Or7c70 (olfactory receptor family 7 subfamily C member 70) - Rat Genome Database

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Gene: Or7c70 (olfactory receptor family 7 subfamily C member 70) Rattus norvegicus
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Symbol: Or7c70
Name: olfactory receptor family 7 subfamily C member 70
RGD ID: 1334014
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Orthologous to several human genes including OR7C2 (olfactory receptor family 7 subfamily C member 2); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; furan.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1086; olfactory receptor gene Olr1086; olfactory receptor Olr1086; Olr1086
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,461,214 - 11,468,390 (+)NCBIGRCr8
mRatBN7.2710,810,624 - 10,811,586 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,799,830 - 10,813,059 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,626,580 - 13,627,542 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,504,023 - 15,504,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,387,098 - 13,388,060 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,698,647 - 13,699,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,698,647 - 13,699,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,862,639 - 13,863,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,362,119 - 12,363,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,362,118 - 12,363,081 (+)NCBI
Celera78,927,720 - 8,928,682 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or7c70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,461,214 - 11,468,390 (+)NCBIGRCr8
mRatBN7.2710,810,624 - 10,811,586 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,799,830 - 10,813,059 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,626,580 - 13,627,542 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,504,023 - 15,504,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,387,098 - 13,388,060 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,698,647 - 13,699,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,698,647 - 13,699,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,862,639 - 13,863,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,362,119 - 12,363,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,362,118 - 12,363,081 (+)NCBI
Celera78,927,720 - 8,928,682 (+)NCBICelera
Cytogenetic Map7q11NCBI
OR7C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,941,489 - 14,942,448 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,941,489 - 14,942,448 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,052,301 - 15,053,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,913,301 - 14,914,260 (+)NCBINCBI36Build 36hg18NCBI36
Build 341914,913,300 - 14,914,260NCBI
Celera1914,948,010 - 14,948,972 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,620,103 - 14,621,065 (+)NCBIHuRef
CHM1_11915,048,677 - 15,049,639 (+)NCBICHM1_1
T2T-CHM13v2.01915,066,276 - 15,067,238 (+)NCBIT2T-CHM13v2.0
Or7c70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,682,785 - 78,683,747 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,680,886 - 78,688,000 (-)EnsemblGRCm39 Ensembl
GRCm381078,846,951 - 78,847,913 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,845,052 - 78,852,166 (-)EnsemblGRCm38mm10GRCm38
MGSCv371078,309,696 - 78,310,658 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361078,249,901 - 78,251,042 (-)NCBIMGSCv36mm8
Celera1079,868,662 - 79,869,624 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
LOC102015215
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554958,328,332 - 8,329,291 (-)NCBIChiLan1.0ChiLan1.0
LOC100976323
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,855,628 - 19,859,251 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,874,051 - 18,876,283 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,490,688 - 14,491,799 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,461,808 - 15,462,770 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,461,808 - 15,462,770 (+)Ensemblpanpan1.1panPan2
OR7C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12047,144,015 - 47,147,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,995,100 - 46,996,089 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,637,212 - 47,638,201 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12046,867,965 - 46,868,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02047,286,022 - 47,287,011 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,558,285 - 47,559,274 (-)NCBIUU_Cfam_GSD_1.0
LOC100736663
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1262,630,428 - 62,632,229 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2262,262,867 - 62,264,606 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103234053
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,532,712 - 13,534,017 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,532,971 - 13,533,933 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,060,427 - 6,061,572 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Or7c70
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:91
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000067342
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat


Expression

RNA-SEQ Expression

ectoderm
nervous system
4 4

Sequence


Ensembl Acc Id: ENSRNOT00000067342   ⟹   ENSRNOP00000061889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,799,830 - 10,812,586 (+)Ensembl
Rnor_6.0 Ensembl713,698,647 - 13,699,609 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113394   ⟹   ENSRNOP00000083346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,800,272 - 10,813,059 (+)Ensembl
RefSeq Acc Id: NM_001000419   ⟹   NP_001000419
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,461,214 - 11,462,176 (+)NCBI
mRatBN7.2710,810,624 - 10,811,586 (+)NCBI
Rnor_6.0713,698,647 - 13,699,609 (+)NCBI
Rnor_5.0713,862,639 - 13,863,601 (+)NCBI
RGSC_v3.4712,362,119 - 12,363,081 (+)RGD
Celera78,927,720 - 8,928,682 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263161   ⟹   XP_063119231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,461,214 - 11,468,390 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001000419 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119231 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89443 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061889.2
  ENSRNOP00000083346.1
RefSeq Acc Id: NP_001000419   ⟸   NM_001000419
- UniProtKB: D4A5L0 (UniProtKB/TrEMBL),   A0A8I6GAN4 (UniProtKB/TrEMBL),   A6K923 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061889   ⟸   ENSRNOT00000067342
Ensembl Acc Id: ENSRNOP00000083346   ⟸   ENSRNOT00000113394
RefSeq Acc Id: XP_063119231   ⟸   XM_063263161
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5L0-F1-model_v2 AlphaFold D4A5L0 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1334014 AgrOrtholog
BioCyc Gene G2FUF-34850 BioCyc
Ensembl Genes ENSRNOG00000042262 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067342.2 UniProtKB/TrEMBL
  ENSRNOT00000113394.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:299588 UniProtKB/TrEMBL
NCBI Gene 299588 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 7C2 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or7c70 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042262 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6GAN4 ENTREZGENE, UniProtKB/TrEMBL
  A6K923 ENTREZGENE, UniProtKB/TrEMBL
  D4A5L0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or7c70  olfactory receptor family 7 subfamily C member 70  Olr1086  olfactory receptor 1086  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1086  olfactory receptor 1086   Olr1086_predicted  olfactory receptor 1086 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1086_predicted  olfactory receptor 1086 (predicted)      Symbol and Name status set to approved 70820 APPROVED