Txndc2 (thioredoxin domain containing 2) - Rat Genome Database

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Gene: Txndc2 (thioredoxin domain containing 2) Rattus norvegicus
Analyze
Symbol: Txndc2
Name: thioredoxin domain containing 2
RGD ID: 1359251
Description: Predicted to enable protein disulfide isomerase activity and thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell differentiation; cellular oxidant detoxification; and spermatogenesis. Predicted to act upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in outer dense fiber. Orthologous to human TXNDC2 (thioredoxin domain containing 2); INTERACTS WITH bisphenol A; 1,2-dichloroethane (ortholog); 4,4'-diaminodiphenylmethane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC94320; similar to spermatid-specific thioredoxin; spermatid-specific thioredoxin-1; sptrx-1; thioredoxin domain containing 2 (spermatozoa); thioredoxin domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89112,677,459 - 112,682,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9112,668,084 - 112,682,092 (-)EnsemblGRCr8
mRatBN7.29105,230,575 - 105,235,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,230,578 - 105,235,126 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9113,640,107 - 113,644,712 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09118,751,364 - 118,755,868 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,106,057 - 117,110,666 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,354,047 - 113,358,558 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,354,053 - 113,358,526 (-)Ensemblrn6Rnor6.0
Rnor_5.09112,886,277 - 112,890,798 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49104,391,636 - 104,396,147 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9102,617,140 - 102,621,651 (-)NCBICelera
RGSC_v3.19104,601,119 - 104,605,609 (-)NCBI
Cytogenetic Map9q37NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein. Jimenez A, etal., Mol Hum Reprod 2002 Aug;8(8):710-8.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11399755   PMID:12390887   PMID:15489334   PMID:23707457  


Genomics

Comparative Map Data
Txndc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89112,677,459 - 112,682,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9112,668,084 - 112,682,092 (-)EnsemblGRCr8
mRatBN7.29105,230,575 - 105,235,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,230,578 - 105,235,126 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9113,640,107 - 113,644,712 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09118,751,364 - 118,755,868 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,106,057 - 117,110,666 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,354,047 - 113,358,558 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,354,053 - 113,358,526 (-)Ensemblrn6Rnor6.0
Rnor_5.09112,886,277 - 112,890,798 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49104,391,636 - 104,396,147 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9102,617,140 - 102,621,651 (-)NCBICelera
RGSC_v3.19104,601,119 - 104,605,609 (-)NCBI
Cytogenetic Map9q37NCBI
TXNDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,885,973 - 9,889,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,885,766 - 9,889,275 (+)Ensemblhg38GRCh38
GRCh37189,885,970 - 9,889,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,875,362 - 9,878,156 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34189,875,801 - 9,878,155NCBI
Celera189,769,333 - 9,771,721 (+)NCBICelera
Cytogenetic Map18p11.22NCBI
HuRef189,847,996 - 9,850,429 (+)NCBIHuRef
CHM1_1189,884,991 - 9,887,424 (+)NCBICHM1_1
T2T-CHM13v2.01810,049,441 - 10,052,739 (+)NCBIT2T-CHM13v2.0
Txndc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391765,944,498 - 65,955,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1765,944,502 - 65,949,163 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381765,637,505 - 65,648,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1765,637,507 - 65,642,168 (-)Ensemblmm10GRCm38
MGSCv371765,986,845 - 65,991,544 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361765,537,057 - 65,539,299 (-)NCBIMGSCv36mm8
Celera1769,940,903 - 69,945,602 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1734.99NCBI
Txndc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554022,332,837 - 2,341,269 (-)Ensembl
ChiLan1.0NW_0049554022,339,130 - 2,341,283 (-)NCBIChiLan1.0ChiLan1.0
TXNDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21728,560,175 - 28,565,275 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11814,252,770 - 14,257,870 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0184,397,565 - 4,401,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1186,681,552 - 6,683,778 (-)NCBIPanPan1.1PanPan1.1panPan2
TXNDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1775,822,005 - 75,824,032 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl775,822,013 - 75,824,007 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha775,219,566 - 75,221,603 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0775,879,581 - 75,884,366 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl775,882,348 - 75,884,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1775,580,645 - 75,582,689 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0775,598,431 - 75,600,468 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0775,907,762 - 75,909,799 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Txndc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049442,380,217 - 2,382,276 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366261,608,877 - 1,610,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1698,271,124 - 98,276,039 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TXNDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11868,757,934 - 68,760,701 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1868,758,946 - 68,760,537 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605043,713,693 - 43,715,448 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txndc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477018,383,444 - 18,385,340 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Txndc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14175,620,662 - 175,622,873 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Txndc2
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:72
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000032330, ENSRNOT00000043492, ENSRNOT00000065073
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
3 3 20 76 32 38 17 23 17 4 128 62 8 58 43 47 21 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000032330   ⟹   ENSRNOP00000034030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9112,668,084 - 112,679,783 (-)Ensembl
mRatBN7.2 Ensembl9105,230,578 - 105,232,899 (-)Ensembl
Rnor_6.0 Ensembl9113,354,053 - 113,357,933 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065073   ⟹   ENSRNOP00000062071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9112,676,483 - 112,681,235 (-)Ensembl
mRatBN7.2 Ensembl9105,230,579 - 105,234,351 (-)Ensembl
Rnor_6.0 Ensembl9113,354,072 - 113,358,526 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097957   ⟹   ENSRNOP00000092660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9112,676,483 - 112,682,092 (-)Ensembl
mRatBN7.2 Ensembl9105,230,579 - 105,235,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172171   ⟹   ENSRNOP00000102385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9112,676,804 - 112,679,783 (-)Ensembl
RefSeq Acc Id: NM_001005559   ⟹   NP_001005559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89112,677,459 - 112,681,966 (-)NCBI
mRatBN7.29105,230,575 - 105,235,082 (-)NCBI
Rnor_6.09113,354,047 - 113,358,558 (-)NCBI
Rnor_5.09112,886,277 - 112,890,798 (-)NCBI
RGSC_v3.49104,391,636 - 104,396,147 (-)RGD
Celera9102,617,140 - 102,621,651 (-)RGD
Sequence:
RefSeq Acc Id: NM_001146004   ⟹   NP_001139476
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89112,677,459 - 112,679,783 (-)NCBI
mRatBN7.29105,230,575 - 105,232,899 (-)NCBI
Rnor_6.09113,354,047 - 113,356,375 (-)NCBI
Rnor_5.09112,886,277 - 112,890,798 (-)NCBI
RGSC_v3.49104,391,636 - 104,396,147 (-)RGD
Celera9102,617,140 - 102,619,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245607   ⟹   XP_006245669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89112,677,459 - 112,682,027 (-)NCBI
mRatBN7.29105,230,580 - 105,235,131 (-)NCBI
Rnor_6.09113,354,052 - 113,358,545 (-)NCBI
Rnor_5.09112,886,277 - 112,890,798 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083806   ⟹   XP_038939734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89112,677,459 - 112,679,680 (-)NCBI
mRatBN7.29105,230,584 - 105,232,807 (-)NCBI
RefSeq Acc Id: NP_001005559   ⟸   NM_001005559
- Peptide Label: isoform 2
- UniProtKB: F1LV53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139476   ⟸   NM_001146004
- Peptide Label: isoform 1
- UniProtKB: Q6AY11 (UniProtKB/Swiss-Prot),   Q5XHX6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245669   ⟸   XM_006245607
- Peptide Label: isoform X1
- UniProtKB: Q5XHX6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062071   ⟸   ENSRNOT00000065073
Ensembl Acc Id: ENSRNOP00000034030   ⟸   ENSRNOT00000032330
RefSeq Acc Id: XP_038939734   ⟸   XM_039083806
- Peptide Label: isoform X2
- UniProtKB: A6JRC0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092660   ⟸   ENSRNOT00000097957
Ensembl Acc Id: ENSRNOP00000102385   ⟸   ENSRNOT00000172171
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XHX6-F1-model_v2 AlphaFold Q5XHX6 1-550 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696903
Promoter ID:EPDNEW_R7427
Type:multiple initiation site
Name:Txndc2_1
Description:thioredoxin domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09113,358,577 - 113,358,637EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359251 AgrOrtholog
BioCyc Gene G2FUF-26487 BioCyc
Ensembl Genes ENSRNOG00000027916 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032330.6 UniProtKB/Swiss-Prot
  ENSRNOT00000065073.4 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132630 IMAGE-MGC_LOAD
  IMAGE:7135313 IMAGE-MGC_LOAD
InterPro Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:316777 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94320 IMAGE-MGC_LOAD
  MGC:95324 IMAGE-MGC_LOAD
NCBI Gene 316777 ENTREZGENE
PANTHER THIOREDOXIN-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot
PhenoGen Txndc2 PhenoGen
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027916 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I6AVY4_RAT UniProtKB/TrEMBL
  A0ABK0LG36_RAT UniProtKB/TrEMBL
  A6JRC0 ENTREZGENE, UniProtKB/TrEMBL
  F1LV53 ENTREZGENE, UniProtKB/TrEMBL
  Q5XHX6 ENTREZGENE
  Q6AY11 ENTREZGENE
  TXND2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6AY11 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Txndc2  thioredoxin domain containing 2  Txndc2  thioredoxin domain containing 2 (spermatozoa)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Txndc2  thioredoxin domain containing 2 (spermatozoa)  MGC94320  similar to spermatid-specific thioredoxin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 MGC94320  similar to spermatid-specific thioredoxin      Symbol and Name status set to provisional 70820 PROVISIONAL