Slc12a7 (solute carrier family 12 member 7) - Rat Genome Database

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Gene: Slc12a7 (solute carrier family 12 member 7) Rattus norvegicus
Analyze
Symbol: Slc12a7
Name: solute carrier family 12 member 7
RGD ID: 1359672
Description: Predicted to enable ammonium transmembrane transporter activity; potassium:chloride symporter activity; and protein kinase binding activity. Involved in cell volume homeostasis. Predicted to be located in membrane and synapse. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human SLC12A7 (solute carrier family 12 member 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: electroneutral potassium-chloride cotransporter 4; furosemide-sensitive KCl cotransporter 4; K-Cl cotransporter 4; K-Cl cotransporter KCC4; Kcc4; LOC308069; solute carrier family 12 (potassium/chloride transporter), member 7; solute carrier family 12 (potassium/chloride transporters), member 7; solute carrier family 12, member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,301,243 - 31,382,825 (-)NCBIGRCr8
mRatBN7.2129,472,692 - 29,554,246 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,472,692 - 29,554,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,273,827 - 29,327,212 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,273,677 - 35,327,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,474,455 - 29,527,840 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,086,755 - 32,167,950 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,086,755 - 32,141,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,511,432 - 33,592,624 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,281,826 - 30,334,183 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,283,750 - 30,337,129 (-)NCBI
Celera128,120,766 - 28,174,109 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-Hydroxypyrene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bumetanide  (ISO)
C60 fullerene  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furosemide  (ISO)
hydrogen cyanide  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
menadione  (ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichlormethiazide  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas. Davies SL, etal., Biochim Biophys Acta 2004 Nov 17;1667(1):7-14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12657561   PMID:16872584   PMID:18984587   PMID:19923415   PMID:19932740   PMID:23376777   PMID:24089410   PMID:24393035   PMID:28246125  


Genomics

Comparative Map Data
Slc12a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,301,243 - 31,382,825 (-)NCBIGRCr8
mRatBN7.2129,472,692 - 29,554,246 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,472,692 - 29,554,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,273,827 - 29,327,212 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,273,677 - 35,327,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,474,455 - 29,527,840 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,086,755 - 32,167,950 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,086,755 - 32,141,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,511,432 - 33,592,624 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,281,826 - 30,334,183 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,283,750 - 30,337,129 (-)NCBI
Celera128,120,766 - 28,174,109 (-)NCBICelera
Cytogenetic Map1p11NCBI
SLC12A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,050,384 - 1,155,899 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,050,384 - 1,112,063 (-)EnsemblGRCh38hg38GRCh38
GRCh3751,050,499 - 1,112,178 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,103,489 - 1,165,172 (-)NCBINCBI36Build 36hg18NCBI36
Build 3451,103,499 - 1,165,109NCBI
Celera51,087,603 - 1,137,533 (-)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,032,225 - 1,074,697 (-)NCBIHuRef
CHM1_151,050,309 - 1,109,639 (-)NCBICHM1_1
T2T-CHM13v2.05955,618 - 1,061,601 (-)NCBIT2T-CHM13v2.0
Slc12a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,881,172 - 73,964,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,881,213 - 73,964,873 (+)EnsemblGRCm39 Ensembl
GRCm381373,733,052 - 73,816,754 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,733,094 - 73,816,754 (+)EnsemblGRCm38mm10GRCm38
MGSCv371373,901,145 - 73,954,191 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,229,699 - 74,282,745 (+)NCBIMGSCv36mm8
Celera1376,093,026 - 76,146,073 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.15NCBI
Slc12a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504530,343 - 568,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955504529,183 - 589,728 (-)NCBIChiLan1.0ChiLan1.0
SLC12A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v241,297,648 - 1,358,631 (-)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl51,094,769 - 1,147,759 (-)Ensemblpanpan1.1panPan2
SLC12A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,411,521 - 11,442,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,411,626 - 11,440,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,916,047 - 15,953,273 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,306,873 - 11,344,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,278,297 - 11,369,935 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,357,510 - 11,394,729 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,337,208 - 11,374,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,548,126 - 11,585,343 (+)NCBIUU_Cfam_GSD_1.0
Slc12a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,468,120 - 244,505,057 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815636,184 - 665,019 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815629,185 - 666,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,357,010 - 79,396,656 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,356,868 - 79,396,652 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC12A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14890,213 - 989,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl4890,202 - 964,263 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,446,259 - 35,506,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624751506,040 - 544,365 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624751508,902 - 544,319 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc12a7
249 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:158
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000022635
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat

Markers in Region
D1Rat9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,521,493 - 29,521,616 (+)MAPPERmRatBN7.2
Rnor_6.0132,135,556 - 32,135,680NCBIRnor6.0
Rnor_5.0133,560,233 - 33,560,357UniSTSRnor5.0
RGSC_v3.4130,329,604 - 30,329,728UniSTSRGSC3.4
RGSC_v3.4130,329,603 - 30,329,728RGDRGSC3.4
RGSC_v3.1130,332,549 - 30,332,673RGD
Celera128,169,528 - 28,169,652UniSTS
RH 3.4 Map1347.42RGD
RH 3.4 Map1347.42UniSTS
RH 2.0 Map1221.4RGD
SHRSP x BN Map115.98RGD
FHH x ACI Map123.2999RGD
Cytogenetic Map1p11UniSTS
D1Cebr11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,515,545 - 29,515,709 (+)MAPPERmRatBN7.2
Rnor_6.0132,129,608 - 32,129,771NCBIRnor6.0
Rnor_5.0133,554,285 - 33,554,448UniSTSRnor5.0
RGSC_v3.4130,323,656 - 30,323,819UniSTSRGSC3.4
Celera128,163,580 - 28,163,743UniSTS
Cytogenetic Map1p11UniSTS
D1Cebr12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,506,202 - 29,506,405 (+)MAPPERmRatBN7.2
Rnor_6.0132,120,265 - 32,120,467NCBIRnor6.0
Rnor_5.0133,544,942 - 33,545,144UniSTSRnor5.0
RGSC_v3.4130,314,313 - 30,314,515UniSTSRGSC3.4
Celera128,154,237 - 28,154,439UniSTS
Cytogenetic Map1p11UniSTS
RH128389  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,472,942 - 29,473,135 (+)MAPPERmRatBN7.2
Rnor_6.0132,087,006 - 32,087,198NCBIRnor6.0
Rnor_5.0133,511,683 - 33,511,875UniSTSRnor5.0
RGSC_v3.4130,281,055 - 30,281,247UniSTSRGSC3.4
Celera128,121,017 - 28,121,209UniSTS
Cytogenetic Map1p11UniSTS
RH133369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,472,794 - 29,472,980 (+)MAPPERmRatBN7.2
Rnor_6.0132,086,858 - 32,087,043NCBIRnor6.0
Rnor_5.0133,511,535 - 33,511,720UniSTSRnor5.0
RGSC_v3.4130,280,907 - 30,281,092UniSTSRGSC3.4
Celera128,120,869 - 28,121,054UniSTS
Cytogenetic Map1p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 38 22 19 22 31 35 34 11
Low 19 19 19 8 11 43 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022635   ⟹   ENSRNOP00000022635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,472,692 - 29,526,073 (-)Ensembl
Rnor_6.0 Ensembl132,086,755 - 32,140,137 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078039   ⟹   ENSRNOP00000074714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,472,692 - 29,554,302 (-)Ensembl
Rnor_6.0 Ensembl132,088,259 - 32,141,036 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081339   ⟹   ENSRNOP00000071618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,472,694 - 29,526,072 (-)Ensembl
Rnor_6.0 Ensembl132,086,757 - 32,140,136 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112535   ⟹   ENSRNOP00000088698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,472,702 - 29,526,095 (-)Ensembl
RefSeq Acc Id: NM_001013144   ⟹   NP_001013162
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,301,243 - 31,354,625 (-)NCBI
mRatBN7.2129,472,692 - 29,526,073 (-)NCBI
Rnor_6.0132,086,755 - 32,140,137 (-)NCBI
Rnor_5.0133,511,432 - 33,592,624 (-)NCBI
Celera128,120,766 - 28,174,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227789   ⟹   XP_006227851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,301,243 - 31,382,825 (-)NCBI
mRatBN7.2129,472,692 - 29,554,245 (-)NCBI
Rnor_6.0132,086,755 - 32,167,950 (-)NCBI
Rnor_5.0133,511,432 - 33,592,624 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288386   ⟹   XP_063144456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,301,243 - 31,382,805 (-)NCBI
RefSeq Acc Id: XM_063288392   ⟹   XP_063144462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,301,243 - 31,354,918 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001013162   ⟸   NM_001013144
- UniProtKB: Q6TUA1 (UniProtKB/Swiss-Prot),   Q6T7Y5 (UniProtKB/Swiss-Prot),   Q6TUA2 (UniProtKB/Swiss-Prot),   Q5RK27 (UniProtKB/Swiss-Prot),   A6JUW3 (UniProtKB/TrEMBL),   A0A8L2QBZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227851   ⟸   XM_006227789
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K8S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074714   ⟸   ENSRNOT00000078039
RefSeq Acc Id: ENSRNOP00000071618   ⟸   ENSRNOT00000081339
RefSeq Acc Id: ENSRNOP00000022635   ⟸   ENSRNOT00000022635
RefSeq Acc Id: ENSRNOP00000088698   ⟸   ENSRNOT00000112535
RefSeq Acc Id: XP_063144456   ⟸   XM_063288386
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063144462   ⟸   XM_063288392
- Peptide Label: isoform X2
Protein Domains
Amino acid permease/ SLC12A   SLC12A transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RK27-F1-model_v2 AlphaFold Q5RK27 1-1083 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689565
Promoter ID:EPDNEW_R90
Type:initiation region
Name:Slc12a7_1
Description:solute carrier family 12 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0132,140,151 - 32,140,211EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359672 AgrOrtholog
BioCyc Gene G2FUF-61930 BioCyc
Ensembl Genes ENSRNOG00000016372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022635 ENTREZGENE
  ENSRNOT00000022635.8 UniProtKB/TrEMBL
  ENSRNOT00000078039.2 UniProtKB/TrEMBL
  ENSRNOT00000081339.2 UniProtKB/TrEMBL
  ENSRNOT00000112535.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCL_cotranspt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:308069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 308069 ENTREZGENE
PANTHER PTHR11827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11827:SF47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc12a7 PhenoGen
PRINTS KCLTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016372 RatGTEx
UniProt A0A0G2K0X6_RAT UniProtKB/TrEMBL
  A0A0G2K8S1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5L8_RAT UniProtKB/TrEMBL
  A0A8L2QBZ1 ENTREZGENE, UniProtKB/TrEMBL
  A6JUW3 ENTREZGENE, UniProtKB/TrEMBL
  Q5RK27 ENTREZGENE
  Q6T7Y5 ENTREZGENE
  Q6TUA1 ENTREZGENE
  Q6TUA2 ENTREZGENE
  S12A7_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6T7Y5 UniProtKB/Swiss-Prot
  Q6TUA1 UniProtKB/Swiss-Prot
  Q6TUA2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc12a7  solute carrier family 12 member 7  Slc12a7  solute carrier family 12 (potassium/chloride transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc12a7  solute carrier family 12 (potassium/chloride transporter), member 7  Slc12a7  solute carrier family 12 (potassium/chloride transporters), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc12a7  solute carrier family 12 (potassium/chloride transporters), member 7  Slc12a7  solute carrier family 12, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Slc12a7  solute carrier family 12, member 7  Slc12a7  solute carrier family 12 (potassium/chloride transporters), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Slc12a7  solute carrier family 12 (potassium/chloride transporters), member 7      Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC308069  K-Cl cotransporter KCC4      Symbol and Name status set to provisional 70820 PROVISIONAL