Cenpq (centromere protein Q) - Rat Genome Database

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Pathways
Gene: Cenpq (centromere protein Q) Rattus norvegicus
Analyze
Symbol: Cenpq
Name: centromere protein Q
RGD ID: 1359451
Description: Predicted to be involved in metaphase chromosome alignment and positive regulation of protein localization to kinetochore. Predicted to be located in chromosome, centromeric region. Predicted to be part of inner kinetochore. Predicted to be active in nucleus. Orthologous to human CENPQ (centromere protein Q); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CENP-Q; centromere protein Q-like; LOC363198; similar to 2610528M18Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,454,339 - 27,469,371 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl927,454,252 - 27,469,366 (+)EnsemblGRCr8
mRatBN7.2919,957,122 - 19,972,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl919,957,048 - 19,972,789 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx928,528,381 - 28,544,024 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0933,602,934 - 33,618,577 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0931,911,702 - 31,926,888 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0923,352,271 - 23,368,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0922,211,293 - 22,226,466 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4915,758,645 - 15,768,747 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera917,634,682 - 17,649,991 (+)NCBICelera
RGSC_v3.1916,091,441 - 16,106,217 (+)NCBI
Cytogenetic Map9q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:25395579  


Genomics

Comparative Map Data
Cenpq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,454,339 - 27,469,371 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl927,454,252 - 27,469,366 (+)EnsemblGRCr8
mRatBN7.2919,957,122 - 19,972,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl919,957,048 - 19,972,789 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx928,528,381 - 28,544,024 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0933,602,934 - 33,618,577 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0931,911,702 - 31,926,888 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0923,352,271 - 23,368,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0922,211,293 - 22,226,466 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4915,758,645 - 15,768,747 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera917,634,682 - 17,649,991 (+)NCBICelera
RGSC_v3.1916,091,441 - 16,106,217 (+)NCBI
Cytogenetic Map9q13NCBI
CENPQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,463,370 - 49,493,107 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl649,463,335 - 49,495,815 (+)Ensemblhg38GRCh38
GRCh37649,431,083 - 49,460,820 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,539,055 - 49,568,779 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34649,539,054 - 49,568,779NCBI
Celera650,987,302 - 51,017,018 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef649,160,017 - 49,190,307 (+)NCBIHuRef
CHM1_1649,434,135 - 49,463,848 (+)NCBICHM1_1
T2T-CHM13v2.0649,305,401 - 49,335,269 (+)NCBIT2T-CHM13v2.0
Cenpq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391741,231,700 - 41,247,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1741,233,942 - 41,245,938 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381740,920,809 - 40,934,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,923,051 - 40,935,047 (-)Ensemblmm10GRCm38
MGSCv371741,060,004 - 41,071,500 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361740,386,539 - 40,398,035 (-)NCBIMGSCv36mm8
Celera1744,336,299 - 44,347,769 (-)NCBICelera
Cytogenetic Map17B2NCBI
cM Map1719.55NCBI
Cenpq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541033,464,976 - 33,476,609 (-)Ensembl
ChiLan1.0NW_00495541033,463,041 - 33,480,573 (-)NCBIChiLan1.0ChiLan1.0
CENPQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2563,954,653 - 63,983,111 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1659,819,374 - 59,848,018 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0649,040,467 - 49,069,115 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1650,302,606 - 50,331,096 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,302,606 - 50,331,096 (+)EnsemblpanPan2panpan1.1
CENPQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,339,914 - 17,355,921 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1217,340,001 - 17,355,937 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1217,239,470 - 17,256,300 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01217,835,667 - 17,852,592 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1217,836,197 - 17,852,592 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11217,355,499 - 17,372,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01217,460,762 - 17,477,607 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01217,590,343 - 17,607,227 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cenpq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494652,752,034 - 52,770,888 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647611,190,535 - 11,201,011 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647611,189,336 - 11,208,154 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CENPQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,624,832 - 43,641,028 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1743,624,734 - 43,639,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,146,201 - 50,161,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CENPQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,898,962 - 22,922,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,900,089 - 22,915,378 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604449,455,607 - 49,478,619 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cenpq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247831,826,368 - 1,836,263 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247831,825,234 - 1,838,794 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cenpq
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1494,947,257 - 94,959,135 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cenpq
113 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 137 95 11 51 35 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000081459   ⟹   ENSRNOP00000072803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl927,454,281 - 27,468,923 (+)Ensembl
mRatBN7.2 Ensembl919,957,048 - 19,972,359 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104636   ⟹   ENSRNOP00000084774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl927,454,252 - 27,469,366 (+)Ensembl
mRatBN7.2 Ensembl919,957,048 - 19,972,789 (+)Ensembl
RefSeq Acc Id: NM_001014215   ⟹   NP_001014237
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8927,454,339 - 27,469,371 (+)NCBI
mRatBN7.2919,957,122 - 19,972,807 (+)NCBI
Rnor_6.0923,352,271 - 23,368,774 (+)NCBI
Rnor_5.0922,211,293 - 22,226,466 (+)NCBI
RGSC_v3.4915,758,645 - 15,768,747 (-)RGD
Celera917,634,682 - 17,649,991 (+)RGD
Sequence:
RefSeq Acc Id: NM_001419500   ⟹   NP_001406429
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8927,454,339 - 27,469,371 (+)NCBI
mRatBN7.2919,957,122 - 19,972,807 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001014237 (Get FASTA)   NCBI Sequence Viewer  
  NP_001406429 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82113 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072803
  ENSRNOP00000084774
GenBank Protein Q66H02 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014237   ⟸   NM_001014215
- Peptide Label: isoform 2
- UniProtKB: Q66H02 (UniProtKB/Swiss-Prot),   A0A8I5ZZW1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072803   ⟸   ENSRNOT00000081459
Ensembl Acc Id: ENSRNOP00000084774   ⟸   ENSRNOT00000104636
RefSeq Acc Id: NP_001406429   ⟸   NM_001419500
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZZW1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H02-F1-model_v2 AlphaFold Q66H02 1-270 view protein structure
AF-A0A0G2K3W4-F1-model_v2 AlphaFold A0A0G2K3W4 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359451 AgrOrtholog
BioCyc Gene G2FUF-28086 BioCyc
Ensembl Genes ENSRNOG00000056226 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000081459 ENTREZGENE
  ENSRNOT00000104636 ENTREZGENE
IMAGE_CLONE IMAGE:7135459 IMAGE-MGC_LOAD
InterPro CAD_CENP-Q UniProtKB/Swiss-Prot
KEGG Report rno:363198 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95330 IMAGE-MGC_LOAD
NCBI Gene 363198 ENTREZGENE
PANTHER CENTROMERE PROTEIN Q UniProtKB/Swiss-Prot
  PTHR31345 UniProtKB/Swiss-Prot
Pfam CENP-Q UniProtKB/Swiss-Prot
PhenoGen Cenpq PhenoGen
RatGTEx ENSRNOG00000056226 RatGTEx
UniProt A0A0G2K3W4_RAT UniProtKB/TrEMBL
  A0A8I5ZZW1 ENTREZGENE, UniProtKB/TrEMBL
  CENPQ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Cenpq  centromere protein Q  LOC100361893  centromere protein Q-like  Data merged from RGD:2319285 1643240 APPROVED
2010-05-05 LOC100361893  centromere protein Q-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Cenpq  centromere protein Q  LOC363198  similar to 2610528M18Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC363198  similar to 2610528M18Rik protein      Symbol and Name status set to provisional 70820 PROVISIONAL