Or52m1 (olfactory receptor family 52 subfamily M member 1) - Rat Genome Database

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Gene: Or52m1 (olfactory receptor family 52 subfamily M member 1) Rattus norvegicus
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Symbol: Or52m1
Name: olfactory receptor family 52 subfamily M member 1
RGD ID: 1333547
Description: Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Orthologous to human OR52M1 (olfactory receptor family 52 subfamily M member 1); INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 48; olfactory receptor gene Olr48; olfactory receptor Olr48; Olr48
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,477,144 - 166,478,097 (+)NCBIGRCr8
mRatBN7.21157,065,217 - 157,066,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1157,065,217 - 157,066,170 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1165,042,972 - 165,043,925 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,223,048 - 172,224,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,130,029 - 165,130,982 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,786,465 - 167,787,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,786,337 - 167,787,409 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,971,894 - 173,972,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41160,275,494 - 160,276,447 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11160,354,510 - 160,355,464 (+)NCBI
Celera1155,130,279 - 155,131,232 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52m1Ratdelta beta-thalassemia  ISOOR52M1 (Homo sapiens)8554872ClinVar Annotator: match by term: Thalassemia and gamma-delta-betaClinVarPMID:2798417

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52m1Rat1,2-dimethylhydrazine decreases expressionISOOr52m1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of OR52M1 mRNACTDPMID:22206623
Or52m1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of OR52M1 mRNACTDPMID:21346803
Or52m1Rataflatoxin B1 increases methylationISOOR52M1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of OR52M1 geneCTDPMID:27153756
Or52m1Ratarsenite(3-) decreases methylationISOOR52M1 (Homo sapiens)6480464arsenite results in decreased methylation of OR52M1 promoterCTDPMID:23974009
Or52m1Ratbenzo[a]pyrene increases methylationISOOR52M1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of OR52M1 promoterCTDPMID:27901495
Or52m1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR52M1 mRNACTDPMID:25181051
Or52m1Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of OR52M1 geneCTDPMID:28505145
Or52m1Ratbisphenol A decreases methylationISOOR52M1 (Homo sapiens)6480464bisphenol A results in decreased methylation of OR52M1 geneCTDPMID:31601247
Or52m1RatCGP 52608 multiple interactionsISOOR52M1 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to OR52M1 gene]CTDPMID:28238834
Or52m1Ratchlorpyrifos increases expressionISOOr52m1 (Mus musculus)6480464Chlorpyrifos results in increased expression of OR52M1 mRNACTDPMID:32715474

1 to 10 of 10 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52m1Ratdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or52m1Ratdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or52m1RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or52m1RatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or52m1RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or52m1Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or52m1Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52m1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or52m1Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or52m1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Or52m1Ratplasma membrane is_active_inIBAMGI:2157548 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52m1RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or52m1RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or52m1Ratolfactory receptor activity enablesIBAPANTHER:PTN002816874 and UniProtKB:Q9H2551600115GO_REF:0000033GO_CentralGO_REF:0000033
Or52m1Ratolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or52m1Ratolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52m1Rattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Or52m1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,477,144 - 166,478,097 (+)NCBIGRCr8
mRatBN7.21157,065,217 - 157,066,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1157,065,217 - 157,066,170 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1165,042,972 - 165,043,925 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,223,048 - 172,224,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,130,029 - 165,130,982 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,786,465 - 167,787,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,786,337 - 167,787,409 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,971,894 - 173,972,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41160,275,494 - 160,276,447 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11160,354,510 - 160,355,464 (+)NCBI
Celera1155,130,279 - 155,131,232 (+)NCBICelera
Cytogenetic Map1q32NCBI
OR52M1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38114,545,191 - 4,546,144 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl114,545,191 - 4,546,144 (+)EnsemblGRCh38hg38GRCh38
GRCh37114,566,421 - 4,567,374 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36114,522,997 - 4,523,950 (+)NCBINCBI36Build 36hg18NCBI36
Build 34114,522,996 - 4,523,950NCBI
Celera114,690,621 - 4,691,574 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef114,224,847 - 4,225,800 (+)NCBIHuRef
CHM1_1114,566,352 - 4,567,305 (+)NCBICHM1_1
T2T-CHM13v2.0114,610,461 - 4,611,414 (+)NCBIT2T-CHM13v2.0
Or52m1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397102,289,455 - 102,290,408 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7102,287,639 - 102,291,762 (+)EnsemblGRCm39 Ensembl
GRCm387102,640,248 - 102,641,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,638,432 - 102,642,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,788,762 - 109,789,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367102,514,069 - 102,515,022 (+)NCBIMGSCv36mm8
Celera7103,003,191 - 103,004,144 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map754.79NCBI
LOC100978707
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v297,007,096 - 7,008,049 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1116,963,872 - 6,964,825 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,720,053 - 4,721,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1114,385,239 - 4,386,192 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl114,385,239 - 4,386,192 (+)Ensemblpanpan1.1panPan2
OR52M2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,889,008 - 26,889,961 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,889,008 - 26,889,961 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,666,040 - 26,666,993 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02127,122,740 - 27,123,693 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12126,889,051 - 26,890,004 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02127,129,531 - 27,130,484 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02127,016,053 - 27,017,006 (-)NCBIUU_Cfam_GSD_1.0
LOC100516094
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl95,588,454 - 5,589,407 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.195,588,354 - 5,589,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.296,330,198 - 6,331,151 (+)NCBISscrofa10.2Sscrofa10.2susScr3

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Variants in Or52m1
4 total Variants

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000024945
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 78 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat

1 to 10 of 78 rows



endoderm
reproductive system
respiratory system
1 2 1



Ensembl Acc Id: ENSRNOT00000024945   ⟹   ENSRNOP00000024945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1167,786,337 - 167,787,409 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000024948   ⟹   ENSRNOP00000024948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1157,065,217 - 157,066,170 (+)Ensembl
RefSeq Acc Id: NM_001000122   ⟹   NP_001000122
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,477,144 - 166,478,097 (+)NCBI
mRatBN7.21157,065,217 - 157,066,170 (+)NCBI
Rnor_6.01167,786,465 - 167,787,418 (+)NCBI
Rnor_5.01173,971,894 - 173,972,847 (+)NCBI
RGSC_v3.41160,275,494 - 160,276,447 (+)RGD
Celera1155,130,279 - 155,131,232 (+)RGD
Sequence:
Protein RefSeqs NP_001000122 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18176 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024948
  ENSRNOP00000024948.4
RefSeq Acc Id: NP_001000122   ⟸   NM_001000122
- UniProtKB: D4ACV2 (UniProtKB/TrEMBL),   A6I754 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024945   ⟸   ENSRNOT00000024945
Ensembl Acc Id: ENSRNOP00000024948   ⟸   ENSRNOT00000024948

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58233 BioCyc
Ensembl Genes ENSRNOG00000018497 Ensembl
  ENSRNOG00000070164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024948 ENTREZGENE
  ENSRNOT00000024948.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_rcpt UniProtKB/TrEMBL
KEGG Report rno:293188 UniProtKB/TrEMBL
NCBI Gene 293188 ENTREZGENE
PANTHER OLFACTORY RECEPTOR 52M1 UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 56B1-RELATED UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or52m1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018497 RatGTEx
  ENSRNOG00000070164 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6I754 ENTREZGENE, UniProtKB/TrEMBL
  D4ACV2 ENTREZGENE, UniProtKB/TrEMBL
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or52m1  olfactory receptor family 52 subfamily M member 1  Olr48  olfactory receptor 48  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr48  olfactory receptor 48   Olr48_predicted  olfactory receptor 48 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr48_predicted  olfactory receptor 48 (predicted)      Symbol and Name status set to approved 70820 APPROVED