Or7a37 (olfactory receptor family 7 subfamily A member 37) - Rat Genome Database

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Gene: Or7a37 (olfactory receptor family 7 subfamily A member 37) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or7a37 (Ensembl: Or7a36)
Name: olfactory receptor family 7 subfamily A member 37 (Ensembl:olfactory receptor family 7 subfamily A member 36)
RGD ID: 1333657
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Orthologous to human OR7A10 (olfactory receptor family 7 subfamily A member 10) and OR7A5 (olfactory receptor family 7 subfamily A member 5); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: olfactory receptor 1078; olfactory receptor-like protein F3; Olr1078; ratchr7-12106889-12105960_ORF
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,228,606 - 11,229,607 (-)NCBIGRCr8
mRatBN7.2710,578,008 - 10,579,009 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,577,151 - 10,592,390 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,444,438 - 13,445,439 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,321,882 - 15,322,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,165,680 - 13,166,681 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,466,347 - 13,492,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,466,347 - 13,467,348 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,670,274 - 13,671,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,105,888 - 12,106,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,105,887 - 12,106,889 (-)NCBI
Celera78,717,866 - 8,718,867 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Buck L and Axel R, Cell 1991 Apr 5;65(1):175-87.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Or7a37
7 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
High
Medium
Low
Below cutoff 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083574   ⟹   ENSRNOP00000074563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,577,151 - 10,592,390 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl713,466,347 - 13,467,348 (-)Ensembl
RefSeq Acc Id: NM_207597   ⟹   NP_997480
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,228,606 - 11,229,607 (-)NCBI
mRatBN7.2710,578,008 - 10,579,009 (-)NCBI
Rnor_6.0713,466,347 - 13,467,348 (-)NCBI
Rnor_5.0713,670,274 - 13,671,275 (-)NCBI
RGSC_v3.4712,105,888 - 12,106,889 (-)RGD
Celera78,717,866 - 8,718,867 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997480 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41739 (Get FASTA)   NCBI Sequence Viewer  
  EDL89440 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074563
  ENSRNOP00000074563.2
GenBank Protein P23265 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_997480   ⟸   NM_207597
- UniProtKB: P23265 (UniProtKB/Swiss-Prot),   A0A0G2K8D3 (UniProtKB/TrEMBL),   A6K920 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074563   ⟸   ENSRNOT00000083574
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23265-F1-model_v2 AlphaFold P23265 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333657 AgrOrtholog
BioCyc Gene G2FUF-34858 BioCyc
Ensembl Genes ENSRNOG00000059517 Ensembl
  ENSRNOG00000062310 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083574 ENTREZGENE
  ENSRNOT00000083574.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299593 UniProtKB/Swiss-Prot
NCBI Gene 299593 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/Swiss-Prot
  OLFACTORY RECEPTOR UniProtKB/Swiss-Prot
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Or7a37 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059517 RatGTEx
  ENSRNOG00000062310 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K8D3 ENTREZGENE, UniProtKB/TrEMBL
  A6K920 ENTREZGENE, UniProtKB/TrEMBL
  O1078_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or7a37  olfactory receptor family 7 subfamily A member 37  Olr1078  olfactory receptor 1078  Symbol and Name Changed 1299863 APPROVED
2005-02-04 Olr1078  olfactory receptor 1078      Symbol and Name status set to approved 70820 APPROVED