Or1b1 (olfactory receptor family 1 subfamily B member 1) - Rat Genome Database

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Gene: Or1b1 (olfactory receptor family 1 subfamily B member 1) Rattus norvegicus
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Symbol: Or1b1
Name: olfactory receptor family 1 subfamily B member 1
RGD ID: 1333333
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human OR1B1 (olfactory receptor family 1 subfamily B member 1); INTERACTS WITH bisphenol A; vinclozolin; Azoxymethane (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 425; olfactory receptor gene Olr425; olfactory receptor Olr425; Olr425
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8341,030,851 - 41,031,804 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl341,030,851 - 41,031,804 (-)EnsemblGRCr8
mRatBN7.2320,639,976 - 20,640,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl320,637,490 - 20,646,767 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx323,708,109 - 23,709,062 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0332,293,017 - 32,293,970 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0330,519,527 - 30,520,480 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0321,147,944 - 21,148,897 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl321,147,944 - 21,148,897 (-)Ensemblrn6Rnor6.0
Rnor_5.0326,393,589 - 26,394,542 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4316,610,435 - 16,611,388 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera315,311,115 - 15,312,068 (-)NCBICelera
RGSC_v3.1316,506,806 - 16,507,760 (-)NCBI
Cytogenetic Map3p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8341,030,851 - 41,031,804 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl341,030,851 - 41,031,804 (-)EnsemblGRCr8
mRatBN7.2320,639,976 - 20,640,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl320,637,490 - 20,646,767 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx323,708,109 - 23,709,062 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0332,293,017 - 32,293,970 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0330,519,527 - 30,520,480 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0321,147,944 - 21,148,897 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl321,147,944 - 21,148,897 (-)Ensemblrn6Rnor6.0
Rnor_5.0326,393,589 - 26,394,542 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4316,610,435 - 16,611,388 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera315,311,115 - 15,312,068 (-)NCBICelera
RGSC_v3.1316,506,806 - 16,507,760 (-)NCBI
Cytogenetic Map3p11NCBI
OR1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,628,125 - 122,657,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,628,125 - 122,657,627 (-)Ensemblhg38GRCh38
GRCh379125,390,404 - 125,419,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,430,679 - 124,431,635 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349122,470,411 - 122,471,368NCBI
Celera996,039,176 - 96,040,132 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef995,005,429 - 95,006,385 (-)NCBIHuRef
CHM1_19125,538,797 - 125,539,753 (-)NCBICHM1_1
T2T-CHM13v2.09134,825,455 - 134,854,952 (-)NCBIT2T-CHM13v2.0
Or1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39236,994,707 - 36,995,660 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl236,991,718 - 37,007,922 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38237,104,695 - 37,105,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl237,101,706 - 37,117,910 (-)Ensemblmm10GRCm38
MGSCv37236,960,215 - 36,961,168 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36236,926,704 - 36,927,657 (-)NCBIMGSCv36mm8
Celera236,796,462 - 36,797,415 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
LOC102006248
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554195,318,963 - 5,319,916 (-)NCBIChiLan1.0ChiLan1.0
LOC100967437
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,686,587 - 16,716,318 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,688,935 - 16,718,666 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0993,755,740 - 93,756,696 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19122,096,625 - 122,097,613 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC101964926
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947191,376,535 - 191,377,501 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648711,145,062 - 11,146,015 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648711,145,062 - 11,146,015 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110258970
(Sus scrofa - pig)		 No map positions available.
OR1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11215,516,356 - 15,518,384 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1215,516,934 - 15,517,890 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666079520,696 - 523,004 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101712607
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476012,306,627 - 12,307,580 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476012,306,627 - 12,307,580 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116900176
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1514,764,053 - 14,765,006 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Or1b1
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:28
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000010501
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)33779691953640235Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)33779691947904329Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

mesenchyme
renal system
reproductive system
1 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000010501   ⟹   ENSRNOP00000010501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl321,147,944 - 21,148,897 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093933   ⟹   ENSRNOP00000083782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl320,637,490 - 20,646,767 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096875   ⟹   ENSRNOP00000087118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl320,637,839 - 20,646,767 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107614   ⟹   ENSRNOP00000086594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl320,637,845 - 20,645,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122866   ⟹   ENSRNOP00000098776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl341,030,851 - 41,031,804 (-)Ensembl
RefSeq Acc Id: NM_001000393   ⟹   NP_001000393
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8341,030,851 - 41,031,804 (-)NCBI
mRatBN7.2320,639,976 - 20,640,929 (-)NCBI
Rnor_6.0321,147,944 - 21,148,897 (-)NCBI
Rnor_5.0326,393,589 - 26,394,542 (-)NCBI
RGSC_v3.4316,610,435 - 16,611,388 (-)RGD
Celera315,311,115 - 15,312,068 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000393 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000098776
  ENSRNOP00000098776.1
RefSeq Acc Id: NP_001000393   ⟸   NM_001000393
- UniProtKB: A6JUJ2 (UniProtKB/TrEMBL),   A0A8I6GF44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010501   ⟸   ENSRNOT00000010501
Ensembl Acc Id: ENSRNOP00000087118   ⟸   ENSRNOT00000096875
Ensembl Acc Id: ENSRNOP00000086594   ⟸   ENSRNOT00000107614
Ensembl Acc Id: ENSRNOP00000083782   ⟸   ENSRNOT00000093933
Ensembl Acc Id: ENSRNOP00000098776   ⟸   ENSRNOT00000122866
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLW2-F1-model_v2 AlphaFold D3ZLW2 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333333 AgrOrtholog
BioCyc Gene G2FUF-49973 BioCyc
Ensembl Genes ENSRNOG00000007986 Ensembl
  ENSRNOG00000067572 Ensembl
  ENSRNOG00000089548 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000122866 ENTREZGENE
  ENSRNOT00000122866.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:296687 UniProtKB/TrEMBL
NCBI Gene 296687 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or1b1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007986 RatGTEx
  ENSRNOG00000067572 RatGTEx
  ENSRNOG00000089548 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6GF44 ENTREZGENE
  A0ABK0LC88_RAT UniProtKB/TrEMBL
  A6JUJ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or1b1  olfactory receptor family 1 subfamily B member 1  Olr425  olfactory receptor 425  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr425  olfactory receptor 425   Olr425_predicted  olfactory receptor 425 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr425_predicted  olfactory receptor 425 (predicted)      Symbol and Name status set to approved 70820 APPROVED