Or11a4 (olfactory receptor family 11 subfamily A member 4) - Rat Genome Database

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Gene: Or11a4 (olfactory receptor family 11 subfamily A member 4) Rattus norvegicus
Analyze
Symbol: Or11a4
Name: olfactory receptor family 11 subfamily A member 4
RGD ID: 1333000
Description: Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR11A1 (olfactory receptor family 11 subfamily A member 1); INTERACTS WITH bisphenol A; cadmium dichloride; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MOR121-1; olfactory receptor 1743; olfactory receptor 8; olfactory receptor gene Olr1743; Olr1743; Or8; ratchr20-1445925-1444984_ORF
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,359,776 - 1,360,717 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl201,359,776 - 1,360,717 (-)EnsemblGRCr8
mRatBN7.2201,354,527 - 1,355,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,353,852 - 1,360,783 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx201,407,971 - 1,408,912 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,411,452 - 1,412,393 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,352,910 - 1,353,851 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0201,845,210 - 1,846,151 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl201,845,209 - 1,846,151 (-)Ensemblrn6Rnor6.0
Rnor_5.0203,886,817 - 3,887,758 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4201,444,984 - 1,445,925 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera202,065,113 - 2,066,054 (-)NCBICelera
RGSC_v3.1201,444,983 - 1,445,925 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
2. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or11a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,359,776 - 1,360,717 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl201,359,776 - 1,360,717 (-)EnsemblGRCr8
mRatBN7.2201,354,527 - 1,355,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,353,852 - 1,360,783 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx201,407,971 - 1,408,912 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,411,452 - 1,412,393 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,352,910 - 1,353,851 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0201,845,210 - 1,846,151 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl201,845,209 - 1,846,151 (-)Ensemblrn6Rnor6.0
Rnor_5.0203,886,817 - 3,887,758 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4201,444,984 - 1,445,925 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera202,065,113 - 2,066,054 (-)NCBICelera
RGSC_v3.1201,444,983 - 1,445,925 (-)NCBI
Cytogenetic Map20p12NCBI
OR11A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38629,425,504 - 29,457,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl629,425,504 - 29,457,071 (-)Ensemblhg38GRCh38
GRCh37629,393,281 - 29,424,848 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,501,260 - 29,503,488 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34629,501,259 - 29,503,488NCBI
Celera630,999,324 - 31,001,552 (-)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,200,435 - 29,202,663 (-)NCBIHuRef
CHM1_1629,395,372 - 29,397,600 (-)NCBICHM1_1
T2T-CHM13v2.0629,300,160 - 29,331,729 (-)NCBIT2T-CHM13v2.0
Or11a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391737,535,982 - 37,537,032 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1737,531,037 - 37,537,564 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381737,225,091 - 37,226,141 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1737,220,146 - 37,226,673 (+)Ensemblmm10GRCm38
MGSCv371737,362,072 - 37,363,013 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361736,833,180 - 36,834,121 (+)NCBIMGSCv36mm8
Celera1740,647,958 - 40,648,899 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1719.16NCBI
LOC100991715
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2544,058,724 - 44,060,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1640,022,040 - 40,024,007 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0629,243,414 - 29,245,369 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1629,903,758 - 29,907,478 (-)NCBIPanPan1.1PanPan1.1panPan2
OR11I1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,127,832 - 41,128,785 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl641,127,832 - 41,128,785 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha643,905,156 - 43,906,109 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0641,459,647 - 41,460,600 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,459,647 - 41,460,600 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1641,179,935 - 41,180,888 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0641,150,434 - 41,151,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,585,820 - 41,586,773 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101958721
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494632,269,046 - 32,269,993 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367231,321,890 - 1,322,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100517349
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2725,396,984 - 25,397,929 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC116886863
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11810,175,166 - 10,176,107 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Or11a4
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000000992
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013629303Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 12 12 15 3 22 3 2 29 23 10 1 14 12 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000000992   ⟹   ENSRNOP00000000992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,353,852 - 1,360,783 (-)Ensembl
Rnor_6.0 Ensembl201,845,209 - 1,846,151 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116827   ⟹   ENSRNOP00000078875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,353,852 - 1,360,783 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117039   ⟹   ENSRNOP00000092256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,353,852 - 1,360,783 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120863   ⟹   ENSRNOP00000098475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl201,359,776 - 1,360,717 (-)Ensembl
RefSeq Acc Id: NM_001001425   ⟹   NP_001001425
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,359,776 - 1,360,717 (-)NCBI
mRatBN7.2201,354,527 - 1,355,468 (-)NCBI
Rnor_6.0201,845,210 - 1,846,151 (-)NCBI
Rnor_5.0203,886,817 - 3,887,758 (-)NCBI
RGSC_v3.4201,444,984 - 1,445,925 (-)RGD
Celera202,065,113 - 2,066,054 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001001425 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE84076 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000098475
  ENSRNOP00000098475.1
RefSeq Acc Id: NP_001001425   ⟸   NM_001001425
- UniProtKB: Q6MFX1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000992   ⟸   ENSRNOT00000000992
Ensembl Acc Id: ENSRNOP00000078875   ⟸   ENSRNOT00000116827
Ensembl Acc Id: ENSRNOP00000092256   ⟸   ENSRNOT00000117039
Ensembl Acc Id: ENSRNOP00000098475   ⟸   ENSRNOT00000120863
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MFX1-F1-model_v2 AlphaFold Q6MFX1 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333000 AgrOrtholog
BioCyc Gene G2FUF-4998 BioCyc
Ensembl Genes ENSRNOG00000000765 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000120863 ENTREZGENE
  ENSRNOT00000120863.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_GPCR1 UniProtKB/TrEMBL
KEGG Report rno:294197 UniProtKB/TrEMBL
NCBI Gene 294197 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 11A1 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or11a4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000765 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt Q6MFX1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or11a4  olfactory receptor family 11 subfamily A member 4  Olr1743  olfactory receptor 1743  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1743  olfactory receptor 1743   Olr1743_predicted  olfactory receptor 1743 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1743_predicted  olfactory receptor 1743 (predicted)      Symbol and Name status set to approved 70820 APPROVED