Ube2k (ubiquitin-conjugating enzyme E2K) - Rat Genome Database

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Gene: Ube2k (ubiquitin-conjugating enzyme E2K) Rattus norvegicus
Analyze
Symbol: Ube2k
Name: ubiquitin-conjugating enzyme E2K
RGD ID: 1311626
Description: Predicted to enable ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Predicted to be involved in several processes, including cellular response to interferon-beta; free ubiquitin chain polymerization; and positive regulation of tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within several processes, including positive regulation of type I interferon-mediated signaling pathway; protein K48-linked ubiquitination; and type I interferon-mediated signaling pathway. Predicted to be located in cytoplasm and filopodium tip. Predicted to be active in nucleus. Orthologous to human UBE2K (ubiquitin conjugating enzyme E2 K); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E2-25k; Hip2; huntingtin interacting protein 2; Hypg; Lig; LOC289623; ubiquitin-conjugating enzyme E2 K; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,011,681 - 43,077,825 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1443,011,681 - 43,072,462 (-)EnsemblGRCr8
mRatBN7.21442,658,016 - 42,718,899 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1442,658,016 - 42,718,630 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1443,011,647 - 43,072,105 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01444,311,686 - 44,372,016 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01442,791,658 - 42,852,126 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01444,289,247 - 44,348,691 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1444,289,247 - 44,348,691 (-)Ensemblrn6Rnor6.0
Rnor_5.01444,108,859 - 44,168,755 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41445,349,287 - 45,411,823 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1441,809,022 - 41,869,333 (-)NCBICelera
RGSC_v3.11445,354,342 - 45,414,183 (-)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dieldrin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furfural  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
mechlorethamine  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
filopodium tip  (ISO)
nucleus  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. Song S, etal., J Cell Biol. 2008 Aug 25;182(4):675-84. doi: 10.1083/jcb.200711066. Epub 2008 Aug 18.
Additional References at PubMed
PMID:14760703   PMID:16714285   PMID:17873885   PMID:18410486   PMID:18511602   PMID:18729231   PMID:20061386   PMID:23376485   PMID:24882218   PMID:26707646  


Genomics

Comparative Map Data
Ube2k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,011,681 - 43,077,825 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1443,011,681 - 43,072,462 (-)EnsemblGRCr8
mRatBN7.21442,658,016 - 42,718,899 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1442,658,016 - 42,718,630 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1443,011,647 - 43,072,105 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01444,311,686 - 44,372,016 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01442,791,658 - 42,852,126 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01444,289,247 - 44,348,691 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1444,289,247 - 44,348,691 (-)Ensemblrn6Rnor6.0
Rnor_5.01444,108,859 - 44,168,755 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41445,349,287 - 45,411,823 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1441,809,022 - 41,869,333 (-)NCBICelera
RGSC_v3.11445,354,342 - 45,414,183 (-)NCBI
Cytogenetic Map14p11NCBI
UBE2K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38439,698,136 - 39,782,792 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl439,698,109 - 39,782,792 (+)Ensemblhg38GRCh38
GRCh37439,699,756 - 39,784,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36439,376,266 - 39,457,977 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34439,522,436 - 39,604,148NCBI
Celera440,137,995 - 40,223,124 (+)NCBICelera
Cytogenetic Map4p14NCBI
HuRef439,024,547 - 39,109,580 (+)NCBIHuRef
CHM1_1439,699,339 - 39,784,070 (+)NCBICHM1_1
T2T-CHM13v2.0439,667,902 - 39,752,430 (+)NCBIT2T-CHM13v2.0
Ube2k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,694,588 - 65,756,332 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,694,576 - 65,756,331 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38565,537,245 - 65,598,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl565,537,233 - 65,598,988 (+)Ensemblmm10GRCm38
MGSCv37565,928,500 - 65,990,228 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36565,816,406 - 65,878,063 (+)NCBIMGSCv36mm8
Celera562,815,933 - 62,878,205 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.72NCBI
Ube2k
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554437,618,379 - 7,656,305 (-)Ensembl
ChiLan1.0NW_0049554437,618,379 - 7,655,542 (-)NCBIChiLan1.0ChiLan1.0
UBE2K
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2339,886,781 - 39,972,600 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1440,079,239 - 40,164,593 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0434,026,942 - 34,111,923 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1439,877,966 - 39,960,402 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl439,877,966 - 39,960,397 (+)EnsemblpanPan2panpan1.1
UBE2K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1372,713,035 - 72,780,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl372,717,236 - 72,780,210 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha375,259,911 - 75,327,198 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0373,485,595 - 73,553,473 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl373,485,593 - 73,553,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1372,752,394 - 72,820,149 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0372,898,341 - 72,966,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0373,284,799 - 73,352,656 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ube2k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528538,975,456 - 39,053,214 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364827,244,967 - 7,323,266 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364827,244,972 - 7,323,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,887,830 - 30,963,762 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1830,887,784 - 30,961,685 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2832,580,147 - 32,654,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2K
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12710,535,091 - 10,618,659 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2710,539,402 - 10,618,573 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604756,921,431 - 57,007,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2k
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476127,205,034 - 27,276,884 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476127,205,034 - 27,277,016 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ube2k
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11122,585,575 - 22,643,442 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ube2k
205 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1026
Count of miRNA genes:346
Interacting mature miRNAs:477
Transcripts:ENSRNOT00000030485
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH130202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21442,659,388 - 42,659,586 (+)MAPPERmRatBN7.2
Rnor_6.01444,290,620 - 44,290,817NCBIRnor6.0
Rnor_5.01444,110,232 - 44,110,429UniSTSRnor5.0
RGSC_v3.41445,350,660 - 45,350,857UniSTSRGSC3.4
Celera1441,810,395 - 41,810,592UniSTS
Cytogenetic Map14p11UniSTS
RH141776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21442,663,184 - 42,663,375 (+)MAPPERmRatBN7.2
Rnor_6.01444,294,416 - 44,294,606NCBIRnor6.0
Rnor_5.01444,114,028 - 44,114,218UniSTSRnor5.0
RGSC_v3.41445,354,456 - 45,354,646UniSTSRGSC3.4
Celera1441,814,191 - 41,814,381UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030485   ⟹   ENSRNOP00000032265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,011,681 - 43,072,214 (-)Ensembl
mRatBN7.2 Ensembl1442,658,016 - 42,718,554 (-)Ensembl
Rnor_6.0 Ensembl1444,289,247 - 44,348,691 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099891   ⟹   ENSRNOP00000085062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,011,681 - 43,066,147 (-)Ensembl
mRatBN7.2 Ensembl1442,658,016 - 42,713,094 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103920   ⟹   ENSRNOP00000085882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1442,661,971 - 42,718,630 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105695   ⟹   ENSRNOP00000079243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,011,681 - 43,072,002 (-)Ensembl
mRatBN7.2 Ensembl1442,658,016 - 42,718,342 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116564   ⟹   ENSRNOP00000096375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1442,662,024 - 42,718,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118995   ⟹   ENSRNOP00000083068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,015,837 - 43,072,214 (-)Ensembl
mRatBN7.2 Ensembl1442,662,172 - 42,718,554 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170213   ⟹   ENSRNOP00000104117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,011,681 - 43,072,462 (-)Ensembl
RefSeq Acc Id: NM_001106006   ⟹   NP_001099476
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,011,681 - 43,072,214 (-)NCBI
mRatBN7.21442,658,016 - 42,718,554 (-)NCBI
Rnor_6.01444,289,247 - 44,348,691 (-)NCBI
Rnor_5.01444,108,859 - 44,168,755 (-)NCBI
RGSC_v3.41445,349,287 - 45,411,823 (-)RGD
Celera1441,809,022 - 41,869,333 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091716   ⟹   XP_038947644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,015,636 - 43,077,825 (-)NCBI
mRatBN7.21442,659,353 - 42,718,899 (-)NCBI
RefSeq Acc Id: XM_039091717   ⟹   XP_038947645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,015,636 - 43,072,270 (-)NCBI
mRatBN7.21442,659,353 - 42,718,548 (-)NCBI
RefSeq Acc Id: XM_063272925   ⟹   XP_063128995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,015,636 - 43,072,152 (-)NCBI
RefSeq Acc Id: XM_063272926   ⟹   XP_063128996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,015,636 - 43,071,961 (-)NCBI
RefSeq Acc Id: XM_063272927   ⟹   XP_063128997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,015,636 - 43,039,156 (-)NCBI
RefSeq Acc Id: NP_001099476   ⟸   NM_001106006
- UniProtKB: A6JDD4 (UniProtKB/TrEMBL),   A0A8I6AV01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032265   ⟸   ENSRNOT00000030485
RefSeq Acc Id: XP_038947644   ⟸   XM_039091716
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2L8 (UniProtKB/TrEMBL),   A0A8I6AV01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947645   ⟸   XM_039091717
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZMB3 (UniProtKB/TrEMBL),   A6JDD3 (UniProtKB/TrEMBL),   A0A8I6AV01 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079243   ⟸   ENSRNOT00000105695
Ensembl Acc Id: ENSRNOP00000083068   ⟸   ENSRNOT00000118995
Ensembl Acc Id: ENSRNOP00000085882   ⟸   ENSRNOT00000103920
Ensembl Acc Id: ENSRNOP00000096375   ⟸   ENSRNOT00000116564
Ensembl Acc Id: ENSRNOP00000085062   ⟸   ENSRNOT00000099891
RefSeq Acc Id: XP_063128995   ⟸   XM_063272925
- Peptide Label: isoform X3
- UniProtKB: A6JDD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128996   ⟸   XM_063272926
- Peptide Label: isoform X3
- UniProtKB: A6JDD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128997   ⟸   XM_063272927
- Peptide Label: isoform X3
- UniProtKB: A6JDD5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104117   ⟸   ENSRNOT00000170213
Protein Domains
UBA   UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXS8-F1-model_v2 AlphaFold D3ZXS8 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699311
Promoter ID:EPDNEW_R9836
Type:initiation region
Name:Ube2k_1
Description:ubiquitin-conjugating enzyme E2K
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01444,348,663 - 44,348,723EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311626 AgrOrtholog
BioCyc Gene G2FUF-15749 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000027088 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030485.7 UniProtKB/TrEMBL
  ENSRNOT00000099891.2 UniProtKB/TrEMBL
  ENSRNOT00000105695 ENTREZGENE
  ENSRNOT00000105695.2 UniProtKB/TrEMBL
  ENSRNOT00000118995.2 UniProtKB/TrEMBL
  ENSRNOT00000170213 ENTREZGENE
  ENSRNOT00000170213.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro Ub_conjugating_enzyme UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
  UBA/transl_elong_EF1B_N_euk UniProtKB/TrEMBL
  UBE2K_UBA UniProtKB/TrEMBL
  UBQ-conjugat_E2 UniProtKB/TrEMBL
  UBQ-conjugating_AS UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/TrEMBL
KEGG Report rno:289623 UniProtKB/TrEMBL
NCBI Gene 289623 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/TrEMBL
  UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/TrEMBL
Pfam UBA UniProtKB/TrEMBL
  UQ_con UniProtKB/TrEMBL
PhenoGen Ube2k PhenoGen
PROSITE UBA UniProtKB/TrEMBL
  UBIQUITIN_CONJUGAT_1 UniProtKB/TrEMBL
  UBIQUITIN_CONJUGAT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027088 RatGTEx
SMART UBA UniProtKB/TrEMBL
  UBCc UniProtKB/TrEMBL
Superfamily-SCOP UBA_like UniProtKB/TrEMBL
  UBQ-conjugat/RWD-like UniProtKB/TrEMBL
UniProt A0A8I5ZMB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYF7_RAT UniProtKB/TrEMBL
  A0A8I6A2L8 ENTREZGENE
  A0A8I6A356_RAT UniProtKB/TrEMBL
  A0A8I6AV01 ENTREZGENE
  A0ABK0LL19_RAT UniProtKB/TrEMBL
  A6JDD3 ENTREZGENE, UniProtKB/TrEMBL
  A6JDD4 ENTREZGENE, UniProtKB/TrEMBL
  A6JDD5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXS8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Ube2k  ubiquitin-conjugating enzyme E2K  Ube2k  ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Ube2k  ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)  Hip2  huntingtin interacting protein 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hip2  huntingtin interacting protein 2   Hip2_predicted  huntingtin interacting protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hip2_predicted  huntingtin interacting protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED