Or10k2 (olfactory receptor family 10 subfamily K member 2) - Rat Genome Database

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Gene: Or10k2 (olfactory receptor family 10 subfamily K member 2) Rattus norvegicus
Analyze
Symbol: Or10k2
Name: olfactory receptor family 10 subfamily K member 2
RGD ID: 1333116
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OR10K2 (olfactory receptor family 10 subfamily K member 2); INTERACTS WITH bisphenol A; thioacetamide; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1667; olfactory receptor gene Olr1667; olfactory receptor Olr1667; Olr1667; ratchr19-26298899-26297955_ORF
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,506,721 - 41,507,665 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,506,721 - 41,507,665 (-)EnsemblGRCr8
mRatBN7.21924,602,019 - 24,602,963 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,601,037 - 24,606,795 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,423,320 - 31,424,264 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01932,077,735 - 32,078,679 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,300,348 - 34,301,292 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,670,699 - 24,671,643 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,670,699 - 24,671,643 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,649,329 - 35,650,273 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,293,129 - 26,294,073 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,142,602 - 24,143,546 (-)NCBICelera
RGSC_v3.11926,297,954 - 26,298,899 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA,IEA)
plasma membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or10k2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,506,721 - 41,507,665 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,506,721 - 41,507,665 (-)EnsemblGRCr8
mRatBN7.21924,602,019 - 24,602,963 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,601,037 - 24,606,795 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,423,320 - 31,424,264 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01932,077,735 - 32,078,679 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,300,348 - 34,301,292 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,670,699 - 24,671,643 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,670,699 - 24,671,643 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,649,329 - 35,650,273 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,293,129 - 26,294,073 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,142,602 - 24,143,546 (-)NCBICelera
RGSC_v3.11926,297,954 - 26,298,899 (-)NCBI
Cytogenetic Map19q11NCBI
OR10K2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381158,418,210 - 158,426,237 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1158,418,210 - 158,426,237 (-)Ensemblhg38GRCh38
GRCh371158,388,000 - 158,396,027 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,656,342 - 156,657,280 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341155,202,790 - 155,203,729NCBI
Celera1131,460,762 - 131,461,700 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1129,747,706 - 129,748,644 (-)NCBIHuRef
CHM1_11159,786,046 - 159,786,984 (-)NCBICHM1_1
T2T-CHM13v2.01157,555,287 - 157,563,315 (-)NCBIT2T-CHM13v2.0
Or10k2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,267,722 - 84,268,817 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,262,409 - 84,271,856 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38883,541,093 - 83,542,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,535,780 - 83,545,227 (+)Ensemblmm10GRCm38
MGSCv37886,064,992 - 86,066,087 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36886,431,251 - 86,432,195 (+)NCBIMGSCv36mm8
Celera887,833,509 - 87,834,604 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
LOC100984808
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2191,421,953 - 91,430,008 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1191,165,826 - 91,173,901 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01133,778,444 - 133,780,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11137,569,108 - 137,570,046 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1137,569,108 - 137,570,046 (-)EnsemblpanPan2panpan1.1
OR10K2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,265,396 - 23,266,340 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,265,396 - 23,266,340 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3823,261,366 - 23,262,310 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03823,396,906 - 23,397,850 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3823,396,906 - 23,397,850 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13823,147,059 - 23,148,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03823,694,763 - 23,695,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03824,102,039 - 24,102,983 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101958447
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050584,820,745 - 4,821,686 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367401,932,824 - 1,933,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100519896
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl491,775,970 - 91,776,908 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1491,775,970 - 91,776,914 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2499,811,296 - 99,812,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223789
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1205,508,521 - 5,510,727 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl205,509,721 - 5,510,659 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660384,692,017 - 4,693,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Or10k2
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:71
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000038213
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
Olfr370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,602,245 - 24,602,782 (-)MAPPERmRatBN7.2
Rnor_6.01924,670,880 - 24,671,416NCBIRnor6.0
Rnor_5.01935,649,510 - 35,650,046UniSTSRnor5.0
RGSC_v3.41926,293,356 - 26,293,892UniSTSRGSC3.4
Celera1924,142,829 - 24,143,365UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 1 16 3 6 1 2 1 15 5 1 13 3 13 5 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000038213   ⟹   ENSRNOP00000030653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,601,038 - 24,606,795 (-)Ensembl
Rnor_6.0 Ensembl1924,670,699 - 24,671,643 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107217   ⟹   ENSRNOP00000084819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,601,037 - 24,606,795 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147863   ⟹   ENSRNOP00000105312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,506,721 - 41,507,665 (-)Ensembl
RefSeq Acc Id: NM_001000537   ⟹   NP_001000537
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,506,721 - 41,507,665 (-)NCBI
mRatBN7.21924,602,019 - 24,602,963 (-)NCBI
Rnor_6.01924,670,699 - 24,671,643 (+)NCBI
Rnor_5.01935,649,329 - 35,650,273 (+)NCBI
RGSC_v3.41926,293,129 - 26,294,073 (-)RGD
Celera1924,142,602 - 24,143,546 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000537 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92272 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000105312
  ENSRNOP00000105312.1
RefSeq Acc Id: NP_001000537   ⟸   NM_001000537
- UniProtKB: D4A8I2 (UniProtKB/TrEMBL),   A6IYE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030653   ⟸   ENSRNOT00000038213
Ensembl Acc Id: ENSRNOP00000084819   ⟸   ENSRNOT00000107217
Ensembl Acc Id: ENSRNOP00000105312   ⟸   ENSRNOT00000147863
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8I2-F1-model_v2 AlphaFold D4A8I2 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333116 AgrOrtholog
BioCyc Gene G2FUF-6010 BioCyc
Ensembl Genes ENSRNOG00000028439 Ensembl
  ENSRNOG00000073756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000147863 ENTREZGENE
  ENSRNOT00000147863.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
NCBI Gene 364979 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or10k2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028439 RatGTEx
  ENSRNOG00000073756 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6IYE4 ENTREZGENE, UniProtKB/TrEMBL
  D4A8I2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or10k2  olfactory receptor family 10 subfamily K member 2  Olr1667  olfactory receptor 1667  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1667  olfactory receptor 1667   Olr1667_predicted  olfactory receptor 1667 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1667_predicted  olfactory receptor 1667 (predicted)      Symbol and Name status set to approved 70820 APPROVED