Or8s8 (olfactory receptor family 8 subfamily S member 8) - Rat Genome Database

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Gene: Or8s8 (olfactory receptor family 8 subfamily S member 8) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or8s8
Name: olfactory receptor family 8 subfamily S member 8
RGD ID: 1333018
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1108; olfactory receptor gene Olr1108; olfactory receptor MOR160-5 like protein; olfactory receptor Olr1108; Olr1108
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,470,811 - 131,471,746 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7131,470,811 - 131,471,746 (+)EnsemblGRCr8
mRatBN7.27129,591,770 - 129,592,705 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,588,021 - 129,596,083 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7131,399,018 - 131,399,953 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,624,563 - 133,625,498 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,537,055 - 133,537,990 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,054,592 - 140,055,527 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,054,592 - 140,055,527 (+)Ensemblrn6Rnor6.0
Rnor_5.07139,195,312 - 139,198,541 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47137,186,238 - 137,187,173 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7126,083,174 - 126,084,109 (+)NCBICelera
RGSC_v3.17137,262,674 - 137,263,610 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15385621  


Genomics

Variants

.
Variants in Or8s8
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000014337
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
mesenchyme
nervous system
renal system
reproductive system
sensory system
visual system
5 1 30 1 7 30 1 25 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000014337   ⟹   ENSRNOP00000014337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7140,054,592 - 140,055,527 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107033   ⟹   ENSRNOP00000093153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,588,021 - 129,596,083 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110334   ⟹   ENSRNOP00000077019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,588,021 - 129,596,083 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138656   ⟹   ENSRNOP00000102128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,470,811 - 131,471,746 (+)Ensembl
RefSeq Acc Id: NM_001000993   ⟹   NP_001000993
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,470,811 - 131,471,746 (+)NCBI
mRatBN7.27129,591,770 - 129,592,705 (+)NCBI
Rnor_6.07140,054,592 - 140,055,527 (+)NCBI
Rnor_5.07139,195,312 - 139,198,541 (+)NCBI
RGSC_v3.47137,186,238 - 137,187,173 (+)RGD
Celera7126,083,174 - 126,084,109 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000993 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV34193 (Get FASTA)   NCBI Sequence Viewer  
  EDL87060 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000102128
  ENSRNOP00000102128.1
RefSeq Acc Id: NP_001000993   ⟸   NM_001000993
- UniProtKB: Q5USB8 (UniProtKB/TrEMBL),   A0A8I5Y718 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014337   ⟸   ENSRNOT00000014337
Ensembl Acc Id: ENSRNOP00000077019   ⟸   ENSRNOT00000110334
Ensembl Acc Id: ENSRNOP00000093153   ⟸   ENSRNOT00000107033
Ensembl Acc Id: ENSRNOP00000102128   ⟸   ENSRNOT00000138656
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5USB8-F1-model_v2 AlphaFold Q5USB8 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333018 AgrOrtholog
BioCyc Gene G2FUF-32138 BioCyc
Ensembl Genes ENSRNOG00000010804 Ensembl
  ENSRNOG00000070632 Ensembl
  ENSRNOG00000071481 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000138656 ENTREZGENE
  ENSRNOT00000138656.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:405353 UniProtKB/TrEMBL
NCBI Gene 405353 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or8s8 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010804 RatGTEx
  ENSRNOG00000070632 RatGTEx
  ENSRNOG00000071481 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5Y718 ENTREZGENE, UniProtKB/TrEMBL
  Q5USB8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or8s8  olfactory receptor family 8 subfamily S member 8  Olr1108  olfactory receptor 1108  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1108  olfactory receptor 1108   Olr1108_predicted  olfactory receptor 1108 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1108_predicted  olfactory receptor 1108 (predicted)      Symbol and Name status set to approved 70820 APPROVED