Pals2 (protein associated with LIN7 2, MAGUK p55 family member) - Rat Genome Database

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Pathways
Gene: Pals2 (protein associated with LIN7 2, MAGUK p55 family member) Rattus norvegicus
Analyze
Symbol: Pals2
Name: protein associated with LIN7 2, MAGUK p55 family member
RGD ID: 1311833
Description: Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in maintenance of postsynaptic density structure. Predicted to be located in dendrite; membrane; and organelle. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CH474011:EDL88200; LOC362359; MAGUK p55 subfamily member 6; membrane palmitoylated protein 6; membrane protein, palmitoylated 6; membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6); MGC189400; Mpp6; protein associated with LIN7 2, MAGUK family member
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,504,298 - 80,584,951 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl480,455,657 - 80,584,950 (+)EnsemblGRCr8
mRatBN7.2479,173,488 - 79,257,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,124,806 - 79,254,140 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,389,410 - 84,474,228 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,164,949 - 80,249,755 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,605,243 - 78,690,062 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,846,506 - 79,928,977 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,846,521 - 79,926,703 (+)Ensemblrn6Rnor6.0
Rnor_5.04144,471,089 - 144,602,046 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,343,494 - 78,424,470 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera474,082,633 - 74,162,987 (+)NCBICelera
RGSC_v3.1478,619,775 - 78,684,435 (+)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
furan  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rotenone  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell-cell junction  (IBA)
dendrite  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, etal., Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):225-42. doi: 10.1002/wrna.1269. Epub 2014 Oct 27.
4. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10753959   PMID:12477932   PMID:15632090   PMID:20458337  


Genomics

Comparative Map Data
Pals2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,504,298 - 80,584,951 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl480,455,657 - 80,584,950 (+)EnsemblGRCr8
mRatBN7.2479,173,488 - 79,257,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,124,806 - 79,254,140 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,389,410 - 84,474,228 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,164,949 - 80,249,755 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,605,243 - 78,690,062 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,846,506 - 79,928,977 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,846,521 - 79,926,703 (+)Ensemblrn6Rnor6.0
Rnor_5.04144,471,089 - 144,602,046 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,343,494 - 78,424,470 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera474,082,633 - 74,162,987 (+)NCBICelera
RGSC_v3.1478,619,775 - 78,684,435 (+)NCBI
Cytogenetic Map4q24NCBI
PALS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,573,452 - 24,694,193 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,572,936 - 24,694,193 (+)Ensemblhg38GRCh38
GRCh37724,613,071 - 24,733,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,579,610 - 24,694,023 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34724,386,324 - 24,500,737NCBI
Celera724,601,884 - 24,715,973 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,544,555 - 24,612,058 (+)NCBIHuRef
CHM1_1724,614,653 - 24,729,063 (+)NCBICHM1_1
T2T-CHM13v2.0724,711,447 - 24,832,205 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,664,991 - 24,779,052 (+)NCBI
Pals2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39650,087,206 - 50,176,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl650,087,221 - 50,175,919 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38650,110,228 - 50,199,154 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl650,110,241 - 50,198,939 (+)Ensemblmm10GRCm38
MGSCv37650,060,240 - 50,148,597 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36650,039,963 - 50,128,169 (+)NCBIMGSCv36mm8
Celera650,618,750 - 50,708,304 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.13NCBI
Pals2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541026,610,758 - 26,697,553 (+)Ensembl
ChiLan1.0NW_00495541026,593,123 - 26,697,553 (+)NCBIChiLan1.0ChiLan1.0
PALS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,430,673 - 29,550,813 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1777,755,407 - 77,873,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0725,248,710 - 25,368,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1724,853,266 - 24,973,190 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl724,899,798 - 24,967,402 (+)EnsemblpanPan2panpan1.1
PALS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11438,095,892 - 38,206,730 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1438,095,716 - 38,213,418 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1437,645,606 - 37,756,631 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01438,032,148 - 38,142,984 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1438,031,672 - 38,142,243 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11438,145,746 - 38,256,586 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01437,838,258 - 37,949,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01438,180,110 - 38,291,374 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pals2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511882,276,116 - 82,439,288 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364781,554,293 - 1,647,787 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364781,554,314 - 1,647,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PALS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,593,049 - 47,710,570 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11847,589,547 - 47,711,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,549,819 - 52,660,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PALS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12133,681,859 - 33,785,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2133,682,127 - 33,737,196 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604270,861,748 - 70,976,955 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pals2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247395,884,253 - 5,970,960 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247395,880,989 - 5,971,570 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pals2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1690,903,917 - 90,987,895 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pals2
376 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:254
Count of miRNA genes:168
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000029332
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)48021363484338055Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
RH127669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,257,277 - 79,257,496 (+)MAPPERmRatBN7.2
Rnor_6.0479,929,841 - 79,930,059NCBIRnor6.0
Rnor_5.04144,601,782 - 144,602,000UniSTSRnor5.0
RGSC_v3.4478,427,607 - 78,427,825UniSTSRGSC3.4
Celera474,166,124 - 74,166,342UniSTS
RH 3.4 Map4499.4UniSTS
Cytogenetic Map4q24UniSTS
RH133592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,174,587 - 79,174,802 (+)MAPPERmRatBN7.2
Rnor_6.0479,847,621 - 79,847,835NCBIRnor6.0
Rnor_5.04144,520,440 - 144,520,654UniSTSRnor5.0
RGSC_v3.4478,344,594 - 78,344,808UniSTSRGSC3.4
Celera474,083,733 - 74,083,947UniSTS
RH 3.4 Map4501.4UniSTS
Cytogenetic Map4q24UniSTS
BF399535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,258,825 - 79,259,075 (+)MAPPERmRatBN7.2
Rnor_6.0479,931,389 - 79,931,638NCBIRnor6.0
Rnor_5.04144,603,330 - 144,603,579UniSTSRnor5.0
RGSC_v3.4478,429,155 - 78,429,404UniSTSRGSC3.4
Celera474,167,667 - 74,167,916UniSTS
RH 3.4 Map4499.5UniSTS
Cytogenetic Map4q24UniSTS
RH138424  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,253,453 - 79,253,590 (+)MAPPERmRatBN7.2
Rnor_6.0479,926,017 - 79,926,153NCBIRnor6.0
Rnor_5.04144,597,958 - 144,598,094UniSTSRnor5.0
Celera474,162,300 - 74,162,436UniSTS
RH 3.4 Map11555.9UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001134982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC169025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000029332   ⟹   ENSRNOP00000037380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,455,657 - 80,584,950 (+)Ensembl
mRatBN7.2 Ensembl479,173,488 - 79,254,140 (+)Ensembl
Rnor_6.0 Ensembl479,846,521 - 79,926,703 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089973   ⟹   ENSRNOP00000073113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,504,618 - 80,584,171 (+)Ensembl
mRatBN7.2 Ensembl479,124,806 - 79,253,583 (+)Ensembl
Rnor_6.0 Ensembl479,868,442 - 79,926,078 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096577   ⟹   ENSRNOP00000097400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,527,313 - 80,584,950 (+)Ensembl
mRatBN7.2 Ensembl479,173,488 - 79,254,140 (+)Ensembl
RefSeq Acc Id: NM_001134982   ⟹   NP_001128454
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,298 - 80,584,951 (+)NCBI
mRatBN7.2479,173,488 - 79,254,141 (+)NCBI
Rnor_6.0479,846,521 - 79,926,704 (+)NCBI
Rnor_5.04144,471,089 - 144,602,046 (+)NCBI
RGSC_v3.4478,343,494 - 78,424,470 (+)RGD
Celera474,082,633 - 74,162,987 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236496   ⟹   XP_006236558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,346 - 80,584,172 (+)NCBI
mRatBN7.2479,173,542 - 79,257,539 (+)NCBI
Rnor_6.0479,846,506 - 79,928,977 (+)NCBI
Rnor_5.04144,471,089 - 144,602,046 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236497   ⟹   XP_006236559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,777 - 80,584,172 (+)NCBI
mRatBN7.2479,173,982 - 79,257,539 (+)NCBI
Rnor_6.0479,846,879 - 79,928,977 (+)NCBI
Rnor_5.04144,471,089 - 144,602,046 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762897   ⟹   XP_008761119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,968 - 80,584,172 (+)NCBI
mRatBN7.2479,174,168 - 79,257,542 (+)NCBI
Rnor_6.0479,847,153 - 79,928,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107784   ⟹   XP_038963712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,348 - 80,584,172 (+)NCBI
mRatBN7.2479,173,538 - 79,257,539 (+)NCBI
RefSeq Acc Id: XM_039107785   ⟹   XP_038963713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,784 - 80,584,172 (+)NCBI
mRatBN7.2479,173,974 - 79,257,539 (+)NCBI
RefSeq Acc Id: XM_039107786   ⟹   XP_038963714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,909 - 80,584,172 (+)NCBI
mRatBN7.2479,174,168 - 79,257,542 (+)NCBI
RefSeq Acc Id: XM_039107787   ⟹   XP_038963715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,336 - 80,584,172 (+)NCBI
mRatBN7.2479,173,532 - 79,257,539 (+)NCBI
RefSeq Acc Id: XM_039107788   ⟹   XP_038963716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,493 - 80,584,172 (+)NCBI
mRatBN7.2479,207,654 - 79,257,542 (+)NCBI
RefSeq Acc Id: XM_063286254   ⟹   XP_063142324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,493 - 80,584,172 (+)NCBI
RefSeq Acc Id: XM_063286255   ⟹   XP_063142325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,422 - 80,584,172 (+)NCBI
RefSeq Acc Id: XM_063286256   ⟹   XP_063142326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,422 - 80,584,172 (+)NCBI
RefSeq Acc Id: XR_005503249
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,493 - 80,581,662 (+)NCBI
mRatBN7.2479,207,654 - 79,250,958 (+)NCBI
RefSeq Acc Id: NP_001128454   ⟸   NM_001134982
- UniProtKB: B5DFE0 (UniProtKB/TrEMBL),   D3ZW03 (UniProtKB/TrEMBL),   A0A9K3Y6Q0 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236558   ⟸   XM_006236496
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236559   ⟸   XM_006236497
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761119   ⟸   XM_008762897
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073113   ⟸   ENSRNOT00000089973
Ensembl Acc Id: ENSRNOP00000037380   ⟸   ENSRNOT00000029332
RefSeq Acc Id: XP_038963715   ⟸   XM_039107787
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963712   ⟸   XM_039107784
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963713   ⟸   XM_039107785
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963714   ⟸   XM_039107786
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963716   ⟸   XM_039107788
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K4N7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097400   ⟸   ENSRNOT00000096577
RefSeq Acc Id: XP_063142325   ⟸   XM_063286255
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142326   ⟸   XM_063286256
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142324   ⟸   XM_063286254
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4N7 (UniProtKB/TrEMBL)
Protein Domains
Guanylate kinase-like   L27   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4N7-F1-model_v2 AlphaFold A0A0G2K4N7 1-557 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693042
Promoter ID:EPDNEW_R3566
Type:initiation region
Name:Mpp6_1
Description:membrane palmitoylated protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0479,846,486 - 79,846,546EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311833 AgrOrtholog
BioCyc Gene G2FUF-44899 BioCyc
Ensembl Genes ENSRNOG00000021579 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029332 ENTREZGENE
  ENSRNOT00000029332.8 UniProtKB/TrEMBL
  ENSRNOT00000089973 ENTREZGENE
  ENSRNOT00000089973.3 UniProtKB/TrEMBL
  ENSRNOT00000096577 ENTREZGENE
  ENSRNOT00000096577.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  L27 domain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Guanylate_kin UniProtKB/TrEMBL
  Guanylate_kin/L-typ_Ca_channel UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  L27_C UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/TrEMBL
  MAGUK UniProtKB/TrEMBL
  MPP6_SH3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:362359 UniProtKB/TrEMBL
NCBI Gene 362359 ENTREZGENE
PANTHER MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Pals2 PhenoGen
PROSITE GUANYLATE_KINASE_1 UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021579 RatGTEx
SMART GuKc UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF101288 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K4N7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y6Q0 ENTREZGENE, UniProtKB/TrEMBL
  A6K0L7 ENTREZGENE, UniProtKB/TrEMBL
  B5DFE0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW03 ENTREZGENE
UniProt Secondary D3ZW03 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-09-23 Pals2  protein associated with LIN7 2, MAGUK p55 family member  Pals2  protein associated with LIN7 2, MAGUK family member  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Pals2  protein associated with LIN7 2, MAGUK family member  Mpp6  membrane palmitoylated protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-14 Mpp6  membrane palmitoylated protein 6  Mpp6  membrane protein, palmitoylated 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-10 Mpp6  membrane protein, palmitoylated 6  Mpp6  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mpp6  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)   Mpp6_predicted  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mpp6_predicted  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (predicted)      Symbol and Name status set to approved 70820 APPROVED