Myg1 (MYG1 exonuclease) - Rat Genome Database

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Gene: Myg1 (MYG1 exonuclease) Rattus norvegicus
Analyze
Symbol: Myg1
Name: MYG1 exonuclease
RGD ID: 1359237
Description: Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to be involved in mRNA processing; mitochondrial RNA metabolic process; and rRNA processing. Predicted to act upstream of or within locomotory exploration behavior. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix; nucleolus; and nucleoplasm. Orthologous to human MYG1 (MYG1 exonuclease); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C12orf10; melanocyte proliferating gene 1; MGC95325; UPF0160 protein MYG1, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,335,364 - 135,342,567 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7135,335,334 - 135,346,740 (+)EnsemblGRCr8
mRatBN7.27133,456,778 - 133,463,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,456,750 - 133,466,969 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7135,217,777 - 135,225,021 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,447,157 - 137,454,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,432,305 - 137,439,549 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,929,662 - 143,936,865 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,929,662 - 143,936,864 (+)Ensemblrn6Rnor6.0
Rnor_5.07141,725,704 - 141,732,907 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47141,080,469 - 141,087,672 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,890,186 - 129,897,389 (+)NCBICelera
RGSC_v3.17141,156,905 - 141,164,108 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IEA,ISO,ISS)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19014353   PMID:19818808   PMID:20377893   PMID:23376485  


Genomics

Comparative Map Data
Myg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,335,364 - 135,342,567 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7135,335,334 - 135,346,740 (+)EnsemblGRCr8
mRatBN7.27133,456,778 - 133,463,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,456,750 - 133,466,969 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7135,217,777 - 135,225,021 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,447,157 - 137,454,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,432,305 - 137,439,549 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,929,662 - 143,936,865 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,929,662 - 143,936,864 (+)Ensemblrn6Rnor6.0
Rnor_5.07141,725,704 - 141,732,907 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47141,080,469 - 141,087,672 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,890,186 - 129,897,389 (+)NCBICelera
RGSC_v3.17141,156,905 - 141,164,108 (+)NCBI
Cytogenetic Map7q36NCBI
MYG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,299,695 - 53,307,177 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,299,695 - 53,307,177 (+)Ensemblhg38GRCh38
GRCh371253,693,479 - 53,700,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,979,737 - 51,987,232 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341251,979,748 - 51,987,229NCBI
Celera1253,342,755 - 53,350,242 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,734,992 - 50,742,478 (+)NCBIHuRef
CHM1_11253,659,909 - 53,667,402 (+)NCBICHM1_1
T2T-CHM13v2.01253,265,406 - 53,272,879 (+)NCBIT2T-CHM13v2.0
Myg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,240,144 - 102,246,574 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,240,144 - 102,246,574 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815102,331,709 - 102,338,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,331,709 - 102,338,139 (+)Ensemblmm10GRCm38
MGSCv3715102,162,140 - 102,168,570 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615102,159,744 - 102,165,885 (+)NCBIMGSCv36mm8
Celera15104,488,769 - 104,495,141 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.49NCBI
Myg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458560,207 - 567,081 (+)Ensembl
ChiLan1.0NW_004955458560,033 - 567,102 (+)NCBIChiLan1.0ChiLan1.0
MYG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,878,978 - 40,886,292 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,875,743 - 40,882,962 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,447,248 - 35,454,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,228,165 - 36,235,474 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,228,165 - 36,235,474 (-)EnsemblpanPan2panpan1.1
MYG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,900,360 - 1,905,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,900,360 - 1,905,931 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2744,343,336 - 44,348,921 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0271,904,821 - 1,910,407 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,885,025 - 1,910,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,923,155 - 1,928,712 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,908,056 - 1,913,641 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,744,034 - 44,749,620 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,575,564 - 62,581,240 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,581,797 - 10,589,250 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,583,552 - 10,589,266 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,517,001 - 18,525,877 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1518,516,947 - 18,526,069 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,952,686 - 18,961,606 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,403,574 - 49,424,193 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037196,643,964 - 196,651,681 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,412,049 - 1,419,365 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249041,412,664 - 1,419,398 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Myg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11260,743,834 - 260,751,155 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000017942
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH127371  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,342,139 - 135,342,538 (+)Marker Load Pipeline
mRatBN7.27133,463,553 - 133,463,952 (+)MAPPERmRatBN7.2
Rnor_6.07143,936,438 - 143,936,836NCBIRnor6.0
Rnor_5.07141,732,480 - 141,732,878UniSTSRnor5.0
RGSC_v3.47141,087,245 - 141,087,643UniSTSRGSC3.4
Celera7129,896,962 - 129,897,360UniSTS
RH 3.4 Map71062.9UniSTS
Cytogenetic Map7q36UniSTS
RH131256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,457,794 - 133,458,011 (+)MAPPERmRatBN7.2
Rnor_6.07143,930,679 - 143,930,895NCBIRnor6.0
Rnor_5.07141,726,721 - 141,726,937UniSTSRnor5.0
RGSC_v3.47141,081,486 - 141,081,702UniSTSRGSC3.4
Celera7129,891,203 - 129,891,419UniSTS
RH 3.4 Map71063.0UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017942   ⟹   ENSRNOP00000017942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7135,335,334 - 135,342,566 (+)Ensembl
mRatBN7.2 Ensembl7133,456,750 - 133,466,969 (+)Ensembl
Rnor_6.0 Ensembl7143,929,662 - 143,936,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136838   ⟹   ENSRNOP00000111052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7135,335,334 - 135,346,740 (+)Ensembl
RefSeq Acc Id: NM_001005545   ⟹   NP_001005545
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,335,364 - 135,342,567 (+)NCBI
mRatBN7.27133,456,778 - 133,463,981 (+)NCBI
Rnor_6.07143,929,662 - 143,936,865 (+)NCBI
Rnor_5.07141,725,704 - 141,732,907 (+)NCBI
RGSC_v3.47141,080,469 - 141,087,672 (+)RGD
Celera7129,890,186 - 129,897,389 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078940   ⟹   XP_038934868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,335,739 - 135,342,567 (+)NCBI
mRatBN7.27133,458,340 - 133,463,985 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001005545 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934868 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82112 (Get FASTA)   NCBI Sequence Viewer  
  EDL86845 (Get FASTA)   NCBI Sequence Viewer  
  EDL86846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017942
  ENSRNOP00000017942.3
GenBank Protein Q641W2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001005545   ⟸   NM_001005545
- Peptide Label: precursor
- UniProtKB: Q641W2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017942   ⟸   ENSRNOT00000017942
RefSeq Acc Id: XP_038934868   ⟸   XM_039078940
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000111052   ⟸   ENSRNOT00000136838

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641W2-F1-model_v2 AlphaFold Q641W2 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695697
Promoter ID:EPDNEW_R6222
Type:initiation region
Name:Myg1_1
Description:melanocyte proliferating gene 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,929,628 - 143,929,688EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359237 AgrOrtholog
BioCyc Gene G2FUF-31940 BioCyc
Ensembl Genes ENSRNOG00000013343 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017942 ENTREZGENE
  ENSRNOT00000017942.7 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7135321 IMAGE-MGC_LOAD
InterPro Met-dep_prot_hydro UniProtKB/Swiss-Prot
KEGG Report rno:300258 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95325 IMAGE-MGC_LOAD
NCBI Gene 300258 ENTREZGENE
PANTHER MYG1 EXONUCLEASE UniProtKB/Swiss-Prot
  PTHR11215 UniProtKB/Swiss-Prot
Pfam UPF0160 UniProtKB/Swiss-Prot
PhenoGen Myg1 PhenoGen
RatGTEx ENSRNOG00000013343 RatGTEx
UniProt A0ABK0LJE2_RAT UniProtKB/TrEMBL
  MYG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-31 Myg1  MYG1 exonuclease  Myg1  melanocyte proliferating gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Myg1  melanocyte proliferating gene 1  C12orf10  MYG1 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 C12orf10  MYG1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL