Dapk1 (death associated protein kinase 1) - Rat Genome Database

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Gene: Dapk1 (death associated protein kinase 1) Rattus norvegicus
Analyze
Symbol: Dapk1
Name: death associated protein kinase 1
RGD ID: 1311629
Description: Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Predicted to be involved in several processes, including cellular response to type II interferon; defense response to tumor cell; and positive regulation of programmed cell death. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be part of DAPK1-calmodulin complex. Predicted to be active in several cellular components, including glutamatergic synapse; nucleus; and postsynaptic density. Human ortholog(s) of this gene implicated in urinary bladder cancer and uterine fibroid. Orthologous to human DAPK1 (death associated protein kinase 1); PARTICIPATES IN type II interferon signaling pathway; urinary bladder cancer pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: death-associated protein kinase 1; LOC306722
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,935,826 - 4,096,858 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,935,625 - 4,096,581 (-)EnsemblGRCr8
mRatBN7.2173,930,223 - 4,090,991 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,930,213 - 4,090,991 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx173,949,771 - 4,110,552 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,491,397 - 5,652,171 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,946,203 - 4,106,990 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,297,038 - 4,454,941 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,297,224 - 4,454,778 (-)Ensemblrn6Rnor6.0
Rnor_5.0176,525,247 - 6,683,920 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,617,607 - 9,779,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,059,212 - 4,219,046 (-)NCBICelera
RGSC_v3.1179,617,606 - 9,779,457 (-)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chelidonine  (ISO)
chloroprene  (ISO)
cholesterol  (EXP)
citalopram  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dimethylarsinous acid  (ISO)
disodium selenite  (ISO)
Doramectin  (EXP)
doxifluridine  (ISO)
doxorubicin  (ISO)
escitalopram  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
glycine betaine  (EXP)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Sanggenon C  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas. Maekawa R, etal., PLoS One. 2013 Jun 20;8(6):e66632. doi: 10.1371/journal.pone.0066632. Print 2013.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The association of death-associated protein kinase hypermethylation with early recurrence in superficial bladder cancers. Tada Y, etal., Cancer Res 2002 Jul 15;62(14):4048-53.
Additional References at PubMed
PMID:7828849   PMID:10629061   PMID:11485996   PMID:12477932   PMID:12730201   PMID:15010850   PMID:16132846   PMID:18583991   PMID:18995835   PMID:19180116   PMID:19712061   PMID:20053891  
PMID:20141836   PMID:21738225   PMID:22095288   PMID:23071094   PMID:28543175   PMID:30419147   PMID:31549396   PMID:37406926   PMID:38777261  


Genomics

Comparative Map Data
Dapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,935,826 - 4,096,858 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,935,625 - 4,096,581 (-)EnsemblGRCr8
mRatBN7.2173,930,223 - 4,090,991 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,930,213 - 4,090,991 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx173,949,771 - 4,110,552 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,491,397 - 5,652,171 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,946,203 - 4,106,990 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,297,038 - 4,454,941 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,297,224 - 4,454,778 (-)Ensemblrn6Rnor6.0
Rnor_5.0176,525,247 - 6,683,920 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,617,607 - 9,779,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,059,212 - 4,219,046 (-)NCBICelera
RGSC_v3.1179,617,606 - 9,779,457 (-)NCBI
Cytogenetic Map17p14NCBI
DAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38987,497,228 - 87,708,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl987,497,228 - 87,709,073 (+)Ensemblhg38GRCh38
GRCh37990,112,143 - 90,323,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,302,576 - 89,513,369 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34987,342,349 - 87,553,097NCBI
Celera960,684,038 - 60,893,765 (+)NCBICelera
Cytogenetic Map9q21.33ENTREZGENE
HuRef959,938,084 - 60,147,991 (+)NCBIHuRef
CHM1_1990,260,553 - 90,471,316 (+)NCBICHM1_1
T2T-CHM13v2.0999,650,695 - 99,862,240 (+)NCBIT2T-CHM13v2.0
Dapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391360,749,506 - 60,911,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1360,749,761 - 60,911,005 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381360,601,723 - 60,763,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1360,601,947 - 60,763,191 (+)Ensemblmm10GRCm38
MGSCv371360,703,308 - 60,864,547 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361360,612,049 - 60,772,424 (+)NCBIMGSCv36mm8
Celera1361,661,141 - 61,823,107 (+)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1332.53NCBI
Dapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543229,197 - 254,379 (-)Ensembl
ChiLan1.0NW_00495543229,925 - 254,327 (-)NCBIChiLan1.0ChiLan1.0
DAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21151,715,504 - 51,921,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1951,717,894 - 51,925,229 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0958,628,872 - 58,836,205 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1986,680,202 - 86,887,333 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,681,953 - 86,887,958 (+)EnsemblpanPan2panpan1.1
DAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,278,939 - 72,448,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl172,280,103 - 72,447,822 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha173,041,924 - 73,209,647 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0172,583,435 - 72,753,483 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl172,584,370 - 72,753,293 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1172,395,534 - 72,563,288 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0172,161,011 - 72,329,008 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,866,793 - 73,034,612 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947118,717,541 - 118,894,952 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366802,842,547 - 3,021,058 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366802,842,930 - 3,020,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,724,648 - 27,954,350 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11027,724,644 - 27,954,708 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,963,591 - 31,970,748 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11298,118,948 - 98,330,435 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1298,118,603 - 98,330,471 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603886,441,902 - 86,652,424 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dapk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248099,586,225 - 9,793,208 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248099,585,426 - 9,794,582 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dapk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11477,393,270 - 77,551,116 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dapk1
455 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:532
Count of miRNA genes:262
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000066950
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat

Markers in Region
RH141019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,931,329 - 3,931,509 (+)MAPPERmRatBN7.2
Rnor_6.0174,298,331 - 4,298,510NCBIRnor6.0
Rnor_5.0176,526,354 - 6,526,533UniSTSRnor5.0
RGSC_v3.4179,618,714 - 9,618,893UniSTSRGSC3.4
Celera174,060,319 - 4,060,498UniSTS
RH 3.4 Map1747.2UniSTS
Cytogenetic Map17p14UniSTS
RH127309  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,930,395 - 3,930,609 (+)MAPPERmRatBN7.2
Rnor_6.0174,297,397 - 4,297,610NCBIRnor6.0
Rnor_5.0176,525,420 - 6,525,633UniSTSRnor5.0
RGSC_v3.4179,617,780 - 9,617,993UniSTSRGSC3.4
Celera174,059,385 - 4,059,598UniSTS
RH 3.4 Map1732.6UniSTS
Cytogenetic Map17p14UniSTS
BE105522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2174,043,118 - 4,043,301 (+)MAPPERmRatBN7.2
Rnor_6.0174,407,746 - 4,407,928NCBIRnor6.0
Rnor_5.0176,636,888 - 6,637,070UniSTSRnor5.0
RGSC_v3.4179,731,586 - 9,731,768UniSTSRGSC3.4
Celera174,171,108 - 4,171,290UniSTS
RH 3.4 Map1732.7UniSTS
Cytogenetic Map17p14UniSTS
BE120223  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2174,088,982 - 4,089,161 (+)MAPPERmRatBN7.2
Rnor_6.0174,452,770 - 4,452,948NCBIRnor6.0
Rnor_5.0176,681,912 - 6,682,090UniSTSRnor5.0
RGSC_v3.4179,777,449 - 9,777,627UniSTSRGSC3.4
Celera174,217,038 - 4,217,216UniSTS
RH 3.4 Map1749.1UniSTS
Cytogenetic Map17p14UniSTS
RH138301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2174,063,402 - 4,063,531 (+)MAPPERmRatBN7.2
Rnor_6.0174,427,193 - 4,427,321NCBIRnor6.0
Rnor_5.0176,656,335 - 6,656,463UniSTSRnor5.0
RGSC_v3.4179,751,872 - 9,752,000UniSTSRGSC3.4
Celera174,191,461 - 4,191,589UniSTS
RH 3.4 Map1747.8UniSTS
Cytogenetic Map17p14UniSTS
RH138879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2174,006,555 - 4,006,693 (+)MAPPERmRatBN7.2
Rnor_6.0174,371,104 - 4,371,241NCBIRnor6.0
Rnor_5.0176,600,246 - 6,600,383UniSTSRnor5.0
RGSC_v3.4179,695,032 - 9,695,169UniSTSRGSC3.4
Celera174,134,491 - 4,134,628UniSTS
RH 3.4 Map1747.7UniSTS
Cytogenetic Map17p14UniSTS
FH3103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,968,517 - 3,969,029 (+)MAPPERmRatBN7.2
Rnor_6.0174,333,072 - 4,333,583NCBIRnor6.0
Rnor_5.0176,562,214 - 6,562,725UniSTSRnor5.0
RGSC_v3.4179,656,999 - 9,657,510UniSTSRGSC3.4
Celera174,096,463 - 4,096,974UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 81 185 91 90 59 152 59 6 477 271 17 160 116 123 31 26 26

Sequence


Ensembl Acc Id: ENSRNOT00000066950   ⟹   ENSRNOP00000062122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl173,935,826 - 4,096,581 (-)Ensembl
mRatBN7.2 Ensembl173,930,223 - 4,090,991 (-)Ensembl
Rnor_6.0 Ensembl174,297,224 - 4,454,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080750   ⟹   ENSRNOP00000073577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl173,935,625 - 4,096,581 (-)Ensembl
mRatBN7.2 Ensembl173,930,213 - 4,090,991 (-)Ensembl
Rnor_6.0 Ensembl174,297,235 - 4,454,701 (-)Ensembl
RefSeq Acc Id: NM_001107335   ⟹   NP_001100805
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,935,826 - 4,096,581 (-)NCBI
mRatBN7.2173,930,223 - 4,090,991 (-)NCBI
Rnor_6.0174,297,224 - 4,454,778 (-)NCBI
Rnor_5.0176,525,247 - 6,683,920 (-)NCBI
RGSC_v3.4179,617,607 - 9,779,457 (-)RGD
Celera174,059,212 - 4,219,046 (-)RGD
Sequence:
RefSeq Acc Id: XM_008771441   ⟹   XP_008769663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,935,831 - 4,096,632 (-)NCBI
mRatBN7.2173,930,228 - 4,090,514 (-)NCBI
Rnor_6.0174,297,038 - 4,454,941 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276328   ⟹   XP_063132398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,935,831 - 4,096,858 (-)NCBI
RefSeq Acc Id: XM_063276329   ⟹   XP_063132399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,935,831 - 4,096,632 (-)NCBI
RefSeq Acc Id: XM_063276330   ⟹   XP_063132400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,935,831 - 4,019,821 (-)NCBI
RefSeq Acc Id: NP_001100805   ⟸   NM_001107335
- UniProtKB: F1LNN8 (UniProtKB/TrEMBL),   B5DFH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769663   ⟸   XM_008771441
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5V8 (UniProtKB/TrEMBL),   B5DFH6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073577   ⟸   ENSRNOT00000080750
Ensembl Acc Id: ENSRNOP00000062122   ⟸   ENSRNOT00000066950
RefSeq Acc Id: XP_063132398   ⟸   XM_063276328
- Peptide Label: isoform X1
- UniProtKB: B5DFH6 (UniProtKB/TrEMBL),   A0A0G2K5V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132399   ⟸   XM_063276329
- Peptide Label: isoform X1
- UniProtKB: B5DFH6 (UniProtKB/TrEMBL),   A0A0G2K5V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132400   ⟸   XM_063276330
- Peptide Label: isoform X2
- UniProtKB: B5DFH6 (UniProtKB/TrEMBL)
Protein Domains
Death   Protein kinase   Roc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5V8-F1-model_v2 AlphaFold A0A0G2K5V8 1-1442 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700275
Promoter ID:EPDNEW_R10794
Type:initiation region
Name:Dapk1_1
Description:death associated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0174,454,714 - 4,454,774EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311629 AgrOrtholog
BioCyc Gene G2FUF-10468 BioCyc
Ensembl Genes ENSRNOG00000018198 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066950 ENTREZGENE
  ENSRNOT00000066950.4 UniProtKB/TrEMBL
  ENSRNOT00000080750 ENTREZGENE
  ENSRNOT00000080750.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  DAPK1 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Myelin_different_resp_MyD88 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  ROC_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:306722 UniProtKB/TrEMBL
NCBI Gene 306722 ENTREZGENE
PANTHER MYD88 UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
  PTHR24342:SF17 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 17 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Dapk1 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ROC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018198 RatGTEx
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K5V8 ENTREZGENE, UniProtKB/TrEMBL
  B5DFH6 ENTREZGENE, UniProtKB/TrEMBL
  F1LNN8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dapk1  death associated protein kinase 1   Dapk1_predicted  death associated protein kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dapk1_predicted  death associated protein kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED