Trex1 (three prime repair exonuclease 1) - Rat Genome Database

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Gene: Trex1 (three prime repair exonuclease 1) Rattus norvegicus
Analyze
Symbol: Trex1
Name: three prime repair exonuclease 1
RGD ID: 1311998
Description: Predicted to enable several functions, including DNA binding activity; WW domain binding activity; and mismatch repair complex binding activity. Predicted to be involved in DNA catabolic process; negative regulation of cGAS/STING signaling pathway; and negative regulation of innate immune response. Predicted to act upstream of or within several processes, including DNA metabolic process; circulatory system development; and regulation of defense response. Predicted to be located in cytosol; endoplasmic reticulum membrane; and nuclear replication fork. Predicted to be part of oligosaccharyltransferase complex and protein-DNA complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1); PARTICIPATES IN DNA replication pathway; G2/M DNA damage checkpoint pathway; INTERACTS WITH (+)-pilocarpine; 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301014; MGC109019; RGD1309596; three-prime repair exonuclease 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,585,082 - 118,586,382 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,585,081 - 118,586,083 (-)EnsemblGRCr8
mRatBN7.28109,706,613 - 109,707,913 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,706,613 - 109,708,796 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,321,502 - 115,322,802 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,520,676 - 113,521,976 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,363,483 - 111,364,783 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,796,127 - 117,797,427 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,796,128 - 117,797,427 (-)Ensemblrn6Rnor6.0
Rnor_5.08117,147,872 - 117,149,172 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,071,508 - 114,072,509 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8108,998,058 - 108,999,059 (-)NCBICelera
RGSC_v3.18114,092,776 - 114,106,801 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of immune response  (ISO)
adaptive immune response  (ISO)
apoptotic cell clearance  (ISO)
atrial cardiac muscle tissue development  (ISO)
blood vessel development  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to hydroxyurea  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to type I interferon  (ISO)
cellular response to UV  (ISO)
defense response to virus  (ISO)
determination of adult lifespan  (ISO)
DNA catabolic process  (IBA,ISO)
DNA damage checkpoint signaling  (ISO)
DNA damage response  (ISO)
DNA metabolic process  (IEA,ISO)
DNA modification  (ISO)
DNA repair  (IEA)
DNA replication  (ISO)
DNA synthesis involved in UV-damage excision repair  (ISO)
establishment of protein localization  (ISO)
generation of precursor metabolites and energy  (ISO)
glycoprotein biosynthetic process  (ISO)
heart morphogenesis  (ISO)
heart process  (ISO)
immune complex formation  (ISO)
immune response  (ISO)
immune response in brain or nervous system  (ISO)
inflammatory response  (ISO)
inflammatory response to antigenic stimulus  (ISO)
innate immune response  (ISO)
kidney development  (ISO)
lymphoid progenitor cell differentiation  (ISO)
macrophage activation involved in immune response  (ISO)
mitotic G1 DNA damage checkpoint signaling  (ISO)
negative regulation of cGAS/STING signaling pathway  (IEA,ISO)
negative regulation of innate immune response  (IEA,ISO)
negative regulation of type I interferon-mediated signaling pathway  (ISO)
organ or tissue specific immune response  (ISO)
protein stabilization  (ISO)
regulation of catalytic activity  (ISO)
regulation of cellular respiration  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of gene expression  (ISO)
regulation of glycolytic process  (ISO)
regulation of immunoglobulin production  (ISO)
regulation of inflammatory response  (ISO)
regulation of innate immune response  (ISO)
regulation of lipid biosynthetic process  (ISO)
regulation of lysosome organization  (ISO)
regulation of protein complex stability  (ISO)
regulation of T cell activation  (ISO)
regulation of tumor necrosis factor production  (ISO)
regulation of type I interferon production  (ISO)
response to UV  (ISO)
retrotransposition  (ISO)
T cell antigen processing and presentation  (ISO)
type I interferon-mediated signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ATR and ATRIP: partners in checkpoint signaling. Cortez D, etal., Science. 2001 Nov 23;294(5547):1713-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10391904   PMID:11279105   PMID:12477932   PMID:15254239   PMID:16713580   PMID:17293595   PMID:17355961   PMID:18045533   PMID:18724932   PMID:19158679   PMID:19923437   PMID:20511593  
PMID:20871604   PMID:23160154   PMID:23993650   PMID:24154727   PMID:24205360   PMID:24218451   PMID:25848017   PMID:26320659   PMID:26371324   PMID:28069950   PMID:28351661   PMID:28835460  


Genomics

Comparative Map Data
Trex1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,585,082 - 118,586,382 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,585,081 - 118,586,083 (-)EnsemblGRCr8
mRatBN7.28109,706,613 - 109,707,913 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,706,613 - 109,708,796 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,321,502 - 115,322,802 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,520,676 - 113,521,976 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,363,483 - 111,364,783 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,796,127 - 117,797,427 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,796,128 - 117,797,427 (-)Ensemblrn6Rnor6.0
Rnor_5.08117,147,872 - 117,149,172 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,071,508 - 114,072,509 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8108,998,058 - 108,999,059 (-)NCBICelera
RGSC_v3.18114,092,776 - 114,106,801 (-)NCBI
Cytogenetic Map8q32NCBI
TREX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,465,830 - 48,467,645 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,465,811 - 48,467,645 (+)Ensemblhg38GRCh38
GRCh37348,507,229 - 48,509,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,482,233 - 48,484,048 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34348,463,221 - 48,482,058NCBI
Celera348,458,088 - 48,459,903 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,560,949 - 48,563,074 (+)NCBIHuRef
CHM1_1348,459,219 - 48,461,344 (+)NCBICHM1_1
T2T-CHM13v2.0348,493,835 - 48,495,650 (+)NCBIT2T-CHM13v2.0
Trex1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,887,000 - 108,888,791 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,887,001 - 108,888,802 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389109,057,932 - 109,059,723 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,057,933 - 109,059,734 (-)Ensemblmm10GRCm38
MGSCv379108,960,446 - 108,962,237 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369108,915,338 - 108,917,129 (-)NCBIMGSCv36mm8
Celera9108,616,714 - 108,618,505 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
Trex1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532533,877 - 535,767 (+)Ensembl
ChiLan1.0NW_004955532533,877 - 535,767 (+)NCBIChiLan1.0ChiLan1.0
TREX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,440,555 - 48,442,557 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,445,488 - 48,447,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,387,762 - 48,389,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,469,406 - 49,471,371 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,470,222 - 49,471,331 (+)EnsemblpanPan2panpan1.1
TREX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,624,845 - 40,626,840 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,624,891 - 40,626,906 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2040,542,323 - 40,544,332 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02041,110,233 - 41,112,242 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,107,235 - 41,112,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,347,667 - 40,349,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,752,252 - 40,754,261 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,032,948 - 41,034,957 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trex1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,503,993 - 63,505,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529264,468 - 266,422 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936529264,535 - 266,451 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,179,291 - 31,180,747 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11331,177,604 - 31,180,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,561,987 - 34,563,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,869,502 - 9,871,659 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041157,219,548 - 157,221,411 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trex1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247302,431,999 - 2,432,959 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247302,431,270 - 2,433,010 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Trex1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18100,326,221 - 100,327,834 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trex1
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000033719
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
AU041952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,706,669 - 109,706,780 (+)MAPPERmRatBN7.2
Rnor_6.08117,796,184 - 117,796,294NCBIRnor6.0
Rnor_5.08117,147,929 - 117,148,039UniSTSRnor5.0
RGSC_v3.48114,071,565 - 114,071,675UniSTSRGSC3.4
Celera8108,998,115 - 108,998,225UniSTS
Cytogenetic Map8q32UniSTS
RH129942  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,706,643 - 109,706,834 (+)MAPPERmRatBN7.2
Rnor_6.08117,796,158 - 117,796,348NCBIRnor6.0
Rnor_5.08117,147,903 - 117,148,093UniSTSRnor5.0
RGSC_v3.48114,071,539 - 114,071,729UniSTSRGSC3.4
Celera8108,998,089 - 108,998,279UniSTS
RH 3.4 Map81115.59UniSTS
Cytogenetic Map8q32UniSTS
RH131155  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,706,148 - 109,706,328 (+)MAPPERmRatBN7.2
Rnor_6.08117,795,663 - 117,795,842NCBIRnor6.0
Rnor_5.08117,147,408 - 117,147,587UniSTSRnor5.0
RGSC_v3.48114,071,044 - 114,071,223UniSTSRGSC3.4
Celera8108,997,594 - 108,997,773UniSTS
RH 3.4 Map81114.9UniSTS
RH 3.4 Map81114.2UniSTS
Cytogenetic Map8q32UniSTS
BE101097  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88118,587,013 - 118,587,482 (+)Marker Load Pipeline
mRatBN7.28109,708,544 - 109,709,013 (+)MAPPERmRatBN7.2
Rnor_6.08117,798,059 - 117,798,527NCBIRnor6.0
Rnor_5.08117,149,804 - 117,150,272UniSTSRnor5.0
RGSC_v3.48114,073,426 - 114,073,894UniSTSRGSC3.4
Celera8108,999,838 - 109,000,306UniSTS
RH 3.4 Map81115.19UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033719   ⟹   ENSRNOP00000034541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,585,081 - 118,586,083 (-)Ensembl
mRatBN7.2 Ensembl8109,706,613 - 109,708,796 (-)Ensembl
Rnor_6.0 Ensembl8117,796,128 - 117,797,427 (-)Ensembl
RefSeq Acc Id: NM_001024989   ⟹   NP_001020160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,585,082 - 118,586,382 (-)NCBI
mRatBN7.28109,706,613 - 109,707,913 (-)NCBI
Rnor_6.08117,796,127 - 117,797,427 (-)NCBI
Rnor_5.08117,147,872 - 117,149,172 (-)NCBI
RGSC_v3.48114,071,508 - 114,072,509 (-)RGD
Celera8108,998,058 - 108,999,059 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020160 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91242 (Get FASTA)   NCBI Sequence Viewer  
  EDL77115 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034541
  ENSRNOP00000034541.3
RefSeq Acc Id: NP_001020160   ⟸   NM_001024989
- UniProtKB: Q5BK16 (UniProtKB/TrEMBL),   F7F432 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034541   ⟸   ENSRNOT00000033719
Protein Domains
Exonuclease

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK16-F1-model_v2 AlphaFold Q5BK16 1-316 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696320
Promoter ID:EPDNEW_R6845
Type:initiation region
Name:Trex1_1
Description:three prime repair exonuclease 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,797,445 - 117,797,505EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311998 AgrOrtholog
BioCyc Gene G2FUF-29095 BioCyc
Ensembl Genes ENSRNOG00000022540 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033719 ENTREZGENE
  ENSRNOT00000033719.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
InterPro Exonuclease_RNaseT/DNA_pol3 UniProtKB/TrEMBL
  PolynucTfrase_RNaseH_fold UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  TREX1/2 UniProtKB/TrEMBL
KEGG Report rno:100049583 UniProtKB/TrEMBL
NCBI Gene 100049583 ENTREZGENE
PANTHER PTHR13058 UniProtKB/TrEMBL
  THREE-PRIME REPAIR EXONUCLEASE 1 UniProtKB/TrEMBL
PhenoGen Trex1 PhenoGen
RatGTEx ENSRNOG00000022540 RatGTEx
SMART EXOIII UniProtKB/TrEMBL
Superfamily-SCOP RNaseH_fold UniProtKB/TrEMBL
UniProt F7F432 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Trex1  three prime repair exonuclease 1  Trex1_predicted  three prime repair exonuclease 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Trex1_predicted  three prime repair exonuclease 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED