Cd226 (CD226 molecule) - Rat Genome Database

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Gene: Cd226 (CD226 molecule) Rattus norvegicus
Analyze
Symbol: Cd226
Name: CD226 molecule
RGD ID: 1311513
Description: Predicted to enable several functions, including identical protein binding activity; integrin binding activity; and protein kinase binding activity. Predicted to be involved in natural killer cell mediated cytotoxicity; positive regulation of immune response; and positive regulation of mast cell activation. Predicted to act upstream of or within positive regulation of natural killer cell cytokine production and positive regulation of type II interferon production. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human CD226 (CD226 molecule); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD226 antigen; LOC307199
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cd226Tn(sb-T2/Bart3)2.141Mcwi  
Genetic Models: F344-Cd226Tn(sb-T2/Bart3)2.141Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81884,723,330 - 84,819,836 (+)NCBIGRCr8
mRatBN7.21882,449,924 - 82,545,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1882,450,568 - 82,543,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1884,505,997 - 84,598,578 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01885,179,224 - 85,271,795 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01883,053,202 - 83,147,001 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01886,299,392 - 86,394,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1886,299,463 - 86,394,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01885,337,942 - 85,433,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41886,064,574 - 86,157,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11886,157,214 - 86,230,246 (+)NCBI
Celera1881,000,246 - 81,093,141 (+)NCBICelera
Cytogenetic Map18q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd226RatChronic Hepatitis C treatmentISOCD226 (Homo sapiens)9068941 RGDPMID:21695691 and REF_RGD_ID:40818295
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd226Ratchromosome 18q deletion syndrome  ISOCD226 (Homo sapiens)8554872ClinVar Annotator: match by term: Monosomy 18q and deletion 18qClinVarPMID:25741868 and PMID:31690835
Cd226Ratintestinal volvulus  ISOCD226 (Homo sapiens)8554872ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIALClinVarPMID:25741868
Cd226RatNeurodevelopmental Disorders  ISOCD226 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Cd226Ratpulmonary valve stenosis  ISOCD226 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary valve stenosisClinVarPMID:25741868
Cd226RatVolvulus Of Midgut  ISOCD226 (Homo sapiens)8554872ClinVar Annotator: match by term: Volvulus of midgutClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd226RatColorectal Neoplasms  ISOCD226 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16015041
Cd226Ratendometriosis  ISOCD226 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642
Cd226RatSpontaneous Abortions  ISOCD226 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18539642
Cd226Ratsystemic lupus erythematosus  ISOCD226 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26808113

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd226Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of CD226 mRNACTDPMID:30723492
Cd226Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CD226 mRNACTDPMID:32741896
Cd226Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CD226 mRNACTDPMID:32741896
Cd226Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCd226 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CD226 mRNACTDPMID:21570461
Cd226Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CD226 mRNACTDPMID:34747641
Cd226Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOCd226 (Mus musculus)64804642 more ...CTDPMID:38648751
Cd226Rataflatoxin B1 increases methylationISOCD226 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of CD226 gene and Aflatoxin B1 results in increased methylation of CD226 intronCTDPMID:27153756 and PMID:30157460
Cd226Rataldehydo-D-glucose multiple interactionsISOCd226 (Mus musculus)6480464[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CD226 mRNACTDPMID:37567420
Cd226Ratalpha-Zearalanol increases expressionEXP 6480464Zeranol results in increased expression of CD226 mRNACTDPMID:35163327
Cd226Ratantirheumatic drug decreases expressionISOCD226 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of CD226 mRNACTDPMID:24449571
Cd226Rataristolochic acid A increases expressionISOCD226 (Homo sapiens)6480464aristolochic acid I results in increased expression of CD226 mRNACTDPMID:33212167
Cd226Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of CD226 geneCTDPMID:28931070
Cd226Ratbenzo[a]pyrene affects methylationISOCD226 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of CD226 intronCTDPMID:30157460
Cd226Ratbenzo[a]pyrene increases expressionISOCD226 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of CD226 mRNACTDPMID:30453624
Cd226Ratbenzo[b]fluoranthene decreases expressionISOCd226 (Mus musculus)6480464benzo(b)fluoranthene results in decreased expression of CD226 mRNACTDPMID:26377693
Cd226Ratbis(2-ethylhexyl) phthalate increases expressionISOCd226 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of CD226 mRNACTDPMID:35550907
Cd226Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CD226 mRNACTDPMID:25181051 and PMID:32145629
Cd226Ratbisphenol A increases expressionISOCd226 (Mus musculus)6480464bisphenol A results in increased expression of CD226 mRNACTDPMID:32156529
Cd226Ratbisphenol A affects methylationISOCD226 (Homo sapiens)6480464bisphenol A affects the methylation of CD226 geneCTDPMID:31601247
Cd226Ratcarbon nanotube decreases expressionISOCd226 (Mus musculus)6480464Nanotubes more ...CTDPMID:25554681

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Biological Process
1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd226Ratbiological_process  ND 15984074/2009: No relevant rat dataRGD 
Cd226Ratnatural killer cell mediated cytotoxicity involved_inISOCD226 (Homo sapiens)1624291 PMID:8673704RGDPMID:8673704
Cd226Ratnatural killer cell mediated cytotoxicity involved_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratpositive regulation of Fc receptor mediated stimulatory signaling pathway involved_inISOCD226 (Homo sapiens)1624291 PMID:16831868RGDPMID:16831868
Cd226Ratpositive regulation of Fc receptor mediated stimulatory signaling pathway involved_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratpositive regulation of Fc receptor mediated stimulatory signaling pathway involved_inIBAPANTHER:PTN002931336 and UniProtKB:Q157621600115GO_REF:0000033GO_CentralGO_REF:0000033
Cd226Ratpositive regulation of immunoglobulin mediated immune response involved_inISOCD226 (Homo sapiens)1624291 PMID:16831868RGDPMID:16831868
Cd226Ratpositive regulation of immunoglobulin mediated immune response involved_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratpositive regulation of immunoglobulin mediated immune response involved_inIBAPANTHER:PTN002931336 and UniProtKB:Q157621600115GO_REF:0000033GO_CentralGO_REF:0000033
Cd226Ratpositive regulation of mast cell activation involved_inISOCD226 (Homo sapiens)1624291 PMID:16831868RGDPMID:16831868
Cd226Ratpositive regulation of mast cell activation involved_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratpositive regulation of natural killer cell cytokine production involved_inIEAInterPro:IPR0428421600115GO_REF:0000002InterProGO_REF:0000002
Cd226Ratpositive regulation of natural killer cell cytokine production acts_upstream_of_or_withinISOCd226 (Mus musculus)1624291MGI:4454325 PMID:24658051RGDPMID:24658051
Cd226Ratpositive regulation of natural killer cell cytokine production acts_upstream_of_or_withinIEAUniProtKB:Q8K4F0 and ensembl:ENSMUSP000001583241600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratpositive regulation of natural killer cell mediated cytotoxicity involved_inISOCD226 (Homo sapiens)1624291 PMID:16304049RGDPMID:16304049
Cd226Ratpositive regulation of natural killer cell mediated cytotoxicity involved_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target involved_inISOCD226 (Homo sapiens)1624291 PMID:12913096RGDPMID:12913096
Cd226Ratpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target involved_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratpositive regulation of T cell receptor signaling pathway involved_inISOCD226 (Homo sapiens)1624291 PMID:26755705RGDPMID:26755705
Cd226Ratpositive regulation of T cell receptor signaling pathway involved_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd226Ratcell surface located_inISOCD226 (Homo sapiens)1624291 PMID:16831868RGDPMID:16831868
Cd226Ratcell surface located_inIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratexternal side of plasma membrane located_inISOCd226 (Mus musculus)1624291 PMID:19648922RGDPMID:19648922
Cd226Ratexternal side of plasma membrane located_inIEAUniProtKB:Q8K4F0 and ensembl:ENSMUSP000001583241600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratexternal side of plasma membrane is_active_inIBAMGI:3039602 and PANTHER:PTN0029313361600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
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Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd226Ratcell adhesion molecule binding enablesIBAPANTHER:PTN002931336 and UniProtKB:Q157621600115GO_REF:0000033GO_CentralGO_REF:0000033
Cd226Ratcell adhesion molecule binding enablesIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratcell adhesion molecule binding enablesISOCD226 (Homo sapiens)1624291UniProtKB:P15151 more ...RGDPMID:12913096
Cd226Ratidentical protein binding enablesISOCD226 (Homo sapiens)1624291UniProtKB:Q15762 more ...RGDPMID:25465800 and PMID:30591568
Cd226Ratidentical protein binding enablesIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratintegrin binding enablesISOCD226 (Homo sapiens)1624291UniProtKB:P05107 and PMID:16831868RGDPMID:16831868
Cd226Ratintegrin binding enablesIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratprotein binding enablesISOCD226 (Homo sapiens)1624291UniProtKB:P15151 more ...RGDPMID:21982860 more ...
Cd226Ratprotein binding enablesISOCd226 (Mus musculus)1624291MGI:107741 more ...RGDPMID:15752754 more ...
Cd226Ratprotein kinase binding enablesISOCD226 (Homo sapiens)1624291UniProtKB:P06241 and PMID:16831868RGDPMID:16831868
Cd226Ratprotein kinase binding enablesIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
Cd226Ratsignaling receptor activity enablesISOCD226 (Homo sapiens)1624291 PMID:15039383RGDPMID:15039383
Cd226Ratsignaling receptor activity enablesIEAUniProtKB:Q15762 and ensembl:ENSP000004619471600115GO_REF:0000107EnsemblGO_REF:0000107
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
PMID:12913096   PMID:15752754   PMID:16304049   PMID:16831868   PMID:19648922   PMID:22728856   PMID:24658051   PMID:26755705  



Cd226
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81884,723,330 - 84,819,836 (+)NCBIGRCr8
mRatBN7.21882,449,924 - 82,545,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1882,450,568 - 82,543,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1884,505,997 - 84,598,578 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01885,179,224 - 85,271,795 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01883,053,202 - 83,147,001 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01886,299,392 - 86,394,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1886,299,463 - 86,394,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01885,337,942 - 85,433,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41886,064,574 - 86,157,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11886,157,214 - 86,230,246 (+)NCBI
Celera1881,000,246 - 81,093,141 (+)NCBICelera
Cytogenetic Map18q13NCBI
CD226
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381869,853,274 - 69,961,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1869,831,158 - 69,961,803 (-)EnsemblGRCh38hg38GRCh38
GRCh371867,520,510 - 67,624,035 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361865,681,172 - 65,775,139 (-)NCBINCBI36Build 36hg18NCBI36
Build 341865,681,174 - 65,775,140NCBI
Celera1864,377,737 - 64,472,107 (-)NCBICelera
Cytogenetic Map18q22.2NCBI
HuRef1864,248,832 - 64,343,180 (-)NCBIHuRef
CHM1_11867,525,491 - 67,619,446 (-)NCBICHM1_1
T2T-CHM13v2.01870,070,086 - 70,220,680 (-)NCBIT2T-CHM13v2.0
Cd226
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391889,195,078 - 89,290,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1889,195,091 - 89,290,353 (+)EnsemblGRCm39 Ensembl
GRCm381889,176,954 - 89,272,232 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1889,176,967 - 89,272,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv371889,366,819 - 89,439,719 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361889,331,620 - 89,404,520 (+)NCBIMGSCv36mm8
Celera1890,925,452 - 90,998,347 (+)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1859.05NCBI
Cd226
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540253,473,131 - 53,560,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540253,408,861 - 53,560,896 (-)NCBIChiLan1.0ChiLan1.0
CD226
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21787,392,451 - 87,488,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11873,072,672 - 73,178,859 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01863,238,477 - 63,379,346 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11866,533,949 - 66,627,580 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1866,533,949 - 66,627,580 (-)Ensemblpanpan1.1panPan2
CD226
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.118,348,628 - 8,437,520 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl18,351,207 - 8,435,145 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha19,360,824 - 9,448,915 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.018,180,313 - 8,268,617 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl18,180,904 - 8,267,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.118,201,794 - 8,289,667 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.018,162,053 - 8,249,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.018,372,145 - 8,460,491 (+)NCBIUU_Cfam_GSD_1.0
CD226
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,882,762 - 152,979,845 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11152,872,878 - 152,977,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21169,304,334 - 169,418,889 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD226
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1189,790,483 - 9,900,376 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl189,811,168 - 9,901,830 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606015,904,002 - 16,007,951 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd226
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480611,324,344 - 11,388,206 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480611,324,239 - 11,390,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cd226
395 total Variants

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:91
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000058152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat

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This gene Cd226 is modified in the following models/strains:




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 47 113 91 90 59 25 59 6 213 92 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_001107370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000058152   ⟹   ENSRNOP00000054956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1882,450,568 - 82,543,051 (+)Ensembl
Rnor_6.0 Ensembl1886,299,463 - 86,392,713 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091778   ⟹   ENSRNOP00000073108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1886,307,646 - 86,394,765 (+)Ensembl
RefSeq Acc Id: NM_001107370   ⟹   NP_001100840
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,725,316 - 84,817,780 (+)NCBI
mRatBN7.21882,450,568 - 82,543,051 (+)NCBI
Rnor_6.01886,299,463 - 86,392,713 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
RGSC_v3.41886,064,574 - 86,157,909 (+)RGD
Celera1881,000,246 - 81,093,141 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255028   ⟹   XP_006255090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,723,330 - 84,819,836 (+)NCBI
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255031   ⟹   XP_006255093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,723,330 - 84,819,836 (+)NCBI
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096758   ⟹   XP_038952686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,731,649 - 84,819,836 (+)NCBI
mRatBN7.21882,456,291 - 82,545,107 (+)NCBI
RefSeq Acc Id: XM_039096759   ⟹   XP_038952687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,723,330 - 84,819,836 (+)NCBI
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
RefSeq Acc Id: XM_063277286   ⟹   XP_063133356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,731,649 - 84,819,836 (+)NCBI
RefSeq Acc Id: NP_001100840   ⟸   NM_001107370
- Peptide Label: precursor
- UniProtKB: D3ZS97 (UniProtKB/TrEMBL),   A6K5P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255090   ⟸   XM_006255028
- Peptide Label: isoform X1
- UniProtKB: A6K5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255093   ⟸   XM_006255031
- Peptide Label: isoform X1
- UniProtKB: A6K5P1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054956   ⟸   ENSRNOT00000058152
Ensembl Acc Id: ENSRNOP00000073108   ⟸   ENSRNOT00000091778
Ig-like

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS97-F1-model_v2 AlphaFold D3ZS97 1-346 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700909
Promoter ID:EPDNEW_R11422
Type:single initiation site
Name:Cd226_1
Description:CD226 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,307,693 - 86,307,753EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-6690 BioCyc
Ensembl Genes ENSRNOG00000038197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058152 ENTREZGENE
  ENSRNOT00000058152.4 UniProtKB/TrEMBL
  ENSRNOT00000172632 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CD226 UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:307199 UniProtKB/TrEMBL
NCBI Gene 307199 ENTREZGENE
PANTHER CD226 ANTIGEN UniProtKB/TrEMBL
  PTHR47011 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Cd226 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038197 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A6K5P0 ENTREZGENE, UniProtKB/TrEMBL
  A6K5P1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZS97 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-18 Cd226  CD226 antigen  Cd226_predicted  CD226 antigen (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Cd226_predicted  CD226 antigen (predicted)      Symbol and Name status set to approved 70820 APPROVED