Or1a1b (olfactory receptor family 1 subfamily A member 1B) - Rat Genome Database

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Gene: Or1a1b (olfactory receptor family 1 subfamily A member 1B) Rattus norvegicus
Analyze
Symbol: Or1a1b
Name: olfactory receptor family 1 subfamily A member 1B
RGD ID: 1334436
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in positive regulation of cytokinesis and signal transduction. Predicted to be active in plasma membrane. Orthologous to several human genes including OR1A1 (olfactory receptor family 1 subfamily A member 1); INTERACTS WITH arsane (ortholog); arsenic atom (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1514; olfactory receptor gene Olr1514; olfactory receptor Olr1514; Olr1514; ratchr10-61507754-61506810_ORF
RGD Orthologs
Human
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81059,568,684 - 59,569,628 (-)NCBIGRCr8
mRatBN7.21059,070,239 - 59,071,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1059,069,404 - 59,075,457 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1063,697,351 - 63,698,295 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01063,202,960 - 63,203,904 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01058,697,535 - 58,698,479 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01061,044,411 - 61,045,355 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1061,044,411 - 61,045,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01060,776,393 - 60,777,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41061,493,187 - 61,494,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11061,506,809 - 61,507,754 (-)NCBI
Celera1058,111,359 - 58,112,303 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or1a1bRatarsane affects methylationISOOR1A2 (Homo sapiens)6480464Arsenic affects the methylation of OR1A2 geneCTDPMID:25304211
Or1a1bRatarsenic atom affects methylationISOOR1A2 (Homo sapiens)6480464Arsenic affects the methylation of OR1A2 geneCTDPMID:25304211
Or1a1bRatbenzo[a]pyrene affects methylationISOOR1A2 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of OR1A2 promoterCTDPMID:27901495
Or1a1bRatcamptothecin decreases response to substanceISOOR1A2 (Homo sapiens)6480464OR1A2 mRNA results in decreased susceptibility to CamptothecinCTDPMID:25269479
Or1a1bRatCGP 52608 multiple interactionsISOOR1A2 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to OR1A2 gene]CTDPMID:28238834
Or1a1bRatcitronellal affects bindingISOOR1A2 (Homo sapiens)6480464citronellal binds to OR1A2 protein and OR1A2 protein binds to citronellalCTDPMID:17601748 and PMID:17681278
Or1a1bRatcitronellal increases expressionISOOR1A2 (Homo sapiens)6480464citronellal results in increased expression of OR1A2 mRNA and citronellal results in increased expression of OR1A2 proteinCTDPMID:25513961
Or1a1bRatcitronellol affects bindingISOOR1A2 (Homo sapiens)6480464citronellol binds to OR1A2 proteinCTDPMID:17601748
Or1a1bRatcrocidolite asbestos affects expressionISOOR1A2 (Homo sapiens)6480464Asbestos and Crocidolite affects the expression of OR1A2 mRNACTDPMID:17331233
Or1a1bRatresveratrol multiple interactionsISOOR1A2 (Homo sapiens)6480464[Plant Extracts co-treated with Resveratrol] results in decreased expression of OR1A2 mRNACTDPMID:23557933

1 to 10 of 10 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or1a1bRatdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or1a1bRatdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or1a1bRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or1a1bRatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or1a1bRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or1a1bRatpositive regulation of cytokinesis involved_inISOOR1A2 (Homo sapiens)1624291 PMID:22888021RGDPMID:22888021
Or1a1bRatsignal transduction involved_inIBAPANTHER:PTN001239850 and UniProtKB:P349821600115GO_REF:0000033GO_CentralGO_REF:0000033
Or1a1bRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or1a1bRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or1a1bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or1a1bRatplasma membrane is_active_inIBAPANTHER:PTN001239850 and UniProtKB:A6NND41600115GO_REF:0000033GO_CentralGO_REF:0000033
Or1a1bRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or1a1bRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or1a1bRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or1a1bRatolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or1a1bRatolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or1a1bRatolfactory receptor activity enablesIBAMGI:1333746 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or1a1bRattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:22888021  



Or1a1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81059,568,684 - 59,569,628 (-)NCBIGRCr8
mRatBN7.21059,070,239 - 59,071,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1059,069,404 - 59,075,457 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1063,697,351 - 63,698,295 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01063,202,960 - 63,203,904 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01058,697,535 - 58,698,479 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01061,044,411 - 61,045,355 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1061,044,411 - 61,045,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01060,776,393 - 60,777,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41061,493,187 - 61,494,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11061,506,809 - 61,507,754 (-)NCBI
Celera1058,111,359 - 58,112,303 (-)NCBICelera
Cytogenetic Map10q24NCBI
OR1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38173,197,519 - 3,198,448 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl173,197,519 - 3,198,448 (+)EnsemblGRCh38hg38GRCh38
GRCh37173,100,813 - 3,101,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,047,563 - 3,048,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 34173,047,562 - 3,048,492NCBI
Celera173,118,886 - 3,119,815 (+)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef172,993,076 - 2,994,005 (+)NCBIHuRef
CHM1_1173,109,714 - 3,110,643 (+)NCBICHM1_1
T2T-CHM13v2.0173,085,790 - 3,086,719 (+)NCBIT2T-CHM13v2.0
LOC100991332
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21910,784,236 - 10,788,136 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11712,753,116 - 12,754,300 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,196,220 - 3,197,575 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1173,195,780 - 3,196,702 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC100513947
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21251,050,704 - 51,052,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242142
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,687,285 - 2,689,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl162,687,427 - 2,688,356 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605919,213,012 - 19,214,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Or1a1b
8 total Variants

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:80
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000048167
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 78 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat

1 to 10 of 78 rows



reproductive system
1



Ensembl Acc Id: ENSRNOT00000048167   ⟹   ENSRNOP00000048662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1059,069,404 - 59,075,457 (-)Ensembl
Rnor_6.0 Ensembl1061,044,411 - 61,045,355 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101793   ⟹   ENSRNOP00000079310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1059,069,471 - 59,075,457 (-)Ensembl
RefSeq Acc Id: NM_001000036   ⟹   NP_001000036
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81059,568,684 - 59,569,628 (-)NCBI
mRatBN7.21059,070,239 - 59,071,183 (-)NCBI
Rnor_6.01061,044,411 - 61,045,355 (-)NCBI
Rnor_5.01060,776,393 - 60,777,337 (-)NCBI
RGSC_v3.41061,493,187 - 61,494,131 (-)RGD
Celera1058,111,359 - 58,112,303 (-)RGD
Sequence:
Protein RefSeqs NP_001000036 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05176 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048662.1
  ENSRNOP00000079310.1
  ENSRNOP00000107082
RefSeq Acc Id: NP_001000036   ⟸   NM_001000036
- UniProtKB: D3ZFE0 (UniProtKB/TrEMBL),   A6HGM1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048662   ⟸   ENSRNOT00000048167
Ensembl Acc Id: ENSRNOP00000079310   ⟸   ENSRNOT00000101793
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFE0-F1-model_v2 AlphaFold D3ZFE0 1-314 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24270 BioCyc
Ensembl Genes ENSRNOG00000033267 Ensembl
  ENSRNOG00000063645 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000087980 ENTREZGENE
Ensembl Transcript ENSRNOT00000048167.2 UniProtKB/TrEMBL
  ENSRNOT00000101793.1 UniProtKB/TrEMBL
  ENSRNOT00000161238 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:287514 UniProtKB/TrEMBL
NCBI Gene 287514 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or1a1b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033267 RatGTEx
  ENSRNOG00000063645 RatGTEx
  ENSRNOG00000087980 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6HGM1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFE0 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or1a1b  olfactory receptor family 1 subfamily A member 1B  Olr1514  olfactory receptor 1514  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1514  olfactory receptor 1514   Olr1514_predicted  olfactory receptor 1514 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1514_predicted  olfactory receptor 1514 (predicted)      Symbol and Name status set to approved 70820 APPROVED