Leg1 (liver enriched gene 1) - Rat Genome Database

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Gene: Leg1 (liver enriched gene 1) Rattus norvegicus
Analyze
Symbol: Leg1
Name: liver enriched gene 1
RGD ID: 1311933
Description: Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human C6orf58 (chromosome 6 open reading frame 58); INTERACTS WITH trichloroethene; (-)-demecolcine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC308056; RGD1311933; similar to RIKEN cDNA 2310057J18
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,628,501 - 30,644,590 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl130,628,501 - 30,644,590 (+)EnsemblGRCr8
mRatBN7.2128,799,902 - 28,816,230 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,799,902 - 28,815,993 (+)EnsemblmRatBN7.2
Rnor_6.0131,409,579 - 31,425,669 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,409,579 - 31,425,662 (+)Ensemblrn6Rnor6.0
Rnor_5.0132,835,727 - 32,851,816 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,599,530 - 29,615,619 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,451,634 - 27,468,035 (+)NCBICelera
RGSC_v3.1129,605,775 - 29,609,624 (+)NCBI
Cytogenetic Map1p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19056867   PMID:25645918  


Genomics

Comparative Map Data
Leg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,628,501 - 30,644,590 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl130,628,501 - 30,644,590 (+)EnsemblGRCr8
mRatBN7.2128,799,902 - 28,816,230 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,799,902 - 28,815,993 (+)EnsemblmRatBN7.2
Rnor_6.0131,409,579 - 31,425,669 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,409,579 - 31,425,662 (+)Ensemblrn6Rnor6.0
Rnor_5.0132,835,727 - 32,851,816 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,599,530 - 29,615,619 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,451,634 - 27,468,035 (+)NCBICelera
RGSC_v3.1129,605,775 - 29,609,624 (+)NCBI
Cytogenetic Map1p11NCBI
C6orf58
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386127,577,174 - 127,591,820 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6127,519,455 - 127,591,820 (+)Ensemblhg38GRCh38
GRCh376127,898,319 - 127,912,965 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366127,940,012 - 127,954,655 (+)NCBIBuild 36Build 36hg18NCBI36
Celera6128,640,558 - 128,655,201 (+)NCBICelera
Cytogenetic Map6q22.33NCBI
HuRef6125,474,561 - 125,489,205 (+)NCBIHuRef
CHM1_16128,162,764 - 128,177,408 (+)NCBICHM1_1
T2T-CHM13v2.06128,766,100 - 128,780,746 (+)NCBIT2T-CHM13v2.0
2310057J18Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391028,848,284 - 28,862,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1028,848,284 - 28,862,299 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381028,972,288 - 28,986,306 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1028,972,288 - 28,986,303 (-)Ensemblmm10GRCm38
MGSCv371028,692,094 - 28,706,112 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361028,661,781 - 28,675,719 (-)NCBIMGSCv36mm8
Celera1029,903,690 - 29,917,734 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1016.46NCBI
C5H6orf58
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25147,564,197 - 147,585,452 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16145,472,936 - 145,494,196 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06125,364,933 - 125,379,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16129,477,073 - 129,491,689 (+)NCBIPanPan1.1PanPan1.1panPan2
C1H6orf58
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,270,546 - 66,281,079 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,270,567 - 66,289,965 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha167,075,581 - 67,088,554 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0166,479,431 - 66,492,393 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,479,476 - 66,498,855 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,402,715 - 66,415,660 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,187,435 - 66,200,389 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,829,782 - 66,842,747 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100511607
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1135,600,478 - 35,621,276 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2139,226,172 - 39,246,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C13H6orf58
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11346,094,903 - 46,114,454 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1346,095,091 - 46,113,862 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604018,343,383 - 18,362,347 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C2H6orf58
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12203,864,356 - 203,881,606 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Leg1
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000016989
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 1 7 27 19 19 4 13 4 3 41 29 17 6 22 15

Sequence


Ensembl Acc Id: ENSRNOT00000016989   ⟹   ENSRNOP00000016989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl130,628,501 - 30,644,590 (+)Ensembl
mRatBN7.2 Ensembl128,799,902 - 28,815,993 (+)Ensembl
Rnor_6.0 Ensembl131,409,579 - 31,425,662 (+)Ensembl
RefSeq Acc Id: XM_217725   ⟹   XP_217725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8130,628,501 - 30,644,590 (+)NCBI
mRatBN7.2128,799,902 - 28,816,230 (+)NCBI
Rnor_6.0131,409,579 - 31,425,669 (+)NCBI
Rnor_5.0132,835,727 - 32,851,816 (+)NCBI
RGSC_v3.4129,599,530 - 29,615,619 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_217725 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87688 (Get FASTA)   NCBI Sequence Viewer  
  EDL87689 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016989
  ENSRNOP00000016989.7
RefSeq Acc Id: XP_217725   ⟸   XM_217725
- UniProtKB: F1M171 (UniProtKB/TrEMBL),   A6JUU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016989   ⟸   ENSRNOT00000016989

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M171-F1-model_v2 AlphaFold F1M171 1-336 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689558
Promoter ID:EPDNEW_R75
Type:multiple initiation site
Name:RGD1311933_1
Description:similar to RIKEN cDNA 2310057J18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0131,409,568 - 31,409,628EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311933 AgrOrtholog
BioCyc Gene G2FUF-61954 BioCyc
Ensembl Genes ENSRNOG00000012581 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016989 ENTREZGENE
  ENSRNOT00000016989.8 UniProtKB/TrEMBL
InterPro DUF781 UniProtKB/TrEMBL
KEGG Report rno:308056 UniProtKB/TrEMBL
NCBI Gene 308056 ENTREZGENE
PANTHER PROTEIN LEG1 HOMOLOG UniProtKB/TrEMBL
  PTHR18820 UniProtKB/TrEMBL
Pfam DUF781 UniProtKB/TrEMBL
PhenoGen Leg1 PhenoGen
RatGTEx ENSRNOG00000012581 RatGTEx
UniProt A6JUU0 ENTREZGENE, UniProtKB/TrEMBL
  F1M171 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-03 Leg1  liver enriched gene 1  RGD1311933  similar to RIKEN cDNA 2310057J18  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1311933  similar to RIKEN cDNA 2310057J18   RGD1311933_predicted  similar to RIKEN cDNA 2310057J18 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1311933_predicted  similar to RIKEN cDNA 2310057J18 (predicted)  LOC308056_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC308056_predicted  similar to RIKEN cDNA 2310057J18 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL