Gene: UPK1A (uroplakin 1A)
Homo sapiens
Symbol:
UPK1A
Name:
uroplakin 1A
Description:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
MGC129751; MGC129752; MGC14388; OTTHUMP00000045789; tetraspanin-21; tspan-21; TSPAN21; UP1A; UPIA; UPKA; uroplakin Ia; uroplakin-1a
Orthologs:
Mus musculus : Upk1a
(uroplakin 1A)
MGI
Upk1a
(uroplakin 1A)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 19 36,316,595 - 36,328,250 + NCBI Human Genome Assembly HuRef 19 32,663,223 - 32,674,496 + NCBI Human Genome Assembly GRCh37 19 36,157,715 - 36,169,367 + NCBI Human Genome Assembly Build 36 19 40,849,555 - 40,861,207 + NCBI Human Cytogenetic Map 19 q13.13 NCBI Human Genome Assembly 19 40,849,554 - 40,861,207 NCBI
Model
Gene-Chemical Interaction Annotations
17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of UPK1A mRNA CTD PMID:19619570 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of UPK1A mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of UPK1A mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1620672 6480464 Tetrachlorodibenzodioxin affects the expression of UPK1A mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of UPK1A mRNA CTD PMID:21998131 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of UPK1A mRNA CTD PMID:19619570 benzo[a]pyrene multiple interactions ISO RGD:1620672 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to UPK1A promoter] CTD PMID:19654925 cyclophosphamide decreases expression ISO RGD:1309849 6480464 Cyclophosphamide results in decreased expression of UPK1A mRNA CTD PMID:19654953 cyclophosphamide multiple interactions ISO RGD:1309849 6480464 Mesna inhibits the reaction [Cyclophosphamide results in decreased expression of UPK1A mRNA] CTD PMID:20186394 cyclophosphamide decreases expression ISO RGD:1309849 6480464 Cyclophosphamide results in decreased expression of UPK1A mRNA CTD PMID:19654953 PMID:20186394 paracetamol affects expression ISO RGD:1620672 6480464 Acetaminophen affects the expression of UPK1A mRNA CTD PMID:17562736 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UPK1A mRNA CTD PMID:19710929
Gene Ontology Annotations
Biological Process epithelial cell differentiation IDA 2290271 PMID:10514386 UniProtKB PMID:10514386 protein oligomerization ISS UniProtKB:P38572 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024
2289216 BW367_H Body weight QTL 367 (human) .0469 Body fat amount percent fat 19 10652925 36652925 Human 1331657 COPD9_H Chronic obstructive pulmonary disease QTL 9 (human) 1.94 Chronic airflow obstruction post-bronchodilator FEV1 19 12712793 57533128 Human 1298436 OSTEAR8_H Osteoarthritis QTL 8 (human) 1.82 Joint/bone inflammation hand osteoarthritis 19 17417129 43417129 Human 1559346 SCL94_H Serum cholesterol level QTL 94 (human) 1.54 .004 Lipid level total cholesterol 19 17417129 43417129 Human 1559351 SCL93_H Serum cholesterol level QTL 93 (human) 2.23 .0007 Lipid level LDL cholesterol 19 17417129 43417129 Human 2293396 PRSTS213_H Prostate tumor susceptibility QTL 213 (human) .0004 Prostate tumor susceptibility 19 17417129 43417129 Human 2315768 GLUCO148_H Glucose level QTL 148 (human) 2.2 .002 Glucose level 19 18914859 44914859 Human 2292899 PRSTS34_H Prostate tumor susceptibility QTL 34 (human) Prostate tumor susceptibility late onset 19 21098259 47098259 Human 1331666 COPD5_H Chronic obstructive pulmonary disease QTL 5 (human) 3.3 Chronic airflow obstruction pre-bronchodilator FEV1 19 21682674 53806756 Human 1357328 AASTH24_H Allergic/atopic asthma related QTL 24 (human) 1.02 Reversible airflow obstruction post-bronchodilator FEV1 19 29153142 55153142 Human 1298467 OSTEAR9_H Osteoarthritis QTL 9 (human) 1.83 Joint/bone inflammation hand osteoarthritis 19 31405702 57405702 Human 1357315 AASTH51_H Allergic/atopic asthma related QTL 51 (human) .0005 Reversible airflow obstruction 19 31405702 57405702 Human 1581531 BP78_H Blood pressure QTL 78 (human) 2.3 .001 Blood pressure pulse pressure 19 31405702 57405702 Human 1559403 SCL118_H Serum cholesterol level QTL 118 (human) 3.16 Lipid level triglyceride 19 31405702 57405702 Human 1559124 SCL23_H Serum cholesterol level QTL 23 (human) 3.24 .000617 Lipid level LDL cholesterol 19 31405702 57405702 Human 2302744 MAMTS26_H Mammary tumor susceptibility QTL 26 (human) .025 Mammary tumor susceptibility 19 31405702 57405702 Human 2302745 MAMTS27_H Mammary tumor susceptibility QTL 27 (human) .034 Mammary tumor susceptibility 19 31405702 57405702 Human 2302750 MAMTS28_H Mammary tumor susceptibility QTL 28 (human) .054 Mammary tumor susceptibility 20 31405702 57405702 Human 1559110 SCL22_H Serum cholesterol level QTL 22 (human) 3.59 .000241 Lipid level LDL cholesterol 19 32410844 58410844 Human 1559230 SAPOE1_H Serum apolipoprotein E level QTL 1 (human) 4.2 Apolipoprotein level apolipoprotein E level 19 34098157 57667065 Human 1300027 BW34_H Body weight QTL 34 (human) 1.5 .0063 Body weight body mass index 19 34098361 41527533 Human 2316701 GLUCO261_H Glucose level QTL 261 (human) 1.5 .0063 Glucose level 19 34098361 41527533 Human 2300240 PRSTS349_H Prostate tumor susceptibility QTL 349 (human) .0001 Prostate tumor susceptibility 19 35332164 59110802 Human
Gene Ontology Annotations
