Or8j3 (olfactory receptor family 8 subfamily J member 3) - Rat Genome Database

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Gene: Or8j3 (olfactory receptor family 8 subfamily J member 3) Rattus norvegicus
Analyze
Symbol: Or8j3
Name: olfactory receptor family 8 subfamily J member 3
RGD ID: 1333455
Description: Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to several human genes including OR8J3 (olfactory receptor family 8 subfamily J member 3); INTERACTS WITH bisphenol A; cadmium dichloride; copper atom.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: LOC100912463; olfactory receptor 484; olfactory receptor 8J3-like; olfactory receptor gene Olr484; olfactory receptor Olr484; Olr484
RGD Orthologs
Human
Mouse
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8391,611,464 - 91,612,411 (-)NCBIGRCr8
mRatBN7.2371,241,345 - 71,242,292 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl371,240,725 - 71,245,983 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl371,204,184 - 71,209,420 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx374,589,749 - 74,590,696 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0383,188,287 - 83,189,234 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0380,972,343 - 80,973,290 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0373,522,096 - 73,523,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl373,522,096 - 73,523,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0380,091,316 - 80,092,263 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4369,378,937 - 69,379,884 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1369,275,308 - 69,276,256 (-)NCBI
Celera370,534,942 - 70,535,889 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8j3Ratintellectual disability  ISOOR8J3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8j3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOOr8j3 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to OR8J3 promoter]CTDPMID:19654925
Or8j3Ratbenzo[a]pyrene affects methylationISOOR8J3 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of OR8J3 promoterCTDPMID:27901495
Or8j3Ratbenzo[a]pyrene decreases methylationISOOR8J3 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of OR8J3 exonCTDPMID:27901495
Or8j3Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR8J3 mRNACTDPMID:25181051
Or8j3Ratcadmium dichloride increases methylationEXP 6480464Cadmium Chloride results in increased methylation of OR8J3 promoterCTDPMID:22457795
Or8j3Ratcopper atom multiple interactionsEXP 6480464[Copper co-treated with Dietary Sucrose] results in increased expression of OR8J3 mRNACTDPMID:26033743
Or8j3Ratcopper atom increases expressionEXP 6480464Copper deficiency results in increased expression of OR8J3 mRNACTDPMID:26033743
Or8j3Ratcopper(0) multiple interactionsEXP 6480464[Copper co-treated with Dietary Sucrose] results in increased expression of OR8J3 mRNACTDPMID:26033743
Or8j3Ratcopper(0) increases expressionEXP 6480464Copper deficiency results in increased expression of OR8J3 mRNACTDPMID:26033743
Or8j3Ratfulvestrant decreases methylationISOOR8J3 (Homo sapiens)6480464Fulvestrant results in decreased methylation of OR8J3 geneCTDPMID:31601247
Or8j3Ratlead diacetate increases expressionISOOr8j3 (Mus musculus)6480464lead acetate results in increased expression of OR8J3 mRNACTDPMID:20542052
Or8j3Ratvalproic acid decreases methylationISOOR8J3 (Homo sapiens)6480464Valproic Acid results in decreased methylation of OR8J3 geneCTDPMID:29154799
Or8j3Ratvalproic acid affects expressionISOOr8j3 (Mus musculus)6480464Valproic Acid affects the expression of OR8J3 mRNACTDPMID:17963808

1 to 13 of 13 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8j3Ratdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or8j3Ratdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or8j3RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or8j3RatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or8j3RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or8j3Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or8j3Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8j3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or8j3Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or8j3Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or8j3Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8j3RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or8j3RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or8j3Ratolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or8j3Ratolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8j3Rattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Or8j3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8391,611,464 - 91,612,411 (-)NCBIGRCr8
mRatBN7.2371,241,345 - 71,242,292 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl371,240,725 - 71,245,983 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl371,204,184 - 71,209,420 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx374,589,749 - 74,590,696 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0383,188,287 - 83,189,234 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0380,972,343 - 80,973,290 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0373,522,096 - 73,523,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl373,522,096 - 73,523,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0380,091,316 - 80,092,263 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4369,378,937 - 69,379,884 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1369,275,308 - 69,276,256 (-)NCBI
Celera370,534,942 - 70,535,889 (-)NCBICelera
Cytogenetic Map3q24NCBI
OR8J3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,134,721 - 56,140,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,134,721 - 56,140,201 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,902,197 - 55,907,677 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,660,823 - 55,661,770 (-)NCBINCBI36Build 36hg18NCBI36
Build 341155,660,822 - 55,661,770NCBI
Celera1153,244,400 - 53,245,347 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1152,233,228 - 52,234,175 (-)NCBIHuRef
CHM1_11155,769,744 - 55,770,691 (-)NCBICHM1_1
T2T-CHM13v2.01156,073,057 - 56,078,534 (-)NCBIT2T-CHM13v2.0
Or8j3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39286,028,147 - 86,029,094 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl286,026,254 - 86,033,353 (-)EnsemblGRCm39 Ensembl
GRCm38286,197,803 - 86,198,750 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl286,195,910 - 86,203,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37286,037,960 - 86,038,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36285,998,642 - 85,999,589 (-)NCBIMGSCv36mm8
Celera287,776,584 - 87,777,531 (-)NCBICelera
Cytogenetic Map2DNCBI
LOC100972109
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2957,295,709 - 57,301,178 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,311,230 - 58,316,702 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01151,381,036 - 51,382,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OR8J3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11839,543,985 - 39,544,914 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1839,543,985 - 39,544,914 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1839,089,661 - 39,090,590 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01840,221,465 - 40,222,394 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1840,221,465 - 40,222,394 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11839,826,034 - 39,826,963 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01839,393,337 - 39,394,266 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,976,434 - 39,977,363 (-)NCBIUU_Cfam_GSD_1.0

.

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000012899, ENSRNOT00000012959
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 48 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat

1 to 10 of 48 rows
UniSTS:489494  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8391,611,464 - 91,612,411 (+)Marker Load Pipeline
mRatBN7.2371,241,344 - 71,242,292 (+)MAPPERmRatBN7.2
mRatBN7.2371,204,800 - 71,205,748 (+)MAPPERmRatBN7.2
Rnor_6.0373,522,096 - 73,523,043NCBIRnor6.0
Rnor_5.0380,179,896 - 80,180,843UniSTSRnor5.0
Rnor_5.0380,091,316 - 80,092,263UniSTSRnor5.0
RGSC_v3.4369,378,937 - 69,379,884UniSTSRGSC3.4
Celera370,534,942 - 70,535,889UniSTS
Cytogenetic Map3q24UniSTS




ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
1 1 1 1 1 2 1 1



Ensembl Acc Id: ENSRNOT00000012959   ⟹   ENSRNOP00000063985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl371,204,332 - 71,209,420 (-)Ensembl
Rnor_6.0 Ensembl373,522,096 - 73,523,043 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097228   ⟹   ENSRNOP00000091921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl371,240,725 - 71,243,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103276   ⟹   ENSRNOP00000079469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl371,240,725 - 71,245,983 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120139   ⟹   ENSRNOP00000079942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl371,204,184 - 71,207,068 (-)Ensembl
RefSeq Acc Id: NM_001000306   ⟹   NP_001000306
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8391,611,464 - 91,612,411 (-)NCBI
mRatBN7.2371,241,345 - 71,242,292 (-)NCBI
Rnor_6.0373,522,096 - 73,523,043 (-)NCBI
Rnor_5.0380,091,316 - 80,092,263 (-)NCBI
RGSC_v3.4369,378,937 - 69,379,884 (-)RGD
Celera370,534,942 - 70,535,889 (-)RGD
Sequence:
Protein RefSeqs NP_001000306 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79364 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063985
  ENSRNOP00000063985.1
  ENSRNOP00000079469.1
  ENSRNOP00000079942.1
  ENSRNOP00000091921.1
RefSeq Acc Id: NP_001000306   ⟸   NM_001000306
- UniProtKB: D3ZA98 (UniProtKB/TrEMBL),   A6HMW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063985   ⟸   ENSRNOT00000012959
Ensembl Acc Id: ENSRNOP00000091921   ⟸   ENSRNOT00000097228
Ensembl Acc Id: ENSRNOP00000079469   ⟸   ENSRNOT00000103276
Ensembl Acc Id: ENSRNOP00000079942   ⟸   ENSRNOT00000120139
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZA98-F1-model_v2 AlphaFold D3ZA98 1-315 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49074 BioCyc
Ensembl Genes ENSRNOG00000045807 Ensembl
  ENSRNOG00000066809 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000067142 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012959 ENTREZGENE
  ENSRNOT00000012959.4 UniProtKB/TrEMBL
  ENSRNOT00000097228.1 UniProtKB/TrEMBL
  ENSRNOT00000103276.1 UniProtKB/TrEMBL
  ENSRNOT00000120139.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:295750 UniProtKB/TrEMBL
NCBI Gene 295750 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or8j3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045807 RatGTEx
  ENSRNOG00000066809 RatGTEx
  ENSRNOG00000067142 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6HMW3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZA98 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or8j3  olfactory receptor family 8 subfamily J member 3  Olr484  olfactory receptor 484  Symbol and Name Changed 1299863 APPROVED
2015-07-29 Olr484  olfactory receptor 484  LOC100912463  olfactory receptor 8J3-like  Data merged from RGD:6487151 737654 PROVISIONAL
2012-07-05 LOC100912463  olfactory receptor 8J3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Olr484  olfactory receptor 484   Olr484_predicted  olfactory receptor 484 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr484_predicted  olfactory receptor 484 (predicted)      Symbol and Name status set to approved 70820 APPROVED