Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DENND3 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | affects expression | ISO | Dennd3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of DENND3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [Estradiol co-treated with Norethindrone Acetate] results in increased expression of DENND3 mRNA | CTD | PMID:22217510 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | DENND3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of DENND3 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of DENND3 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of DENND3 mRNA | CTD | PMID:34747641 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA more ... | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of DENND3 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Dennd3 (Mus musculus) | 6480464 | bisphenol S affects the methylation of DENND3 gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DENND3 mRNA | CTD | PMID:36041667 | 4-hydroxyphenyl retinamide | increases expression | ISO | Dennd3 (Mus musculus) | 6480464 | Fenretinide results in increased expression of DENND3 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of DENND3 mRNA | CTD | PMID:24780913 | acrolein | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of DENND3 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | aflatoxin B1 | increases methylation | ISO | DENND3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of DENND3 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | DENND3 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of DENND3 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | DENND3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of DENND3 mRNA | CTD | PMID:16054129 and PMID:33167477 | alpha-pinene | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of DENND3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of DENND3 mRNA | CTD | PMID:32699268 | amosite asbestos | increases methylation | ISO | DENND3 (Homo sapiens) | 6480464 | Asbestos and Amosite results in increased methylation of DENND3 promoter | CTD | PMID:29626692 | antirheumatic drug | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of DENND3 mRNA | CTD | PMID:24449571 | arsane | affects methylation | ISO | DENND3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of DENND3 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | DENND3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of DENND3 gene | CTD | PMID:25304211 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of DENND3 gene | CTD | PMID:35440735 | benzo[a]pyrene | increases expression | ISO | Dennd3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of DENND3 mRNA | CTD | PMID:21569818 more ... | benzo[a]pyrene | increases expression | ISO | DENND3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of DENND3 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | decreases methylation | ISO | DENND3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of DENND3 5' UTR | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of DENND3 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DENND3 mRNA | CTD | PMID:36041667 | bisphenol A | decreases methylation | ISO | DENND3 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of DENND3 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DENND3 mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DENND3 mRNA | CTD | PMID:36041667 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of DENND3 mRNA | CTD | PMID:19167457 | carbon nanotube | increases expression | ISO | Dennd3 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of DENND3 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to DENND3 gene] | CTD | PMID:28238834 | chlordecone | decreases expression | ISO | Dennd3 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of DENND3 mRNA | CTD | PMID:29980752 | chromium(6+) | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | chromium hexavalent ion results in decreased expression of DENND3 mRNA | CTD | PMID:30690063 | ciguatoxin CTX1B | affects expression | ISO | Dennd3 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of DENND3 mRNA | CTD | PMID:18353800 | coumarin | decreases phosphorylation | ISO | DENND3 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of DENND3 protein | CTD | PMID:35688186 | deguelin | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | deguelin results in decreased expression of DENND3 mRNA | CTD | PMID:33512557 | dexamethasone | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA more ... | CTD | PMID:28628672 | folic acid | increases expression | ISO | Dennd3 (Mus musculus) | 6480464 | Folic Acid results in increased expression of DENND3 mRNA | CTD | PMID:25629700 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of DENND3 mRNA | CTD | PMID:33387578 | indometacin | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA more ... | CTD | PMID:28628672 | lead diacetate | multiple interactions | ISO | Dennd3 (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of DENND3 exon and [lead acetate results in increased abundance of Lead] which results in increased methylation of DENND3 intron | CTD | PMID:33445541 | lead(0) | multiple interactions | ISO | Dennd3 (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of DENND3 exon and [lead acetate results in increased abundance of Lead] which results in increased methylation of DENND3 intron | CTD | PMID:33445541 | methyl methanesulfonate | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of DENND3 mRNA | CTD | PMID:23649840 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of DENND3 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of DENND3 mRNA more ... | CTD | PMID:32699268 more ... | ozone | multiple interactions | ISO | Dennd3 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of DENND3 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of DENND3 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | Dennd3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of DENND3 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of DENND3 mRNA | CTD | PMID:33387578 | picoxystrobin | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of DENND3 mRNA | CTD | PMID:33512557 | pirinixic acid | multiple interactions | ISO | Dennd3 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DENND3 mRNA | CTD | PMID:19710929 | potassium chromate | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DENND3 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of DENND3 mRNA | CTD | PMID:22079256 and PMID:22714537 | pyrimidifen | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | pyrimidifen results in decreased expression of DENND3 mRNA | CTD | PMID:33512557 | resveratrol | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of DENND3 mRNA | CTD | PMID:23557933 | silicon dioxide | increases expression | ISO | DENND3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of DENND3 mRNA | CTD | PMID:25895662 | sodium arsenate | increases expression | ISO | Dennd3 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of DENND3 mRNA | CTD | PMID:30953684 | sodium arsenite | increases expression | ISO | DENND3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of DENND3 mRNA | CTD | PMID:29301061 | sodium arsenite | decreases expression | ISO | Dennd3 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of DENND3 mRNA | CTD | PMID:37682722 | sotorasib | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DENND3 mRNA | CTD | PMID:36139627 | sulforaphane | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of DENND3 mRNA | CTD | PMID:31838189 | tert-butyl hydroperoxide | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of DENND3 mRNA | CTD | PMID:15336504 | testosterone | decreases expression | ISO | Dennd3 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of DENND3 mRNA | CTD | PMID:33848595 | testosterone | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of DENND3 mRNA | CTD | PMID:33359661 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of DENND3 mRNA | CTD | PMID:25729387 | trametinib | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DENND3 mRNA | CTD | PMID:36139627 | tris(2-butoxyethyl) phosphate | affects expression | ISO | DENND3 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of DENND3 mRNA | CTD | PMID:29024780 | urethane | decreases expression | ISO | DENND3 (Homo sapiens) | 6480464 | Urethane results in decreased expression of DENND3 mRNA | CTD | PMID:28818685 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of DENND3 mRNA | CTD | PMID:19015723 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of DENND3 gene | CTD | PMID:31682807 | zinc atom | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of DENND3 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | DENND3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of DENND3 mRNA | CTD | PMID:18593933 | |