Or2h2c (olfactory receptor family 2 subfamily H member 2C) - Rat Genome Database

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Gene: Or2h2c (olfactory receptor family 2 subfamily H member 2C) Rattus norvegicus
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Symbol: Or2h2c
Name: olfactory receptor family 2 subfamily H member 2C
RGD ID: 1332725
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human OR2H1 (olfactory receptor family 2 subfamily H member 1) and OR2H2 (olfactory receptor family 2 subfamily H member 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1746; olfactory receptor 5; olfactory receptor gene Olr1746; Olr1746; Or5
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,404,211 - 1,405,149 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl201,404,211 - 1,405,149 (+)EnsemblGRCr8
mRatBN7.2201,398,964 - 1,399,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,395,108 - 1,400,441 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx201,452,402 - 1,453,340 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,455,883 - 1,456,821 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,397,429 - 1,398,367 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0201,889,652 - 1,890,590 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl201,889,652 - 1,890,590 (+)Ensemblrn6Rnor6.0
Rnor_5.0203,931,254 - 3,932,192 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4201,489,421 - 1,490,359 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera202,109,490 - 2,110,428 (+)NCBICelera
RGSC_v3.1201,489,420 - 1,490,359 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or2h2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,404,211 - 1,405,149 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl201,404,211 - 1,405,149 (+)EnsemblGRCr8
mRatBN7.2201,398,964 - 1,399,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,395,108 - 1,400,441 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx201,452,402 - 1,453,340 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,455,883 - 1,456,821 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,397,429 - 1,398,367 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0201,889,652 - 1,890,590 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl201,889,652 - 1,890,590 (+)Ensemblrn6Rnor6.0
Rnor_5.0203,931,254 - 3,932,192 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4201,489,421 - 1,490,359 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera202,109,490 - 2,110,428 (+)NCBICelera
RGSC_v3.1201,489,420 - 1,490,359 (+)NCBI
Cytogenetic Map20p12NCBI
OR2H2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38629,585,121 - 29,590,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl629,585,121 - 29,590,500 (+)Ensemblhg38GRCh38
GRCh37629,552,898 - 29,558,277 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,663,662 - 29,664,724 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34629,663,700 - 29,664,639NCBI
Celera631,161,772 - 31,162,834 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,362,769 - 29,363,831 (+)NCBIHuRef
CHM1_1629,557,830 - 29,558,892 (+)NCBICHM1_1
T2T-CHM13v2.0629,459,801 - 29,465,179 (+)NCBIT2T-CHM13v2.0
Or2h2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391737,396,083 - 37,397,128 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1737,394,763 - 37,399,391 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381737,085,191 - 37,086,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1737,083,871 - 37,088,499 (-)Ensemblmm10GRCm38
MGSCv371737,222,136 - 37,223,181 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361736,693,284 - 36,694,216 (-)NCBIMGSCv36mm8
Celera1740,508,167 - 40,509,212 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1719.16NCBI
OR2H10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.18332,802 - 334,413 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl8332,802 - 333,740 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha8358,612 - 359,484 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.08380,633 - 381,505 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl8380,633 - 381,571 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.18319,952 - 320,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.08281,955 - 282,827 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.08408,804 - 409,676 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Or2h2c
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000000996
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013629303Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 8 4 2 7 2 6 14 11 2 1 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000000996   ⟹   ENSRNOP00000061882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl201,889,652 - 1,890,590 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000068508   ⟹   ENSRNOP00000062508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl201,889,652 - 1,890,572 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109249   ⟹   ENSRNOP00000082538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,395,108 - 1,400,441 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136570   ⟹   ENSRNOP00000099212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl201,404,211 - 1,405,149 (+)Ensembl
RefSeq Acc Id: NM_001001427   ⟹   NP_001001427
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,404,211 - 1,405,149 (+)NCBI
mRatBN7.2201,398,964 - 1,399,902 (+)NCBI
Rnor_6.0201,889,652 - 1,890,590 (+)NCBI
Rnor_5.0203,931,254 - 3,932,192 (+)NCBI
RGSC_v3.4201,489,421 - 1,490,359 (+)RGD
Celera202,109,490 - 2,110,428 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001001427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE84073 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000099212
  ENSRNOP00000099212.1
RefSeq Acc Id: NP_001001427   ⟸   NM_001001427
- UniProtKB: Q6MFX4 (UniProtKB/TrEMBL),   A6KR56 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062508   ⟸   ENSRNOT00000068508
Ensembl Acc Id: ENSRNOP00000061882   ⟸   ENSRNOT00000000996
Ensembl Acc Id: ENSRNOP00000082538   ⟸   ENSRNOT00000109249
Ensembl Acc Id: ENSRNOP00000099212   ⟸   ENSRNOT00000136570
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MFX4-F1-model_v2 AlphaFold Q6MFX4 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1332725 AgrOrtholog
BioCyc Gene G2FUF-4994 BioCyc
Ensembl Genes ENSRNOG00000050443 Ensembl
  ENSRNOG00000062729 Ensembl
  ENSRNOG00000085017 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000136570 ENTREZGENE
  ENSRNOT00000136570.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:405201 UniProtKB/TrEMBL
NCBI Gene 405201 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or2h2c PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050443 RatGTEx
  ENSRNOG00000062729 RatGTEx
  ENSRNOG00000085017 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6KR56 ENTREZGENE, UniProtKB/TrEMBL
  Q6MFX4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or2h2c  olfactory receptor family 2 subfamily H member 2C  Olr1746  olfactory receptor 1746  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1746  olfactory receptor 1746   Olr1746_predicted  olfactory receptor 1746 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1746_predicted  olfactory receptor 1746 (predicted)      Symbol and Name status set to approved 70820 APPROVED