Bcar3 (BCAR3 adaptor protein, NSP family member) - Rat Genome Database

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Gene: Bcar3 (BCAR3 adaptor protein, NSP family member) Rattus norvegicus
Analyze
Symbol: Bcar3
Name: BCAR3 adaptor protein, NSP family member
RGD ID: 1311688
Description: Predicted to enable kinase binding activity and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; endothelin receptor signaling pathway; and positive regulation of GTPase activity. Predicted to act upstream of or within lens morphogenesis in camera-type eye. Predicted to be located in focal adhesion and membrane. Orthologous to human BCAR3 (BCAR3 adaptor protein, NSP family member); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCAR3 adapter protein, NSP family member; BCAR3, NSP family adaptor protein; BCAR3, NSP family adaptor protein 3; breast cancer anti-estrogen resistance 3; breast cancer anti-estrogen resistance protein 3; breast cancer anti-estrogen resistance protein 3 homolog; LOC310838; novel SH2-containing protein 2; p130Cas-binding protein AND-34; SH2 domain-containing protein 3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,209,907 - 213,323,305 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2213,209,893 - 213,323,302 (+)EnsemblGRCr8
mRatBN7.22210,525,260 - 210,638,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,525,260 - 210,638,798 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2218,201,286 - 218,314,077 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,109,048 - 216,221,848 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,952,480 - 211,065,400 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02226,563,050 - 226,679,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2226,563,050 - 226,679,438 (+)Ensemblrn6Rnor6.0
Rnor_5.02245,929,016 - 246,041,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42219,075,206 - 219,188,344 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2202,953,635 - 203,067,717 (+)NCBICelera
RGSC_v3.12219,044,367 - 219,151,409 (+)NCBI
Cytogenetic Map2q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fenofibrate  (EXP)
ferroheme b  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
GSK-J4  (ISO)
heme b  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
metformin  (EXP)
methylmercury chloride  (ISO)
nickel dichloride  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
focal adhesion  (IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation. Oh MJ, etal., Biochem Biophys Res Commun. 2013 Nov 29;441(4):911-6. doi: 10.1016/j.bbrc.2013.10.161. Epub 2013 Nov 9.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18722344   PMID:19086031   PMID:19365570   PMID:22801373  


Genomics

Comparative Map Data
Bcar3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,209,907 - 213,323,305 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2213,209,893 - 213,323,302 (+)EnsemblGRCr8
mRatBN7.22210,525,260 - 210,638,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,525,260 - 210,638,798 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2218,201,286 - 218,314,077 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,109,048 - 216,221,848 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,952,480 - 211,065,400 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02226,563,050 - 226,679,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2226,563,050 - 226,679,438 (+)Ensemblrn6Rnor6.0
Rnor_5.02245,929,016 - 246,041,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42219,075,206 - 219,188,344 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2202,953,635 - 203,067,717 (+)NCBICelera
RGSC_v3.12219,044,367 - 219,151,409 (+)NCBI
Cytogenetic Map2q42NCBI
BCAR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,561,741 - 93,848,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,561,741 - 93,847,488 (-)Ensemblhg38GRCh38
GRCh37194,027,298 - 94,313,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,799,936 - 93,919,973 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34193,739,371 - 93,859,223NCBI
Celera192,281,411 - 92,401,455 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef192,148,818 - 92,431,346 (-)NCBIHuRef
CHM1_1194,142,284 - 94,427,714 (-)NCBICHM1_1
T2T-CHM13v2.0193,407,475 - 93,693,898 (-)NCBIT2T-CHM13v2.0
Bcar3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,213,406 - 122,323,840 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,087,785 - 122,323,840 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383122,419,757 - 122,530,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,294,136 - 122,530,191 (+)Ensemblmm10GRCm38
MGSCv373122,122,698 - 122,233,101 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363122,411,849 - 122,522,205 (+)NCBIMGSCv36mm8
Celera3128,819,836 - 128,930,961 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.41NCBI
Bcar3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423991,057 - 1,105,033 (+)Ensembl
ChiLan1.0NW_004955423991,046 - 1,105,033 (+)NCBIChiLan1.0ChiLan1.0
BCAR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21133,177,830 - 133,455,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11132,490,296 - 132,610,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,230,498 - 96,508,028 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,960,969 - 95,104,869 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,960,966 - 95,080,565 (-)EnsemblpanPan2panpan1.1
BCAR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1655,276,300 - 55,525,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl655,347,955 - 55,525,246 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha658,076,009 - 58,232,203 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0655,743,759 - 55,899,988 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,764,481 - 55,899,985 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1655,423,562 - 55,579,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0655,408,217 - 55,564,415 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,861,300 - 56,017,521 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bcar3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058103,285,698 - 103,399,549 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365375,548,434 - 5,662,736 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365375,548,422 - 5,662,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,440,571 - 123,666,598 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14123,440,571 - 123,666,603 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,115,751 - 135,322,614 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCAR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12039,399,818 - 39,679,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2039,566,157 - 39,680,660 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603378,358,639 - 78,653,780 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcar3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,948,910 - 4,067,761 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247423,934,971 - 4,067,691 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bcar3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1337,310,848 - 37,355,820 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bcar3
1307 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:51
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000065111
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat

Markers in Region
D2Got146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,525,750 - 210,525,927 (+)MAPPERmRatBN7.2
Rnor_6.02226,563,541 - 226,563,715NCBIRnor6.0
Rnor_5.02245,929,507 - 245,929,681UniSTSRnor5.0
RGSC_v3.42219,075,696 - 219,075,871RGDRGSC3.4
RGSC_v3.42219,075,697 - 219,075,871UniSTSRGSC3.4
Celera2202,954,126 - 202,954,300UniSTS
RGSC_v3.12219,038,759 - 219,038,933RGD
RH 3.4 Map21536.9UniSTS
RH 3.4 Map21536.9RGD
RH 2.0 Map21102.9RGD
Cytogenetic Map2q42UniSTS
RH136843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,638,326 - 210,638,507 (+)MAPPERmRatBN7.2
Rnor_6.02226,679,094 - 226,679,274NCBIRnor6.0
Rnor_5.02246,040,772 - 246,040,952UniSTSRnor5.0
RGSC_v3.42219,188,000 - 219,188,180UniSTSRGSC3.4
Celera2203,067,373 - 203,067,553UniSTS
Cytogenetic Map2q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
24 13 83 236 91 90 59 159 59 6 509 286 24 221 132 136 31 39 39

Sequence


Ensembl Acc Id: ENSRNOT00000065111   ⟹   ENSRNOP00000062880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2213,209,893 - 213,323,302 (+)Ensembl
mRatBN7.2 Ensembl2210,525,260 - 210,638,671 (+)Ensembl
Rnor_6.0 Ensembl2226,563,050 - 226,679,438 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107706   ⟹   ENSRNOP00000076885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2213,217,407 - 213,323,302 (+)Ensembl
mRatBN7.2 Ensembl2210,532,766 - 210,638,798 (+)Ensembl
RefSeq Acc Id: NM_001107722   ⟹   NP_001101192
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82213,209,907 - 213,323,302 (+)NCBI
mRatBN7.22210,525,260 - 210,638,671 (+)NCBI
Rnor_6.02226,563,050 - 226,679,438 (+)NCBI
Rnor_5.02245,929,016 - 246,041,127 (+)NCBI
RGSC_v3.42219,075,206 - 219,188,344 (+)RGD
Celera2202,953,635 - 203,067,717 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233270   ⟹   XP_006233332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82213,272,586 - 213,323,305 (+)NCBI
mRatBN7.22210,590,410 - 210,638,674 (+)NCBI
Rnor_6.02226,630,994 - 226,679,449 (+)NCBI
Rnor_5.02245,929,016 - 246,041,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102442   ⟹   XP_038958370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82213,209,958 - 213,323,305 (+)NCBI
mRatBN7.22210,525,296 - 210,638,674 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101192 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233332 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958370 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZAZ5 (Get FASTA)   NCBI Sequence Viewer  
  EDL82101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062880
  ENSRNOP00000062880.1
  ENSRNOP00000076885
RefSeq Acc Id: NP_001101192   ⟸   NM_001107722
- UniProtKB: D3ZAZ5 (UniProtKB/TrEMBL),   A0A8I5Y0X0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233332   ⟸   XM_006233270
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y0X0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062880   ⟸   ENSRNOT00000065111
RefSeq Acc Id: XP_038958370   ⟸   XM_039102442
- Peptide Label: isoform X1
- UniProtKB: D3ZAZ5 (UniProtKB/Swiss-Prot),   A0A8I5Y0X0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076885   ⟸   ENSRNOT00000107706
Protein Domains
Ras-GEF   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAZ5-F1-model_v2 AlphaFold D3ZAZ5 1-825 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691724
Promoter ID:EPDNEW_R2249
Type:multiple initiation site
Name:Bcar3_1
Description:BCAR3, NSP family adaptor protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02226,563,279 - 226,563,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311688 AgrOrtholog
BioCyc Gene G2FUF-51356 BioCyc
Ensembl Genes ENSRNOG00000013737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065111 ENTREZGENE
  ENSRNOT00000065111.2 UniProtKB/Swiss-Prot
  ENSRNOT00000107706 ENTREZGENE
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
InterPro Ras_GEF_dom_sf UniProtKB/Swiss-Prot
  RASGEF_cat_dom UniProtKB/Swiss-Prot
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2-Ras-GEF_adapter UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH2_SHEP1/BCAR3/NSP1 UniProtKB/Swiss-Prot
KEGG Report rno:310838 UniProtKB/Swiss-Prot
NCBI Gene 310838 ENTREZGENE
PANTHER BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN UniProtKB/Swiss-Prot
  PTHR14247:SF10 UniProtKB/Swiss-Prot
Pfam RasGEF UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Bcar3 PhenoGen
PROSITE RASGEF_CAT UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013737 RatGTEx
SMART RasGEF UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48366 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A8I5Y0X0 ENTREZGENE, UniProtKB/TrEMBL
  BCAR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-01 Bcar3  BCAR3 adaptor protein, NSP family member  Bcar3  BCAR3, NSP family adaptor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-11-02 Bcar3  BCAR3, NSP family adaptor protein  Bcar3  BCAR3, NSP family adaptor protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-10-31 Bcar3  BCAR3, NSP family adaptor protein 3  Bcar3  breast cancer anti-estrogen resistance 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Bcar3  breast cancer anti-estrogen resistance 3   Bcar3_predicted  breast cancer anti-estrogen resistance 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Bcar3_predicted  breast cancer anti-estrogen resistance 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED