Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hmgn3 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HMGN3 mRNA | CTD | PMID:22079256 | Hmgn3 | Rat | 17beta-estradiol | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of HMGN3 mRNA | CTD | PMID:23019147 | Hmgn3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HMGN3 mRNA | CTD | PMID:19770486 | Hmgn3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HMGN3 mRNA | CTD | PMID:34747641 | Hmgn3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Hmgn3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HMGN3 promoter] | CTD | PMID:19654925 | Hmgn3 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of HMGN3 mRNA | CTD | PMID:21346803 | Hmgn3 | Rat | 2-hydroxypropanoic acid | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of HMGN3 mRNA | CTD | PMID:30851411 | Hmgn3 | Rat | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:32119087 | Hmgn3 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of HMGN3 mRNA | CTD | PMID:26251327 | Hmgn3 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of HMGN3 protein | CTD | PMID:34186270 | Hmgn3 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of HMGN3 mRNA | CTD | PMID:28973697 | Hmgn3 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of HMGN3 mRNA | CTD | PMID:31881176 | Hmgn3 | Rat | acrylamide | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of HMGN3 mRNA | CTD | PMID:32763439 | Hmgn3 | Rat | aflatoxin B1 | increases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of HMGN3 mRNA | CTD | PMID:19770486 | Hmgn3 | Rat | aflatoxin B1 | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of HMGN3 mRNA | CTD | PMID:27153756 | Hmgn3 | Rat | aflatoxin B1 | decreases methylation | ISO | HMGN3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HMGN3 gene | CTD | PMID:27153756 | Hmgn3 | Rat | aflatoxin M1 | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Aflatoxin M1 results in decreased expression of HMGN3 mRNA | CTD | PMID:30928695 | Hmgn3 | Rat | all-trans-retinoic acid | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of HMGN3 mRNA | CTD | PMID:17218384 | Hmgn3 | Rat | all-trans-retinoic acid | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of HMGN3 mRNA | CTD | PMID:33167477 | Hmgn3 | Rat | aristolochic acid A | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HMGN3 mRNA | CTD | PMID:33212167 | Hmgn3 | Rat | arsenite(3-) | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to HMGN3 mRNA] | CTD | PMID:32406909 | Hmgn3 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of HMGN3 gene | CTD | PMID:28931070 | Hmgn3 | Rat | azathioprine | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Azathioprine results in decreased expression of HMGN3 mRNA | CTD | PMID:22623647 | Hmgn3 | Rat | benzo[a]pyrene | decreases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of HMGN3 mRNA | CTD | PMID:19770486 | Hmgn3 | Rat | benzo[a]pyrene | affects methylation | ISO | HMGN3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HMGN3 promoter | CTD | PMID:27901495 | Hmgn3 | Rat | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of HMGN3 mRNA | CTD | PMID:21839799 | Hmgn3 | Rat | beta-lapachone | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of HMGN3 mRNA | CTD | PMID:38218311 | Hmgn3 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of HMGN3 mRNA | CTD | PMID:25181051 | Hmgn3 | Rat | bisphenol A | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of HMGN3 protein | CTD | PMID:34186270 | Hmgn3 | Rat | bisphenol A | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of HMGN3 protein | CTD | PMID:33376534 and PMID:37664457 | Hmgn3 | Rat | bisphenol A | affects expression | ISO | HMGN3 (Homo sapiens) | 6480464 | bisphenol A affects the expression of HMGN3 mRNA | CTD | PMID:30903817 | Hmgn3 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of HMGN3 gene | CTD | PMID:28505145 | Hmgn3 | Rat | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of HMGN3 mRNA | CTD | PMID:24136188 | Hmgn3 | Rat | choline | multiple interactions | ISO | Hmgn3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HMGN3 mRNA | CTD | PMID:20938992 | Hmgn3 | Rat | cisplatin | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | Cisplatin promotes the reaction [Piroxicam results in decreased expression of HMGN3 mRNA] | CTD | PMID:21858171 | Hmgn3 | Rat | cobalt dichloride | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of HMGN3 mRNA | CTD | PMID:19320972 and PMID:19376846 | Hmgn3 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of HMGN3 mRNA | CTD | PMID:30556269 | Hmgn3 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of HMGN3 mRNA | CTD | PMID:30556269 | Hmgn3 | Rat | copper(II) sulfate | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of HMGN3 mRNA | CTD | PMID:19549813 | Hmgn3 | Rat | coumestrol | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMGN3 mRNA | CTD | PMID:19167446 | Hmgn3 | Rat | cyclosporin A | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of HMGN3 mRNA | CTD | PMID:20106945 more ... | Hmgn3 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of HMGN3 mRNA | CTD | PMID:21266533 and PMID:24893172 | Hmgn3 | Rat | dicrotophos | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of HMGN3 mRNA | CTD | PMID:28302478 | Hmgn3 | Rat | dimethylselenide | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | [[Ozone results in increased oxidation of dimethylselenide] which results in decreased expression of HMGN3-AS1 mRNA] which results in decreased expression of HMGN3 mRNA | CTD | PMID:33656867 | Hmgn3 | Rat | doxorubicin | affects response to substance | ISO | HMGN3 (Homo sapiens) | 6480464 | HMGN3 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | Hmgn3 | Rat | doxorubicin | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of HMGN3 mRNA | CTD | PMID:29803840 | Hmgn3 | Rat | Enterolactone | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMGN3 mRNA | CTD | PMID:19167446 | Hmgn3 | Rat | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of HMGN3 mRNA | CTD | PMID:24136188 | Hmgn3 | Rat | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of HMGN3 mRNA | CTD | PMID:23962444 | Hmgn3 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of HMGN3 mRNA | CTD | PMID:24136188 | Hmgn3 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of HMGN3 mRNA | CTD | PMID:24793618 | Hmgn3 | Rat | folic acid | multiple interactions | ISO | Hmgn3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HMGN3 mRNA | CTD | PMID:20938992 | Hmgn3 | Rat | FR900359 | increases phosphorylation | ISO | HMGN3 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of HMGN3 protein | CTD | PMID:37730182 | Hmgn3 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of HMGN3 mRNA | CTD | PMID:25539665 | Hmgn3 | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of HMGN3 mRNA | CTD | PMID:24136188 | Hmgn3 | Rat | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of HMGN3 mRNA | CTD | PMID:21396975 | Hmgn3 | Rat | ivermectin | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of HMGN3 protein | CTD | PMID:32959892 | Hmgn3 | Rat | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of HMGN3 mRNA | CTD | PMID:20080153 | Hmgn3 | Rat | L-methionine | multiple interactions | ISO | Hmgn3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HMGN3 mRNA | CTD | PMID:20938992 | Hmgn3 | Rat | leflunomide | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of HMGN3 mRNA | CTD | PMID:28988120 | Hmgn3 | Rat | methylparaben | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | methylparaben results in increased expression of HMGN3 mRNA | CTD | PMID:31745603 | Hmgn3 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of HMGN3 gene | CTD | PMID:33148267 | Hmgn3 | Rat | ozone | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | [[Ozone results in increased oxidation of dimethylselenide] which results in decreased expression of HMGN3-AS1 mRNA] which results in decreased expression of HMGN3 mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of HMGN3 mRNA | CTD | PMID:33656867 and PMID:35430440 | Hmgn3 | Rat | paclitaxel | affects response to substance | ISO | HMGN3 (Homo sapiens) | 6480464 | HMGN3 protein affects the susceptibility to Paclitaxel | CTD | PMID:16217747 | Hmgn3 | Rat | paracetamol | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of HMGN3 mRNA | CTD | PMID:29067470 | Hmgn3 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of HMGN3 gene | CTD | PMID:33148267 | Hmgn3 | Rat | pirinixic acid | multiple interactions | ISO | Hmgn3 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HMGN3 mRNA | CTD | PMID:19710929 | Hmgn3 | Rat | piroxicam | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | Cisplatin promotes the reaction [Piroxicam results in decreased expression of HMGN3 mRNA] | CTD | PMID:21858171 | Hmgn3 | Rat | piroxicam | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of HMGN3 mRNA | CTD | PMID:21858171 | Hmgn3 | Rat | potassium chromate | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of HMGN3 mRNA | CTD | PMID:22079256 | Hmgn3 | Rat | potassium chromate | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HMGN3 mRNA | CTD | PMID:22079256 | Hmgn3 | Rat | progesterone | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Progesterone results in increased expression of HMGN3 mRNA | CTD | PMID:18070364 | Hmgn3 | Rat | quercetin | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of HMGN3 mRNA | CTD | PMID:21632981 and PMID:30152185 | Hmgn3 | Rat | rac-lactic acid | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of HMGN3 mRNA | CTD | PMID:30851411 | Hmgn3 | Rat | SB 431542 | multiple interactions | ISO | HMGN3 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of HMGN3 protein | CTD | PMID:37664457 | Hmgn3 | Rat | silicon dioxide | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of HMGN3 mRNA | CTD | PMID:25895662 | Hmgn3 | Rat | sodium arsenite | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of HMGN3 mRNA | CTD | PMID:22714537 and PMID:28595984 | Hmgn3 | Rat | sodium arsenite | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of HMGN3 mRNA | CTD | PMID:38568856 | Hmgn3 | Rat | sunitinib | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of HMGN3 mRNA | CTD | PMID:31533062 | Hmgn3 | Rat | testosterone | decreases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of HMGN3 mRNA | CTD | PMID:33848595 | Hmgn3 | Rat | tetrachloromethane | affects expression | ISO | Hmgn3 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of HMGN3 mRNA | CTD | PMID:17484886 | Hmgn3 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of HMGN3 mRNA | CTD | PMID:30723492 | Hmgn3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of HMGN3 mRNA | CTD | PMID:23411599 | Hmgn3 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of HMGN3 mRNA | CTD | PMID:34492290 | Hmgn3 | Rat | thiram | decreases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Thiram results in decreased expression of HMGN3 mRNA | CTD | PMID:38568856 | Hmgn3 | Rat | titanium dioxide | increases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of HMGN3 mRNA | CTD | PMID:23557971 | Hmgn3 | Rat | titanium dioxide | decreases methylation | ISO | Hmgn3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of HMGN3 gene | CTD | PMID:35295148 | Hmgn3 | Rat | titanium dioxide | decreases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of HMGN3 mRNA | CTD | PMID:29264374 | Hmgn3 | Rat | topotecan | affects response to substance | ISO | HMGN3 (Homo sapiens) | 6480464 | HMGN3 protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | Hmgn3 | Rat | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of HMGN3 mRNA | CTD | PMID:24136188 | Hmgn3 | Rat | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of HMGN3 mRNA | CTD | PMID:24136188 | Hmgn3 | Rat | valproic acid | decreases methylation | ISO | HMGN3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of HMGN3 gene | CTD | PMID:29154799 | Hmgn3 | Rat | valproic acid | affects expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HMGN3 mRNA | CTD | PMID:25979313 | Hmgn3 | Rat | valproic acid | increases expression | ISO | HMGN3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HMGN3 mRNA | CTD | PMID:23179753 | Hmgn3 | Rat | valproic acid | increases expression | ISO | Hmgn3 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of HMGN3 mRNA | CTD | PMID:21427059 | Hmgn3 | Rat | vincaleukoblastine | affects response to substance | ISO | HMGN3 (Homo sapiens) | 6480464 | HMGN3 protein affects the susceptibility to Vinblastine | CTD | PMID:16217747 | |