Or6c68 (olfactory receptor family 6 subfamily C member 68) - Rat Genome Database

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Gene: Or6c68 (olfactory receptor family 6 subfamily C member 68) Rattus norvegicus
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Symbol: Or6c68
Name: olfactory receptor family 6 subfamily C member 68
RGD ID: 1333022
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR6C68 (olfactory receptor family 6 subfamily C member 68); INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1006; olfactory receptor gene Olr1006; olfactory receptor Olr1006; Olr1006; ratchr7-6593123-6592173_ORF
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr875,848,671 - 5,849,621 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl75,848,671 - 5,849,621 (-)EnsemblGRCr8
mRatBN7.275,197,831 - 5,198,781 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl75,197,831 - 5,198,781 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx78,085,732 - 8,086,682 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.079,961,393 - 9,962,343 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.077,803,152 - 7,804,102 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.076,096,690 - 6,097,640 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl76,096,690 - 6,097,640 (+)Ensemblrn6Rnor6.0
Rnor_5.076,204,173 - 6,205,123 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.476,592,173 - 6,593,123 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera73,445,850 - 3,446,800 (-)NCBICelera
RGSC_v3.176,592,172 - 6,593,123 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or6c68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr875,848,671 - 5,849,621 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl75,848,671 - 5,849,621 (-)EnsemblGRCr8
mRatBN7.275,197,831 - 5,198,781 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl75,197,831 - 5,198,781 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx78,085,732 - 8,086,682 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.079,961,393 - 9,962,343 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.077,803,152 - 7,804,102 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.076,096,690 - 6,097,640 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl76,096,690 - 6,097,640 (+)Ensemblrn6Rnor6.0
Rnor_5.076,204,173 - 6,205,123 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.476,592,173 - 6,593,123 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera73,445,850 - 3,446,800 (-)NCBICelera
RGSC_v3.176,592,172 - 6,593,123 (-)NCBI
Cytogenetic Map7q11NCBI
OR6C68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,492,378 - 55,493,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,492,378 - 55,493,316 (+)Ensemblhg38GRCh38
GRCh371255,886,162 - 55,887,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,172,414 - 54,173,367 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341254,172,413 - 54,173,367NCBI
Celera1255,538,531 - 55,539,484 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1252,924,918 - 52,925,856 (+)NCBIHuRef
CHM1_11255,852,945 - 55,853,883 (+)NCBICHM1_1
T2T-CHM13v2.01255,458,923 - 55,459,861 (+)NCBIT2T-CHM13v2.0
Or6c68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910129,157,494 - 129,158,432 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10129,153,986 - 129,160,010 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810129,321,625 - 129,322,563 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10129,318,117 - 129,324,141 (+)Ensemblmm10GRCm38
MGSCv3710128,758,681 - 128,759,619 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610128,724,574 - 128,725,512 (+)NCBIMGSCv36mm8
Celera10131,709,451 - 131,710,389 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.3NCBI
OR6C53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,407,197 - 31,408,159 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,407,197 - 31,424,896 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha333,379,614 - 33,380,576 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0331,368,097 - 31,369,059 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl331,368,097 - 31,369,059 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1331,405,880 - 31,406,842 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0331,332,642 - 31,333,604 (+)NCBIUNSW_CanFamBas_1.0
LOC100156758
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2521,979,513 - 21,980,499 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Or6c68
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000051694
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

appendage
mesenchyme
renal system
reproductive system
1 2 1 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001000075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000051694   ⟹   ENSRNOP00000039478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl75,848,671 - 5,849,621 (-)Ensembl
mRatBN7.2 Ensembl75,197,831 - 5,198,781 (-)Ensembl
Rnor_6.0 Ensembl76,096,690 - 6,097,640 (+)Ensembl
RefSeq Acc Id: NM_001000075   ⟹   NP_001000075
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr875,848,671 - 5,849,621 (-)NCBI
mRatBN7.275,197,831 - 5,198,781 (-)NCBI
Rnor_6.076,096,690 - 6,097,640 (+)NCBI
Rnor_5.076,204,173 - 6,205,123 (+)NCBI
RGSC_v3.476,592,173 - 6,593,123 (-)RGD
Celera73,445,850 - 3,446,800 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000075 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039478
  ENSRNOP00000039478.1
RefSeq Acc Id: NP_001000075   ⟸   NM_001000075
- UniProtKB: D3ZH49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039478   ⟸   ENSRNOT00000051694
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH49-F1-model_v2 AlphaFold D3ZH49 1-316 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333022 AgrOrtholog
BioCyc Gene G2FUF-35160 BioCyc
Ensembl Genes ENSRNOG00000032428 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051694 ENTREZGENE
  ENSRNOT00000051694.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
KEGG Report rno:288886 UniProtKB/TrEMBL
NCBI Gene 288886 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 6C68 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6c68 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032428 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D3ZH49 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6c68  olfactory receptor family 6 subfamily C member 68  Olr1006  olfactory receptor 1006  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1006  olfactory receptor 1006   Olr1006_predicted  olfactory receptor 1006 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1006_predicted  olfactory receptor 1006 (predicted)      Symbol and Name status set to approved 70820 APPROVED