Prc1 (protein regulator of cytokinesis 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prc1 (protein regulator of cytokinesis 1) Rattus norvegicus
Analyze
Symbol: Prc1
Name: protein regulator of cytokinesis 1
RGD ID: 1311754
Description: Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Orthologous to human PRC1 (protein regulator of cytokinesis 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC308761
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,659,312 - 143,681,019 (+)NCBIGRCr8
mRatBN7.21134,250,086 - 134,271,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,250,081 - 134,271,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,159,077 - 142,180,630 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,328,474 - 149,350,028 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,246,366 - 142,267,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,087,181 - 142,108,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,087,208 - 142,108,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,039,951 - 143,061,006 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,112,674 - 136,133,720 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,197,141 - 136,212,122 (+)NCBI
Celera1126,310,372 - 126,331,869 (+)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
amsacrine  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
daunorubicin  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
Echimidine  (ISO)
enzyme inhibitor  (ISO)
etoposide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glycidol  (EXP)
hydroxyurea  (ISO)
ifosfamide  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
Lasiocarpine  (ISO)
leflunomide  (EXP)
leptomycin B  (ISO)
lidocaine  (EXP)
lucanthone  (ISO)
metformin  (EXP)
methotrexate  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
riddelliine  (ISO)
rotenone  (EXP,ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Identification of hypertension-related genes through an integrated genomic-transcriptomic approach. Yagil C, etal., Circ Res. 2005 Apr 1;96(6):617-25. Epub 2005 Feb 24.
Additional References at PubMed
PMID:16431929   PMID:16603632   PMID:17351640   PMID:17409436   PMID:20691902   PMID:23870126  


Genomics

Comparative Map Data
Prc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,659,312 - 143,681,019 (+)NCBIGRCr8
mRatBN7.21134,250,086 - 134,271,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,250,081 - 134,271,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,159,077 - 142,180,630 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,328,474 - 149,350,028 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,246,366 - 142,267,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,087,181 - 142,108,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,087,208 - 142,108,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,039,951 - 143,061,006 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,112,674 - 136,133,720 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,197,141 - 136,212,122 (+)NCBI
Celera1126,310,372 - 126,331,869 (+)NCBICelera
Cytogenetic Map1q31NCBI
PRC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,966,040 - 90,994,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,966,040 - 90,995,629 (-)EnsemblGRCh38hg38GRCh38
GRCh371591,509,270 - 91,537,765 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,310,272 - 89,338,808 (-)NCBINCBI36Build 36hg18NCBI36
Build 341589,310,272 - 89,338,808NCBI
Celera1567,918,486 - 67,947,023 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,620,243 - 67,648,754 (-)NCBIHuRef
CHM1_11591,350,870 - 91,379,451 (-)NCBICHM1_1
T2T-CHM13v2.01588,725,621 - 88,754,118 (-)NCBIT2T-CHM13v2.0
Prc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,944,224 - 79,966,007 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,944,198 - 79,966,007 (+)EnsemblGRCm39 Ensembl
GRCm38780,294,445 - 80,316,259 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,294,450 - 80,316,259 (+)EnsemblGRCm38mm10GRCm38
MGSCv37787,439,351 - 87,461,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,168,030 - 80,189,772 (+)NCBIMGSCv36mm8
Celera777,695,309 - 77,717,026 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.62NCBI
Prc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,023,620 - 15,045,958 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,023,620 - 15,045,958 (-)NCBIChiLan1.0ChiLan1.0
PRC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,519,893 - 80,550,894 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,218,514 - 84,250,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,659,420 - 69,687,707 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,856,316 - 88,884,071 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,856,323 - 88,884,071 (-)Ensemblpanpan1.1panPan2
PRC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,252,893 - 53,279,717 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,253,626 - 53,279,211 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,890,693 - 55,917,468 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,668,946 - 53,695,845 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,669,547 - 53,695,841 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,188,305 - 53,214,980 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,399,528 - 53,426,227 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,739,932 - 53,766,713 (+)NCBIUU_Cfam_GSD_1.0
Prc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,272,662 - 130,300,022 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,034,550 - 16,060,909 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,034,577 - 16,061,856 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,869,821 - 55,900,978 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,869,749 - 55,900,640 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,866,919 - 8,895,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,866,969 - 8,894,691 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,831,004 - 37,859,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,266,964 - 17,288,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,266,850 - 17,289,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prc1
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:352
Count of miRNA genes:205
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000017532
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
RH130290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,271,502 - 134,271,658 (+)MAPPERmRatBN7.2
Rnor_6.01142,108,484 - 142,108,639NCBIRnor6.0
Rnor_5.01143,060,744 - 143,060,899UniSTSRnor5.0
RGSC_v3.41136,133,458 - 136,133,613UniSTSRGSC3.4
Celera1126,331,607 - 126,331,762UniSTS
RH 3.4 Map11074.29UniSTS
Cytogenetic Map1q31UniSTS
RH143848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,270,769 - 134,270,913 (+)MAPPERmRatBN7.2
Rnor_6.01142,107,751 - 142,107,894NCBIRnor6.0
Rnor_5.01143,060,011 - 143,060,154UniSTSRnor5.0
RGSC_v3.41136,132,725 - 136,132,868UniSTSRGSC3.4
Celera1126,330,874 - 126,331,017UniSTS
RH 3.4 Map11075.7UniSTS
Cytogenetic Map1q31UniSTS
AI712463  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,259,880 - 134,261,121 (+)MAPPERmRatBN7.2
mRatBN7.21134,260,922 - 134,261,121 (+)MAPPERmRatBN7.2
Rnor_6.01142,097,908 - 142,098,106NCBIRnor6.0
Rnor_6.01142,096,866 - 142,098,106NCBIRnor6.0
Rnor_5.01143,050,668 - 143,050,866UniSTSRnor5.0
Rnor_5.01143,049,626 - 143,050,866UniSTSRnor5.0
RGSC_v3.41136,122,340 - 136,123,580UniSTSRGSC3.4
RGSC_v3.41136,123,382 - 136,123,580UniSTSRGSC3.4
Celera1126,321,028 - 126,321,226UniSTS
Celera1126,319,986 - 126,321,226UniSTS
RH 3.4 Map11072.9UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017532   ⟹   ENSRNOP00000017532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,250,223 - 134,271,765 (+)Ensembl
Rnor_6.0 Ensembl1142,087,208 - 142,108,746 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094806   ⟹   ENSRNOP00000089328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,250,081 - 134,271,761 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095280   ⟹   ENSRNOP00000095742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,250,081 - 134,271,761 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101538   ⟹   ENSRNOP00000090144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,250,238 - 134,271,745 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110073   ⟹   ENSRNOP00000095649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,250,238 - 134,271,758 (+)Ensembl
RefSeq Acc Id: NM_001107529   ⟹   NP_001100999
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,481 - 143,681,019 (+)NCBI
mRatBN7.21134,250,223 - 134,271,765 (+)NCBI
Rnor_6.01142,087,208 - 142,108,746 (+)NCBI
Rnor_5.01143,039,951 - 143,061,006 (+)NCBI
RGSC_v3.41136,112,674 - 136,133,720 (+)RGD
Celera1126,310,372 - 126,331,869 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229433   ⟹   XP_006229495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,351 - 143,681,015 (+)NCBI
mRatBN7.21134,250,086 - 134,271,761 (+)NCBI
Rnor_6.01142,087,181 - 142,108,742 (+)NCBI
Rnor_5.01143,039,951 - 143,061,006 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229435   ⟹   XP_006229497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,351 - 143,681,015 (+)NCBI
mRatBN7.21134,250,086 - 134,271,761 (+)NCBI
Rnor_6.01142,087,181 - 142,108,742 (+)NCBI
Rnor_5.01143,039,951 - 143,061,006 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229437   ⟹   XP_006229499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,312 - 143,681,015 (+)NCBI
mRatBN7.21134,250,086 - 134,271,761 (+)NCBI
Rnor_6.01142,087,184 - 142,108,742 (+)NCBI
Rnor_5.01143,039,951 - 143,061,006 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039113001   ⟹   XP_038968929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,351 - 143,681,015 (+)NCBI
mRatBN7.21134,250,086 - 134,271,752 (+)NCBI
RefSeq Acc Id: XM_039113007   ⟹   XP_038968935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,351 - 143,681,015 (+)NCBI
mRatBN7.21134,250,086 - 134,271,761 (+)NCBI
RefSeq Acc Id: XM_039113027   ⟹   XP_038968955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,351 - 143,681,015 (+)NCBI
mRatBN7.21134,250,086 - 134,271,761 (+)NCBI
RefSeq Acc Id: XM_063262643   ⟹   XP_063118713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,351 - 143,681,015 (+)NCBI
RefSeq Acc Id: XM_063262649   ⟹   XP_063118719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,659,351 - 143,681,015 (+)NCBI
RefSeq Acc Id: NP_001100999   ⟸   NM_001107529
- UniProtKB: D3ZES9 (UniProtKB/TrEMBL),   A6JC96 (UniProtKB/TrEMBL),   A6JC95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229495   ⟸   XM_006229433
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APJ5 (UniProtKB/TrEMBL),   A6JC95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229499   ⟸   XM_006229437
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A8F8 (UniProtKB/TrEMBL),   A6JC97 (UniProtKB/TrEMBL),   A0A8I6APR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229497   ⟸   XM_006229435
- Peptide Label: isoform X4
- UniProtKB: A6JC95 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017532   ⟸   ENSRNOT00000017532
RefSeq Acc Id: XP_038968955   ⟸   XM_039113027
- Peptide Label: isoform X8
- UniProtKB: A0A8I6APR6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968935   ⟸   XM_039113007
- Peptide Label: isoform X3
- UniProtKB: A6JC95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968929   ⟸   XM_039113001
- Peptide Label: isoform X2
- UniProtKB: A6JC95 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095742   ⟸   ENSRNOT00000095280
Ensembl Acc Id: ENSRNOP00000090144   ⟸   ENSRNOT00000101538
Ensembl Acc Id: ENSRNOP00000095649   ⟸   ENSRNOT00000110073
Ensembl Acc Id: ENSRNOP00000089328   ⟸   ENSRNOT00000094806
RefSeq Acc Id: XP_063118713   ⟸   XM_063262643
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063118719   ⟸   XM_063262649
- Peptide Label: isoform X7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZES9-F1-model_v2 AlphaFold D3ZES9 1-606 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690143
Promoter ID:EPDNEW_R666
Type:multiple initiation site
Name:Prc1_1
Description:protein regulator of cytokinesis 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,087,220 - 142,087,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311754 AgrOrtholog
BioCyc Gene G2FUF-58743 BioCyc
Ensembl Genes ENSRNOG00000013057 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017532.6 UniProtKB/TrEMBL
  ENSRNOT00000094806.1 UniProtKB/TrEMBL
  ENSRNOT00000095280.1 UniProtKB/TrEMBL
  ENSRNOT00000101538.1 UniProtKB/TrEMBL
  ENSRNOT00000110073.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1520 UniProtKB/TrEMBL
InterPro Microtubule-assoc_MAP65_ASE1 UniProtKB/TrEMBL
KEGG Report rno:308761 UniProtKB/TrEMBL
NCBI Gene 308761 ENTREZGENE
PANTHER MAP65_ASE1 UniProtKB/TrEMBL
  PTHR19321:SF1 UniProtKB/TrEMBL
Pfam MAP65_ASE1 UniProtKB/TrEMBL
PhenoGen Prc1 PhenoGen
RatGTEx ENSRNOG00000013057 RatGTEx
UniProt A0A8I6A8F8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABV7_RAT UniProtKB/TrEMBL
  A0A8I6APJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APR6 ENTREZGENE, UniProtKB/TrEMBL
  A6JC95 ENTREZGENE, UniProtKB/TrEMBL
  A6JC96 ENTREZGENE, UniProtKB/TrEMBL
  A6JC97 ENTREZGENE, UniProtKB/TrEMBL
  D3ZES9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Prc1  protein regulator of cytokinesis 1   Prc1_predicted  protein regulator of cytokinesis 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prc1_predicted  protein regulator of cytokinesis 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease identified as a possible hypertension gene 1559295