Phospho2 (phosphatase, orphan 2) - Rat Genome Database

Name: Phospho2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Phospho2 (phosphatase, orphan 2) Rattus norvegicus

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Symbol:

Phospho2

Name:

phosphatase, orphan 2

RGD ID:

1359274

Description:

Predicted to enable phosphatase activity. Orthologous to human PHOSPHO2 (phosphatase, orphan 2); PARTICIPATES IN vitamin B6 metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC93920; pyridoxal phosphate phosphatase PHOSPHO2; similar to RIKEN cDNA 1700048E23

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PHOSPHO2 (phosphatase, orphan 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Phospho2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Phospho2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PHOSPHO2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PHOSPHO2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Phospho2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PHOSPHO2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PHOSPHO2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Phospho2 (phosphatase, orphan 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RYR2 (ryanodine receptor 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Phospho2 (phosphatase, orphan 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PHOSPHO2 (phosphatase, orphan 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	phospho2 (phosphatase, orphan 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12237	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14212	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	phospho2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	74,962,649 - 74,969,810 (+)	NCBI		GRCr8
mRatBN7.2	3	54,554,829 - 54,561,990 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	54,554,733 - 54,562,238 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	57,955,623 - 57,964,506 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	66,539,213 - 66,548,095 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	64,301,592 - 64,310,475 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	56,030,915 - 56,038,076 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	56,030,915 - 56,038,075 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	62,667,716 - 62,674,877 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	51,937,823 - 51,944,984 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	51,834,194 - 51,841,355 (+)	NCBI
Celera	3	54,115,211 - 54,122,372 (+)	NCBI		Celera
Cytogenetic Map	3	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

aflatoxin B1 (ISO)

arsenous acid (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

ethanol (ISO)

fenthion (ISO)

flutamide (EXP)

indometacin (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

SB 431542 (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

metal ion binding (IEA)

phosphatase activity (IBA)

protein binding (ISO)

pyridoxal phosphatase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

vitamin B6 metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334

Genomics

Comparative Map Data

Phospho2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	74,962,649 - 74,969,810 (+)	NCBI		GRCr8
mRatBN7.2	3	54,554,829 - 54,561,990 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	54,554,733 - 54,562,238 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	57,955,623 - 57,964,506 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	66,539,213 - 66,548,095 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	64,301,592 - 64,310,475 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	56,030,915 - 56,038,076 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	56,030,915 - 56,038,075 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	62,667,716 - 62,674,877 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	51,937,823 - 51,944,984 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	51,834,194 - 51,841,355 (+)	NCBI
Celera	3	54,115,211 - 54,122,372 (+)	NCBI		Celera
Cytogenetic Map	3	q21	NCBI

PHOSPHO2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	169,694,469 - 169,701,708 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	169,694,454 - 169,701,708 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	170,550,979 - 170,558,218 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	170,259,221 - 170,266,464 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	164,169,782 - 164,177,027 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	162,441,619 - 162,448,877 (+)	NCBI		HuRef
CHM1_1	2	170,557,297 - 170,564,555 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	170,174,071 - 170,181,317 (+)	NCBI		T2T-CHM13v2.0

Phospho2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	69,620,081 - 69,627,567 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	69,619,967 - 69,630,349 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	69,789,605 - 69,797,223 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	69,789,623 - 69,800,005 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	69,627,794 - 69,635,225 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	69,590,576 - 69,598,007 (+)	NCBI		MGSCv36	mm8
Celera	2	71,458,902 - 71,466,338 (+)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	40.95	NCBI

Phospho2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	4,877,521 - 4,885,927 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	4,877,521 - 4,885,927 (-)	NCBI	ChiLan1.0	ChiLan1.0

PHOSPHO2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	72,357,189 - 72,370,036 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	72,372,162 - 72,385,009 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	56,968,836 - 56,976,115 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	174,436,522 - 174,443,796 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	174,443,060 - 174,443,785 (+)	Ensembl	panpan1.1		panPan2

PHOSPHO2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	14,399,025 - 14,402,244 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	14,401,508 - 14,402,233 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	14,408,303 - 14,414,303 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	14,516,430 - 14,519,710 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	14,518,977 - 14,519,702 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	14,598,398 - 14,604,390 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	14,589,126 - 14,595,136 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	14,700,509 - 14,706,498 (+)	NCBI		UU_Cfam_GSD_1.0

Phospho2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	131,664,078 - 131,669,734 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	217,909 - 223,626 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	217,910 - 224,413 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PHOSPHO2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	76,007,197 - 76,014,008 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	76,007,205 - 76,014,020 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	85,127,087 - 85,133,913 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PHOSPHO2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	55,220,338 - 55,227,930 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	55,227,194 - 55,227,919 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	144,302,909 - 144,310,479 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Phospho2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	7,214,682 - 7,220,047 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	7,214,612 - 7,220,047 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Phospho2
28 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	361
Count of miRNA genes:	217
Interacting mature miRNAs:	243
Transcripts:	ENSRNOT00000010489
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	28249687	73249687	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	28249687	73249687	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1582249	Bw77	Body weight QTL 77	3.2	0.0025	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	64655484	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31426403	70668733	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31426403	70668733	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31426403	70668733	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31426403	70668733	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31426403	70668733	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	27936919	72936919	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	28468571	73468571	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	28468571	73468571	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	33703347	61017857	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	62951183	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	28249687	73249687	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	28249687	73249687	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	16954708	61954708	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	28249687	73249687	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31426403	70668733	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat

Markers in Region

RH127377

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	54,561,572 - 54,561,771 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	56,037,659 - 56,037,857	NCBI	Rnor6.0
Rnor_5.0	3	62,674,460 - 62,674,658	UniSTS	Rnor5.0
RGSC_v3.4	3	51,944,567 - 51,944,765	UniSTS	RGSC3.4
Celera	3	54,121,955 - 54,122,153	UniSTS
Cytogenetic Map	3	q21	UniSTS

AI661517

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	54,560,625 - 54,560,709 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	56,036,712 - 56,036,795	NCBI	Rnor6.0
Rnor_5.0	3	62,673,513 - 62,673,596	UniSTS	Rnor5.0
RGSC_v3.4	3	51,943,620 - 51,943,703	UniSTS	RGSC3.4
Celera	3	54,121,008 - 54,121,091	UniSTS
Cytogenetic Map	3	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010489 ⟹ ENSRNOP00000010489

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	54,554,733 - 54,562,238 (+)	Ensembl
Rnor_6.0 Ensembl	3	56,030,915 - 56,038,075 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106872 ⟹ ENSRNOP00000088734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	54,554,773 - 54,561,982 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112246 ⟹ ENSRNOP00000090811

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	54,557,848 - 54,562,238 (+)	Ensembl

RefSeq Acc Id:

NM_001007642 ⟹ NP_001007643

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	74,962,649 - 74,969,810 (+)	NCBI
mRatBN7.2	3	54,554,829 - 54,561,990 (+)	NCBI
Rnor_6.0	3	56,030,915 - 56,038,076 (+)	NCBI
Rnor_5.0	3	62,667,716 - 62,674,877 (+)	NCBI
RGSC_v3.4	3	51,937,823 - 51,944,984 (+)	RGD
Celera	3	54,115,211 - 54,122,372 (+)	RGD

Sequence:

show sequence

CTGGAACGGATGCTGGTGACCGGCTGCGACCCAGGCCAGGGTCAGTGAGGAGCCCTCGGTCCCG
TCCAGCCGGTTCCGTTTTTCTGAGACGCTGCGCTAGTTTGGAGCCGGCCGGTGTGCGAGTCGAG
GCCCAGGCTGGGTTTCTACACTGCGCCTCGCTGACTGAGGTTTTCTATCAGATGTTCCACTCTA
ATAATGCTGGAATTAAGAAGTCTTCGTTCCTTTGCTACCTATCAGAGCAATTTCTCTGCATACA
GAAATGAAGTAATATTTAAAAACAACTGGCAAACTGAAGATTGCAGTAACCTAAGCTCTGTGCT
GAAGTAAGATTAATTGGACTGCAACTACCAGTTTGGGGTAATCCAAGTCTGTTACTGGAACCAT
GAAAGTTCTGTTGGTGTTTGACTTTGACAATACAATCATAGACGACAACAGCGACACCTGGATT
ATACAGTGTGCTCCAGACAAGAAGCTTCCCATTGAGCTACAAGATTCTTATCAGAAGGGGCTTT
GGACAGAATTTATGGGCAGAGTCTTTAAGTATTTGAGAGATGAGGGGGTTAAAGAAGAGGAACT
GAAAAGGGCAGTGACGTCACTACCCTTCACCTCAGGGATGATAGAACTTCTCAGCTTTCTGAGG
ATGAATAAGGACAGATTTGACTGCATCATCATTTCAGACTCAAATTCCATCTTCATAGATTGGG
TTTTAGAAGCTGCTGCCTTTCATGATGTCTTTGATACCGTGTTTACCAATCCAGCGTCTTTTGA
TAGCACTGGTCGCCTCACAGTGAGAAATTGCCATACTCATGCTTGCACTAGGTGCCCAAAGAAC
CTTTGCAAAAATACAGTTTTGGGAGAGTTCATCGACAAACAGTTACAAAAGGGAGTGAGGTACA
CGCGGATTGTTTATATCGGCGATGGCGGAAATGATGTCTGTCCAGTAACTTTTTTAAAGAAAAA
TGATGTTGCCATGCCGAGGGAAGGATATACTTTACATAGGACTCTTGACAAAATGTCTCAGAAT
CTTGAGCCTATGGCATCTTCTATTGTAGTTTGGTCTTCAGGGATGGAAATAATTTCTCATTTAC
AATTTCTAATACAGATGTGATGTGCCAACAGTTGAAATGTGTATTAGTTAAGGTCAGGCTCAGC
AACATAAAACTAAATTCCCAATATCAGTACCTTTAAAGATGTGAGAGGTTTTCCTCTTTGAAGA
ATTCTGGTCCTATGTCAAGGCCACTTTGTTGCTTAGACATCCTCAGCTTTTGGTTCTAACCCAT
GATTTGAGATTGTTCTCTAAGCTCGCGTCCTCACAACAAACATTGTGACCAGCGCGAGCCAGGG
CAGTATGCTTGAAACCCTTTGTTCAAGAATGTTTTTCAGTTGTACCAAGGTTCGAATACCACTA
GCTAAAACCCAGTCAGAGCCTTCCCTAACTGCAAAGACGGGAAATGCAGCTTTCATTCCAGGCA
GTCATGTGCCCAGGAAGAAGGGGGCAAACAATACATAATTGAGGTGTGTGGAGCTTATAGTCTG
TACTAAGGACGGTTAATAGATGGTATTTTTTCTATTTCTGAAGAAAGTGGCTTTATTTTACTCT
CTTTTAAACATATACACAATAGTCACAAATGTCGAATGCTGAAGAGCCCTCTCCCCCTGCTGTC
AGCAAGTCATACAGACACTCAATGAGTTCACGATTCAACTCCACGCACAACCGCTACTATGGCT
AAGGAAGGCATTACTGCTGGAGGTGTAATGGACGCTGATACTGCCTAACAGGAGCCCTGAAGAC
CACCTTCATCCGAGAGGGCCCAGCATGGGGTTCATGCAGAGCTGAGCTGCCAAAGCCTTAAGCA
AGTGCATGCTTGAACCCAGTTGTGATGAGCCTATGCGTGTCAAGTTGTTGGAGGAGCTTTGTGC
GAGCATGAAGATCAACCTAATTAGGCATCTGAAAACGGGAGAGGAACCCTATAAACTTGGTTGT
GGTGTGTTAAGGACGCCAATTGAAGACTACTTCAAATGCAAGAAATAAAACTGGCTTTATTTTC
TCAACAACAAAAAGCATGATACTTTATTCACATAAGAATAAAAGGCTCTCAAATGTAAAAAAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007643	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81926	(Get FASTA)	NCBI Sequence Viewer
	EDL79066	(Get FASTA)	NCBI Sequence Viewer
	EDL79067	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010489.3
	ENSRNOP00000088734.1
	ENSRNOP00000090811.1
	ENSRNOP00055033310
	ENSRNOP00055033315
	ENSRNOP00055033318
	ENSRNOP00060003160
	ENSRNOP00060003162
	ENSRNOP00060003164
	ENSRNOP00065021589
	ENSRNOP00065021597
	ENSRNOP00065021604
GenBank Protein	Q66HC4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001007643 ⟸ NM_001007642

- UniProtKB:

Q66HC4 (UniProtKB/Swiss-Prot), A6HM16 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKVLLVFDFDNTIIDDNSDTWIIQCAPDKKLPIELQDSYQKGLWTEFMGRVFKYLRDEGVKEEE
LKRAVTSLPFTSGMIELLSFLRMNKDRFDCIIISDSNSIFIDWVLEAAAFHDVFDTVFTNPASF
DSTGRLTVRNCHTHACTRCPKNLCKNTVLGEFIDKQLQKGVRYTRIVYIGDGGNDVCPVTFLKK
NDVAMPREGYTLHRTLDKMSQNLEPMASSIVVWSSGMEIISHLQFLIQM

hide sequence

Ensembl Acc Id:

ENSRNOP00000010489 ⟸ ENSRNOT00000010489

Ensembl Acc Id:

ENSRNOP00000088734 ⟸ ENSRNOT00000106872

Ensembl Acc Id:

ENSRNOP00000090811 ⟸ ENSRNOT00000112246

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HC4-F1-model_v2	AlphaFold	Q66HC4	1-241	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692123

Promoter ID:

EPDNEW_R2647

Type:

initiation region

Name:

Phospho2_1

Description:

phosphatase, orphan 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	56,030,843 - 56,030,903	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359274	AgrOrtholog
BioCyc Gene	G2FUF-49500	BioCyc
Ensembl Genes	ENSRNOG00000007979	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055023885	UniProtKB/Swiss-Prot
	ENSRNOG00060002789	UniProtKB/Swiss-Prot
	ENSRNOG00065016502	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010489.5	UniProtKB/Swiss-Prot
	ENSRNOT00000106872.1	UniProtKB/Swiss-Prot
	ENSRNOT00000112246.1	UniProtKB/Swiss-Prot
	ENSRNOT00055040980	UniProtKB/Swiss-Prot
	ENSRNOT00055040985	UniProtKB/Swiss-Prot
	ENSRNOT00055040988	UniProtKB/Swiss-Prot
	ENSRNOT00060004466	UniProtKB/Swiss-Prot
	ENSRNOT00060004468	UniProtKB/Swiss-Prot
	ENSRNOT00060004470	UniProtKB/Swiss-Prot
	ENSRNOT00065027462	UniProtKB/Swiss-Prot
	ENSRNOT00065027470	UniProtKB/Swiss-Prot
	ENSRNOT00065027477	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.1000	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113082	IMAGE-MGC_LOAD
InterPro	HAD-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HAD_hydro_PyrdxlP_Pase-like	UniProtKB/TrEMBL
	HAD_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pase_PHOSPHO-typ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PyrdxlP_Pase-rel	UniProtKB/Swiss-Prot
KEGG Report	rno:295663	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93920	IMAGE-MGC_LOAD
NCBI Gene	295663	ENTREZGENE
PANTHER	PHOSPHATASE, ORPHAN 1, 2	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	PYRIDOXAL PHOSPHATE PHOSPHATASE PHOSPHO2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Put_Phosphatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Phospho2	PhenoGen
PIRSF	PyrdxlP_Pase_PHOSPHO2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007979	RatGTEx
	ENSRNOG00055023885	RatGTEx
	ENSRNOG00060002789	RatGTEx
	ENSRNOG00065016502	RatGTEx
Superfamily-SCOP	HAD-like	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6HM16	ENTREZGENE, UniProtKB/TrEMBL
	PHOP2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Phospho2	phosphatase, orphan 2	MGC93920	similar to RIKEN cDNA 1700048E23	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	MGC93920	similar to RIKEN cDNA 1700048E23			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)