Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Siglec1 | Rat | 17beta-estradiol | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Estradiol results in increased expression of SIGLEC1 mRNA | CTD | PMID:19484750 | Siglec1 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of SIGLEC1 mRNA | CTD | PMID:35192832 | Siglec1 | Rat | 17beta-estradiol | decreases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Estradiol results in decreased expression of SIGLEC1 mRNA | CTD | PMID:39298647 | Siglec1 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SIGLEC1 mRNA | CTD | PMID:32741896 | Siglec1 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SIGLEC1 mRNA | CTD | PMID:32741896 | Siglec1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Siglec1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIGLEC1 mRNA | CTD | PMID:28922406 | Siglec1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIGLEC1 mRNA | CTD | PMID:34747641 | Siglec1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SIGLEC1 mRNA | CTD | PMID:32109520 | Siglec1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of SIGLEC1 mRNA | CTD | PMID:30951980 | Siglec1 | Rat | 4,4'-sulfonyldiphenol | affects expression | ISO | Siglec1 (Mus musculus) | 6480464 | bisphenol S affects the expression of SIGLEC1 mRNA | CTD | PMID:39298647 | Siglec1 | Rat | 5-fluorouracil | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [Fluorouracil co-treated with irinotecan] results in increased expression of SIGLEC1 mRNA | CTD | PMID:16391804 | Siglec1 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SIGLEC1 mRNA | CTD | PMID:30047161 | Siglec1 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SIGLEC1 mRNA | CTD | PMID:31881176 | Siglec1 | Rat | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of SIGLEC1 mRNA | CTD | PMID:33354967 | Siglec1 | Rat | aldehydo-D-glucose | multiple interactions | ISO | Siglec1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... | CTD | PMID:37567420 | Siglec1 | Rat | all-trans-retinoic acid | increases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SIGLEC1 mRNA | CTD | PMID:33167477 | Siglec1 | Rat | alpha-Zearalanol | increases expression | EXP | | 6480464 | Zeranol results in increased expression of SIGLEC1 mRNA | CTD | PMID:35163327 | Siglec1 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of SIGLEC1 mRNA | CTD | PMID:30047161 | Siglec1 | Rat | amphotericin B | increases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Amphotericin B analog results in increased expression of SIGLEC1 mRNA | CTD | PMID:28534445 | Siglec1 | Rat | antirheumatic drug | decreases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SIGLEC1 mRNA | CTD | PMID:24449571 | Siglec1 | Rat | arsane | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Siglec1 | Rat | arsenic atom | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Siglec1 | Rat | benzo[a]pyrene | decreases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SIGLEC1 mRNA | CTD | PMID:22228805 | Siglec1 | Rat | benzo[a]pyrene | decreases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SIGLEC1 mRNA | CTD | PMID:32234424 | Siglec1 | Rat | benzo[a]pyrene | affects methylation | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SIGLEC1 3' UTR | CTD | PMID:27901495 | Siglec1 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SIGLEC1 mRNA | CTD | PMID:35818422 | Siglec1 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [Diethylhexyl Phthalate co-treated with Asian ginseng] results in decreased expression of SIGLEC1 mRNA | CTD | PMID:35818422 | Siglec1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SIGLEC1 mRNA | CTD | PMID:25181051 | Siglec1 | Rat | bisphenol A | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SIGLEC1 mRNA | CTD | PMID:38701888 | Siglec1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in decreased expression of SIGLEC1 mRNA | CTD | PMID:31129395 | Siglec1 | Rat | bisphenol F | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | bisphenol F results in increased expression of SIGLEC1 mRNA | CTD | PMID:30951980|PMID:38685157 | Siglec1 | Rat | cadmium atom | multiple interactions | ISO | Siglec1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIGLEC1 more ... | CTD | PMID:37236586 | Siglec1 | Rat | cadmium dichloride | multiple interactions | ISO | Siglec1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIGLEC1 more ... | CTD | PMID:37236586 | Siglec1 | Rat | carbon nanotube | decreases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of SIGLEC1 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25620056 | Siglec1 | Rat | carbon nanotube | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of SIGLEC1 mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681 | Siglec1 | Rat | clotrimazole | decreases expression | EXP | | 6480464 | Clotrimazole results in decreased expression of SIGLEC1 mRNA | CTD | PMID:30047161 | Siglec1 | Rat | coumarin | decreases phosphorylation | ISO | SIGLEC1 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of SIGLEC1 protein | CTD | PMID:35688186 | Siglec1 | Rat | D-glucose | multiple interactions | ISO | Siglec1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... | CTD | PMID:37567420 | Siglec1 | Rat | dichlorine | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Chlorine results in increased expression of SIGLEC1 mRNA | CTD | PMID:30189237 | Siglec1 | Rat | dioxygen | multiple interactions | EXP | | 6480464 | [dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with more ... | CTD | PMID:33729688 | Siglec1 | Rat | fructose | multiple interactions | ISO | Siglec1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... | CTD | PMID:37567420 | Siglec1 | Rat | genistein | decreases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Genistein results in decreased expression of SIGLEC1 mRNA | CTD | PMID:32186404 | Siglec1 | Rat | glucose | multiple interactions | ISO | Siglec1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... | CTD | PMID:37567420 | Siglec1 | Rat | irinotecan | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [Fluorouracil co-treated with Irinotecan] results in increased expression of SIGLEC1 mRNA | CTD | PMID:16391804 | Siglec1 | Rat | manganese atom | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Siglec1 | Rat | manganese(0) | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Siglec1 | Rat | manganese(II) chloride | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Siglec1 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of SIGLEC1 mRNA | CTD | PMID:30047161 | Siglec1 | Rat | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of SIGLEC1 mRNA | CTD | PMID:31378766 | Siglec1 | Rat | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of SIGLEC1 mRNA | CTD | PMID:28801915 | Siglec1 | Rat | nickel atom | increases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Nickel results in increased expression of SIGLEC1 mRNA | CTD | PMID:25583101 | Siglec1 | Rat | O-methyleugenol | decreases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of SIGLEC1 mRNA | CTD | PMID:32234424 | Siglec1 | Rat | ozone | multiple interactions | ISO | Siglec1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... | CTD | PMID:34911549 | Siglec1 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of SIGLEC1 mRNA | CTD | PMID:32680482 | Siglec1 | Rat | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of SIGLEC1 mRNA | CTD | PMID:32721576 | Siglec1 | Rat | silicon dioxide | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of SIGLEC1 mRNA | CTD | PMID:38811393 | Siglec1 | Rat | silver atom | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Silver results in increased expression of SIGLEC1 mRNA | CTD | PMID:27131904 | Siglec1 | Rat | silver(0) | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | Silver results in increased expression of SIGLEC1 mRNA | CTD | PMID:27131904 | Siglec1 | Rat | sodium arsenite | increases expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SIGLEC1 mRNA | CTD | PMID:29301061 | Siglec1 | Rat | sodium arsenite | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Siglec1 | Rat | sodium arsenite | decreases expression | ISO | Siglec1 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of SIGLEC1 mRNA | CTD | PMID:39515575 | Siglec1 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SIGLEC1 mRNA | CTD | PMID:32741896 | Siglec1 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SIGLEC1 mRNA | CTD | PMID:31150632 | Siglec1 | Rat | Theaflavin 3,3'-digallate | affects expression | ISO | SIGLEC1 (Homo sapiens) | 6480464 | theaflavin-3,3'-digallate affects the expression of SIGLEC1 mRNA | CTD | PMID:34925699 | Siglec1 | Rat | titanium dioxide | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SIGLEC1 mRNA | CTD | PMID:29264374|PMID:35295148 | Siglec1 | Rat | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of SIGLEC1 mRNA | CTD | PMID:30012374 | Siglec1 | Rat | tributylstannane | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in decreased expression of SIGLEC1 mRNA | CTD | PMID:31129395 | Siglec1 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of SIGLEC1 mRNA | CTD | PMID:33387578 | Siglec1 | Rat | trimellitic anhydride | decreases expression | ISO | Siglec1 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of SIGLEC1 mRNA | CTD | PMID:19042947 | Siglec1 | Rat | triptonide | increases expression | ISO | Siglec1 (Mus musculus) | 6480464 | triptonide results in increased expression of SIGLEC1 mRNA | CTD | PMID:33045310 | Siglec1 | Rat | valproic acid | increases methylation | ISO | SIGLEC1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SIGLEC1 gene | CTD | PMID:29154799 | Siglec1 | Rat | zidovudine | multiple interactions | ISO | SIGLEC1 (Homo sapiens) | 6480464 | [Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA | CTD | PMID:20370541 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















