Or7c70 (olfactory receptor family 7 subfamily C member 70) - Rat Genome Database

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Gene: Or7c70 (olfactory receptor family 7 subfamily C member 70) Rattus norvegicus
Analyze
Symbol: Or7c70
Name: olfactory receptor family 7 subfamily C member 70
RGD ID: 1334014
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Orthologous to several human genes including OR7C2 (olfactory receptor family 7 subfamily C member 2); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; furan.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1086; olfactory receptor gene Olr1086; olfactory receptor Olr1086; Olr1086
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,461,214 - 11,468,390 (+)NCBIGRCr8
mRatBN7.2710,810,624 - 10,811,586 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,799,830 - 10,813,059 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,626,580 - 13,627,542 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,504,023 - 15,504,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,387,098 - 13,388,060 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,698,647 - 13,699,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,698,647 - 13,699,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,862,639 - 13,863,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,362,119 - 12,363,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,362,118 - 12,363,081 (+)NCBI
Celera78,927,720 - 8,928,682 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or7c70Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of OR7C70 mRNACTDPMID:27840820
Or7c70Ratbenzo[a]pyrene affects methylationISORGD:13447736480464Benzo(a)pyrene affects the methylation of OR7C2 promoterCTDPMID:27901495
Or7c70Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR7C2 mRNACTDPMID:25181051
Or7c70Ratcamptothecin decreases response to substanceISORGD:13447736480464OR7C2 mRNA results in decreased susceptibility to CamptothecinCTDPMID:25269479
Or7c70Ratcrocidolite asbestos affects expressionISORGD:13447736480464Asbestos, Crocidolite affects the expression of OR7C2 mRNACTDPMID:17331233
Or7c70Ratfuran increases methylationEXP 6480464furan results in increased methylation of OR7C70 geneCTDPMID:22079235


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or7c70Ratdetection of chemical stimulus involved in sensory perception of smell  IEARGD:51314831303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or7c70Ratdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or7c70RatG protein-coupled receptor signaling pathway  IEARGD:51314831303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or7c70RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276|InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or7c70RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or7c70Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or7c70Ratsignal transduction involved_inIBAPANTHER:PTN001239850|UniProtKB:P349821600115GO_REF:0000033GO_CentralGO_REF:0000033
Or7c70Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or7c70Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or7c70Ratmembrane located_inIEAInterPro:IPR000276|InterPro:IPR000725|InterPro:IPR0174521600115GO_REF:0000002InterProGO_REF:0000002
Or7c70Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or7c70Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Or7c70Ratplasma membrane is_active_inIBAPANTHER:PTN001239850|UniProtKB:A6NND41600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or7c70RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or7c70RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or7c70Ratolfactory receptor activity  IEARGD:51314831303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or7c70Ratolfactory receptor activity enablesIBAMGI:1333746|PANTHER:PTN001239850|UniProtKB:A6NND4|UniProtKB:P349821600115GO_REF:0000033GO_CentralGO_REF:0000033
Or7c70Ratolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or7c70Ratprotein binding enablesISORGD:13447731624291UniProtKB:P63167 PMID:32296183RGDPMID:32296183

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or7c70Rattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Or7c70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,461,214 - 11,468,390 (+)NCBIGRCr8
mRatBN7.2710,810,624 - 10,811,586 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,799,830 - 10,813,059 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,626,580 - 13,627,542 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,504,023 - 15,504,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,387,098 - 13,388,060 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,698,647 - 13,699,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,698,647 - 13,699,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,862,639 - 13,863,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,362,119 - 12,363,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,362,118 - 12,363,081 (+)NCBI
Celera78,927,720 - 8,928,682 (+)NCBICelera
Cytogenetic Map7q11NCBI
OR7C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,941,489 - 14,942,448 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,941,489 - 14,942,448 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,052,301 - 15,053,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,913,301 - 14,914,260 (+)NCBINCBI36Build 36hg18NCBI36
Build 341914,913,300 - 14,914,260NCBI
Celera1914,948,010 - 14,948,972 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,620,103 - 14,621,065 (+)NCBIHuRef
CHM1_11915,048,677 - 15,049,639 (+)NCBICHM1_1
T2T-CHM13v2.01915,066,276 - 15,067,238 (+)NCBIT2T-CHM13v2.0
Or7c70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,682,785 - 78,683,747 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,680,886 - 78,688,000 (-)EnsemblGRCm39 Ensembl
GRCm381078,846,951 - 78,847,913 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,845,052 - 78,852,166 (-)EnsemblGRCm38mm10GRCm38
MGSCv371078,309,696 - 78,310,658 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361078,249,901 - 78,251,042 (-)NCBIMGSCv36mm8
Celera1079,868,662 - 79,869,624 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
LOC102015215
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554958,328,332 - 8,329,291 (-)NCBIChiLan1.0ChiLan1.0
LOC100976323
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,855,628 - 19,859,251 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,874,051 - 18,876,283 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,490,688 - 14,491,799 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,461,808 - 15,462,770 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,461,808 - 15,462,770 (+)Ensemblpanpan1.1panPan2
OR7C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12047,144,015 - 47,147,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,995,100 - 46,996,089 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,637,212 - 47,638,201 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12046,867,965 - 46,868,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02047,286,022 - 47,287,011 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,558,285 - 47,559,274 (-)NCBIUU_Cfam_GSD_1.0
LOC100736663
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1262,630,428 - 62,632,229 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2262,262,867 - 62,264,606 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OR7C2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,532,712 - 13,534,017 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,532,971 - 13,533,933 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,060,427 - 6,061,572 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Or7c70
3 total Variants

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:91
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000067342
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat

1 to 10 of 16 rows



ectoderm
nervous system
4 4



Ensembl Acc Id: ENSRNOT00000067342   ⟹   ENSRNOP00000061889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,799,830 - 10,812,586 (+)Ensembl
Rnor_6.0 Ensembl713,698,647 - 13,699,609 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113394   ⟹   ENSRNOP00000083346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,800,272 - 10,813,059 (+)Ensembl
RefSeq Acc Id: NM_001000419   ⟹   NP_001000419
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,461,214 - 11,462,176 (+)NCBI
mRatBN7.2710,810,624 - 10,811,586 (+)NCBI
Rnor_6.0713,698,647 - 13,699,609 (+)NCBI
Rnor_5.0713,862,639 - 13,863,601 (+)NCBI
RGSC_v3.4712,362,119 - 12,363,081 (+)RGD
Celera78,927,720 - 8,928,682 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263161   ⟹   XP_063119231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,461,214 - 11,468,390 (+)NCBI
Protein RefSeqs NP_001000419 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119231 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89443 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061889.2
  ENSRNOP00000083346.1
  ENSRNOP00000104548
RefSeq Acc Id: NP_001000419   ⟸   NM_001000419
- UniProtKB: D4A5L0 (UniProtKB/TrEMBL),   A0A8I6GAN4 (UniProtKB/TrEMBL),   A6K923 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061889   ⟸   ENSRNOT00000067342
Ensembl Acc Id: ENSRNOP00000083346   ⟸   ENSRNOT00000113394
RefSeq Acc Id: XP_063119231   ⟸   XM_063263161
- Peptide Label: isoform X1
- UniProtKB: D4A5L0 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5L0-F1-model_v2 AlphaFold D4A5L0 1-320 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34850 BioCyc
Ensembl Genes ENSRNOG00000042262 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000073768 ENTREZGENE
Ensembl Transcript ENSRNOT00000067342.2 UniProtKB/TrEMBL
  ENSRNOT00000113394.1 UniProtKB/TrEMBL
  ENSRNOT00000121907 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:299588 UniProtKB/TrEMBL
NCBI Gene 299588 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or7c70 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042262 RatGTEx
  ENSRNOG00000073768 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6GAN4 ENTREZGENE, UniProtKB/TrEMBL
  A6K923 ENTREZGENE, UniProtKB/TrEMBL
  D4A5L0 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or7c70  olfactory receptor family 7 subfamily C member 70  Olr1086  olfactory receptor 1086  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1086  olfactory receptor 1086   Olr1086_predicted  olfactory receptor 1086 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1086_predicted  olfactory receptor 1086 (predicted)      Symbol and Name status set to approved 70820 APPROVED