 - 10,450,085 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	10,432,042 - 10,449,009 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	10,549,630 - 10,565,518 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	10,671,578 - 10,689,735 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	10,671,657 - 10,689,703 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	10,645,194 - 10,661,076 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	10,708,391 - 10,724,287 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	10,756,857 - 10,772,738 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

OAS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	38,827,660 - 38,860,820 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	38,827,667 - 38,847,697 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	41,196,297 - 41,208,970 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OAS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	108,218,645 - 108,251,485 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	108,218,665 - 108,252,836 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	136,834,580 - 136,867,628 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Oas2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	19,378,418 - 19,396,913 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	19,373,645 - 19,397,289 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Oas2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	33,071,658 - 33,094,622 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Oas2
102 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	41
Count of miRNA genes:	37
Interacting mature miRNAs:	37
Transcripts:	ENSRNOT00000072024
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	48	155	87	86	55	92	55	6	332	172	11	134	81	91	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY230746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000072024 ⟹ ENSRNOP00000066845

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,467,315 - 41,495,881 (+)	Ensembl
mRatBN7.2 Ensembl	12	35,806,759 - 35,829,371 (+)	Ensembl
Rnor_6.0 Ensembl	12	41,341,417 - 41,363,161 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077542 ⟹ ENSRNOP00000074985

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	41,340,815 - 41,361,522 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091460 ⟹ ENSRNOP00000073899

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	41,341,457 - 41,363,092 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000146981 ⟹ ENSRNOP00000103870

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,467,315 - 41,491,362 (+)	Ensembl

RefSeq Acc Id:

NM_001009715 ⟹ NP_001009715

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,467,370 - 41,489,936 (+)	NCBI
mRatBN7.2	12	35,806,759 - 35,829,334 (+)	NCBI
Rnor_6.0	12	41,341,417 - 41,363,124 (+)	NCBI
Rnor_5.0	12	43,198,845 - 43,220,552 (+)	NCBI
Celera	12	37,468,525 - 37,491,086 (+)	RGD

Sequence:

show sequence

AGTGCTCTGCCTCTGTCATTCACAAGCCCAGCTAGCAACTATGGGAAACTGGATGCCTGGCTGG
TCATCCAGTGGGTCTTTGGGGGTGCCCCCCATGCCAGTGCAGAAGCTAGAAAAGTCTGTCCAGG
TAAACCTTGAACCAGATGAAAAATGTCTGAGTCAGACCGAGGTGTCCTCTGTACCATCCCAGAA
GCTAGAAGAATATATCCAGGCAAACCTCAAACCCGATGAAGAATCTCTGAAGCAGATAGACCAG
GCTGTGGATGCCATCTCTGACCTGCTGTGCAGTGAGGTGATGATCGATGTGCTGAAAGTGGTTA
AGGGTGGCTCCTATGGTCGGAAAACAGTCCTAAGAGACTGCTCCGATGGTACACTTGTTCTCTT
CACCGGTCTCTTCAAACAGTTCCAAGACCAGAAGAAATACCAAGATAAGCTCCTTGACTTGATT
GAACAACGGCTGAAAAGCCATGAGAAATACAAGAAGTCAGTAAAACGTAAACTTAGCCTCCTTG
AAGTACAAGTGTCTATACCAGGGCAGAGTATACTCTTGCAGTTGCTTCCAACCTTCAATCCTCT
GTGCATCAGTGAGAATCCCAGCGCCCAGGTCTATCAGAATCTCAAAAGATCCATGGATCAAGTA
AAAGCATCACCTGGGGAATTCTCAGACTGCTTCACCACACTGCAGCAGAGGTTTTTCGAGAAAT
ATCCCGGGAGACTGAAGGATTTGATTCTATTGGTCAAGCACTGGTATAAACAGTTGCAGGATAA
GTGGATAATACCCTCACCTCCGCCATTGCTATATGCACTGGAGCTGCTTACTGTGTATGCCTGG
GAACAGGGCTGCCAGACTAAAGACTTTGACATCACGCAAGGTATCAGGACTGTGCTGCAACTCA
TCAGTCAGCCGACAAACCTGTGTGTCTACTGGTTAGACAATTACAACTTTGAGGATGAGACAGT
CCGGAACAACCTTCTGCACCAGCTCAACTCCCCAAGACCGGTCATCTTGGATCCAACCGACCCA
ACCAACAATGTGGGCAAAGATGACAGGTTCTGGCAGCTACTGGCAGAAGAGGCTCAGGAGTGGC
TGAACTCTCTCAGACTGAATAAGCCACACAAACCATGTTGGGATGTTCTGCCCATGCCATTTTT
CATCACCCCAAGCCACTGCCTGGACAAGTTCATCAAAGACTTCCTCCAACCTGACAAGGTCTTC
CTAAACCAAATCAAAAGAGCTGTTGACATTATCTGTTCATTCTTAAAAGAGACCTGCTTCCAGA
ATTCTGACATCAAAGTCCTGAAGATCATCAAGGGAGGATCCACTGCCAAAGGCACAGCTCTGCA
GCAGAGATCAGATGCTGACATCATAGTGTTCCTCAGCTCACTGGATAGTTATGACTCCCTAGAA
ACTGAACGCTCCCAGTACGTCCAGGAGATCCGAAAGCAGTTAGAAGCCTGCCAGAAGGCCTTTA
ATTTAGGGGTGAAGTTTGATATTTCCAAATGGATGGCCCCCAGGGTGCTGAGTTTTACCCTGGA
ATCCAAGAGTCTCAAGCAAAGTGTGGAGTTCGATGTCCTTCCCGCCTATGATGCACTAGGTCAG
CTGCGGTCTGACTACACCTCCAGGCTCAAAGCCTACAAGAAGCTCATTGAGCTGTATGCCTCAC
AGGACAGCCTCAAAGGAGGGGAGTTTTCAGTCTGTTTTACAGAGCTACAGAGAGACTTCATTGA
AACCAGGCCCACCAAACTCAAGGGTCTGATCCGCCTGATCAAGCACTGGTACAAACAGTGTGAA
AGGAAGATGAAGCCAAAAGCATCTTTGCCTCCAAAGTACGCACTGGAGCTGCTCACCGTGTATG
CGTGGGAGCATGGCAGTGGCACAGATGGCTTCGACACTGCTGAAGGCTTCCGGACCGTCCTGGA
CTTGGTCATAAGATACCGGCAGCTCTGCGTCTTCTGGACAGTCAATTACAACTTTGAGGAGGAT
CACATGAGGAAGTTCCTACTGACCCAGATCCAGAAAAAGAGGCCTGTGATCCTGGATCCAGCAG
ATCCCACAGGTGATGTGGGAGGAGGTGACCGCTGGTGTTGGCATCTTCTAGCCAAAGAAGCAAA
GGAGTGGCTGTCCTCCTCCTGTTTCCAAGTGGAGCCAAAAAGCCCCGTGCAGCCGTGGAAAGTA
CCAGTAGTACAGACTCCAGGAAGCTGTGGAGCTCAGATCTACCCTGTGGTGGGTGGGGTGTACT
AAGAGAGTGCATTCAGCTCTGGAGGGAAAATGCT

hide sequence

RefSeq Acc Id:

XM_039089648 ⟹ XP_038945576

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,467,556 - 41,492,036 (+)	NCBI
mRatBN7.2	12	35,806,945 - 35,830,778 (+)	NCBI

RefSeq Acc Id:

XR_005491653

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,464,568 - 41,492,036 (+)	NCBI
mRatBN7.2	12	35,802,824 - 35,830,778 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009715	(Get FASTA)	NCBI Sequence Viewer
	XP_038945576	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP57396	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000103870
GenBank Protein	Q5MYU0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001009715 ⟸ NM_001009715

- UniProtKB:

Q5MYU0 (UniProtKB/Swiss-Prot), M0RBB5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGNWMPGWSSSGSLGVPPMPVQKLEKSVQVNLEPDEKCLSQTEVSSVPSQKLEEYIQANLKPDE
ESLKQIDQAVDAISDLLCSEVMIDVLKVVKGGSYGRKTVLRDCSDGTLVLFTGLFKQFQDQKKY
QDKLLDLIEQRLKSHEKYKKSVKRKLSLLEVQVSIPGQSILLQLLPTFNPLCISENPSAQVYQN
LKRSMDQVKASPGEFSDCFTTLQQRFFEKYPGRLKDLILLVKHWYKQLQDKWIIPSPPPLLYAL
ELLTVYAWEQGCQTKDFDITQGIRTVLQLISQPTNLCVYWLDNYNFEDETVRNNLLHQLNSPRP
VILDPTDPTNNVGKDDRFWQLLAEEAQEWLNSLRLNKPHKPCWDVLPMPFFITPSHCLDKFIKD
FLQPDKVFLNQIKRAVDIICSFLKETCFQNSDIKVLKIIKGGSTAKGTALQQRSDADIIVFLSS
LDSYDSLETERSQYVQEIRKQLEACQKAFNLGVKFDISKWMAPRVLSFTLESKSLKQSVEFDVL
PAYDALGQLRSDYTSRLKAYKKLIELYASQDSLKGGEFSVCFTELQRDFIETRPTKLKGLIRLI
KHWYKQCERKMKPKASLPPKYALELLTVYAWEHGSGTDGFDTAEGFRTVLDLVIRYRQLCVFWT
VNYNFEEDHMRKFLLTQIQKKRPVILDPADPTGDVGGGDRWCWHLLAKEAKEWLSSSCFQVEPK
SPVQPWKVPVVQTPGSCGAQIYPVVGGVY

hide sequence

Ensembl Acc Id:

ENSRNOP00000074985 ⟸ ENSRNOT00000077542

Ensembl Acc Id:

ENSRNOP00000073899 ⟸ ENSRNOT00000091460

Ensembl Acc Id:

ENSRNOP00000066845 ⟸ ENSRNOT00000072024

RefSeq Acc Id:	XP_038945576 ⟸ XM_039089648
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000103870 ⟸ ENSRNOT00000146981

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5MYU0-F1-model_v2	AlphaFold	Q5MYU0	1-733	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698669

Promoter ID:

EPDNEW_R9189

Type:

single initiation site

Name:

Oas2_1

Description:

2'-5' oligoadenylate synthetase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	41,341,389 - 41,341,449	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359697	AgrOrtholog
BioCyc Gene	G2FUF-19189	BioCyc
Ensembl Genes	ENSRNOG00000049282	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000146981	ENTREZGENE
Gene3D-CATH	2'-5'-oligoadenylate synthetase 1, domain 2	UniProtKB/Swiss-Prot
	3.30.460.10	UniProtKB/Swiss-Prot
InterPro	2-5-oligoadenylate_synth_CS	UniProtKB/Swiss-Prot
	2-5-oligoadenylate_synth_N	UniProtKB/Swiss-Prot
	2-5-oligoAdlate_synth_1_dom2/C	UniProtKB/Swiss-Prot
	2-5OAS_N_CS	UniProtKB/Swiss-Prot
	NT_sf	UniProtKB/Swiss-Prot
	Polymerase_NTP_transf_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:363938	UniProtKB/Swiss-Prot
NCBI Gene	363938	ENTREZGENE
PANTHER	2'-5'-OLIGOADENYLATE SYNTHASE 2	UniProtKB/Swiss-Prot
	PTHR11258	UniProtKB/Swiss-Prot
Pfam	NTP_transf_2	UniProtKB/Swiss-Prot
	OAS1_C	UniProtKB/Swiss-Prot
PhenoGen	Oas2	PhenoGen
PROSITE	25A_SYNTH_1	UniProtKB/Swiss-Prot
	25A_SYNTH_2	UniProtKB/Swiss-Prot
	25A_SYNTH_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000049282	RatGTEx
Superfamily-SCOP	PAP/OAS1 substrate-binding domain	UniProtKB/Swiss-Prot
	SSF81301	UniProtKB/Swiss-Prot
UniProt	A0ABK0LRJ8_RAT	UniProtKB/TrEMBL
	M0RBB5	ENTREZGENE, UniProtKB/TrEMBL
	OAS2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-11-06	Oas2	2'-5' oligoadenylate synthetase 2	Oas2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Oas2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	Oas2	2' -5' oligoadenylate synthetase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Oas2	2' -5' oligoadenylate synthetase 2		2 ' -5 ' oligoadenylate synthetase 2	Name updated	1299863	APPROVED
2005-07-29	Oas2	2 ' -5 ' oligoadenylate synthetase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)