Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1) - Rat Genome Database

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Gene: Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1) Rattus norvegicus
Analyze
Symbol: Ndufs1
Name: NADH:ubiquinone oxidoreductase core subunit S1
RGD ID: 1359670
Description: Predicted to enable electron transfer activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93795; NADH dehydrogenase (ubiquinone) Fe-S protein 1; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,040,286 - 72,073,605 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl972,040,090 - 72,073,605 (-)EnsemblGRCr8
mRatBN7.2964,546,430 - 64,579,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl964,546,225 - 64,579,893 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx973,049,877 - 73,083,200 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0978,170,168 - 78,204,120 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0976,476,771 - 76,510,751 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0969,919,863 - 69,953,182 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl969,919,867 - 69,953,182 (-)Ensemblrn6Rnor6.0
Rnor_5.0969,728,932 - 69,762,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4961,798,141 - 61,831,964 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera961,964,379 - 61,997,783 (-)NCBICelera
RGSC_v3.1961,945,124 - 61,978,946 (-)NCBI
Cytogenetic Map9q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R,R)-tramadol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
chlorpyrifos  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
dihydroxyacetone  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
dopamine  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furfural  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
genistein  (EXP)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lamivudine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nobiletin  (ISO)
ochratoxin A  (ISO)
osimertinib  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
Propiverine  (EXP)
Pseudolaric acid B  (ISO)
pyrroloquinoline quinone  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tapentadol  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tramadol  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Large-scale deletion and point mutations of the nuclear NDUFV1 and NDUFS1 genes in mitochondrial complex I deficiency. Benit P, etal., Am J Hum Genet 2001 Jun;68(6):1344-52. Epub 2001 May 7.
2. Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model. Danielson SR, etal., J Biol Chem. 2011 Mar 4;286(9):7601-8. Epub 2011 Jan 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models. Kelly-Aubert M, etal., Hum Mol Genet. 2011 Jul 15;20(14):2745-59. Epub 2011 Apr 25.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. Shinmura K, etal., Circ Res. 2011 Aug 5;109(4):396-406. doi: 10.1161/CIRCRESAHA.111.243097. Epub 2011 Jun 23.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12611891   PMID:14651853   PMID:15186778   PMID:15489334   PMID:15824269   PMID:16478720   PMID:16870178   PMID:17634366   PMID:18614015   PMID:18973802   PMID:19429081   PMID:21752959  
PMID:23106098   PMID:25002582   PMID:26316108   PMID:29476059   PMID:29867124   PMID:36402252  


Genomics

Comparative Map Data
Ndufs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,040,286 - 72,073,605 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl972,040,090 - 72,073,605 (-)EnsemblGRCr8
mRatBN7.2964,546,430 - 64,579,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl964,546,225 - 64,579,893 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx973,049,877 - 73,083,200 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0978,170,168 - 78,204,120 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0976,476,771 - 76,510,751 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0969,919,863 - 69,953,182 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl969,919,867 - 69,953,182 (-)Ensemblrn6Rnor6.0
Rnor_5.0969,728,932 - 69,762,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4961,798,141 - 61,831,964 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera961,964,379 - 61,997,783 (-)NCBICelera
RGSC_v3.1961,945,124 - 61,978,946 (-)NCBI
Cytogenetic Map9q32NCBI
NDUFS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382206,114,817 - 206,159,444 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2206,114,817 - 206,159,522 (-)Ensemblhg38GRCh38
GRCh372206,979,541 - 207,024,168 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362206,696,048 - 206,732,432 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342206,813,308 - 206,849,693NCBI
Celera2200,745,218 - 200,781,616 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2198,836,332 - 198,872,823 (-)NCBIHuRef
CHM1_12206,994,334 - 207,030,799 (-)NCBICHM1_1
T2T-CHM13v2.02206,596,710 - 206,641,337 (-)NCBIT2T-CHM13v2.0
Ndufs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,182,751 - 63,215,981 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,182,755 - 63,215,992 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38163,143,592 - 63,176,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl163,143,596 - 63,176,833 (-)Ensemblmm10GRCm38
MGSCv37163,190,166 - 63,223,396 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36163,077,874 - 63,110,985 (-)NCBIMGSCv36mm8
Celera163,653,959 - 63,687,212 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.29NCBI
Ndufs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554578,838,216 - 8,883,481 (+)Ensembl
ChiLan1.0NW_0049554578,838,216 - 8,879,059 (+)NCBIChiLan1.0ChiLan1.0
NDUFS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213108,735,668 - 108,773,190 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B108,751,932 - 108,788,172 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B93,363,092 - 93,399,326 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B211,493,021 - 211,528,496 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B211,493,021 - 211,528,496 (-)EnsemblpanPan2panpan1.1
NDUFS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13714,680,908 - 14,713,838 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3714,683,083 - 14,713,754 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3715,557,654 - 15,590,612 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03714,616,264 - 14,649,231 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3714,616,260 - 14,649,178 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13714,570,542 - 14,603,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03714,542,759 - 14,575,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03714,539,074 - 14,572,034 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ndufs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303162,868,082 - 162,903,922 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366312,499,062 - 2,538,801 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366312,503,353 - 2,538,957 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15109,409,771 - 109,451,676 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115109,413,726 - 109,451,813 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215120,962,189 - 121,000,375 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11091,893,337 - 91,927,559 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1091,893,616 - 91,927,592 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040107,451,554 - 107,485,782 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247659,962,447 - 9,993,790 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247659,962,254 - 9,993,790 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ndufs1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14137,131,240 - 137,164,898 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ndufs1
201 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:50
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000015852
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
1578659Tspe1Trichinella spiralis expulsion QTL 14.8parasite quantity (VT:0010441)logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)96887549773185088Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH134359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2964,546,412 - 64,546,625 (+)MAPPERmRatBN7.2
Rnor_6.0969,919,846 - 69,920,058NCBIRnor6.0
Rnor_5.0969,728,915 - 69,729,127UniSTSRnor5.0
RGSC_v3.4961,798,124 - 61,798,336UniSTSRGSC3.4
Celera961,964,362 - 61,964,574UniSTS
RH 3.4 Map9530.1UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015852   ⟹   ENSRNOP00000015851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl964,546,225 - 64,579,809 (-)Ensembl
Rnor_6.0 Ensembl969,919,867 - 69,953,182 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098172   ⟹   ENSRNOP00000083908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl972,040,090 - 72,068,983 (-)Ensembl
mRatBN7.2 Ensembl964,546,225 - 64,575,129 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104288   ⟹   ENSRNOP00000087012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl972,040,090 - 72,073,605 (-)Ensembl
mRatBN7.2 Ensembl964,546,243 - 64,579,893 (-)Ensembl
RefSeq Acc Id: NM_001005550   ⟹   NP_001005550
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,040,286 - 72,073,605 (-)NCBI
mRatBN7.2964,546,430 - 64,579,751 (-)NCBI
Rnor_6.0969,919,863 - 69,953,182 (-)NCBI
Rnor_5.0969,728,932 - 69,762,079 (-)NCBI
RGSC_v3.4961,798,141 - 61,831,964 (-)RGD
Celera961,964,379 - 61,997,783 (-)RGD
Sequence:
RefSeq Acc Id: NP_001005550   ⟸   NM_001005550
- Peptide Label: precursor
- UniProtKB: Q66HF1 (UniProtKB/Swiss-Prot),   A6IPF8 (UniProtKB/TrEMBL),   A0A8I5ZXM3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015851   ⟸   ENSRNOT00000015852
Ensembl Acc Id: ENSRNOP00000083908   ⟸   ENSRNOT00000098172
Ensembl Acc Id: ENSRNOP00000087012   ⟸   ENSRNOT00000104288
Protein Domains
2Fe-2S ferredoxin-type   4Fe-4S His(Cys)3-ligated-type   4Fe-4S Mo/W bis-MGD-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HF1-F1-model_v2 AlphaFold Q66HF1 1-727 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696710
Promoter ID:EPDNEW_R7235
Type:multiple initiation site
Name:Ndufs1_1
Description:NADH:ubiquinone oxidoreductase core subunit S1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0969,953,221 - 69,953,281EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359670 AgrOrtholog
BioCyc Gene G2FUF-27353 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
Ensembl Genes ENSRNOG00000011849 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000104288 ENTREZGENE
  ENSRNOT00000104288.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.740 UniProtKB/Swiss-Prot
  3.30.200.210 UniProtKB/Swiss-Prot
  3.30.70.20 UniProtKB/Swiss-Prot
  3.40.50.740 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109875 IMAGE-MGC_LOAD
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot
  Mopterin_OxRdtase UniProtKB/Swiss-Prot
  Mopterin_OxRdtase_4Fe-4S_dom UniProtKB/Swiss-Prot
  NADH_UbQ_OxRdtase_75kDa_su_CS UniProtKB/Swiss-Prot
  NADH_UbQ_OxRdtase_ferredoxin UniProtKB/Swiss-Prot
  NADH_UbQ_OxRdtase_Gsu UniProtKB/Swiss-Prot
  NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd UniProtKB/Swiss-Prot
  NuoG_C UniProtKB/Swiss-Prot
  Prok_molybdopt-oxidoreductase UniProtKB/Swiss-Prot
KEGG Report rno:301458 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93795 IMAGE-MGC_LOAD
NCBI Gene 301458 ENTREZGENE
PANTHER NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot
  RESPIRATORY NITRATE REDUCTASE UniProtKB/Swiss-Prot
Pfam Fer2_4 UniProtKB/Swiss-Prot
  Molybdopterin UniProtKB/Swiss-Prot
  NADH-G_4Fe-4S_3 UniProtKB/Swiss-Prot
  NADH_dhqG_C UniProtKB/Swiss-Prot
  NDSU1_4Fe-4S UniProtKB/Swiss-Prot
  Nqo3_Fer4 UniProtKB/Swiss-Prot
PhenoGen Ndufs1 PhenoGen
PROSITE 2FE2S_FER_2 UniProtKB/Swiss-Prot
  4FE4S_HC3 UniProtKB/Swiss-Prot
  4FE4S_MOW_BIS_MGD UniProtKB/Swiss-Prot
  COMPLEX1_75K_1 UniProtKB/Swiss-Prot
  COMPLEX1_75K_2 UniProtKB/Swiss-Prot
  COMPLEX1_75K_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011849 RatGTEx
SMART NADH-G_4Fe-4S_3 UniProtKB/Swiss-Prot
Superfamily-SCOP 4Fe-4S ferredoxins UniProtKB/Swiss-Prot
  Formate dehydrogenase/DMSO reductase, domains 1-3 UniProtKB/Swiss-Prot
  SSF54292 UniProtKB/Swiss-Prot
UniProt A0A8I5ZXM3 ENTREZGENE, UniProtKB/TrEMBL
  A6IPF5_RAT UniProtKB/TrEMBL
  A6IPF8 ENTREZGENE, UniProtKB/TrEMBL
  NDUS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Ndufs1  NADH:ubiquinone oxidoreductase core subunit S1  Ndufs1  NADH dehydrogenase (ubiquinone) Fe-S protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ndufs1  NADH dehydrogenase (ubiquinone) Fe-S protein 1    NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa  Name updated 1299863 APPROVED
2005-07-29 Ndufs1  NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa      Symbol and Name status set to provisional 70820 PROVISIONAL