Cenpq (centromere protein Q) - Rat Genome Database

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Gene: Cenpq (centromere protein Q) Rattus norvegicus
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Symbol: Cenpq
Name: centromere protein Q
RGD ID: 1359451
Description: Predicted to be involved in metaphase chromosome alignment and positive regulation of protein localization to kinetochore. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of inner kinetochore. Predicted to be active in nucleus. Orthologous to human CENPQ (centromere protein Q); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CENP-Q; centromere protein Q-like; LOC363198; similar to 2610528M18Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,454,339 - 27,469,371 (+)NCBIGRCr8
mRatBN7.2919,957,122 - 19,972,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl919,957,048 - 19,972,789 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx928,528,381 - 28,544,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0933,602,934 - 33,618,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0931,911,702 - 31,926,888 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0923,352,271 - 23,368,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0922,211,293 - 22,226,466 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4915,758,645 - 15,768,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1916,091,441 - 16,106,217 (+)NCBI
Celera917,634,682 - 17,649,991 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:25395579  


Genomics

Comparative Map Data
Cenpq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,454,339 - 27,469,371 (+)NCBIGRCr8
mRatBN7.2919,957,122 - 19,972,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl919,957,048 - 19,972,789 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx928,528,381 - 28,544,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0933,602,934 - 33,618,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0931,911,702 - 31,926,888 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0923,352,271 - 23,368,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0922,211,293 - 22,226,466 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4915,758,645 - 15,768,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1916,091,441 - 16,106,217 (+)NCBI
Celera917,634,682 - 17,649,991 (+)NCBICelera
Cytogenetic Map9q13NCBI
CENPQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,463,370 - 49,493,107 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl649,463,370 - 49,493,107 (+)EnsemblGRCh38hg38GRCh38
GRCh37649,431,083 - 49,460,820 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,539,055 - 49,568,779 (+)NCBINCBI36Build 36hg18NCBI36
Build 34649,539,054 - 49,568,779NCBI
Celera650,987,302 - 51,017,018 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef649,160,017 - 49,190,307 (+)NCBIHuRef
CHM1_1649,434,135 - 49,463,848 (+)NCBICHM1_1
T2T-CHM13v2.0649,305,401 - 49,335,269 (+)NCBIT2T-CHM13v2.0
Cenpq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391741,231,700 - 41,247,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1741,233,942 - 41,245,938 (-)EnsemblGRCm39 Ensembl
GRCm381740,920,809 - 40,934,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,923,051 - 40,935,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv371741,060,004 - 41,071,500 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361740,386,539 - 40,398,035 (-)NCBIMGSCv36mm8
Celera1744,336,299 - 44,347,769 (-)NCBICelera
Cytogenetic Map17B2NCBI
cM Map1719.55NCBI
Cenpq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541033,464,976 - 33,476,609 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541033,463,041 - 33,480,573 (-)NCBIChiLan1.0ChiLan1.0
CENPQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2563,954,653 - 63,983,111 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1659,819,374 - 59,848,018 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0649,040,467 - 49,069,115 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1650,302,606 - 50,331,096 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,302,606 - 50,331,096 (+)Ensemblpanpan1.1panPan2
CENPQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,339,914 - 17,355,921 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1217,340,001 - 17,355,937 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1217,239,470 - 17,256,300 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01217,835,667 - 17,852,592 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1217,836,197 - 17,852,592 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11217,355,499 - 17,372,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01217,460,762 - 17,477,607 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01217,590,343 - 17,607,227 (+)NCBIUU_Cfam_GSD_1.0
Cenpq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494652,752,034 - 52,770,888 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647611,190,535 - 11,201,011 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647611,189,336 - 11,208,154 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CENPQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,624,832 - 43,641,028 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1743,624,734 - 43,639,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,146,201 - 50,161,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CENPQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,898,962 - 22,922,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,900,089 - 22,915,378 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604449,455,607 - 49,478,619 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cenpq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247831,826,368 - 1,836,263 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247831,825,234 - 1,838,794 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cenpq
59 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000081459   ⟹   ENSRNOP00000072803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl919,957,048 - 19,972,359 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104636   ⟹   ENSRNOP00000084774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl919,957,048 - 19,972,789 (+)Ensembl
RefSeq Acc Id: NM_001014215   ⟹   NP_001014237
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8927,454,339 - 27,469,371 (+)NCBI
mRatBN7.2919,957,122 - 19,972,807 (+)NCBI
Rnor_6.0923,352,271 - 23,368,774 (+)NCBI
Rnor_5.0922,211,293 - 22,226,466 (+)NCBI
RGSC_v3.4915,758,645 - 15,768,747 (-)RGD
Celera917,634,682 - 17,649,991 (+)RGD
Sequence:
RefSeq Acc Id: NM_001419500   ⟹   NP_001406429
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8927,454,339 - 27,469,371 (+)NCBI
mRatBN7.2919,957,122 - 19,972,807 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001014237 (Get FASTA)   NCBI Sequence Viewer  
  NP_001406429 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82113 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072803
  ENSRNOP00000072803.2
  ENSRNOP00000084774
  ENSRNOP00000084774.1
GenBank Protein Q66H02 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014237   ⟸   NM_001014215
- Peptide Label: isoform 2
- UniProtKB: Q66H02 (UniProtKB/Swiss-Prot),   A0A8I5ZZW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072803   ⟸   ENSRNOT00000081459
RefSeq Acc Id: ENSRNOP00000084774   ⟸   ENSRNOT00000104636
RefSeq Acc Id: NP_001406429   ⟸   NM_001419500
- Peptide Label: isoform 1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H02-F1-model_v2 AlphaFold Q66H02 1-270 view protein structure
AF-A0A0G2K3W4-F1-model_v2 AlphaFold A0A0G2K3W4 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359451 AgrOrtholog
BioCyc Gene G2FUF-28086 BioCyc
Ensembl Genes ENSRNOG00000056226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081459 ENTREZGENE
  ENSRNOT00000081459.2 UniProtKB/TrEMBL
  ENSRNOT00000104636 ENTREZGENE
  ENSRNOT00000104636.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135459 IMAGE-MGC_LOAD
InterPro CAD_CENP-Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363198 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95330 IMAGE-MGC_LOAD
NCBI Gene 363198 ENTREZGENE
PANTHER CENTROMERE PROTEIN Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31345 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CENP-Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cenpq PhenoGen
RatGTEx ENSRNOG00000056226 RatGTEx
UniProt A0A0G2K3W4_RAT UniProtKB/TrEMBL
  A0A8I5ZZW1 ENTREZGENE, UniProtKB/TrEMBL
  CENPQ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Cenpq  centromere protein Q  LOC100361893  centromere protein Q-like  Data merged from RGD:2319285 1643240 APPROVED
2010-05-05 LOC100361893  centromere protein Q-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Cenpq  centromere protein Q  LOC363198  similar to 2610528M18Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC363198  similar to 2610528M18Rik protein      Symbol and Name status set to provisional 70820 PROVISIONAL