Srsf6 (serine and arginine rich splicing factor 6) - Rat Genome Database

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Gene: Srsf6 (serine and arginine rich splicing factor 6) Rattus norvegicus
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Symbol: Srsf6
Name: serine and arginine rich splicing factor 6
RGD ID: 1359241
Description: Predicted to enable mRNA binding activity and pre-mRNA binding activity. Involved in negative regulation of gene expression; negative regulation of type B pancreatic cell apoptotic process; and response to insulin. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to human SRSF6 (serine and arginine rich splicing factor 6); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362264; pre-mRNA-splicing factor SRP55; serine/arginine-rich splicing factor 6; Sfrs6; similar to dJ862K6.2.2 (splicing factor, arginine/serine-rich 6 (SRP55-2)(isoform 2)); splicing factor, arginine/serine-rich 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Srsf6-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,009,072 - 172,014,395 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3172,009,061 - 172,014,392 (+)EnsemblGRCr8
mRatBN7.23151,589,546 - 151,594,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3151,589,535 - 151,594,860 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3155,397,888 - 155,403,214 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03163,896,848 - 163,902,174 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03161,640,441 - 161,645,767 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03159,305,345 - 159,310,668 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,305,345 - 159,310,668 (+)Ensemblrn6Rnor6.0
Rnor_5.03165,502,385 - 165,507,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43153,795,483 - 153,799,026 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3150,247,637 - 150,252,960 (+)NCBICelera
RGSC_v3.13153,701,518 - 153,705,060 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic UMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calyculin A  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dibenzo[a,l]pyrene  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
GSK690693  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
ozone  (ISO)
paraquat  (ISO)
PCB138  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
testosterone enanthate  (ISO)
tetraphene  (ISO)
thiram  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
nuclear speck  (IEA,ISO,ISS)
nucleus  (IBA,IEA)

Molecular Function
mRNA binding  (IBA)
nucleic acid binding  (IEA)
pre-mRNA binding  (IEA,ISO,ISS)
protein binding  (ISO)
RNA binding  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Splicing factor polymorphisms, the control of VEGF isoforms and association with angiogenic eye disease. Carter JG, etal., Curr Eye Res. 2011 Apr;36(4):328-35. doi: 10.3109/02713683.2010.548892. Epub 2011 Feb 10.
2. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
3. The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers. Cohen-Eliav M, etal., J Pathol. 2013 Mar;229(4):630-9. doi: 10.1002/path.4129.
4. Huntington's disease is a four-repeat tauopathy with tau nuclear rods. Fernandez-Nogales M, etal., Nat Med. 2014 Aug;20(8):881-5. doi: 10.1038/nm.3617. Epub 2014 Jul 20.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Altered expression of heterogenous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas. Ghigna C, etal., Cancer Res. 1998 Dec 15;58(24):5818-24.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact. Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3.
9. Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Jensen MA, etal., Nat Struct Mol Biol. 2014 Feb;21(2):189-97. doi: 10.1038/nsmb.2756. Epub 2014 Jan 19.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Genetic variants in Ser-Arg protein-coding genes are associated with the risk of nonobstructive azoospermia in Chinese men. Ni B, etal., Fertil Steril. 2014 Jun;101(6):1711-7.e1-2. doi: 10.1016/j.fertnstert.2014.02.033. Epub 2014 Mar 21.
12. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. Nogueira TC, etal., PLoS Genet. 2013 May;9(5):e1003532. doi: 10.1371/journal.pgen.1003532. Epub 2013 May 30.
13. Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells. Patel NA, etal., J Biol Chem. 2001 Jun 22;276(25):22648-54. Epub 2001 Mar 30.
14. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
20. Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver. Walsh CM, etal., J Biol Chem. 2013 Jan 25;288(4):2816-28. doi: 10.1074/jbc.M112.410803. Epub 2012 Dec 11.
Additional References at PubMed
PMID:12549914   PMID:15009664   PMID:22658674   PMID:22681889   PMID:22767602   PMID:29476059   PMID:30361391   PMID:31505169  


Genomics

Comparative Map Data
Srsf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,009,072 - 172,014,395 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3172,009,061 - 172,014,392 (+)EnsemblGRCr8
mRatBN7.23151,589,546 - 151,594,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3151,589,535 - 151,594,860 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3155,397,888 - 155,403,214 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03163,896,848 - 163,902,174 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03161,640,441 - 161,645,767 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03159,305,345 - 159,310,668 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,305,345 - 159,310,668 (+)Ensemblrn6Rnor6.0
Rnor_5.03165,502,385 - 165,507,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43153,795,483 - 153,799,026 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3150,247,637 - 150,252,960 (+)NCBICelera
RGSC_v3.13153,701,518 - 153,705,060 (+)NCBI
Cytogenetic Map3q42NCBI
SRSF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382043,457,896 - 43,464,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2043,457,893 - 43,466,046 (+)Ensemblhg38GRCh38
GRCh372042,086,536 - 42,092,883 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,519,932 - 41,525,655 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342041,519,931 - 41,525,655NCBI
Celera2038,793,993 - 38,799,734 (+)NCBICelera
Cytogenetic Map20q13.11NCBI
HuRef2038,822,762 - 38,828,474 (+)NCBIHuRef
CHM1_12041,990,350 - 41,996,091 (+)NCBICHM1_1
T2T-CHM13v2.02045,191,165 - 45,197,503 (+)NCBIT2T-CHM13v2.0
Srsf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392162,773,428 - 162,779,041 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2162,773,448 - 162,779,041 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382162,931,508 - 162,937,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2162,931,528 - 162,937,121 (+)Ensemblmm10GRCm38
MGSCv372162,757,244 - 162,762,857 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362162,622,982 - 162,628,562 (+)NCBIMGSCv36mm8
Celera2168,878,554 - 168,884,169 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map283.87NCBI
Srsf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544513,661,209 - 13,669,102 (-)Ensembl
ChiLan1.0NW_00495544513,663,474 - 13,669,102 (-)NCBIChiLan1.0ChiLan1.0
SRSF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22149,193,875 - 49,203,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12049,186,976 - 49,196,276 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02039,795,659 - 39,801,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12040,888,396 - 40,892,152 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2040,888,560 - 40,891,853 (+)EnsemblpanPan2panpan1.1
SRSF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12431,217,190 - 31,222,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2431,217,184 - 31,218,618 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2430,860,739 - 30,866,500 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02431,924,806 - 31,930,549 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2431,924,822 - 31,930,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12431,188,536 - 31,194,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02431,299,944 - 31,305,686 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02431,840,352 - 31,846,095 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srsf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640180,213,648 - 180,219,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365303,086,680 - 3,092,828 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365303,086,944 - 3,092,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1746,119,409 - 46,125,126 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11746,119,612 - 46,122,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21751,513,133 - 51,516,063 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1220,340,163 - 20,345,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl220,342,681 - 20,346,122 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605069,083,496 - 69,089,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srsf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479010,812,013 - 10,817,833 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479010,812,013 - 10,817,414 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Srsf6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15155,043,649 - 155,048,999 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1074
Count of miRNA genes:340
Interacting mature miRNAs:462
Transcripts:ENSRNOT00000008427
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
AW146126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23151,594,680 - 151,594,786 (+)MAPPERmRatBN7.2
Rnor_6.03159,310,480 - 159,310,585NCBIRnor6.0
Rnor_5.03165,507,520 - 165,507,625UniSTSRnor5.0
RGSC_v3.43153,800,609 - 153,800,714UniSTSRGSC3.4
Celera3150,252,772 - 150,252,877UniSTS
Cytogenetic Map3q42UniSTS
RH131453  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23151,589,307 - 151,589,523 (+)MAPPERmRatBN7.2
Rnor_6.03159,305,107 - 159,305,322NCBIRnor6.0
Rnor_5.03165,502,147 - 165,502,362UniSTSRnor5.0
RGSC_v3.43153,795,236 - 153,795,451UniSTSRGSC3.4
Celera3150,247,399 - 150,247,614UniSTS
RH 3.4 Map31391.0UniSTS
Cytogenetic Map3q42UniSTS
AA874922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23151,592,459 - 151,592,647 (+)MAPPERmRatBN7.2
Rnor_6.03159,308,259 - 159,308,446NCBIRnor6.0
Rnor_5.03165,505,299 - 165,505,486UniSTSRnor5.0
RGSC_v3.43153,798,388 - 153,798,575UniSTSRGSC3.4
Celera3150,250,551 - 150,250,738UniSTS
RH 3.4 Map31387.9UniSTS
Cytogenetic Map3q42UniSTS
RH139802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23151,594,171 - 151,594,351 (+)MAPPERmRatBN7.2
Rnor_6.03159,309,971 - 159,310,150NCBIRnor6.0
Rnor_5.03165,507,011 - 165,507,190UniSTSRnor5.0
RGSC_v3.43153,800,100 - 153,800,279UniSTSRGSC3.4
Celera3150,252,263 - 150,252,442UniSTS
RH 3.4 Map31387.9UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008427   ⟹   ENSRNOP00000008427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3172,009,061 - 172,014,392 (+)Ensembl
mRatBN7.2 Ensembl3151,589,535 - 151,594,860 (+)Ensembl
Rnor_6.0 Ensembl3159,305,345 - 159,310,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117899   ⟹   ENSRNOP00000086011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3172,009,061 - 172,010,572 (+)Ensembl
mRatBN7.2 Ensembl3151,589,542 - 151,592,959 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137369   ⟹   ENSRNOP00000107258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3172,011,143 - 172,014,392 (+)Ensembl
RefSeq Acc Id: NM_001014185   ⟹   NP_001014207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,009,072 - 172,014,395 (+)NCBI
mRatBN7.23151,589,546 - 151,594,869 (+)NCBI
Rnor_6.03159,305,345 - 159,310,668 (+)NCBI
Rnor_5.03165,502,385 - 165,507,708 (+)NCBI
RGSC_v3.43153,795,483 - 153,799,026 (+)RGD
Celera3150,247,637 - 150,252,960 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001014207 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87121 (Get FASTA)   NCBI Sequence Viewer  
  EDL96600 (Get FASTA)   NCBI Sequence Viewer  
  EDL96601 (Get FASTA)   NCBI Sequence Viewer  
  EDL96602 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008427
  ENSRNOP00000008427.5
GenBank Protein G3V6S8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014207   ⟸   NM_001014185
- UniProtKB: Q5PQM1 (UniProtKB/Swiss-Prot),   G3V6S8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008427   ⟸   ENSRNOT00000008427
Ensembl Acc Id: ENSRNOP00000086011   ⟸   ENSRNOT00000117899
Ensembl Acc Id: ENSRNOP00000107258   ⟸   ENSRNOT00000137369
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6S8-F1-model_v2 AlphaFold G3V6S8 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692631
Promoter ID:EPDNEW_R3154
Type:multiple initiation site
Name:Srsf6_1
Description:serine and arginine rich splicing factor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03159,305,334 - 159,305,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359241 AgrOrtholog
BioCyc Gene G2FUF-46928 BioCyc
Ensembl Genes ENSRNOG00000006380 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008427 ENTREZGENE
  ENSRNOT00000008427.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106749 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM2_SRSF4/6 UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
  RRT5_SRSF_SR UniProtKB/Swiss-Prot
KEGG Report rno:362264 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94786 IMAGE-MGC_LOAD
NCBI Gene 362264 ENTREZGENE
PANTHER RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot
  SERINE/ARGININE-RICH SPLICING FACTOR 6 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Srsf6 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006380 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8I6A2U9_RAT UniProtKB/TrEMBL
  A0ABK0LA19_RAT UniProtKB/TrEMBL
  G3V6S8 ENTREZGENE
  Q5PQM1 ENTREZGENE
  SRSF6_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5PQM1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Srsf6  serine and arginine rich splicing factor 6  Srsf6  serine/arginine-rich splicing factor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Srsf6  serine/arginine-rich splicing factor 6  Sfrs6  splicing factor, arginine/serine-rich 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Sfrs6  splicing factor, arginine/serine-rich 6  Srsf6  serine/arginine-rich splicing factor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srsf6  serine/arginine-rich splicing factor 6  Sfrs6  splicing factor, arginine/serine-rich 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Sfrs6  splicing factor, arginine/serine-rich 6  Srsf6  serine/arginine-rich splicing factor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-14 Srsf6  serine/arginine-rich splicing factor 6  Sfrs6  splicing factor, arginine/serine-rich 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Sfrs6  splicing factor, arginine/serine-rich 6  LOC362264  similar to dJ862K6.2.2 (splicing factor, arginine/serine-rich 6 (SRP55-2)(isoform 2))  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED