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Gene: Lynx1 (Ly6/neurotoxin 1) Rattus norvegicus

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Symbol:

Lynx1

Name:

Ly6/neurotoxin 1

RGD ID:

1312017

Description:

Predicted to enable acetylcholine receptor binding activity; acetylcholine receptor inhibitor activity; and ion channel inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to act upstream of or within cholinergic synaptic transmission. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including LYNX1 (Ly6/neurotoxin 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC300018; ly-6/neurotoxin-like protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LYNX1 (Ly6/neurotoxin 1)	RGD	RGD
Mus musculus (house mouse):	Lynx1 (Ly6/neurotoxin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LYNX1 (Ly6/neurotoxin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LYNX1 (Ly6/neurotoxin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lynx1 (Ly6/neurotoxin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CATSPERG (catsper channel auxiliary subunit gamma)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Lynx1 (Ly6/neurotoxin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lynx1 (Ly6/neurotoxin 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LYNX1 (Ly6/neurotoxin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LYNX1 (Ly6/neurotoxin 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LYNX1-SLURP2 (LYNX1-SLURP2 readthrough)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LYNX1-SLURP2 (LYNX1-SLURP2 readthrough)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Bp335

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	108,521,783 - 108,527,012 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	108,521,780 - 108,527,130 (-)	Ensembl				GRCr8
mRatBN7.2	7	106,632,800 - 106,638,003 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	106,632,797 - 106,638,023 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	108,390,888 - 108,396,098 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	110,614,567 - 110,619,777 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	110,560,497 - 110,565,707 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	115,982,877 - 115,988,121 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	115,982,876 - 115,988,090 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	115,888,263 - 115,893,505 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	112,862,566 - 112,867,769 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	103,033,948 - 103,039,151 (-)	NCBI		Celera
RGSC_v3.1	7	112,899,790 - 112,901,986 (-)	NCBI
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetylcholine (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

arsane (ISO)

arsenic atom (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

cantharidin (ISO)

choline (ISO)

cisplatin (ISO)

Cuprizon (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP,ISO)

doxorubicin (ISO)

epibatidine (EXP)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

imidacloprid (EXP)

indole-3-methanol (EXP)

inulin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

methylmercury chloride (ISO)

nitrates (ISO)

paraquat (ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenformin (EXP)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

testosterone (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trimethyltin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (IBA)

regulation of neurotransmitter receptor activity (ISO)

synaptic transmission, cholinergic (ISO)

Cellular Component

dendrite (IEA)

endoplasmic reticulum (IEA)

membrane (ISO)

plasma membrane (IBA,IEA,ISO)

side of membrane (IEA)

synapse (IEA)

Molecular Function

acetylcholine receptor binding (IBA,ISO)

acetylcholine receptor inhibitor activity (IBA,ISO)

acetylcholine receptor regulator activity (ISO)

ion channel inhibitor activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11906696	PMID:16575903	PMID:19246390	PMID:21252236	PMID:27460145	PMID:27485575

Genomics

Comparative Map Data

Lynx1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	108,521,783 - 108,527,012 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	108,521,780 - 108,527,130 (-)	Ensembl				GRCr8
mRatBN7.2	7	106,632,800 - 106,638,003 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	106,632,797 - 106,638,023 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	108,390,888 - 108,396,098 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	110,614,567 - 110,619,777 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	110,560,497 - 110,565,707 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	115,982,877 - 115,988,121 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	115,982,876 - 115,988,090 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	115,888,263 - 115,893,505 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	112,862,566 - 112,867,769 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	103,033,948 - 103,039,151 (-)	NCBI		Celera
RGSC_v3.1	7	112,899,790 - 112,901,986 (-)	NCBI
Cytogenetic Map	7	q34	NCBI

LYNX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	142,771,197 - 142,777,872 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	142,771,197 - 142,777,859 (-)	Ensembl			hg38	GRCh38
GRCh37	8	143,852,615 - 143,859,288 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	143,842,758 - 143,856,642 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	8	140,155,485 - 140,169,371 (-)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	139,097,902 - 139,111,799 (-)	NCBI		HuRef
CHM1_1	8	143,885,943 - 143,899,792 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	143,914,639 - 143,921,325 (-)	NCBI		T2T-CHM13v2.0

Lynx1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	74,619,705 - 74,624,828 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	74,619,701 - 74,624,895 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	74,747,856 - 74,752,979 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	74,747,852 - 74,753,046 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	74,578,286 - 74,583,409 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	74,575,111 - 74,580,234 (-)	NCBI		MGSCv36	mm8
Celera	15	76,252,812 - 76,257,935 (-)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	34.27	NCBI

LYNX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	1,450,147 - 1,455,889 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	1,450,112 - 1,455,000 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LYNX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	137,014,986 - 137,026,502 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	137,015,247 - 137,025,381 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666039	2,923,057 - 2,925,058 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lynx1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	247,493,515 - 247,495,694 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lynx1
19 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	18
Interacting mature miRNAs:	18
Transcripts:	ENSRNOT00000007988
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	92388565	119280177	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	31770293	110435881	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	73618702	118618702	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	71621154	114982716	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
1331723	Bw25	Body weight QTL 25	3.348		body mass (VT:0001259)	body weight (CMO:0000012)	7	96700404	111672180	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	63889858	108889858	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	73557047	118557047	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	96700404	118618702	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	49682832	115766396	Rat
10450862	Kidm55	Kidney mass QTL 55	4.9		kidney mass (VT:0002707)	kidney weight (CMO:0000081)	7	72725037	117725037	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	63889858	108889858	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
10450856	Livw4	Liver weight QTL 4	3.8		liver mass (VT:0003402)	liver weight (CMO:0000092)	7	72725037	117725037	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	49682832	115766396	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	49682832	115766396	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	71621154	119349044	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

RH137585

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	106,636,212 - 106,636,387 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	115,986,292 - 115,986,466	NCBI	Rnor6.0
Rnor_5.0	7	115,891,681 - 115,891,855	UniSTS	Rnor5.0
RGSC_v3.4	7	112,865,979 - 112,866,153	UniSTS	RGSC3.4
Celera	7	103,037,361 - 103,037,535	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	66	156	91	90	59	77	59	6	335	175	10	128	77	88	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001130546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000076708 ⟹ ENSRNOP00000067992

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	108,521,780 - 108,527,130 (-)	Ensembl
mRatBN7.2 Ensembl	7	106,632,797 - 106,638,023 (-)	Ensembl
Rnor_6.0 Ensembl	7	115,982,876 - 115,988,090 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076822 ⟹ ENSRNOP00000068518

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	115,986,206 - 115,988,036 (-)	Ensembl

RefSeq Acc Id:

NM_001130546 ⟹ NP_001124018

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	108,521,783 - 108,526,986 (-)	NCBI
mRatBN7.2	7	106,632,800 - 106,638,003 (-)	NCBI
Rnor_6.0	7	115,982,879 - 115,988,082 (-)	NCBI
Rnor_5.0	7	115,888,263 - 115,893,505 (-)	NCBI
RGSC_v3.4	7	112,862,566 - 112,867,769 (-)	RGD
Celera	7	103,033,948 - 103,039,151 (-)	RGD

Sequence:

show sequence

GCGCTGCGGATCTGTTGCGGTGGCGGAGCCTACTCCACCTGCCTGCGATGCGGTACAAACACCG
CACGAAGTGTGTACAGATTCACTGTCAGACTGCGGGAGGGACCTGGGAGCGGCCACGGGTAACT
GGAAATTAGTGATACCCACTGAGCTGGGAGGCTCTTGTGACTGCCCCAGCCCAGCTGTCATCAC
AAGTCTCTTATCATCGTCTATGCAAGGCTGCTTTATCACTAGGAGACCAAGAGCTCAAGCAGGG
CCTCTGTGTCCTGCTTCTTCTCTGACCTGAGTTGGATCCAGGACCAGCTGCTGTCCTCCTGTTC
CCTCCGACACTGTCCTCACAGCTCCGTCATGACCCACTTGCTGACAGTATTCCTGGTGGCTCTG
ATGGGCCTGCCTGTGGCCCAGGCTCTGGAGTGCCACGTATGTGCCTACAATGGAGACAACTGCT
TCAAACCCATGCGATGCCCCGCCATGGCCACCTACTGTATGACCACTCGAACTTACTTCACCCC
GTACCGGATGAAGGTGAGGAAGTCCTGTGTTCCCAGCTGCTTTGAGACCGTGTACGATGGCTAC
TCCAAGCACGCATCTGCCACCTCCTGTTGCCAGTACTACCTGTGCAATGGTGCTGGCTTTGCTA
CCCCAGTGACCTTGGCCCTGGTCCCGGCACTCCTAGCTACCTTCTGGAGCTTGCTATGAAGAGC
TTTGTTCCCCAAACCAGACCCCCTCAAACACAACACTCTTTAAAAAATACAGTTACCCCCTCTC
GCCCACTTGCTTCACCCAACCCTCTTCCCTCTGAGACTCCTCAGCCATGAGGTTCCGTGGCTGT
CTATGAAAGGACTGATGCCATCCAGATACCTCACTCCAAGGTCATTTTCAGAAGGCTGATGTAT
GGACCTGGAATGTGCCCAGTCATGGGTGGGGCAGGCTCGGCTCCTCCTCTACCCAGGATTAGGA
GTATCTGGGAGAGTGATGTTTATGGGGGGAGGGATCATTGCTTAAGTCAAGGAATACTGGTTTA
ATAGAATTAGTAGCCAAACTCCACCTTCATAGTGTCAGGACCCTGCCTCAGTCTACCCAGTAGA
GGATAGGTCTCCTGGAGGTGGGGGTGATAATGAACTGGCTAGAAGCAGAGAAAGACTCAGCAGA
GCTATCTCCTAAATCCAGCAGCTTCCCAGGGCAAACATGATGTGGAAGCCATGTGAGGAAGCCC
TTGTTGTTCCTACTTATCTGAGGAACTCTGCCAGACCTGCCCTCAGGATAGCCATTGGCCAAGG
GTTGCTAGCAACGGCTTCATTTCCATAGGCCACTGAGATCCCTCCAGCCCCAGCTCAGCCAGCC
CTTTGACCTCCACTACAGTCCCTCACTCACATACTGGCTGCTGGGACTTCAGGCTGGCAGGGAC
ATGCGGGCGGGCGGGTGACCCATGCTATATTTTGTCTGGCCTGCACACTGGCCAGAGCTATTCT
GGGCATGGCAGGATGGGATCAGAGGCAGTCAGAGCAGGTTAGTGGGGTAACTGAGACAGGGACG
CAGACTTTAGCCAGACTACCCAGGTCCCGTAGACAGCTCCTATGTCCTTCAGTCTCTTGGTAAG
TTATTGGGAGACGAGTGTACAGAGAGCCAGCCCAATCCCTAGGTGACTGCCTGTGACATCTGTG
GTGGCTGAAGACTGCTGGGTATCAAGTCTCAGGAGAACCCAGCCCAGATTTAGGAGACACCTTT
CATGCCATGTAGTTGTCTCTGAGAGCCTTACCCTGCTCTCCAACTAGTACTCCAACTCATGTGC
CACTGAGGAACCCTGCTGAAGCTGGCCCAGCCCAGGGGTCAGAATGCTGGCCAGTGTCCATATA
GTGGGATTACCTATGGTGAGTCCTAGTGGTCACTATGTCTCGAATGTTTTTTCCAGACCTCCCA
TGGCAGAAGCTCAGGGACACAGAGGCCCAACCTGGGGACCTTCCTCCCTGTTCTCGGCAGACCT
GAGCTCTGTCTGCTGCTAGAGCTGATGTGCTTTTCTGCCTCAGTTTCCTCCTCCTCTGGGGATA
GGCCACTGGAGGATTTGGGAGGGGGAGGGCATTCTGCTGATAGGCTTGCCTAGATTCTTAGGCA
TAGGAACTGTGGGGCTTTATTACATAGGTGAATTGGGTGGGAAATGGCTTGGAGCTGAGGAGAC
ATTGACTACCCTAAGGGAAGACGAGTCTCAAGGAAGGCCAGGAAGGGGGAGAGTGAAATGCACA
TGCACATGTGCACGCAGGCAGTGGTTACAGATGGCTGTGGTGTCCCCTGAGGTCTAGGCAGGAT
ACTGGGATGAAGCCAGTGCTGCCTGGACCTGAGCTTGCATGGAACACACACACACGCACGCACG
CACGCACGCACACACACACACACCAAGCAGCCAGCATTGGGGCTGACCTGTGGAAGCCACAGGA
CACTGGCAAGGAGGGTCAGAGGCAGGCCCCTGACTCAGTGGGTGAGGCCTGGGAAACATTATCC
TGTTACCCTGCTTGTGCAAGTTCATTATCCCCAGTTAGGTGGCACCCTCAGCCAAAACTGGGAG
GAGCCCGAGATCAGGTTCCCCCGCCTACCACAAGGGGGTGATGTGGTAGAGGCTTGATTATCTG
TGGCCCCAAAGCAAAGCGCTGCGGCTGCTGCAGTGCTGGGGTCAGCTTCTTTCACCTGCCTCTG
GACACCAACCAGATAGGCCCCACAGTGGCCACACTGCCACTCAGCCCTGCAGGAAGCTCTGTGC
CTAGCTAGCCTGTCCTTGGTGCTTAGCATAGAGCCCCAAAAGGTGCTCGATTAATACAGGGCCA
AGTCTGCCAGTGGGAGATGCAGGTTAGGGGAACAGTACCAGATGGCCTGTCCTGAATCCTGTCT
GGGCTGCTGTGATGAACATCTGTCTAGCTCACTGCAGGTGACTCTCCACACTCCACAGCGGTTC
TGCAAAAGCATACGGGGAGGTCATTCCTGCCCCCCTTTGACAGGTAAAGACACTGAGGCACAGA
AGAGTGAGGCACTTCGTTCTCCTCAGCCATTCGTCTTTCCAGTACCAACCCATTCAACTACGGG
TGCTCCTCCAACGGCTGGGGTTCTTTGAGGCTGTGCACCCATGAGATGATAGTGACTTCATAAG
CCAGAGAATTTCAGAGTGAAGTGTTGTCAGAGCCTATGAACCTGAAACTTTAGATCTGGAGGTC
TGAGTGATTGAGGGGAAGGCCAGGGGTATCCAGCCCTGAAGATCCAGAGAAGTACAAAGGAACA
TCAGCCTTTGTCAGGGCTAATGCTGTCAGGGACGAGGGCTCAAGGCCGTTGAGTGTTCTCACAC
TGTGATAAACAGTGGCCCCTCAACACTGGGGTGTCCAGGGCGGCTGGCAGCAGTTATCTATAGA
GCTGCCGTGTGGAAGTGTCTTGGTAGTCACTGGAGAGAGGCTGCTGGACCGCACAGTGAGACAC
ACATGGAGTGTGTGTACTTCCGTGGGATTTGATGAAGCCGGGTCAGCACATGAAGTCAAAACAT
ACTTCAGGGCAGAGAGAGGTGTCTGGTCTGGTCCACCAGAGAGAAGCTGTCCAGTGAGAGCCAT
GCTCTGCCACCGTCTCTGTGATTGGCTTCCCCAAAAGCAGATGAGGAGAGGAGTGGTGCCGAGC
ACCCACGTCTTCATCTCCTGCAGCAAGCACATGAGTCAGCATTCTGAAACTCTAGATTTTCAGG
AGTAGGGTAGCCCTTTGCTTTGGTGCGTGGTTACTTCCTGGCAAGCACCATGGCACCCTGTAGC
ACGGAACGACCTGGGCTCCTCAAGCCCAGACTCAGGTTCCAGCCATCTCATCGGTGAAATGACA
GTGACAGTGCCCTCTCTACTGGCTCTTGGAGGTCCCTTGCCTGGGGTCTGCACAGAGGCGGCCC
CAAAGGATGCATGGATCTGTGATGTCTTGCACTTCCCTTGGTTGTGTCTCTGCTAACCCCAAGC
TCTCACCCAGCAAGGACATGAAATCCACTTTTATGCCACATCTCCCTTCTCCCAGCCAGCTCCA
TGTACCTCTACTTCAGAGTGGCCCCGTCAATGTCCATCCCCCTCGGAATGAATAAACAAGTGAA
GGAC

hide sequence

RefSeq Acc Id:

XM_063263264 ⟹ XP_063119334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	108,521,783 - 108,527,012 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001124018	(Get FASTA)	NCBI Sequence Viewer
	NP_001416050	(Get FASTA)	NCBI Sequence Viewer
	XP_063119334	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16089	(Get FASTA)	NCBI Sequence Viewer
	EDM16090	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000067992
	ENSRNOP00000067992.2

RefSeq Acc Id:	NP_001124018 ⟸ NM_001130546
- Peptide Label:	precursor
- UniProtKB:	A6HRY3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTHLLTVFLVALMGLPVAQALECHVCAYNGDNCFKPMRCPAMATYCMTTRTYFTPYRMKVRKSC VPSCFETVYDGYSKHASATSCCQYYLCNGAGFATPVTLALVPALLATFWSLL hide sequence

Ensembl Acc Id:

ENSRNOP00000068518 ⟸ ENSRNOT00000076822

Ensembl Acc Id:

ENSRNOP00000067992 ⟸ ENSRNOT00000076708

RefSeq Acc Id:	XP_063119334 ⟸ XM_063263264
- Peptide Label:	isoform X1
- UniProtKB:	D4A6F2 (UniProtKB/TrEMBL)

Protein Domains

UPAR/Ly6

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A6F2-F1-model_v2	AlphaFold	D4A6F2	1-116	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695380

Promoter ID:

EPDNEW_R5901

Type:

initiation region

Name:

Lynx1_1

Description:

Ly6/neurotoxin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	115,988,093 - 115,988,153	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1312017	AgrOrtholog
BioCyc Gene	G2FUF-33014	BioCyc
Ensembl Genes	ENSRNOG00000006086	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000076708	ENTREZGENE
	ENSRNOT00000076708.4	UniProtKB/TrEMBL
Gene3D-CATH	2.10.60.10	UniProtKB/TrEMBL
InterPro	Ly-6/neurotoxin-like_GPI-ap	UniProtKB/TrEMBL
	LY6_UPA_recep-like	UniProtKB/TrEMBL
	Snake_toxin-like_sf	UniProtKB/TrEMBL
	Toxin/TOLIP	UniProtKB/TrEMBL
KEGG Report	rno:300018	UniProtKB/TrEMBL
NCBI Gene	300018	ENTREZGENE
PANTHER	LY-6/NEUROTOXIN-LIKE PROTEIN 1	UniProtKB/TrEMBL
	UPAR/LY6 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	Toxin_TOLIP	UniProtKB/TrEMBL
PhenoGen	Lynx1	PhenoGen
RatGTEx	ENSRNOG00000006086	RatGTEx
SMART	SM00134	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57302	UniProtKB/TrEMBL
UniProt	A6HRY3	ENTREZGENE, UniProtKB/TrEMBL
	D4A6F2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Lynx1	Ly6/neurotoxin 1	Lynx1_predicted	Ly6/neurotoxin 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Lynx1_predicted	Ly6/neurotoxin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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