Lrrc2 (leucine rich repeat containing 2) - Rat Genome Database

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Gene: Lrrc2 (leucine rich repeat containing 2) Rattus norvegicus
Analyze
Symbol: Lrrc2
Name: leucine rich repeat containing 2
RGD ID: 1311716
Description: Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Orthologous to human LRRC2 (leucine rich repeat containing 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine-rich repeat-containing protein 2; LOC301033
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,814,514 - 119,847,587 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,814,509 - 119,847,583 (+)EnsemblGRCr8
mRatBN7.28110,936,119 - 110,969,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,938,165 - 110,969,185 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,549,916 - 116,583,092 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,749,124 - 114,782,298 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,591,952 - 112,625,124 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,226,651 - 119,259,649 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,228,612 - 119,259,645 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,565,954 - 118,602,413 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,355,358 - 115,387,125 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,220,169 - 110,251,534 (+)NCBICelera
RGSC_v3.18115,374,812 - 115,406,576 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:20439489  


Genomics

Comparative Map Data
Lrrc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,814,514 - 119,847,587 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,814,509 - 119,847,583 (+)EnsemblGRCr8
mRatBN7.28110,936,119 - 110,969,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,938,165 - 110,969,185 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,549,916 - 116,583,092 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,749,124 - 114,782,298 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,591,952 - 112,625,124 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,226,651 - 119,259,649 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,228,612 - 119,259,645 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,565,954 - 118,602,413 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,355,358 - 115,387,125 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,220,169 - 110,251,534 (+)NCBICelera
RGSC_v3.18115,374,812 - 115,406,576 (+)NCBI
Cytogenetic Map8q32NCBI
LRRC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,515,385 - 46,566,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,515,385 - 46,607,097 (-)Ensemblhg38GRCh38
GRCh37346,556,875 - 46,607,792 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,531,917 - 46,596,576 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34346,534,875 - 46,596,576NCBI
Celera346,494,616 - 46,545,734 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,599,115 - 46,650,230 (-)NCBIHuRef
CHM1_1346,507,038 - 46,558,224 (-)NCBICHM1_1
T2T-CHM13v2.0346,531,490 - 46,582,384 (-)NCBIT2T-CHM13v2.0
Lrrc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,780,613 - 110,813,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,780,613 - 110,813,134 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389110,951,545 - 110,984,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,951,545 - 110,984,066 (+)Ensemblmm10GRCm38
MGSCv379110,854,049 - 110,886,570 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369110,796,361 - 110,828,878 (+)NCBIMGSCv36mm8
MGSCv369112,061,477 - 112,093,604 (+)NCBIMGSCv36mm8
Celera9110,676,980 - 110,707,487 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
Lrrc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,491,010 - 25,528,530 (+)Ensembl
ChiLan1.0NW_00495542025,492,277 - 25,528,530 (+)NCBIChiLan1.0ChiLan1.0
LRRC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,467,199 - 46,520,849 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,471,964 - 46,525,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,413,776 - 46,463,131 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,518,600 - 47,567,020 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,518,600 - 47,567,020 (-)EnsemblpanPan2panpan1.1
LRRC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,156,097 - 42,193,523 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,156,154 - 42,191,681 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2042,072,061 - 42,109,675 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02042,638,501 - 42,676,070 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,638,511 - 42,675,915 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,879,793 - 41,917,320 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,281,176 - 42,318,717 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,562,061 - 42,599,611 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrrc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,872,777 - 200,891,862 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596420,567 - 441,090 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936596420,678 - 440,937 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,478,114 - 29,536,539 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11329,477,790 - 29,524,177 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,727,338 - 32,749,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,937,167 - 7,987,249 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,934,217 - 7,986,666 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041159,177,321 - 159,212,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,564,923 - 74,592,337 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473074,564,889 - 74,594,276 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lrrc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18101,534,981 - 101,561,670 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lrrc2
292 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:271
Count of miRNA genes:180
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000043737
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 159 87 86 55 33 55 6 281 129 11 138 73 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000043737   ⟹   ENSRNOP00000046666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,816,346 - 119,847,583 (+)Ensembl
mRatBN7.2 Ensembl8110,938,165 - 110,969,185 (+)Ensembl
Rnor_6.0 Ensembl8119,228,730 - 119,259,645 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078439   ⟹   ENSRNOP00000070434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8119,228,612 - 119,258,682 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143222   ⟹   ENSRNOP00000098870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,816,582 - 119,847,583 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151434   ⟹   ENSRNOP00000099546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,814,509 - 119,846,322 (+)Ensembl
RefSeq Acc Id: NM_001393940   ⟹   NP_001380869
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,814,524 - 119,847,587 (+)NCBI
mRatBN7.28110,936,119 - 110,969,189 (+)NCBI
RefSeq Acc Id: NR_172058
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,816,615 - 119,847,587 (+)NCBI
mRatBN7.28110,938,210 - 110,969,189 (+)NCBI
RefSeq Acc Id: XM_006243926   ⟹   XP_006243988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,816,396 - 119,847,587 (+)NCBI
mRatBN7.28110,938,113 - 110,969,189 (+)NCBI
Rnor_6.08119,228,427 - 119,257,744 (+)NCBI
Rnor_5.08118,565,954 - 118,602,413 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595598   ⟹   XP_017451087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,814,514 - 119,847,587 (+)NCBI
mRatBN7.28110,936,119 - 110,969,189 (+)NCBI
Rnor_6.08119,226,651 - 119,257,744 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081251   ⟹   XP_038937179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,816,471 - 119,847,587 (+)NCBI
mRatBN7.28110,938,118 - 110,969,189 (+)NCBI
RefSeq Acc Id: XM_039081252   ⟹   XP_038937180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,816,458 - 119,843,195 (+)NCBI
mRatBN7.28110,938,105 - 110,964,787 (+)NCBI
RefSeq Acc Id: XM_039081253   ⟹   XP_038937181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,816,487 - 119,847,587 (+)NCBI
mRatBN7.28110,938,117 - 110,969,189 (+)NCBI
RefSeq Acc Id: XP_006243988   ⟸   XM_006243926
- Peptide Label: isoform X1
- UniProtKB: F7F213 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451087   ⟸   XM_017595598
- Peptide Label: isoform X1
- UniProtKB: F7F213 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046666   ⟸   ENSRNOT00000043737
Ensembl Acc Id: ENSRNOP00000070434   ⟸   ENSRNOT00000078439
RefSeq Acc Id: XP_038937180   ⟸   XM_039081252
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038937181   ⟸   XM_039081253
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038937179   ⟸   XM_039081251
- Peptide Label: isoform X2
- UniProtKB: Q5U2S4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380869   ⟸   NM_001393940
- UniProtKB: Q5U2S4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098870   ⟸   ENSRNOT00000143222
Ensembl Acc Id: ENSRNOP00000099546   ⟸   ENSRNOT00000151434

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2S4-F1-model_v2 AlphaFold Q5U2S4 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696343
Promoter ID:EPDNEW_R6866
Type:single initiation site
Name:Lrrc2_1
Description:leucine rich repeat containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,228,660 - 119,228,720EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311716 AgrOrtholog
BioCyc Gene G2FUF-29040 BioCyc
Ensembl Genes ENSRNOG00000030688 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043737 ENTREZGENE
  ENSRNOT00000043737.7 UniProtKB/TrEMBL
  ENSRNOT00000143222.1 UniProtKB/TrEMBL
  ENSRNOT00000151434 ENTREZGENE
  ENSRNOT00000151434.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192145 IMAGE-MGC_LOAD
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_4 UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_domain-containing UniProtKB/TrEMBL
MGC_CLONE MGC:94665 IMAGE-MGC_LOAD
NCBI Gene 301033 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  PTHR48051 UniProtKB/TrEMBL
  ZGC:77287 UniProtKB/TrEMBL
Pfam LRR_4 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PhenoGen Lrrc2 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030688 RatGTEx
SMART LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A0ABK0L536_RAT UniProtKB/TrEMBL
  A0ABK0LC29_RAT UniProtKB/TrEMBL
  F7F213 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2S4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Lrrc2  leucine rich repeat containing 2  Lrrc2_predicted  leucine rich repeat containing 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrrc2_predicted  leucine rich repeat containing 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED