Ptbp2 (polypyrimidine tract binding protein 2) - Rat Genome Database

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Gene: Ptbp2 (polypyrimidine tract binding protein 2) Rattus norvegicus
Analyze
Symbol: Ptbp2
Name: polypyrimidine tract binding protein 2
RGD ID: 1359267
Description: Predicted to enable mRNA binding activity. Involved in cerebellum development; negative regulation of RNA splicing; and spinal cord development. Located in growth cone and neuronal cell body. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC95244; neural polypyrimidine tract-binding protein; nPTB; polypyrimidine tract-binding protein 2; PTB-like protein; Ptb2; PTBLP; PTBLP-L; PTBLP-S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82210,497,610 - 210,558,497 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2210,497,706 - 210,558,291 (-)EnsemblGRCr8
mRatBN7.22207,812,659 - 207,874,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2207,812,920 - 207,873,506 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2215,463,900 - 215,523,276 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02213,387,983 - 213,447,341 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02208,213,458 - 208,272,785 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02223,261,444 - 223,323,075 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2223,262,852 - 223,322,585 (-)Ensemblrn6Rnor6.0
Rnor_5.02241,306,857 - 241,368,189 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42216,188,745 - 216,249,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2200,269,277 - 200,328,535 (-)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
furan  (EXP)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
nicotine  (ISO)
obeticholic acid  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. Ashiya M and Grabowski PJ, RNA. 1997 Sep;3(9):996-1015.
2. Dynamic integration of splicing within gene regulatory pathways. Braunschweig U, etal., Cell. 2013 Mar 14;152(6):1252-69. doi: 10.1016/j.cell.2013.02.034.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Role of PTB-like protein, a neuronal RNA-binding protein, during the differentiation of PC12 cells. Ichikawa M, etal., J Biochem. 2002 Jun;131(6):861-8.
5. Molecular cloning and characterization of a new neuron-specific homologue of rat polypyrimidine tract binding protein. Kikuchi T, etal., J Biochem. 2000 Nov;128(5):811-21.
6. Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons. Kumar DV, etal., J Neurobiol 2002 Aug;52(2):156-65.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene. Rahman L, etal., Genomics 2004 Jan;83(1):76-84.
9. Alternative splicing of neurexins: a role for neuronal polypyrimidine tract binding protein. Resnick M, etal., Neurosci Lett. 2008 Jul 18;439(3):235-40. doi: 10.1016/j.neulet.2008.05.034. Epub 2008 May 16.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. Zhang L, etal., RNA. 1999 Jan;5(1):117-30.
Additional References at PubMed
PMID:10829067   PMID:11694331   PMID:15489334   PMID:18335065   PMID:21139978   PMID:22658674   PMID:22681889   PMID:22802532  


Genomics

Comparative Map Data
Ptbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82210,497,610 - 210,558,497 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2210,497,706 - 210,558,291 (-)EnsemblGRCr8
mRatBN7.22207,812,659 - 207,874,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2207,812,920 - 207,873,506 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2215,463,900 - 215,523,276 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02213,387,983 - 213,447,341 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02208,213,458 - 208,272,785 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02223,261,444 - 223,323,075 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2223,262,852 - 223,322,585 (-)Ensemblrn6Rnor6.0
Rnor_5.02241,306,857 - 241,368,189 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42216,188,745 - 216,249,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2200,269,277 - 200,328,535 (-)NCBICelera
Cytogenetic Map2q42NCBI
PTBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,721,784 - 96,823,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,721,573 - 96,823,738 (+)Ensemblhg38GRCh38
GRCh37197,187,340 - 97,289,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,959,966 - 97,052,937 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34196,899,398 - 96,992,367NCBI
Celera195,441,461 - 95,534,886 (+)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef195,308,506 - 95,401,741 (+)NCBIHuRef
CHM1_1197,303,210 - 97,396,589 (+)NCBICHM1_1
T2T-CHM13v2.0196,569,913 - 96,671,844 (+)NCBIT2T-CHM13v2.0
Ptbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393119,512,390 - 119,578,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3119,512,391 - 119,578,115 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383119,718,741 - 119,784,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3119,718,742 - 119,784,466 (-)Ensemblmm10GRCm38
MGSCv373119,421,660 - 119,486,306 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363119,710,998 - 119,775,262 (-)NCBIMGSCv36mm8
Celera3126,129,123 - 126,191,916 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.18NCBI
Ptbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554351,702,962 - 1,774,334 (+)Ensembl
ChiLan1.0NW_0049554351,703,588 - 1,773,016 (+)NCBIChiLan1.0ChiLan1.0
PTBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21130,211,817 - 130,303,081 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,366,565 - 129,457,692 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,382,924 - 99,474,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,105,913 - 98,196,729 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,105,913 - 98,196,723 (+)EnsemblpanPan2panpan1.1
PTBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1652,870,944 - 52,948,673 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl652,872,310 - 52,949,025 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha655,556,557 - 55,640,856 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0653,223,659 - 53,275,783 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl653,223,576 - 53,303,282 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1652,917,509 - 52,995,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0652,896,678 - 52,974,367 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0653,342,619 - 53,426,749 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058106,199,552 - 106,271,053 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365372,676,130 - 2,747,524 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365372,676,920 - 2,748,568 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4120,961,381 - 121,041,802 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14120,961,211 - 121,041,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24132,800,514 - 132,848,125 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12036,465,812 - 36,559,480 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2036,464,689 - 36,559,307 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603381,500,833 - 81,593,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624742783,612 - 855,900 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624742783,612 - 856,039 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptbp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1339,994,896 - 40,056,682 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptbp2
447 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:103
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000015036
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat

Markers in Region
RH143836  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22207,824,571 - 207,824,673 (+)MAPPERmRatBN7.2
Rnor_6.02223,273,621 - 223,273,722NCBIRnor6.0
Rnor_5.02241,318,871 - 241,318,972UniSTSRnor5.0
RGSC_v3.42216,199,207 - 216,199,308UniSTSRGSC3.4
Celera2200,279,736 - 200,279,837UniSTS
RH 3.4 Map21483.9UniSTS
Cytogenetic Map2q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015036   ⟹   ENSRNOP00000015036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2210,498,900 - 210,540,753 (-)Ensembl
mRatBN7.2 Ensembl2207,814,114 - 207,855,967 (-)Ensembl
Rnor_6.0 Ensembl2223,262,852 - 223,322,585 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099622   ⟹   ENSRNOP00000095200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2210,538,867 - 210,558,291 (-)Ensembl
mRatBN7.2 Ensembl2207,854,083 - 207,873,506 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104266   ⟹   ENSRNOP00000091829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2210,497,706 - 210,558,291 (-)Ensembl
mRatBN7.2 Ensembl2207,812,920 - 207,873,506 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108304   ⟹   ENSRNOP00000084664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2207,813,146 - 207,818,340 (-)Ensembl
RefSeq Acc Id: NM_001005555   ⟹   NP_001005555
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,498,898 - 210,558,277 (-)NCBI
mRatBN7.22207,814,112 - 207,873,492 (-)NCBI
Rnor_6.02223,262,895 - 223,322,542 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
RGSC_v3.42216,188,745 - 216,249,176 (-)RGD
Celera2200,269,277 - 200,328,535 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233236   ⟹   XP_006233298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,558,467 (-)NCBI
mRatBN7.22207,812,659 - 207,874,019 (-)NCBI
Rnor_6.02223,261,444 - 223,323,075 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233237   ⟹   XP_006233299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,558,467 (-)NCBI
mRatBN7.22207,812,659 - 207,874,019 (-)NCBI
Rnor_6.02223,261,444 - 223,323,074 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233238   ⟹   XP_006233300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,558,467 (-)NCBI
mRatBN7.22207,812,659 - 207,874,019 (-)NCBI
Rnor_6.02223,261,444 - 223,323,074 (-)NCBI
Rnor_5.02241,306,857 - 241,368,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102435   ⟹   XP_038958363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,497,610 - 210,527,760 (-)NCBI
mRatBN7.22207,812,659 - 207,872,012 (-)NCBI
RefSeq Acc Id: XR_010063614
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82210,499,546 - 210,558,497 (-)NCBI
RefSeq Acc Id: NP_001005555   ⟸   NM_001005555
- UniProtKB: Q78ZE9 (UniProtKB/Swiss-Prot),   Q7TNW8 (UniProtKB/Swiss-Prot),   Q66H20 (UniProtKB/Swiss-Prot),   A6HVC5 (UniProtKB/TrEMBL),   A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233300   ⟸   XM_006233238
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233299   ⟸   XM_006233237
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233298   ⟸   XM_006233236
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q799 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015036   ⟸   ENSRNOT00000015036
RefSeq Acc Id: XP_038958363   ⟸   XM_039102435
- Peptide Label: isoform X4
- UniProtKB: A6HVC6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091829   ⟸   ENSRNOT00000104266
Ensembl Acc Id: ENSRNOP00000095200   ⟸   ENSRNOT00000099622
Ensembl Acc Id: ENSRNOP00000084664   ⟸   ENSRNOT00000108304
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H20-F1-model_v2 AlphaFold Q66H20 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691715
Promoter ID:EPDNEW_R2240
Type:multiple initiation site
Name:Ptbp2_1
Description:polypyrimidine tract binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02223,322,535 - 223,322,595EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359267 AgrOrtholog
BioCyc Gene G2FUF-51444 BioCyc
Ensembl Genes ENSRNOG00000010827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015036 ENTREZGENE
  ENSRNOT00000104266 ENTREZGENE
  ENSRNOT00000104266.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133221 IMAGE-MGC_LOAD
InterPro HnRNP-L/PTB UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PTBP1_RRM UniProtKB/Swiss-Prot
  PTBP2_RRM1 UniProtKB/Swiss-Prot
  PTBP2_RRM3 UniProtKB/Swiss-Prot
  PTBP2_RRM4 UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:310820 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95244 IMAGE-MGC_LOAD
NCBI Gene 310820 ENTREZGENE
PANTHER MATRIN 3/NUCLEAR PROTEIN 220-RELATED UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
  RRM_5 UniProtKB/Swiss-Prot
  RRM_8 UniProtKB/Swiss-Prot
PhenoGen Ptbp2 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010827 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8I6GL20_RAT UniProtKB/TrEMBL
  A0A8L2Q799 ENTREZGENE, UniProtKB/TrEMBL
  A6HVC5 ENTREZGENE, UniProtKB/TrEMBL
  A6HVC6 ENTREZGENE, UniProtKB/TrEMBL
  A6HVC7_RAT UniProtKB/TrEMBL
  PTBP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q78ZE9 ENTREZGENE
  Q7TNW8 ENTREZGENE
UniProt Secondary Q78ZE9 UniProtKB/Swiss-Prot
  Q7TNW8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ptbp2  polypyrimidine tract binding protein 2      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Ptbp2  polypyrimidine tract binding protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript contains several alternatively spliced transcripts including alternative splicing of exon 10, this exon is retained exclusively in brain 1359764