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Gene: Tinag (tubulointerstitial nephritis antigen) Rattus norvegicus

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Symbol:

Tinag

Name:

tubulointerstitial nephritis antigen

RGD ID:

1359482

Description:

Predicted to enable cysteine-type peptidase activity. Predicted to be involved in cell adhesion. Predicted to be located in basement membrane. Predicted to be active in extracellular space and lysosome. Orthologous to human TINAG (tubulointerstitial nephritis antigen); INTERACTS WITH 2,2,2-tetramine; 3-chloropropane-1,2-diol; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC93772

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TINAG (tubulointerstitial nephritis antigen)	HGNC	Ensembl, HomoloGene, NCBI
Mus musculus (house mouse):	Tinag (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tinag (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TINAG (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TINAG (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tinag (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TINAG (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TINAG (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tinag (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tinag (tubulointerstitial nephritis antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TINAG (tubulointerstitial nephritis antigen)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tinag (tubulointerstitial nephritis antigen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tinagl1 (tubulointerstitial nephritis antigen-like 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	tinagl1 (tubulointerstitial nephritis antigen-like 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F26E4.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F26E4.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Swim	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Swim	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tinagl1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	86,680,441 - 86,765,485 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	86,680,442 - 86,765,485 (-)	Ensembl				GRCr8
mRatBN7.2	8	77,800,031 - 77,885,077 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	77,800,032 - 77,885,077 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	83,276,974 - 83,362,057 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	81,553,612 - 81,638,691 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	79,376,319 - 79,461,402 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	84,122,113 - 84,320,714 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	84,279,229 - 84,320,746 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	83,701,248 - 83,707,015 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	8	83,850,917 - 83,892,349 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	81,947,234 - 82,032,994 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	77,559,246 - 77,643,998 (-)	NCBI		Celera
RGSC_v3.1	8	81,966,287 - 82,052,047 (+)	NCBI
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Diabetic Nephropathies (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2,2-tetramine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-amino-2-deoxy-D-glucopyranose (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

amiodarone (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

beta-D-glucosamine (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

cidofovir anhydrous (ISO)

ciguatoxin CTX1B (ISO)

cyclosporin A (ISO)

dibenzofurans (ISO)

dioxygen (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (ISO)

ozone (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

rotenone (EXP)

sodium arsenite (ISO)

streptozocin (EXP)

sulforaphane (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

vincristine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA,ISO)

proteolysis (IEA)

Cellular Component

basement membrane (IEA,ISO)

extracellular region (IEA)

extracellular space (IBA)

lysosome (IBA)

Molecular Function

cysteine-type peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Tubulointerstitial nephritis antigen: an extracellular matrix protein that selectively regulates tubulogenesis vs. glomerulogenesis during mammalian renal development.	Kanwar YS, etal., Proc Natl Acad Sci U S A 1999 Sep 28;96(20):11323-8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:1762287	PMID:8770961

Genomics

Comparative Map Data

Tinag
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	86,680,441 - 86,765,485 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	86,680,442 - 86,765,485 (-)	Ensembl				GRCr8
mRatBN7.2	8	77,800,031 - 77,885,077 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	77,800,032 - 77,885,077 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	83,276,974 - 83,362,057 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	81,553,612 - 81,638,691 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	79,376,319 - 79,461,402 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	84,122,113 - 84,320,714 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	84,279,229 - 84,320,746 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	83,701,248 - 83,707,015 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	8	83,850,917 - 83,892,349 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	81,947,234 - 82,032,994 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	77,559,246 - 77,643,998 (-)	NCBI		Celera
RGSC_v3.1	8	81,966,287 - 82,052,047 (+)	NCBI
Cytogenetic Map	8	q24	NCBI

TINAG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	54,307,862 - 54,390,142 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	54,307,859 - 54,390,142 (+)	Ensembl			hg38	GRCh38
GRCh37	6	54,173,239 - 54,254,940 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	54,281,162 - 54,362,872 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	54,281,161 - 54,362,870	NCBI
Celera	6	55,835,406 - 55,917,161 (+)	NCBI		Celera
Cytogenetic Map	6	p12.1	NCBI
HuRef	6	54,006,797 - 54,088,545 (+)	NCBI		HuRef
CHM1_1	6	54,169,072 - 54,250,812 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	54,147,922 - 54,230,307 (+)	NCBI		T2T-CHM13v2.0

Tinag
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	76,858,980 - 76,953,084 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	76,858,975 - 76,953,076 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	76,951,698 - 77,045,802 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	76,951,693 - 77,045,794 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	76,799,505 - 76,893,588 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	76,737,607 - 76,831,635 (-)	NCBI		MGSCv36	mm8
Celera	9	74,124,104 - 74,218,134 (-)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	42.67	NCBI

Tinag
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	1,717,026 - 1,810,055 (-)	Ensembl
ChiLan1.0	NW_004955411	1,718,969 - 1,809,370 (-)	NCBI	ChiLan1.0	ChiLan1.0

TINAG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	68,780,315 - 68,862,227 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	64,656,891 - 64,738,823 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	53,861,919 - 53,945,740 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	55,499,195 - 55,581,273 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	55,499,752 - 55,581,273 (+)	Ensembl			panPan2	panpan1.1

TINAG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	21,787,042 - 21,879,867 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	21,786,669 - 21,879,091 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	21,678,221 - 21,770,538 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	22,290,935 - 22,384,182 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	22,291,568 - 22,383,681 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	21,776,256 - 21,868,361 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	21,892,394 - 21,984,392 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	22,024,071 - 22,116,481 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tinag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	57,282,207 - 57,355,074 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	6,605,128 - 6,677,995 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	6,605,128 - 6,677,995 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TINAG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	26,446,306 - 26,522,965 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	26,448,612 - 26,522,993 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	30,958,003 - 31,030,257 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TINAG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	17,130,641 - 17,214,277 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	17,130,385 - 17,213,903 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666058	23,306,834 - 23,391,078 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tinag
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624850	1,653,926 - 1,766,839 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624850	1,653,926 - 1,766,591 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tinag
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	71,217,446 - 71,303,425 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tinag
606 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	58991697	91341052	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	58991697	91341052	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	58991697	91341052	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat

Markers in Region

D8Got119

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	77,809,975 - 77,810,186 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	84,132,057 - 84,132,267	NCBI	Rnor6.0
Rnor_5.0	8	83,711,192 - 83,711,402	UniSTS	Rnor5.0
RGSC_v3.4	8	82,022,839 - 82,023,050	RGD	RGSC3.4
RGSC_v3.4	8	82,022,840 - 82,023,050	UniSTS	RGSC3.4
Celera	8	77,568,996 - 77,569,203	UniSTS
RGSC_v3.1	8	82,041,893 - 82,042,104	RGD
RH 3.4 Map	8	916.5	UniSTS
RH 3.4 Map	8	916.5	RGD
RH 2.0 Map	8	738.6	RGD
Cytogenetic Map	8	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	58	62	30	30	11	17	11	2	206	92	4	57	79	56	19	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000079356 ⟹ ENSRNOP00000071497

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	77,800,230 - 77,885,077 (-)	Ensembl
Rnor_6.0 Ensembl	8	84,279,283 - 84,320,714 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088487 ⟹ ENSRNOP00000075369

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	86,680,442 - 86,765,485 (-)	Ensembl
mRatBN7.2 Ensembl	8	77,800,032 - 77,885,077 (-)	Ensembl
Rnor_6.0 Ensembl	8	84,279,229 - 84,320,746 (-)	Ensembl

RefSeq Acc Id:

NM_001005549 ⟹ NP_001005549

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	86,680,441 - 86,765,485 (-)	NCBI
mRatBN7.2	8	77,800,031 - 77,885,077 (-)	NCBI
Rnor_6.0	8	84,122,113 - 84,320,714 (-)	NCBI
Rnor_5.0	8	83,701,248 - 83,707,015 (-)	NCBI
Rnor_5.0	8	83,850,917 - 83,892,349 (-)	NCBI
RGSC_v3.4	8	81,947,234 - 82,032,994 (+)	RGD
Celera	8	77,559,246 - 77,643,998 (-)	RGD

Sequence:

show sequence

CGACGAAAAGAATTGGGTATAGCTGAAGGAGGAAGCTGAACTGACAACCAGAGAATGTGGATCG
GATATAAGATCTTAATCTTCTTCTCTCTGATGACAGAAATCTGTGCAGGAACTCATTATTTATC
AGGAGGAGAAGTGGATCCAGGGCTGAGTTTCACTAGAAACCACACCAGTTTTGAAGGTACTCGG
CACAAAAGAGCCATTTTCCAAGGGGAATACTGTAGGCGCTTTGGCTGCTGTGAAGCCAGAGATG
ACACCTGTGTCACTCAGTTCTATGAGGCCAATGCATTGTGCTACTGTGACAGCTTCTGTGAGCG
GGACACCTCTGATTGCTGTCCTGATTACAAGTCATTCTGCCGTGAAGGAAAAGATGGGCCTCCT
CTCCAACAGCCTTTAGACCCGGAAGGTTGCTCCAGAGATAGTCAACATTATGAAGAAGGATCAG
TGATTAAAGAAAACTGCAACTTTTGTACATGTTCAGGACAACAATGGAAATGTTCCCAACATGT
TTGCCTTGTTCTTCCAGAATTAATTGATCACATCAATAAAGGAGACTACGGATGGACAGCACAG
AACTACAGCCAATTCTGGGGAATGACCTTAGAAGAAGGATTCAAATTTCGCCTTGGCACCTTGC
CACCTAGTCCCATGCTTCTGAGCATGAATGAAATGACAGCATCTTATCCCAGAGCTGATCTTCC
TGAGGTTTTCATTGCTTCTTATAAGTGGCCTGGATGGACTCATGGTCCACTGGATCAAAAGAAC
TGTGCTGCATCCTGGGCTTTTTCTACCGCAAGTGTAGCAGCTGACCGAATTGCAATTCAGTCCA
AGGGTCGATACACAGCCAACCTCTCCCCTCAGAATTTGATCTCCTGTTGTGCAAAGAACCGTCA
TGGATGCAACAGTGGAAGCATAGATAGGGCCTGGTGGTTCCTGAGAAAACGTGGACTGGTATCT
CATGCATGCTACCCACTTTTCAAGGAACAAAGCACTAACAATAATAGCTGTGCTATGGCCAGCA
GATCAGATGGGCGGGGGAAACGGCATGCCACAAGGCCGTGTCCCAACAGCTTCGAGAAATCCAA
CAGGATTTATCAGTGTTCTCCTCCATACAGAATCTCTTCCAATGAAACTGAAATCATGAGAGAA
ATCATACAAAATGGACCAGTTCAAGCCATAATGCAGGTCCATGAAGATTTCTTCTATTATAAGA
CAGGAATATACAGACATGTTGTCAGCACAAATGAAGAACCAGAAAAGTACAGAAAACTTCGGAC
ACATGCAGTTAAACTCACTGGATGGGGCACACTGAGAGGAGCACAAGGGAAGAAAGAAAAATTT
TGGATTGCTGCCAATTCCTGGGGAAAGTCATGGGGAGAGAATGGCTATTTTAGGATTCTTCGAG
GAGTAAATGAATCTGACATTGAAAAATTGATTATCGCAGCATGGGGGCAACTGACAAGTTCAGA
TGATCCATAGCTATCACATTTCCATAAGGTCATGCATTTAAGTAACTCATTAAATTGAATTTTA
GCAATCAAAGATTCTCTGTGCCAGGGGAAGTGTTGTATTTTTGCTGCATGCATAGAGCATTCCT
GTTTTCTTGGTTTACTCCAGGCTTTATCTGTTCTCTTTATATTATTAAAATACTAATAAAAGGA
AGAATGACTGAATGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001005549	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81887	(Get FASTA)	NCBI Sequence Viewer
	EDL77770	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075369
	ENSRNOP00000075369.2

RefSeq Acc Id:	NP_001005549 ⟸ NM_001005549
- Peptide Label:	precursor
- UniProtKB:	Q66HF6 (UniProtKB/TrEMBL), A0A0G2KAE5 (UniProtKB/TrEMBL), A0A9K3Y6P4 (UniProtKB/TrEMBL), A0A0G2K0L8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWIGYKILIFFSLMTEICAGTHYLSGGEVDPGLSFTRNHTSFEGTRHKRAIFQGEYCRRFGCCE ARDDTCVTQFYEANALCYCDSFCERDTSDCCPDYKSFCREGKDGPPLQQPLDPEGCSRDSQHYE EGSVIKENCNFCTCSGQQWKCSQHVCLVLPELIDHINKGDYGWTAQNYSQFWGMTLEEGFKFRL GTLPPSPMLLSMNEMTASYPRADLPEVFIASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIA IQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWFLRKRGLVSHACYPLFKEQSTNNNSCA MASRSDGRGKRHATRPCPNSFEKSNRIYQCSPPYRISSNETEIMREIIQNGPVQAIMQVHEDFF YYKTGIYRHVVSTNEEPEKYRKLRTHAVKLTGWGTLRGAQGKKEKFWIAANSWGKSWGENGYFR ILRGVNESDIEKLIIAAWGQLTSSDDP hide sequence

Ensembl Acc Id:

ENSRNOP00000071497 ⟸ ENSRNOT00000079356

Ensembl Acc Id:

ENSRNOP00000075369 ⟸ ENSRNOT00000088487

Protein Domains

SMB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2KAE5-F1-model_v2	AlphaFold	A0A0G2KAE5	1-431	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696141

Promoter ID:

EPDNEW_R6659

Type:

single initiation site

Name:

Tinag_1

Description:

tubulointerstitial nephritis antigen

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	84,320,764 - 84,320,824	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359482	AgrOrtholog
BioCyc Gene	G2FUF-29796	BioCyc
Ensembl Genes	ENSRNOG00000058120	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000088487	ENTREZGENE
	ENSRNOT00000088487.3	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine proteinases	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7109073	IMAGE-MGC_LOAD
InterPro	Papain_like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_asp_AS	UniProtKB/TrEMBL
	Peptidase_C1A	UniProtKB/TrEMBL
	Peptidase_C1A_C	UniProtKB/TrEMBL
	Somatomedin_B	UniProtKB/TrEMBL
KEGG Report	rno:300846	UniProtKB/TrEMBL
MGC_CLONE	MGC:93772	IMAGE-MGC_LOAD
NCBI Gene	300846	ENTREZGENE
PANTHER	CYSTEINE PROTEASE FAMILY C1-RELATED	UniProtKB/TrEMBL
Pfam	Peptidase_C1	UniProtKB/TrEMBL
PhenoGen	Tinag	PhenoGen
PROSITE	SMB_1	UniProtKB/TrEMBL
	SMB_2	UniProtKB/TrEMBL
	THIOL_PROTEASE_ASN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058120	RatGTEx
SMART	Pept_C1	UniProtKB/TrEMBL
	SM00201	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	A0A0G2K0L8	ENTREZGENE
	A0A0G2KAE5	ENTREZGENE
	A0A9K3Y6P4	ENTREZGENE, UniProtKB/TrEMBL
	Q66HF6	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A0G2KAE5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Tinag	tubulointerstitial nephritis antigen			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Tinag	tubulointerstitial nephritis antigen			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD