Ptbp2 (polypyrimidine tract binding protein 2) - Rat Genome Database

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Gene: Ptbp2 (polypyrimidine tract binding protein 2) Rattus norvegicus
Analyze
Symbol: Ptbp2
Name: polypyrimidine tract binding protein 2
RGD ID: 1359267
Description: Predicted to enable mRNA binding activity. Involved in cerebellum development; negative regulation of RNA splicing; and spinal cord development. Located in growth cone and neuronal cell body. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC95244; neural polypyrimidine tract-binding protein; nPTB; polypyrimidine tract-binding protein 2; PTB-like protein; Ptb2; PTBLP; PTBLP-L; PTBLP-S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82210,497,610 - 210,558,497 (-)NCBIGRCr8
mRatBN7.22207,812,659 - 207,874,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2207,812,920 - 207,873,506 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2215,463,900 - 215,523,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02213,387,983 - 213,447,341 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02208,213,458 - 208,272,785 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02223,261,444 - 223,323,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2223,262,852 - 223,322,585 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02241,306,857 - 241,368,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42216,188,745 - 216,249,176 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2200,269,277 - 200,328,535 (-)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
furan  (EXP)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
nicotine  (ISO)
obeticholic acid  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
mRNA binding  (IBA,IEA,ISO)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. Ashiya M and Grabowski PJ, RNA. 1997 Sep;3(9):996-1015.
2. Dynamic integration of splicing within gene regulatory pathways. Braunschweig U, etal., Cell. 2013 Mar 14;152(6):1252-69. doi: 10.1016/j.cell.2013.02.034.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Role of PTB-like protein, a neuronal RNA-binding protein, during the differentiation of PC12 cells. Ichikawa M, etal., J Biochem. 2002 Jun;131(6):861-8.
5. Molecular cloning and characterization of a new neuron-specific homologue of rat polypyrimidine tract binding protein. Kikuchi T, etal., J Biochem. 2000 Nov;128(5):811-21.
6. Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons. Kumar DV, etal., J Neurobiol 2002 Aug;52(2):156-65.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene. Rahman L, etal., Genomics 2004 Jan;83(1):76-84.
9. Alternative splicing of neurexins: a role for neuronal polypyrimidine tract binding protein. Resnick M, etal., Neurosci Lett. 2008 Jul 18;439(3):235-40. doi: 10.1016/j.neulet.2008.05.034. Epub 2008 May 16.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. Zhang L, etal., RNA. 1999 Jan;5(1):117-30.
Additional References at PubMed
PMID:10829067   PMID:11694331   PMID:15489334   PMID:18335065   PMID:21139978   PMID:22658674   PMID:22681889   PMID:22802532  


Genomics

Comparative Map Data
Ptbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82210,497,610 - 210,558,497 (-)NCBIGRCr8
mRatBN7.22207,812,659 - 207,874,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2207,812,920 - 207,873,506 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2215,463,900 - 215,523,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02213,387,983 - 213,447,341 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02208,213,458 - 208,272,785 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02223,261,444 - 223,323,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2223,262,852 - 223,322,585 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02241,306,857 - 241,368,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42216,188,745 - 216,249,176 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2200,269,277 - 200,328,535 (-)NCBICelera
Cytogenetic Map2q42NCBI
PTBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,721,784 - 96,823,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,721,665 - 96,823,738 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,187,340 - 97,289,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,959,966 - 97,052,937 (+)NCBINCBI36Build 36hg18NCBI36
Build 34196,899,398 - 96,992,367NCBI
Celera195,441,461 - 95,534,886 (+)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef195,308,506 - 95,401,741 (+)NCBIHuRef
CHM1_1197,303,210 - 97,396,589 (+)NCBICHM1_1
T2T-CHM13v2.0196,569,913 - 96,671,844 (+)NCBIT2T-CHM13v2.0
Ptbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393119,512,390 - 119,578,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3119,512,391 - 119,578,115 (-)EnsemblGRCm39 Ensembl
GRCm383119,718,741 - 119,784,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3119,718,742 - 119,784,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv373119,421,660 - 119,486,306 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363119,710,998 - 119,775,262 (-)NCBIMGSCv36mm8
Celera3126,129,123 - 126,191,916 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.18NCBI
Ptbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554351,702,962 - 1,774,334 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554351,703,588 - 1,773,016 (+)NCBIChiLan1.0ChiLan1.0
PTBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21130,211,817 - 130,303,081 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,366,565 - 129,457,692 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,382,924 - 99,474,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,105,913 - 98,196,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,105,913 - 98,196,723 (+)Ensemblpanpan1.1panPan2
PTBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1652,870,944 - 52,948,673 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl652,872,310 - 52,949,025 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha655,556,557 - 55,640,856 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0653,223,659 - 53,275,783 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl653,223,576 - 53,303,282 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1652,917,509 - 52,995,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0652,896,678 - 52,974,367 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0653,342,619 - 53,426,749 (-)NCBIUU_Cfam_GSD_1.0
Ptbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058106,199,552 - 106,271,053 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365372,676,130 - 2,747,524 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365372,676,920 - 2,748,568 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4120,961,381 - 121,041,802 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14120,961,211 - 121,041,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24132,800,514 - 132,848,125 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12036,465,812 - 36,559,480 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2036,464,689 - 36,559,307 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603381,500,833 - 81,593,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624742783,612 - 855,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624742783,612 - 856,039 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptbp2
185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:103
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000015036
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
RH143836  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22207,824,571 - 207,824,673 (+)MAPPERmRatBN7.2
Rnor_6.02223,273,621 - 223,273,722NCBIRnor6.0
Rnor_5.02241,318,871 - 241,318,972UniSTSRnor5.0
RGSC_v3.42216,199,207 - 216,199,308UniSTSRGSC3.4
Celera2200,279,736 - 200,279,837UniSTS
RH 3.4 Map21483.9UniSTS
Cytogenetic Map2q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 40 23 7 19 7 8 8 74 30 41 11 8
Low 1 3 34 34 34 3 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000015036   ⟹   ENSRNOP00000015036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2207,814,114 - 207,855,967 (-)Ensembl
Rnor_6.0 Ensembl2223,262,852 - 223,322,585 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099622   ⟹   ENSRNOP00000095200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2207,854,083 - 207,873,506 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104266   ⟹   ENSRNOP00000091829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2207,812,920 - 207,873,506 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108304   ⟹   ENSRNOP00000084664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2207,813,146 - 207,818,340 (-)Ensembl
RefSeq Acc Id: NM_001005555   ⟹   NP_001005555
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,498,898 - 210,558,277 (-)NCBI
mRatBN7.22207,814,112 - 207,873,492 (-)NCBI
Rnor_6.02223,262,895 - 223,322,542 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
RGSC_v3.42216,188,745 - 216,249,176 (-)RGD
Celera2200,269,277 - 200,328,535 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233236   ⟹   XP_006233298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,558,467 (-)NCBI
mRatBN7.22207,812,659 - 207,874,019 (-)NCBI
Rnor_6.02223,261,444 - 223,323,075 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233237   ⟹   XP_006233299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,558,467 (-)NCBI
mRatBN7.22207,812,659 - 207,874,019 (-)NCBI
Rnor_6.02223,261,444 - 223,323,074 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233238   ⟹   XP_006233300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,558,467 (-)NCBI
mRatBN7.22207,812,659 - 207,874,019 (-)NCBI
Rnor_6.02223,261,444 - 223,323,074 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102435   ⟹   XP_038958363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,527,760 (-)NCBI
mRatBN7.22207,812,659 - 207,872,012 (-)NCBI
RefSeq Acc Id: XR_010063614
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,499,546 - 210,558,497 (-)NCBI
RefSeq Acc Id: NP_001005555   ⟸   NM_001005555
- UniProtKB: Q78ZE9 (UniProtKB/Swiss-Prot),   Q7TNW8 (UniProtKB/Swiss-Prot),   Q66H20 (UniProtKB/Swiss-Prot),   A6HVC5 (UniProtKB/TrEMBL),   A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233300   ⟸   XM_006233238
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233299   ⟸   XM_006233237
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233298   ⟸   XM_006233236
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015036   ⟸   ENSRNOT00000015036
RefSeq Acc Id: XP_038958363   ⟸   XM_039102435
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000091829   ⟸   ENSRNOT00000104266
RefSeq Acc Id: ENSRNOP00000095200   ⟸   ENSRNOT00000099622
RefSeq Acc Id: ENSRNOP00000084664   ⟸   ENSRNOT00000108304
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H20-F1-model_v2 AlphaFold Q66H20 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691715
Promoter ID:EPDNEW_R2240
Type:multiple initiation site
Name:Ptbp2_1
Description:polypyrimidine tract binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02223,322,535 - 223,322,595EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359267 AgrOrtholog
BioCyc Gene G2FUF-51444 BioCyc
Ensembl Genes ENSRNOG00000010827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015036 ENTREZGENE
  ENSRNOT00000015036.8 UniProtKB/TrEMBL
  ENSRNOT00000099622.1 UniProtKB/TrEMBL
  ENSRNOT00000104266.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108304.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133221 IMAGE-MGC_LOAD
InterPro HnRNP-L/PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTBP1-like_RRM2 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PTBP2_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTBP2_RRM3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTBP2_RRM4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95244 IMAGE-MGC_LOAD
NCBI Gene 310820 ENTREZGENE
PANTHER MATRIN 3/NUCLEAR PROTEIN 220-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLYPYRIMIDINE TRACT-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptbp2 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010827 RatGTEx
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GAT9_RAT UniProtKB/TrEMBL
  A0A8I6GL20_RAT UniProtKB/TrEMBL
  A0A8L2Q799 ENTREZGENE, UniProtKB/TrEMBL
  A6HVC5 ENTREZGENE, UniProtKB/TrEMBL
  A6HVC6_RAT UniProtKB/TrEMBL
  A6HVC7_RAT UniProtKB/TrEMBL
  PTBP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q78ZE9 ENTREZGENE
  Q7TNW8 ENTREZGENE
UniProt Secondary Q78ZE9 UniProtKB/Swiss-Prot
  Q7TNW8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ptbp2  polypyrimidine tract binding protein 2      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Ptbp2  polypyrimidine tract binding protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript contains several alternatively spliced transcripts including alternative splicing of exon 10, this exon is retained exclusively in brain 1359764