Or6k2 (olfactory receptor family 6 subfamily K member 2) - Rat Genome Database

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Gene: Or6k2 (olfactory receptor family 6 subfamily K member 2) Rattus norvegicus
Analyze
Symbol: Or6k2
Name: olfactory receptor family 6 subfamily K member 2
RGD ID: 1333784
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OR6K2 (olfactory receptor family 6 subfamily K member 2); INTERACTS WITH bisphenol A; ethanol; lidocaine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1596; olfactory receptor gene Olr1596; olfactory receptor Olr1596; Olr1596; ratchr13-90126336-90127301_ORF
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,721,361 - 88,722,326 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1388,721,361 - 88,722,326 (+)EnsemblGRCr8
mRatBN7.21386,186,442 - 86,190,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,185,529 - 86,190,815 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1388,700,466 - 88,701,431 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,100,744 - 90,101,709 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,285,493 - 87,286,458 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,249,759 - 92,250,724 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,249,759 - 92,250,724 (+)Ensemblrn6Rnor6.0
Rnor_5.01396,767,915 - 96,768,880 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41389,937,452 - 89,938,417 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1385,791,781 - 85,792,746 (+)NCBICelera
RGSC_v3.11390,126,335 - 90,127,301 (+)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or6k2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,721,361 - 88,722,326 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1388,721,361 - 88,722,326 (+)EnsemblGRCr8
mRatBN7.21386,186,442 - 86,190,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,185,529 - 86,190,815 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1388,700,466 - 88,701,431 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,100,744 - 90,101,709 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,285,493 - 87,286,458 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,249,759 - 92,250,724 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,249,759 - 92,250,724 (+)Ensemblrn6Rnor6.0
Rnor_5.01396,767,915 - 96,768,880 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41389,937,452 - 89,938,417 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1385,791,781 - 85,792,746 (+)NCBICelera
RGSC_v3.11390,126,335 - 90,127,301 (+)NCBI
Cytogenetic Map13q24NCBI
OR6K2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381158,699,678 - 158,700,652 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1158,699,678 - 158,700,652 (-)Ensemblhg38GRCh38
GRCh371158,669,468 - 158,670,442 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,936,092 - 156,937,066 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341155,482,540 - 155,483,515NCBI
Celera1131,740,163 - 131,741,137 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1130,026,881 - 130,027,855 (-)NCBIHuRef
CHM1_11160,065,480 - 160,066,454 (-)NCBICHM1_1
T2T-CHM13v2.01157,836,759 - 157,837,733 (-)NCBIT2T-CHM13v2.0
Or6k2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,986,288 - 173,987,333 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1173,983,199 - 173,989,761 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381174,158,722 - 174,159,767 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,155,633 - 174,162,195 (+)Ensemblmm10GRCm38
MGSCv371176,088,853 - 176,089,898 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361175,995,450 - 175,996,415 (+)NCBIMGSCv36mm8
Celera1181,262,032 - 181,263,077 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.95NCBI
LOC100981216
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2191,147,251 - 91,148,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1190,891,096 - 90,892,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01134,058,226 - 134,059,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11137,849,046 - 137,850,158 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1137,849,135 - 137,850,115 (-)EnsemblpanPan2panpan1.1
OR6K2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,042,900 - 23,045,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,043,721 - 23,044,686 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3823,065,822 - 23,066,787 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03823,175,283 - 23,176,248 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.13822,938,358 - 22,939,322 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03823,473,085 - 23,474,050 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,904,351 - 23,905,316 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
OR6K2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1205,221,383 - 5,224,559 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660384,390,507 - 4,391,761 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Or6k2
7 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 2 11 44 27 31 7 65 7 128 91 11 30 27 11 24 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000089352   ⟹   ENSRNOP00000071568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,185,529 - 86,190,815 (+)Ensembl
Rnor_6.0 Ensembl1392,249,759 - 92,250,724 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136042   ⟹   ENSRNOP00000100369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1388,721,361 - 88,722,326 (+)Ensembl
RefSeq Acc Id: NM_001000501   ⟹   NP_001000501
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,721,361 - 88,722,326 (+)NCBI
mRatBN7.21386,189,032 - 86,189,997 (+)NCBI
Rnor_6.01392,249,759 - 92,250,724 (+)NCBI
Rnor_5.01396,767,915 - 96,768,880 (+)NCBI
RGSC_v3.41389,937,452 - 89,938,417 (+)RGD
Celera1385,791,781 - 85,792,746 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000501 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94757 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000100369
  ENSRNOP00000100369.1
RefSeq Acc Id: NP_001000501   ⟸   NM_001000501
- UniProtKB: A0A0G2K0S9 (UniProtKB/TrEMBL),   A6JGA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071568   ⟸   ENSRNOT00000089352
Ensembl Acc Id: ENSRNOP00000100369   ⟸   ENSRNOT00000136042
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0S9-F1-model_v2 AlphaFold A0A0G2K0S9 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333784 AgrOrtholog
BioCyc Gene G2FUF-17257 BioCyc
Ensembl Genes ENSRNOG00000057400 Ensembl
  ENSRNOG00000089681 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000136042 ENTREZGENE
  ENSRNOT00000136042.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_GPCR1 UniProtKB/TrEMBL
KEGG Report rno:304991 UniProtKB/TrEMBL
NCBI Gene 304991 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6k2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057400 RatGTEx
  ENSRNOG00000089681 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0G2K0S9 ENTREZGENE
  A0ABK0KYZ2_RAT UniProtKB/TrEMBL
  A6JGA1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6k2  olfactory receptor family 6 subfamily K member 2  Olr1596  olfactory receptor 1596  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1596  olfactory receptor 1596   Olr1596_predicted  olfactory receptor 1596 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1596_predicted  olfactory receptor 1596 (predicted)      Symbol and Name status set to approved 70820 APPROVED