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Gene: Mcrs1 (microspherule protein 1) Rattus norvegicus

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Symbol:

Mcrs1

Name:

microspherule protein 1

RGD ID:

1311607

Description:

Predicted to enable RNA binding activity and telomerase inhibitor activity. Predicted to be involved in several processes, including positive regulation of protein localization to nucleolus; positive regulation of transcription by RNA polymerase II; and regulation of DNA metabolic process. Located in dendrite. Orthologous to human MCRS1 (microspherule protein 1); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC300222; MGC109421; MSP58

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MCRS1 (microspherule protein 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Mcrs1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mcrs1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MCRS1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MCRS1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mcrs1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MCRS1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MCRS1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mcrs1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mcrs1 (microspherule protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MCRS1 (microspherule protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mcrs1 (microspherule protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mcrs1 (microspherule protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mcrs-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rcd5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rcd5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mcrs1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mcrs1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	132,262,719 - 132,271,533 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	132,262,722 - 132,271,533 (-)	Ensembl				GRCr8
mRatBN7.2	7	130,383,853 - 130,392,667 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,383,853 - 130,392,685 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	132,193,830 - 132,202,646 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,419,409 - 134,428,225 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,331,919 - 134,340,735 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	140,910,420 - 140,919,234 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	140,910,423 - 140,919,234 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	115,414,774 - 115,423,588 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	138,002,551 - 138,011,365 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	126,866,681 - 126,874,120 (-)	NCBI		Celera
RGSC_v3.1	7	138,079,213 - 138,087,806 (-)	NCBI
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP)

aflatoxin B1 (ISO)

Aroclor 1254 (ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

bisphenol F (EXP,ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

caffeine (ISO)

cannabidiol (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

clofibrate (ISO)

cobalt dichloride (ISO)

dexamethasone (ISO)

diazinon (EXP)

dieldrin (EXP)

diuron (ISO)

elemental selenium (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

indometacin (ISO)

lead(0) (ISO)

N-ethyl-N-nitrosourea (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

tacrolimus hydrate (ISO)

tert-butyl hydroperoxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin organization (IEA)

chromatin remodeling (IEA,ISO)

DNA damage response (IEA)

DNA recombination (IEA)

DNA repair (IEA)

negative regulation of telomere maintenance via telomere lengthening (ISO)

positive regulation of DNA repair (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of macromolecule metabolic process (IEA)

positive regulation of protein localization to nucleolus (IEA,ISO,ISS)

positive regulation of telomere maintenance in response to DNA damage (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IBA)

regulation of cell cycle (IEA,ISO)

regulation of chromosome organization (IEA,ISO)

regulation of DNA repair (IEA,ISO)

regulation of DNA replication (IEA,ISO)

regulation of DNA strand elongation (IEA,ISO)

regulation of embryonic development (IEA,ISO)

regulation of telomere maintenance (IEA)

telomere maintenance (IEA,ISO)

Cellular Component

centriolar satellite (IEA)

cytoplasm (IEA,ISO)

dendrite (IDA)

histone acetyltransferase complex (IEA,ISO)

Ino80 complex (IEA,ISO)

kinetochore (IEA)

lysosome (IEA)

MLL1 complex (IEA,ISO)

NSL complex (IBA,IEA,ISO)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

perikaryon (IDA)

spindle pole (IEA)

Molecular Function

G-quadruplex RNA binding (IEA,ISO,ISS)

poly(G) binding (IEA,ISO,ISS)

poly(U) RNA binding (IEA,ISO,ISS)

protein binding (ISO)

telomerase inhibitor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

INO80 family mediated chromatin remodeling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.	Davidovic L, etal., Hum Mol Genet. 2006 May 1;15(9):1525-38. Epub 2006 Mar 28.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics.	Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.

Additional References at PubMed

PMID:12477932	PMID:15044100	PMID:15960975	PMID:20018852	PMID:21303910

Genomics

Comparative Map Data

Mcrs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	132,262,719 - 132,271,533 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	132,262,722 - 132,271,533 (-)	Ensembl				GRCr8
mRatBN7.2	7	130,383,853 - 130,392,667 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,383,853 - 130,392,685 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	132,193,830 - 132,202,646 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,419,409 - 134,428,225 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,331,919 - 134,340,735 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	140,910,420 - 140,919,234 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	140,910,423 - 140,919,234 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	115,414,774 - 115,423,588 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	138,002,551 - 138,011,365 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	126,866,681 - 126,874,120 (-)	NCBI		Celera
RGSC_v3.1	7	138,079,213 - 138,087,806 (-)	NCBI
Cytogenetic Map	7	q36	NCBI

MCRS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	49,558,299 - 49,568,142 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	49,556,544 - 49,568,145 (-)	Ensembl			hg38	GRCh38
GRCh37	12	49,952,082 - 49,961,925 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	48,238,352 - 48,248,178 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	48,238,352 - 48,248,178	NCBI
Celera	12	48,746,544 - 48,756,370 (-)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	46,982,929 - 46,992,780 (-)	NCBI		HuRef
CHM1_1	12	49,918,314 - 49,928,165 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	49,520,555 - 49,530,398 (-)	NCBI		T2T-CHM13v2.0

Mcrs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	99,140,698 - 99,149,838 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	99,140,698 - 99,149,842 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	99,242,817 - 99,251,961 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	99,242,817 - 99,251,961 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	99,073,248 - 99,082,392 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	99,070,854 - 99,079,967 (-)	NCBI		MGSCv36	mm8
Celera	15	101,398,527 - 101,407,671 (-)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	56.09	NCBI

Mcrs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	178,301 - 189,980 (-)	Ensembl
ChiLan1.0	NW_004955547	180,783 - 189,980 (-)	NCBI	ChiLan1.0	ChiLan1.0

MCRS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	44,616,544 - 44,626,408 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	44,612,895 - 44,623,169 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	39,183,112 - 39,192,925 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	40,073,860 - 40,083,655 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	40,073,860 - 40,083,655 (+)	Ensembl			panPan2	panpan1.1

MCRS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	5,076,075 - 5,085,483 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	5,076,470 - 5,085,488 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	41,173,380 - 41,182,754 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	5,124,907 - 5,134,295 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	5,125,245 - 5,134,295 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	5,090,764 - 5,100,131 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	5,080,322 - 5,089,690 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	41,567,101 - 41,576,478 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mcrs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	65,877,421 - 65,887,087 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	7,276,584 - 7,287,427 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	7,277,739 - 7,287,389 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCRS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	15,517,032 - 15,526,510 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	15,517,028 - 15,526,567 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	15,923,507 - 15,932,634 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCRS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	45,801,520 - 45,811,768 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	45,798,495 - 45,811,771 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	200,313,701 - 200,323,956 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mcrs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624816	2,673,058 - 2,683,306 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mcrs1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	272,048,890 - 272,057,740 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mcrs1
77 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	68
Count of miRNA genes:	53
Interacting mature miRNAs:	63
Transcripts:	ENSRNOT00000050487
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	132099939	137014596	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	119280025	135560836	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000082470 ⟹ ENSRNOP00000070375

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	132,262,722 - 132,271,533 (-)	Ensembl
mRatBN7.2 Ensembl	7	130,383,853 - 130,392,685 (-)	Ensembl
Rnor_6.0 Ensembl	7	140,910,423 - 140,919,234 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102790 ⟹ ENSRNOP00000086041

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	132,262,722 - 132,269,604 (-)	Ensembl
mRatBN7.2 Ensembl	7	130,383,853 - 130,392,685 (-)	Ensembl

RefSeq Acc Id:

NM_001013106 ⟹ NP_001013124

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	132,262,719 - 132,271,533 (-)	NCBI
mRatBN7.2	7	130,383,853 - 130,392,667 (-)	NCBI
Rnor_6.0	7	140,910,420 - 140,919,234 (-)	NCBI
Rnor_5.0	X	115,414,774 - 115,423,588 (-)	NCBI
RGSC_v3.4	7	138,002,551 - 138,011,365 (-)	RGD
Celera	7	126,866,681 - 126,874,120 (-)	RGD

Sequence:

show sequence

CGGAAGCCGGCTTTGGCCCTGCGGCTCCTGCCGTCGCCGCGGAGAAATTGTTGAAGCTGGCAGC
CTAGGAATGACTCTCTTCTCAGCATCCCAGCTCACTTGGTCAGAACCCTTGGATGAGCCTGTGG
GACCCTTCCTCCTCGCCGTGTGGTGTGGAACCAGTGGCTTTGGGACTGTGAGAGGATGGACAAA
GATTCACAGGGGCTGTTAGATTCATCCCTGATGGCGTCAGGCACTGCCAGCCGCTCAGAGGATG
AGGAGTCACTGGCAGGACAGAAACGAGCTTCCTCCCAGGCCCTGGGTACTATCCCTAAACGGAG
AAGCTCCTCCAGGTTCATCAAGAGGAAGAAGTTTGATGATGAACTGGTAGAGAGCAGCCTGGCC
AAGTCCTCCACCCGGGTGAAGGGGGCCGGCAGCGTGGAGTCGGGCCGCTGCTCGGGGAGCGAGC
CCTCGTCTAGTGAGAAGAAGAAGGTATCCAAGGCTCCCAGTACTCCTGTCCCACCCAGCCCTGC
CCCAACCCCTGGACTTACCAAGCGTGTGAAGAAAAGCAAACAGCCACTTCAGGTGACCAAGGAT
CTGGGCCGATGGAAGCCTGCAGATGACCTCCTCCTCATCAATGCTGTGCTACAGACTAACGACC
TGACATCTGTCCACCTGGGTGTGAAGTTCAGCTGCCGCTTCACCCTTCGGGAAGTTCAGGAGCG
CTGGTACGCCCTGCTCTACGACCCCGTCATCTCCAAACTGGCTTGCCAGGCCATGAGGCAGTTA
CACCCAGAAGCCATTGCAGCCATTCAGAGCAAGGCCCTGTTCAGCAAGGCTGAGGAGCAGCTGC
TGAGCAAAGTAGGATCGACCAGCCAGCCCACCTTGGAAACCTTCCAGGACTTGCTGCACAGACA
CCCTGATGCCTTCTACCTGGCCCGTACTGCCAAGGCTCTGCAGGCCCACTGGCAGCTCATGAAA
CAGTATTACCTACTGGAGGATCAGACAGTGCAGCCACTGCCTAAGGGGGACCAAGTGCTAAACT
TCTCAGATGCAGAGGACCTGATTGACGACAGTGAGCTCAAGGACATGCGAGATGAAGTCCTGGA
ACATGAGCTGACAGTGGCTGATCGGCGCCAGAAACGAGAGATCCGGCAGCTGGAACAGGAGCTG
CATAAGTGGCAGGTGCTAGTGGACAGCATCACAGGCATGAGTTCTCCAGACTTCGACAACCAGA
CCCTGGCCGTGTTGCGGGGCCGCATGGTGCGGTACCTAATGCGCTCCCGTGAGATAACCCTGGG
CAGAGCAACCAAGGACAACCAGATTGATGTGGACTTGTCTCTAGAAGGTCCAGCCTGGAAGATC
TCCCGAAAGCAAGGTGTCATCAAGCTGAAAAACAATGGTGACTTCTTCATTGCCAACGAGGGCC
GGCGGCCCATCTATATCGACGGGCGGCCTGTGCTGTGTGGCTCCAAGTGGCGCCTTAGCAACAA
CTCTGTGGTGGAGATCGCCAGCCTGCGATTTGTCTTCCTCATCAACCAGGACCTCATTGCCCTC
ATCCGGGCTGAGGCTGCCAAGATCACACCACAGTGAGGCGGGTAGCAGAAACCAGGGCATTCTC
TGGCCTCAGTTTCCCCTGTCATTCCAGCTCCCTTGAGCTGGGAACTCAGGCTCCTGGAAATCGC
TTGTACCCAGAGTGGGTAGTGGCCCAACTGCTGGACCATTGATTGAGCCTTTGAGGCAAGGTGG
GGTCACCGTGGGGACGCCAGGAGAGGCTGGGACCCCTGTGCCTCCCCAGAGCCAGAGCCCCCAC
CATTGCCACATCACTCCTGTGTCTCCAGTGGATCAGCTTTAGATTCCTCCTTTTTGTTTTCGTT
TTTTGTAAATAAAAAGTACTGAGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013124	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91366	(Get FASTA)	NCBI Sequence Viewer
	EDL86997	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070375
	ENSRNOP00000070375.1
	ENSRNOP00000086041.2

RefSeq Acc Id:

NP_001013124 ⟸ NM_001013106

- UniProtKB:

Q5BJR5 (UniProtKB/TrEMBL), A0A8I6A524 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVES
SLAKSSTRVKGAGSVESGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPTPGLTKRVKKSKQPLQV
TKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLYDPVISKLACQAM
RQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLLHRHPDAFYLARTAKALQAHWQ
LMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSELKDMRDEVLEHELTVADRRQKREIRQLE
QELHKWQVLVDSITGMSSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPA
WKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDL
IALIRAEAAKITPQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000070375 ⟸ ENSRNOT00000082470

Ensembl Acc Id:

ENSRNOP00000086041 ⟸ ENSRNOT00000102790

Protein Domains

FHA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V9E0-F1-model_v2	AlphaFold	G3V9E0	1-462	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695641

Promoter ID:

EPDNEW_R6166

Type:

multiple initiation site

Name:

Mcrs1_1

Description:

microspherule protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	140,919,257 - 140,919,317	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311607	AgrOrtholog
BioCyc Gene	G2FUF-32080	BioCyc
Ensembl Genes	ENSRNOG00000054838	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000082470	ENTREZGENE
	ENSRNOT00000082470.3	UniProtKB/TrEMBL
	ENSRNOT00000102790.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.200.20	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7319183	IMAGE-MGC_LOAD
InterPro	FHA_dom	UniProtKB/TrEMBL
	MCRS1	UniProtKB/TrEMBL
	MCRS_N	UniProtKB/TrEMBL
	SMAD_FHA_domain	UniProtKB/TrEMBL
KEGG Report	rno:300222	UniProtKB/TrEMBL
MGC_CLONE	MGC:109421	IMAGE-MGC_LOAD
NCBI Gene	300222	ENTREZGENE
PANTHER	MICROSPHERULE PROTEIN 1	UniProtKB/TrEMBL
	PTHR13233	UniProtKB/TrEMBL
Pfam	FHA	UniProtKB/TrEMBL
	MCRS_N	UniProtKB/TrEMBL
PhenoGen	Mcrs1	PhenoGen
PROSITE	FHA_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000054838	RatGTEx
SMART	FHA	UniProtKB/TrEMBL
Superfamily-SCOP	SMAD_FHA	UniProtKB/TrEMBL
UniProt	A0A8I6A524	ENTREZGENE, UniProtKB/TrEMBL
	A6KCE5_RAT	UniProtKB/TrEMBL
	G3V9E0_RAT	UniProtKB/TrEMBL
	Q5BJR5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Mcrs1	microspherule protein 1	Mcrs1_predicted	microspherule protein 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Mcrs1_predicted	microspherule protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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RGD Manual Annotations