Oas2 (2'-5'-oligoadenylate synthetase 2) - Rat Genome Database

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Gene: Oas2 (2'-5'-oligoadenylate synthetase 2) Heterocephalus glaber
Analyze
Symbol: Oas2
Name: 2'-5'-oligoadenylate synthetase 2
RGD ID: 18904990
Description: ENCODES a protein that exhibits ATP binding (ortholog); INVOLVED IN interleukin-27-mediated signaling pathway (ortholog); positive regulation of interferon-beta production (ortholog); positive regulation of tumor necrosis factor production (ortholog); ASSOCIATED WITH Human Influenza (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 2'-5'-oligoadenylate synthase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,378,418 - 19,396,913 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,373,645 - 19,397,289 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Oas2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,378,418 - 19,396,913 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,373,645 - 19,397,289 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
OAS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,978,519 - 113,011,723 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,978,395 - 113,011,723 (+)EnsemblGRCh38hg38GRCh38
GRCh3712113,416,324 - 113,449,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,900,657 - 111,933,911 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412111,879,114 - 111,911,741NCBI
Celera12113,043,310 - 113,076,547 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,428,832 - 110,462,054 (+)NCBIHuRef
CHM1_112113,384,631 - 113,417,877 (+)NCBICHM1_1
T2T-CHM13v2.012112,955,143 - 112,988,347 (+)NCBIT2T-CHM13v2.0
Oas2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395120,868,398 - 120,887,949 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5120,868,398 - 120,887,918 (-)EnsemblGRCm39 Ensembl
GRCm385120,730,333 - 120,749,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,730,333 - 120,749,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,180,342 - 121,199,857 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365120,990,951 - 121,010,405 (-)NCBIMGSCv36mm8
Celera5117,816,435 - 117,836,109 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.64NCBI
Oas2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,464,568 - 41,492,036 (+)NCBIGRCr8
mRatBN7.21235,802,824 - 35,830,778 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,806,759 - 35,829,371 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,986,622 - 37,009,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,597,840 - 37,620,309 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,650,302 - 36,672,772 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,341,417 - 41,363,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,340,815 - 41,363,161 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,198,845 - 43,220,552 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1237,468,525 - 37,491,086 (+)NCBICelera
Cytogenetic Map12q16NCBI
Oas2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554829,364,516 - 9,386,852 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554829,365,400 - 9,386,314 (+)NCBIChiLan1.0ChiLan1.0
OAS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210121,067,822 - 121,100,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112121,064,213 - 121,097,316 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl12113,968,061 - 114,001,209 (+)Ensemblpanpan1.1panPan2
OAS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,431,881 - 10,450,085 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,432,042 - 10,449,009 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,549,630 - 10,565,518 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,671,578 - 10,689,735 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,671,657 - 10,689,703 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,645,194 - 10,661,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,708,391 - 10,724,287 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,756,857 - 10,772,738 (+)NCBIUU_Cfam_GSD_1.0
OAS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,827,660 - 38,860,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11438,827,667 - 38,847,697 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,196,297 - 41,208,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OAS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,218,645 - 108,251,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,218,665 - 108,252,836 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037136,834,580 - 136,867,628 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000022784   ⟹   ENSHGLP00000022570
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474719,378,418 - 19,396,913 (-)Ensembl
RefSeq Acc Id: XM_004843755   ⟹   XP_004843812
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474719,373,645 - 19,397,289 (-)NCBI
RefSeq Acc Id: XM_004843756   ⟹   XP_004843813
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474719,374,661 - 19,397,286 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004843812 (Get FASTA)   NCBI Sequence Viewer  
  XP_004843813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA97653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022570
GenBank Protein JAN97647 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004843812   ⟸   XM_004843755
- Peptide Label: isoform X1
- UniProtKB: A0A0P6IZY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843813   ⟸   XM_004843756
- Peptide Label: isoform X2
- UniProtKB: G5AKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000022570   ⟸   ENSHGLT00000022784


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016098 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000022784 ENTREZGENE
Gene3D-CATH 2'-5'-oligoadenylate synthetase 1, domain 2 UniProtKB/TrEMBL
  3.30.460.10 UniProtKB/TrEMBL
InterPro 2-5-oligoAdlate_synth_1_dom2/C UniProtKB/TrEMBL
  2-5OAS_C_CS UniProtKB/TrEMBL
  2-5OAS_N_CS UniProtKB/TrEMBL
  NT_2-5OAS_ClassI-CCAase UniProtKB/TrEMBL
  NT_sf UniProtKB/TrEMBL
  Polymerase_NTP_transf_dom UniProtKB/TrEMBL
NCBI Gene Oas2 ENTREZGENE
PANTHER 2'-5'-OLIGOADENYLATE SYNTHASE 2 UniProtKB/TrEMBL
  PTHR11258 UniProtKB/TrEMBL
Pfam NTP_transf_2 UniProtKB/TrEMBL
  OAS1_C UniProtKB/TrEMBL
PROSITE 25A_SYNTH_1 UniProtKB/TrEMBL
  25A_SYNTH_2 UniProtKB/TrEMBL
  25A_SYNTH_3 UniProtKB/TrEMBL
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/TrEMBL
  SSF81301 UniProtKB/TrEMBL
UniProt A0A0P6IZY1 ENTREZGENE, UniProtKB/TrEMBL
  G5AKW0 ENTREZGENE, UniProtKB/TrEMBL