Or2t35 (olfactory receptor family 2 subfamily T member 35) - Rat Genome Database

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Gene: Or2t35 (olfactory receptor family 2 subfamily T member 35) Rattus norvegicus
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Symbol: Or2t35
Name: olfactory receptor family 2 subfamily T member 35
RGD ID: 1333947
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human OR2T2 (olfactory receptor family 2 subfamily T member 2) and OR2T35 (olfactory receptor family 2 subfamily T member 35 (gene/pseudogene)); INTERACTS WITH aflatoxin B1 (ortholog); atrazine (ortholog); resveratrol (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1605; olfactory receptor gene Olr1605; olfactory receptor Olr1605; Olr1605; ratchr15-12385736-12384768_ORF
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81513,293,867 - 13,294,835 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1513,293,867 - 13,294,835 (-)EnsemblGRCr8
mRatBN7.21510,863,347 - 10,864,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1510,859,208 - 10,870,161 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1512,999,674 - 13,000,642 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01513,914,237 - 13,915,205 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01512,212,953 - 12,213,921 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01512,128,252 - 12,129,220 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1512,128,252 - 12,129,220 (-)Ensemblrn6Rnor6.0
Rnor_5.01516,165,180 - 16,166,148 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41512,384,768 - 12,385,736 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1510,874,031 - 10,874,999 (-)NCBICelera
RGSC_v3.11512,384,767 - 12,385,736 (-)NCBI
Cytogenetic Map15p16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
aflatoxin B1  (ISO)
atrazine  (ISO)
resveratrol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or2t35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81513,293,867 - 13,294,835 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1513,293,867 - 13,294,835 (-)EnsemblGRCr8
mRatBN7.21510,863,347 - 10,864,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1510,859,208 - 10,870,161 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1512,999,674 - 13,000,642 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01513,914,237 - 13,915,205 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01512,212,953 - 12,213,921 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01512,128,252 - 12,129,220 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1512,128,252 - 12,129,220 (-)Ensemblrn6Rnor6.0
Rnor_5.01516,165,180 - 16,166,148 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41512,384,768 - 12,385,736 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1510,874,031 - 10,874,999 (-)NCBICelera
RGSC_v3.11512,384,767 - 12,385,736 (-)NCBI
Cytogenetic Map15p16NCBI
OR2T35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,636,356 - 248,645,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,636,356 - 248,645,278 (-)Ensemblhg38GRCh38
GRCh371248,799,657 - 248,808,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,868,211 - 246,869,182 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341245,127,628 - 245,128,600NCBI
Celera1221,898,855 - 221,899,829 (+)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1219,176,556 - 219,177,525 (-)NCBIHuRef
CHM1_11250,073,666 - 250,074,635 (-)NCBICHM1_1
T2T-CHM13v2.01248,074,945 - 248,083,605 (-)NCBIT2T-CHM13v2.0
Or2t35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39148,061,565 - 8,062,539 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl148,059,668 - 8,068,465 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381414,407,224 - 14,408,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1414,401,298 - 14,410,095 (+)Ensemblmm10GRCm38
MGSCv371415,240,314 - 15,240,712 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361413,201,067 - 13,201,465 (+)NCBIMGSCv36mm8
Celera1410,083,733 - 10,084,131 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
LOC110259584
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1253,126,795 - 53,127,763 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Or2t35
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:17
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000029318
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15115177511Rat


Expression

RNA-SEQ Expression

appendage
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
1 1 1 2 5 2 2 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000029318   ⟹   ENSRNOP00000038706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1512,128,252 - 12,129,220 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095904   ⟹   ENSRNOP00000085098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,860,794 - 10,870,161 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104722   ⟹   ENSRNOP00000089344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,859,208 - 10,870,161 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114022   ⟹   ENSRNOP00000080395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,859,208 - 10,867,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000126046   ⟹   ENSRNOP00000111642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1513,293,867 - 13,294,835 (-)Ensembl
RefSeq Acc Id: NM_001000088   ⟹   NP_001000088
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,293,867 - 13,294,835 (-)NCBI
mRatBN7.21510,863,347 - 10,864,315 (-)NCBI
Rnor_6.01512,128,252 - 12,129,220 (-)NCBI
Rnor_5.01516,165,180 - 16,166,148 (-)NCBI
RGSC_v3.41512,384,768 - 12,385,736 (-)RGD
Celera1510,874,031 - 10,874,999 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000088 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111642
  ENSRNOP00000111642.1
RefSeq Acc Id: NP_001000088   ⟸   NM_001000088
- UniProtKB: A0A8I6A1I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038706   ⟸   ENSRNOT00000029318
Ensembl Acc Id: ENSRNOP00000085098   ⟸   ENSRNOT00000095904
Ensembl Acc Id: ENSRNOP00000089344   ⟸   ENSRNOT00000104722
Ensembl Acc Id: ENSRNOP00000080395   ⟸   ENSRNOT00000114022
Ensembl Acc Id: ENSRNOP00000111642   ⟸   ENSRNOT00000126046
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A103-F1-model_v2 AlphaFold D4A103 1-322 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333947 AgrOrtholog
BioCyc Gene G2FUF-14387 BioCyc
Ensembl Genes ENSRNOG00000021557 Ensembl
  ENSRNOG00000062911 Ensembl
  ENSRNOG00000084001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000126046 ENTREZGENE
  ENSRNOT00000126046.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
NCBI Gene 289923 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or2t35 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021557 RatGTEx
  ENSRNOG00000062911 RatGTEx
  ENSRNOG00000084001 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6A1I2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or2t35  olfactory receptor family 2 subfamily T member 35  Olr1605  olfactory receptor 1605  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1605  olfactory receptor 1605   Olr1605_predicted  olfactory receptor 1605 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1605_predicted  olfactory receptor 1605 (predicted)      Symbol and Name status set to approved 70820 APPROVED