Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pals2 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | PALS2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PALS2 mRNA | CTD | PMID:22079256 | Pals2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of PALS2 mRNA | CTD | PMID:22206623 | Pals2 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PALS2 mRNA | CTD | PMID:29097150 | Pals2 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Pals2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PALS2 mRNA | CTD | PMID:17555576 | Pals2 | Rat | 17beta-estradiol | multiple interactions | ISO | PALS2 (Homo sapiens) | 6480464 | EGF protein promotes the reaction [Estradiol results in increased expression of PALS2 mRNA] | CTD | PMID:24758408 | Pals2 | Rat | 17beta-estradiol | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Estradiol results in increased expression of MPP6 protein alternative form; Estradiol results in increased expression more ... | CTD | PMID:26903627|PMID:39298647 | Pals2 | Rat | 17beta-estradiol | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of PALS2 mRNA | CTD | PMID:23019147|PMID:24758408 | Pals2 | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl results in increased expression of PALS2 mRNA | CTD | PMID:31388691 | Pals2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PALS2 mRNA | CTD | PMID:21632981 | Pals2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PALS2 mRNA | CTD | PMID:32553695 | Pals2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pals2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PALS2 mRNA | CTD | PMID:21570461 | Pals2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PALS2 promoter] | CTD | PMID:19654925 | Pals2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PALS2 mRNA | CTD | PMID:21215274 | Pals2 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Pals2 (Mus musculus) | 6480464 | 2,2',4,4',5-brominated diphenyl ether affects the expression of MPP6 mRNA | CTD | PMID:38648751 | Pals2 | Rat | 2-methylcholine | affects expression | ISO | PALS2 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of PALS2 mRNA | CTD | PMID:21179406 | Pals2 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PALS2 mRNA | CTD | PMID:30071829 | Pals2 | Rat | 3-methylcholanthrene | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Methylcholanthrene results in increased expression of PALS2 mRNA | CTD | PMID:20713471 | Pals2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PALS2 mRNA | CTD | PMID:39298647 | Pals2 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Fenretinide results in increased expression of PALS2 mRNA | CTD | PMID:28973697 | Pals2 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | PALS2 (Homo sapiens) | 6480464 | Decitabine affects the expression of PALS2 mRNA | CTD | PMID:23300844 | Pals2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PALS2 mRNA | CTD | PMID:24780913 | Pals2 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of PALS2 mRNA | CTD | PMID:31881176 | Pals2 | Rat | aflatoxin B1 | decreases methylation | ISO | PALS2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PALS2 gene | CTD | PMID:27153756 | Pals2 | Rat | all-trans-retinoic acid | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PALS2 mRNA | CTD | PMID:21934132 | Pals2 | Rat | all-trans-retinoic acid | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Tretinoin results in increased expression of MPP6 mRNA | CTD | PMID:36189433 | Pals2 | Rat | all-trans-retinoic acid | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of MPP6 mRNA | CTD | PMID:36189433 | Pals2 | Rat | antirheumatic drug | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of PALS2 mRNA | CTD | PMID:24449571 | Pals2 | Rat | Aroclor 1254 | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PALS2 mRNA | CTD | PMID:23650126 | Pals2 | Rat | benzo[a]pyrene | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PALS2 mRNA | CTD | PMID:20064835 | Pals2 | Rat | benzo[a]pyrene | affects methylation | ISO | PALS2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PALS2 5' UTR | CTD | PMID:27901495 | Pals2 | Rat | benzo[a]pyrene | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Benzo(a)pyrene metabolite results in increased expression of PALS2 mRNA; Benzo(a)pyrene results in increased expression of more ... | CTD | PMID:20713471|PMID:22228805|PMID:32553695 | Pals2 | Rat | benzo[a]pyrene | increases methylation | ISO | Pals2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of PALS2 intron | CTD | PMID:27901495 | Pals2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of PALS2 more ... | CTD | PMID:32553695 | Pals2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PALS2 mRNA | CTD | PMID:19150397 | Pals2 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of MPP6 mRNA | CTD | PMID:33754040 | Pals2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PALS2 mRNA | CTD | PMID:25181051 | Pals2 | Rat | bisphenol A | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PALS2 protein | CTD | PMID:37567409 | Pals2 | Rat | bisphenol A | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PALS2 mRNA | CTD | PMID:33221593 | Pals2 | Rat | bisphenol A | affects response to substance | ISO | Pals2 (Mus musculus) | 6480464 | PALS2 mRNA alternative form affects the susceptibility to bisphenol A | CTD | PMID:31020848 | Pals2 | Rat | bisphenol A | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of MPP6 protein alternative form; bisphenol A results in more ... | CTD | PMID:26903627|PMID:31020848 | Pals2 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PALS2 gene | CTD | PMID:28505145 | Pals2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PALS2 mRNA | CTD | PMID:30816183|PMID:34947998 | Pals2 | Rat | Bisphenol B | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of PALS2 protein | CTD | PMID:34186270 | Pals2 | Rat | bisphenol F | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of PALS2 protein | CTD | PMID:34186270 | Pals2 | Rat | cadmium dichloride | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of PALS2 mRNA | CTD | PMID:25851441 | Pals2 | Rat | carbon nanotube | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of PALS2 mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681 | Pals2 | Rat | CGP 52608 | multiple interactions | ISO | PALS2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PALS2 gene] | CTD | PMID:28238834 | Pals2 | Rat | chlordecone | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of PALS2 mRNA | CTD | PMID:33711761 | Pals2 | Rat | chlorpyrifos | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of PALS2 mRNA | CTD | PMID:37019170 | Pals2 | Rat | cisplatin | affects expression | ISO | PALS2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of PALS2 mRNA | CTD | PMID:23300844 | Pals2 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of PALS2 mRNA | CTD | PMID:27523638 | Pals2 | Rat | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PALS2 mRNA | CTD | PMID:21865292 | Pals2 | Rat | cyclosporin A | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PALS2 mRNA | CTD | PMID:25562108 | Pals2 | Rat | cytarabine | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of PALS2 mRNA | CTD | PMID:21198554 | Pals2 | Rat | diethylstilbestrol | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Diethylstilbestrol results in increased expression of PALS2 mRNA | CTD | PMID:36621641 | Pals2 | Rat | dioxygen | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PALS2 mRNA | CTD | PMID:30529165 | Pals2 | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of PALS2 mRNA | CTD | PMID:25152437 | Pals2 | Rat | ethyl methanesulfonate | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of PALS2 mRNA | CTD | PMID:23649840 | Pals2 | Rat | formaldehyde | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PALS2 mRNA | CTD | PMID:23649840 | Pals2 | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of PALS2 mRNA | CTD | PMID:27387713 | Pals2 | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of PALS2 gene | CTD | PMID:22079235|PMID:27387713 | Pals2 | Rat | Indeno[1,2,3-cd]pyrene | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | indeno(1,2,3-cd)pyrene results in decreased expression of PALS2 mRNA | CTD | PMID:26377693 | Pals2 | Rat | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PALS2 mRNA | CTD | PMID:22129741 | Pals2 | Rat | ivermectin | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PALS2 protein | CTD | PMID:32959892 | Pals2 | Rat | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of PALS2 mRNA | CTD | PMID:11578147 | Pals2 | Rat | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of PALS2 mRNA | CTD | PMID:30467583 | Pals2 | Rat | methyl methanesulfonate | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of PALS2 mRNA | CTD | PMID:23649840 | Pals2 | Rat | methylmercury chloride | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PALS2 mRNA | CTD | PMID:23179753|PMID:28001369 | Pals2 | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of MPP6 mRNA | CTD | PMID:36189433 | Pals2 | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PALS2 mRNA | CTD | PMID:22129741 | Pals2 | Rat | ozone | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... | CTD | PMID:34911549 | Pals2 | Rat | p-toluidine | decreases expression | EXP | | 6480464 | 4-toluidine results in decreased expression of PALS2 mRNA | CTD | PMID:27638505 | Pals2 | Rat | paracetamol | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PALS2 mRNA | CTD | PMID:26690555 | Pals2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of MPP6 mRNA | CTD | PMID:33387578 | Pals2 | Rat | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of MPP6 mRNA | CTD | PMID:32680482 | Pals2 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of MPP6 mRNA | CTD | PMID:36331819 | Pals2 | Rat | phenobarbital | affects expression | ISO | PALS2 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of PALS2 mRNA | CTD | PMID:19159669 | Pals2 | Rat | phenobarbital | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of PALS2 mRNA | CTD | PMID:23091169 | Pals2 | Rat | potassium chromate | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PALS2 mRNA | CTD | PMID:22079256 | Pals2 | Rat | potassium chromate | multiple interactions | ISO | PALS2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PALS2 mRNA | CTD | PMID:22079256 | Pals2 | Rat | quercetin | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of PALS2 mRNA | CTD | PMID:21632981 | Pals2 | Rat | rotenone | decreases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of PALS2 protein | CTD | PMID:39603559 | Pals2 | Rat | succimer | multiple interactions | ISO | Pals2 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PALS2 mRNA | CTD | PMID:21641980 | Pals2 | Rat | sunitinib | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PALS2 mRNA | CTD | PMID:31533062 | Pals2 | Rat | tamoxifen | affects expression | ISO | Pals2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PALS2 mRNA | CTD | PMID:17555576 | Pals2 | Rat | tetrachloromethane | increases expression | ISO | Pals2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PALS2 mRNA | CTD | PMID:31919559 | Pals2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PALS2 mRNA | CTD | PMID:34492290 | Pals2 | Rat | titanium dioxide | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PALS2 mRNA | CTD | PMID:23557971 | Pals2 | Rat | trichostatin A | increases expression | ISO | PALS2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PALS2 mRNA | CTD | PMID:24935251 | Pals2 | Rat | triptonide | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | triptonide results in decreased expression of PALS2 mRNA | CTD | PMID:33045310 | Pals2 | Rat | trovafloxacin | decreases expression | ISO | Pals2 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of MPP6 mRNA | CTD | PMID:35537566 | Pals2 | Rat | valproic acid | affects expression | ISO | PALS2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PALS2 mRNA | CTD | PMID:25979313 | Pals2 | Rat | valproic acid | affects expression | ISO | Pals2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of PALS2 mRNA | CTD | PMID:17963808 | Pals2 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PALS2 mRNA | CTD | PMID:19015723 | | |||||||||||||||||||||||||||||||||||||||||||||||||






















