Txndc2 (thioredoxin domain containing 2)

Gene: Txndc2 (thioredoxin domain containing 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Txndc2

Name:

thioredoxin domain containing 2

RGD ID:

12620466

Description:

ENCODES a protein that exhibits protein disulfide isomerase activity (ortholog); thioredoxin-disulfide reductase (NADPH) activity (ortholog); INVOLVED IN cellular response to reactive oxygen species (ortholog); flagellated sperm motility (ortholog); ASSOCIATED WITH chromosome 18p deletion syndrome (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); outer dense fiber (ortholog); sperm flagellum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

thioredoxin domain-containing protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	2,380,217 - 2,382,276 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936626	1,608,877 - 1,610,472 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18p deletion syndrome (ISO)

dystonia (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to reactive oxygen species (ISO)

flagellated sperm motility (ISO)

Cellular Component

cytoplasm (ISO)

outer dense fiber (ISO)

sperm flagellum (ISO)

Molecular Function

protein binding (ISO)

protein disulfide isomerase activity (ISO)

thioredoxin-disulfide reductase (NADPH) activity (ISO)

References

Genomics

Comparative Map Data

Txndc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	2,380,217 - 2,382,276 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936626	1,608,877 - 1,610,472 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TXNDC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	9,885,973 - 9,889,275 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	9,885,766 - 9,889,275 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	9,885,970 - 9,889,272 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	9,875,362 - 9,878,156 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	9,875,801 - 9,878,155	NCBI
Celera	18	9,769,333 - 9,771,721 (+)	NCBI		Celera
Cytogenetic Map	18	p11.22	NCBI
HuRef	18	9,847,996 - 9,850,429 (+)	NCBI		HuRef
CHM1_1	18	9,884,991 - 9,887,424 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	10,049,441 - 10,052,739 (+)	NCBI		T2T-CHM13v2.0

Txndc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	65,944,498 - 65,955,871 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	65,944,502 - 65,949,163 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	65,637,505 - 65,648,874 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	65,637,507 - 65,642,168 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	65,986,845 - 65,991,544 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	65,537,057 - 65,539,299 (-)	NCBI		MGSCv36	mm8
Celera	17	69,940,903 - 69,945,602 (-)	NCBI		Celera
Cytogenetic Map	17	E1.1	NCBI
cM Map	17	34.99	NCBI

Txndc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	112,677,459 - 112,682,027 (-)	NCBI		GRCr8
mRatBN7.2	9	105,230,575 - 105,235,131 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	105,230,578 - 105,235,126 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	113,640,107 - 113,644,712 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	118,751,364 - 118,755,868 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	117,106,057 - 117,110,666 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	113,354,047 - 113,358,558 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	113,354,053 - 113,358,526 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	112,886,277 - 112,890,798 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	104,391,636 - 104,396,147 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	104,601,119 - 104,605,609 (-)	NCBI
Celera	9	102,617,140 - 102,621,651 (-)	NCBI		Celera
Cytogenetic Map	9	q37	NCBI

Txndc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955402	2,339,130 - 2,341,283 (-)	NCBI	ChiLan1.0	ChiLan1.0

TXNDC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	28,560,175 - 28,565,275 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	14,252,770 - 14,257,870 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	4,397,565 - 4,401,236 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	6,681,552 - 6,683,778 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

TXNDC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	75,822,005 - 75,824,032 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	75,822,013 - 75,824,007 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	75,219,566 - 75,221,603 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	75,879,581 - 75,884,366 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	7	75,580,645 - 75,582,689 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	75,598,431 - 75,600,468 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	75,907,762 - 75,909,799 (+)	NCBI		UU_Cfam_GSD_1.0

TXNDC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	98,271,124 - 98,276,039 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TXNDC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	68,757,934 - 68,760,701 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	68,758,946 - 68,760,537 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	43,713,693 - 43,715,448 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Txndc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624770	18,383,444 - 18,385,340 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005334899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005334899 ⟹ XP_005334956

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404944	2,380,217 - 2,382,276 (-)	NCBI
SpeTri2.0	NW_004936626	1,608,877 - 1,610,472 (-)	NCBI

Sequence:

show sequence

ATGCGGGCTGGGCAGACATGGCCCTGGCACTCCAGTGCCCGTGTGGATAGCAGGGCAGAGGGGC
AGGGCACCCCTCACCATGAGGCCTCTGCGAAGGGTCAGGATGGGCGGAGGCAGGGGCCGGAAAT
GGACAGTGTTCCATCCAGAGCCGCAGAAGAGTCTCAAATGAGATCGGACGATCCAGAAGAAACC
GCTGAGGATGACGCCAATGAAAGCCCATTACAGGTTCTGCCCAACAAAGGGGCTCTTCGGGTCC
CCGAGTTCTTGGACACAGCCAAGGCCAAAGAGAAGACCTTTGTCCCTGGGGTCGATCACGCTCT
CCAGCTCGCCACAGAAAGGTCCCAGAGCCTGCAGCAGAGCAGTGACCTCCCCAAGTTCTCAGCG
AAAAACCCCCAGTCTCCGCAGTTCTCTAAGACCACAGCCAAAACTGTGCTCCCCAAGCCGGGGA
GCATTCCCAAGTCCTCTGCAGACCCTGCCCAGCCCAAGCCAGGCAGCACCCCCAAGCTCCTGGC
GAAAGCCATGCAGCTCAAGCTCAGGAACCCCCCCAAGGCCCCCGCCAACATCACAGAGCCCCTG
CAGGGCCACAGTCTGCAGGCCTCCGAGAAGGGCACCCAGCCCAAGAAGTGGGACTCCCCCAAGT
CCCTAGACGAAGCCATCCATGCCAGAGCGGGGAAGGCCCCCAAGTCCTTCGGACCAGCCACCCA
GTCCAGGTTGGGCATCATCTCCAAGACCTTAGGACAAGCCTTCCAGCCCAGGGTGGGCAGTGTC
CCCAAGTCCTTAGAAGAAGCCACTGAGGCCACAGTGGGAATGGCCCCCAAGTCAATAGAGGAGA
CCTTCCAGCCCGTGTTGGGCAGTGTCCCTGCCTCTGTAGAGGAAGCCCTGCAGCCCGAGCCGGG
TGATGTCCCCGAGCCCTCCGAGGAAGCCCTCCCGCCCAAAGACGACGACCTCCTGGAGCCCGAG
GACAAGGCGCCGGAGCCCCTGGAGGAGGACTTGGTGAAAGTGATCTTGGACAAGGAGGACCTCC
AGGAGGTGCTCACGACGGCCGGCGAGCGGCTGGTGGCCGTGGAATTCTCGGCCACCTGGTGCGG
GCCTTGCAGGCATATCCGGCCGCTCTTCCACGCCCTGTCCCTGAGGCACAAGGACGTGCTGTTC
CTGGAGGTGGACATTGACGCCTGCGAGGAGCTGGTGAAGGACTTGGAGGTCTTCTCCCTTCCAA
CCTTCCAGTTTTATAAGAAGGAGGAGAAGGTGGGCGAGTTCAGCGGGGCCCTGGTAGAGAAACT
CGAGGCAGCCATCGCAGAATTAAAGTGA

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Protein Sequences


Protein RefSeqs	XP_005334956	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3293504	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005334956 ⟸ XM_005334899

- Sequence:

show sequence

MRAGQTWPWHSSARVDSRAEGQGTPHHEASAKGQDGRRQGPEMDSVPSRAAEESQMRSDDPEET
AEDDANESPLQVLPNKGALRVPEFLDTAKAKEKTFVPGVDHALQLATERSQSLQQSSDLPKFSA
KNPQSPQFSKTTAKTVLPKPGSIPKSSADPAQPKPGSTPKLLAKAMQLKLRNPPKAPANITEPL
QGHSLQASEKGTQPKKWDSPKSLDEAIHARAGKAPKSFGPATQSRLGIISKTLGQAFQPRVGSV
PKSLEEATEATVGMAPKSIEETFQPVLGSVPASVEEALQPEPGDVPEPSEEALPPKDDDLLEPE
DKAPEPLEEDLVKVILDKEDLQEVLTTAGERLVAVEFSATWCGPCRHIRPLFHALSLRHKDVLF
LEVDIDACEELVKDLEVFSLPTFQFYKKEEKVGEFSGALVEKLEAAIAELK

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Txndc2	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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