Dennd3 (DENN domain containing 3) - Rat Genome Database

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Gene: Dennd3 (DENN domain containing 3) Rattus norvegicus
Analyze
Symbol: Dennd3
Name: DENN domain containing 3
RGD ID: 1311559
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in endosome to lysosome transport; protein catabolic process; and regulation of Rab protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND3 (DENN domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DENN domain-containing protein 3; DENN/MADD domain containing 3; hypothetical LOC315055; LOC315055; RGD1311559
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87107,304,860 - 107,362,573 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7107,220,192 - 107,362,573 (+)EnsemblGRCr8
mRatBN7.27105,415,870 - 105,473,583 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7105,415,677 - 105,473,592 (+)EnsemblmRatBN7.2
Rnor_6.07114,724,644 - 114,812,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,724,610 - 114,812,708 (+)Ensemblrn6Rnor6.0
Rnor_5.07114,657,996 - 114,736,407 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47111,218,116 - 111,275,479 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7101,823,319 - 101,881,083 (+)NCBICelera
RGSC_v3.17111,225,832 - 111,309,709 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amosite asbestos  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
coumarin  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
nitrogen dioxide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20937701   PMID:21718402  


Genomics

Comparative Map Data
Dennd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87107,304,860 - 107,362,573 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7107,220,192 - 107,362,573 (+)EnsemblGRCr8
mRatBN7.27105,415,870 - 105,473,583 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7105,415,677 - 105,473,592 (+)EnsemblmRatBN7.2
Rnor_6.07114,724,644 - 114,812,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,724,610 - 114,812,708 (+)Ensemblrn6Rnor6.0
Rnor_5.07114,657,996 - 114,736,407 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47111,218,116 - 111,275,479 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7101,823,319 - 101,881,083 (+)NCBICelera
RGSC_v3.17111,225,832 - 111,309,709 (+)NCBI
Cytogenetic Map7q34NCBI
DENND3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388141,128,589 - 141,195,804 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8141,117,278 - 141,195,808 (+)Ensemblhg38GRCh38
GRCh378142,138,688 - 142,205,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368142,207,902 - 142,275,083 (+)NCBIBuild 36Build 36hg18NCBI36
Celera8138,306,916 - 138,374,104 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8137,450,378 - 137,517,552 (+)NCBIHuRef
CHM1_18142,178,995 - 142,246,171 (+)NCBICHM1_1
T2T-CHM13v2.08142,248,713 - 142,315,919 (+)NCBIT2T-CHM13v2.0
Dennd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391573,384,333 - 73,444,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1573,384,409 - 73,444,091 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381573,512,560 - 73,572,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,512,560 - 73,572,242 (+)Ensemblmm10GRCm38
MGSCv371573,342,990 - 73,402,672 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361573,339,816 - 73,399,498 (+)NCBIMGSCv36mm8
Celera1575,014,224 - 75,076,612 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.01NCBI
Dennd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955454185,299 - 253,428 (+)Ensembl
ChiLan1.0NW_004955454185,299 - 253,935 (+)NCBIChiLan1.0ChiLan1.0
DENND3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27158,526,548 - 158,594,680 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18134,056,809 - 134,125,286 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08137,805,456 - 137,873,492 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18140,889,347 - 140,956,973 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8140,889,343 - 140,956,967 (+)EnsemblpanPan2panpan1.1
DENND3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,649,797 - 35,696,149 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,685,829 - 35,694,800 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1335,505,304 - 35,555,435 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01336,031,571 - 36,081,695 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1336,031,391 - 36,081,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11335,751,650 - 35,801,765 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01335,841,295 - 35,891,529 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01336,261,339 - 36,311,719 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dennd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053032,793,039 - 2,838,863 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647010,217,394 - 10,264,956 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647010,217,404 - 10,264,911 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl42,530,649 - 2,578,098 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.142,530,640 - 2,578,104 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.242,284,519 - 2,300,731 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DENND3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18135,367,847 - 135,437,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8135,368,076 - 135,437,559 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660394,695,279 - 4,765,143 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473515,160,024 - 15,224,123 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473515,158,892 - 15,224,895 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dennd3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11246,270,696 - 246,329,489 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dennd3
362 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:61
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000014541
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
BI303224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,473,372 - 105,473,540 (+)MAPPERmRatBN7.2
Rnor_6.07114,812,261 - 114,812,428NCBIRnor6.0
Rnor_5.07114,736,197 - 114,736,364UniSTSRnor5.0
RGSC_v3.47111,275,269 - 111,275,436UniSTSRGSC3.4
Celera7101,880,873 - 101,881,040UniSTS
RH 3.4 Map7753.51UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014541   ⟹   ENSRNOP00000014542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7107,220,192 - 107,362,573 (+)Ensembl
mRatBN7.2 Ensembl7105,415,677 - 105,473,592 (+)Ensembl
Rnor_6.0 Ensembl7114,724,610 - 114,812,708 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097499   ⟹   ENSRNOP00000078310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7107,304,916 - 107,362,573 (+)Ensembl
mRatBN7.2 Ensembl7105,415,896 - 105,473,592 (+)Ensembl
RefSeq Acc Id: NM_001427258   ⟹   NP_001414187
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,304,916 - 107,362,573 (+)NCBI
RefSeq Acc Id: XM_006241738   ⟹   XP_006241800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,304,863 - 107,362,573 (+)NCBI
mRatBN7.27105,415,871 - 105,473,583 (+)NCBI
Rnor_6.07114,724,644 - 114,812,471 (+)NCBI
Rnor_5.07114,657,996 - 114,736,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595246   ⟹   XP_017450735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,304,861 - 107,358,256 (+)NCBI
mRatBN7.27105,415,870 - 105,469,261 (+)NCBI
Rnor_6.07114,724,644 - 114,808,134 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080223   ⟹   XP_038936151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,315,483 - 107,362,573 (+)NCBI
mRatBN7.27105,426,488 - 105,473,583 (+)NCBI
RefSeq Acc Id: XM_039080224   ⟹   XP_038936152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,322,538 - 107,362,573 (+)NCBI
mRatBN7.27105,433,544 - 105,473,583 (+)NCBI
RefSeq Acc Id: XM_039080225   ⟹   XP_038936153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,330,751 - 107,362,573 (+)NCBI
mRatBN7.27105,441,761 - 105,473,583 (+)NCBI
RefSeq Acc Id: XM_063263576   ⟹   XP_063119646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,304,860 - 107,348,226 (+)NCBI
RefSeq Acc Id: XP_006241800   ⟸   XM_006241738
- Peptide Label: isoform X1
- UniProtKB: D4A2H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450735   ⟸   XM_017595246
- Peptide Label: isoform X2
- UniProtKB: D4A2H4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014542   ⟸   ENSRNOT00000014541
RefSeq Acc Id: XP_038936151   ⟸   XM_039080223
- Peptide Label: isoform X4
- UniProtKB: A0A8I6G2K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936152   ⟸   XM_039080224
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038936153   ⟸   XM_039080225
- Peptide Label: isoform X6
- UniProtKB: A6HRV6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078310   ⟸   ENSRNOT00000097499
RefSeq Acc Id: XP_063119646   ⟸   XM_063263576
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001414187   ⟸   NM_001427258
- UniProtKB: D4A2H4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2H4-F1-model_v2 AlphaFold D4A2H4 1-1278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311559 AgrOrtholog
BioCyc Gene G2FUF-33051 BioCyc
Ensembl Genes ENSRNOG00000010794 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014541.8 UniProtKB/TrEMBL
  ENSRNOT00000097499 ENTREZGENE
  ENSRNOT00000097499.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.30.450.200 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
InterPro dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  DENN_Domain_GEFs UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN_dom UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 315055 ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
  DENN DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam DENN UniProtKB/TrEMBL
  TPR_DENND3 UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Dennd3 PhenoGen
PROSITE DENN UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010794 RatGTEx
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A0A8I6G2K6 ENTREZGENE, UniProtKB/TrEMBL
  A6HRV6 ENTREZGENE, UniProtKB/TrEMBL
  D4A2H4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Dennd3  DENN domain containing 3  Dennd3  DENN/MADD domain containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Dennd3  DENN/MADD domain containing 3  RGD1311559_predicted  hypothetical LOC315055 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311559_predicted  hypothetical LOC315055 (predicted)  LOC315055_predicted    Symbol and Name status set to approved 1331353 APPROVED