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Gene: Srpra (SRP receptor subunit alpha) Rattus norvegicus

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Symbol:

Srpra

Name:

SRP receptor subunit alpha

RGD ID:

1311504

Description:

Predicted to enable GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in membrane. Predicted to be part of signal recognition particle receptor complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SRPRA (SRP receptor subunit alpha); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC315548; MGC124867; signal recognition particle receptor; signal recognition particle receptor ('docking protein'); signal recognition particle receptor subunit alpha; SRP receptor alpha subunit; Srpr

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SRPRA (SRP receptor subunit alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Srpra (signal recognition particle receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Srpra (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SRPRA (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SRPRA (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Srpra (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SRPRA (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SRPRA (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Srpra (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Srpra (SRP receptor subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KCNK7 (potassium two pore domain channel subfamily K member 7)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SRPRA (SRP receptor subunit alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Srpra (signal recognition particle receptor alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F38A1.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gtp-bp	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SRP101	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	srpra	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	srpra	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	41,818,199 - 41,824,292 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	41,818,229 - 41,824,280 (+)	Ensembl				GRCr8
mRatBN7.2	8	33,560,365 - 33,566,458 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	33,560,348 - 33,566,470 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	37,630,487 - 37,636,631 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	35,913,527 - 35,919,671 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	33,776,372 - 33,782,516 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	36,410,683 - 36,416,766 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	36,410,683 - 36,416,296 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	36,428,866 - 36,434,949 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	34,992,187 - 34,998,270 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	34,979,915 - 34,986,044 (+)	NCBI		Celera
RGSC_v3.1	8	35,000,954 - 35,007,031 (+)	NCBI
Cytogenetic Map	8	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Shwachman-Diamond syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

bathocuproine disulfonic acid (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

buspirone (EXP)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

clobetasol (ISO)

clofibrate (ISO)

cyclosporin A (ISO)

cyproconazole (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

geldanamycin (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

haloperidol (ISO)

indometacin (ISO)

ionomycin (ISO)

isoniazide (ISO)

ivermectin (ISO)

methapyrilene (EXP)

methidathion (ISO)

methotrexate (ISO)

methylparaben (ISO)

nitrates (ISO)

ochratoxin A (ISO)

ozone (ISO)

paclitaxel (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

propiconazole (ISO)

pyrrolidine dithiocarbamate (ISO)

resveratrol (ISO)

silicon dioxide (EXP)

sodium arsenite (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

thapsigargin (ISO)

thimerosal (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular protein transport (IEA)

SRP-dependent cotranslational protein targeting to membrane (IEA)

Cellular Component

endoplasmic reticulum membrane (IEA)

membrane (IEA,ISO)

signal recognition particle receptor complex (IEA,ISO)

Molecular Function

GTP binding (IEA)

GTPase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

signal recognition particle binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:19199708	PMID:22375059	PMID:22658674	PMID:31505169

Genomics

Comparative Map Data

Srpra
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	41,818,199 - 41,824,292 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	41,818,229 - 41,824,280 (+)	Ensembl				GRCr8
mRatBN7.2	8	33,560,365 - 33,566,458 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	33,560,348 - 33,566,470 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	37,630,487 - 37,636,631 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	35,913,527 - 35,919,671 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	33,776,372 - 33,782,516 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	36,410,683 - 36,416,766 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	36,410,683 - 36,416,296 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	36,428,866 - 36,434,949 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	34,992,187 - 34,998,270 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	34,979,915 - 34,986,044 (+)	NCBI		Celera
RGSC_v3.1	8	35,000,954 - 35,007,031 (+)	NCBI
Cytogenetic Map	8	q21	NCBI

SRPRA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	126,235,930 - 126,268,895 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	126,262,912 - 126,269,144 (-)	Ensembl			hg38	GRCh38
GRCh37	11	126,132,833 - 126,138,790 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	125,638,043 - 125,643,960 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	125,638,042 - 125,643,960	NCBI
Celera	11	123,297,838 - 123,303,901 (-)	NCBI		Celera
Cytogenetic Map	11	q24.2	NCBI
HuRef	11	122,075,206 - 122,081,269 (-)	NCBI		HuRef
CHM1_1	11	126,019,105 - 126,025,168 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	126,265,417 - 126,298,379 (-)	NCBI		T2T-CHM13v2.0

Srpra
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	35,122,499 - 35,128,299 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	35,111,471 - 35,159,269 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	35,211,203 - 35,217,003 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	35,200,175 - 35,247,973 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	35,018,788 - 35,024,588 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	34,960,874 - 34,966,674 (+)	NCBI		MGSCv36	mm8
Celera	9	32,447,922 - 32,453,726 (+)	NCBI		Celera
Cytogenetic Map	9	A4	NCBI
cM Map	9	20.06	NCBI

Srpra
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	27,287,368 - 27,293,362 (-)	Ensembl
ChiLan1.0	NW_004955412	27,287,359 - 27,293,362 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRPRA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	126,938,808 - 126,952,604 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	128,048,049 - 128,060,239 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	121,071,054 - 121,083,106 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	124,987,307 - 124,993,347 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	124,987,307 - 124,993,347 (-)	Ensembl			panPan2	panpan1.1

SRPRA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	8,247,608 - 8,253,411 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	8,224,416 - 8,254,792 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	8,308,830 - 8,314,605 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	8,203,219 - 8,208,993 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	8,203,231 - 8,208,989 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	8,272,836 - 8,278,587 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	8,246,523 - 8,252,291 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	8,280,726 - 8,286,491 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Srpra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	108,493,753 - 108,499,710 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936572	5,950,530 - 5,958,025 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936572	5,950,608 - 5,956,620 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRPRA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	53,358,534 - 53,365,653 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	53,358,522 - 53,365,085 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	58,968,922 - 58,974,223 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRPRA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	117,388,341 - 117,394,358 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	117,387,044 - 117,394,415 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	8,677,830 - 8,683,823 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srpra
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624812	416,727 - 422,823 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624812	416,727 - 422,820 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Srpra
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	30,763,331 - 30,769,382 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Srpra
72 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	44
Count of miRNA genes:	44
Interacting mature miRNAs:	44
Transcripts:	ENSRNOT00000015177
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
61337	Bp22	Blood pressure QTL 22	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	51589833	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	37760859	58991895	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	34125902	55607752	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
70206	Alc20	Alcohol consumption QTL 20	2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	8	39106258	49610361	Rat

Markers in Region

RH131034

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	33,564,003 - 33,564,190 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	36,414,312 - 36,414,498	NCBI	Rnor6.0
Rnor_5.0	8	36,432,495 - 36,432,681	UniSTS	Rnor5.0
RGSC_v3.4	8	34,995,816 - 34,996,002	UniSTS	RGSC3.4
Celera	8	34,983,544 - 34,983,730	UniSTS
RH 3.4 Map	8	289.1	UniSTS
Cytogenetic Map	8	q21	UniSTS

UniSTS:236630

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	33,560,453 - 33,561,647 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	36,410,762 - 36,411,955	NCBI	Rnor6.0
Rnor_5.0	8	36,428,945 - 36,430,138	UniSTS	Rnor5.0
RGSC_v3.4	8	34,992,266 - 34,993,459	UniSTS	RGSC3.4
Celera	8	34,979,994 - 34,981,187	UniSTS
Cytogenetic Map	8	q21	UniSTS

GDB:197863

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	41,821,221 - 41,821,508 (+)	Marker Load Pipeline
mRatBN7.2	8	33,563,387 - 33,563,674 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	36,413,696 - 36,413,982	NCBI	Rnor6.0
Rnor_5.0	8	36,431,879 - 36,432,165	UniSTS	Rnor5.0
RGSC_v3.4	8	34,995,200 - 34,995,486	UniSTS	RGSC3.4
Celera	8	34,982,928 - 34,983,214	UniSTS
Cytogenetic Map	8	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001034150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015177 ⟹ ENSRNOP00000015177

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	41,818,229 - 41,824,280 (+)	Ensembl
mRatBN7.2 Ensembl	8	33,560,348 - 33,566,470 (+)	Ensembl
Rnor_6.0 Ensembl	8	36,410,683 - 36,416,296 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113037 ⟹ ENSRNOP00000087621

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	33,560,395 - 33,566,450 (+)	Ensembl

RefSeq Acc Id:

NM_001034150 ⟹ NP_001029322

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	41,818,199 - 41,824,292 (+)	NCBI
mRatBN7.2	8	33,560,365 - 33,566,458 (+)	NCBI
Rnor_6.0	8	36,410,683 - 36,416,766 (+)	NCBI
Rnor_5.0	8	36,428,866 - 36,434,949 (+)	NCBI
RGSC_v3.4	8	34,992,187 - 34,998,270 (+)	RGD
Celera	8	34,979,915 - 34,986,044 (+)	RGD

Sequence:

show sequence

GGGGGCTGCTGGTGTGACGTGTCCCGCGCTTGGCGCAGCAGGAAGCGGCGGCGGACGCGGCCCG
AGTTCCCGGCGCCGGTCTCGGCCCCAAGTCTTCTCCCGCTTCCATCATGCTTGACTTCTTCACC
ATCTTCTCGAAGGGCGGGCTTGTGCTCTGGTGTTTCCAGGGCGTGAGCGACTCGTGCACCGGGC
CCGTGAACGCGTTGATTCGTTCTGTACTGCTGCAGGAACGGGGAGGTAACAACTCTTTCACTCA
TGAGGCTCTCACACTCAAGTATAAACTGGACAACCAGTTTGAACTGGTGTTTGTGGTTGGCTTT
CAGAAGATCCTCACACTGACCTATGTAGACAAATTGATAGATGATGTGCACCGGCTGTTCCGGG
ATAAGTACCGCACAGAGATCCAACAACAGAGTGCTTTAAGTTTATTGAATGGCACTTTTGATTT
CCAAAATGACTTCCTGCGGCTCCTTCGTGAAGCAGAGGAGAGCAGTAAGATCCGTGCTCCCACT
ACCATGAAGAAATTTGAAGATTCTGAAAAAGCTAAGAAACCTGTGAGATCCATGATTGAAACAC
GGGGGGAAAAGACCAAGGAAAAAGCAAAAAACAACAAAAAAAAGGGGTCCAAAAAGGAAGGTTC
TGATGGCCCTTTGGCTACCAGCAAAACAGCCCCTGCAGAAAAGTCAGGTCTCCCAGTGGGACCT
GAGAATGGGGAACTTTCCAAAGAGGAGCTGATACGTAGGAAGAGAGAGGAGTTCATTCAGAAGC
ATGGGAAGGGCCTGGACAAATCCAGTAAATCTACAAAGTCAGATATTCCAAAGGAGAAAGGCAA
AAAAGCACCCCGGGTGTGGGAACTAGGTGGCTGTGCTAACAAGGAAGTCTTGGATTACAGTACT
CCCACCACCAATGGAACTCCAGAGGCAGCCCTTTCTGAAGATATCAACTTGATTCGAGGAACTG
GGCCTGGGGGACAGCTTCAAGATCTGGATTGCAGCAGTTCAGATGATGAAGGGGCCACTCAAAA
CACCAAACCTAGTGCTACCAAGGGAACTCTGGGTGGCATGTTTGGGATGCTGAAGGGTCTGGTG
GGTTCCAAGAGCTTGAGTCGAGAAGACATGGAATCTGTGCTAGACAAGATGCGTGATCATCTCA
TTGCTAAGAATGTGGCTGCTGACATTGCTGTCCAGCTCTGTGAATCTGTTGCCAACAAGTTAGA
AGGCAAAGTGATGGGGACATTTAGCACTGTGACTTCAACAGTGAAGCAAGCTCTACAAGAGTCT
CTGGTGCAGATCCTGCAGCCACAGCGTCGAGTAGACATGCTCCGGGATATCATGGATGCCCAAC
GTCGCCAGCGCCCTTACGTAGTTACCTTCTGTGGTGTTAATGGAGTGGGGAAGTCTACTAATCT
TGCCAAGATCTCCTTCTGGCTTTTAGAGAATGGCTTTAGCGTCCTCATTGCTGCCTGCGATACA
TTTCGTGCTGGGGCTGTTGAGCAGCTCCGCACACACACCCGGCGCCTGACTGCCCTTCATCCCC
CGGAGAAGCATGGTGGCCGAACGATGGTGCAGTTGTTTGAAAAAGGCTATGGCAAGGACGCTGC
TGGCATTGCCATGGAAGCCATTGCCTTTGCACGTAACCAAGGCTTTGACGTGGTGCTGGTGGAC
ACTGCTGGCCGCATGCAAGACAATGCTCCTCTGATGACTGCCCTGGCCAAACTCATTACTGTCA
ATACACCTGACTTGGTGCTGTTTGTGGGGGAGGCCTTAGTAGGCAATGAAGCTGTGGATCAACT
GGTCAAGTTCAACAGAGCCTTAGCTGACCATTCTATGGCTCAGACACCTCGGCTCATTGATGGC
ATTGTTCTAACCAAATTTGACACCATTGATGACAAGGTGGGAGCTGCTATTTCTATGACATACA
TCACAAGCAAACCCATCGTCTTTGTGGGTACTGGCCAGACCTACTGTGACCTACGCAGTCTCAA
TGCCAAGGCTGTGGTGGCTGCCCTCATGAAGGCTTAATGTGGCTCTTGCCTAATACCAAATCGC
CGCTTGCCCAAGTCCCTATTCCTGTATCAAGAATGTGCTTTAGAGTATGTGAGCAACTTGTCTT
CAGTGTAGTACAAAGGCAGAGTGAGGGGAGCTTTGGAGACTTGCAGCTCCTTCTAACCCAACCC
TTTGTTCACCCCTACCTCCTGCAAGGAGGGTCTAATCATGTTACAATCACTGCCCAGTGACCTT
CCCTCTTCCTACTCAGGCATCCCCTTCACTCTGCCTACAGACTCCATCCATATCATAGCTTTGA
CCAGTGGTTGAGGAACCCTGTACCTAGAGTGTTGCTAACTAGTGTTGCAGAGCCATGGTGAGAT
AAGGAGCAGTTTGAGGTCCCAGCTCTAATGAGTTACTTCTGGAGCCAGCTCTGGATCTTAGTGG
CACCTATCTAGAATACAGCTTCTGGGTCCCTGGTGCCAGGATGGGTCACCTCACTGTGGCAGTG
ATGGTGGCCCATTCTTAATTGCTGCTAATTATAAATCTGGTGATGAAAACTCCACACCTGATTG
TTGCCCCAAAGCATCAGTTAGGCCTTGTTACAAATGCGAGGTAAGTGCCCACTTCTCTCAGAAA
CAAAGGGAGCAGAGTTGCCTTCCAACCTGTCCCTGCTCCCAAAATCCAGATGGAAGCTTTGCAT
GTTTGCCTTCCTGGGAGAAAACCAGTTGTTAGAAGTGTTACTGTCCATATCCCACCCAACCCAA
CCCTTAAGCTCCTGAGCAGGTCCTGGCTTTTCCTCATTCTCTTCTACAGTGCCTGGTAGACAAG
TGCTACGTTCAAGAACACAAACCTCTTGTTAAGACTTGTCCTGTAGTTTGGTATTACAGATGTG
CTACTAGTGCAATAAGGTGAAGGCTGTCTGCCCAGAGAAATACATAATTTATATAAGAAAATAA
ATTTCATAAAGAAATTGCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001029322	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05783	(Get FASTA)	NCBI Sequence Viewer
	EDL83276	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015177
	ENSRNOP00000015177.6

RefSeq Acc Id:

NP_001029322 ⟸ NM_001034150

- UniProtKB:

Q3KRC3 (UniProtKB/TrEMBL), A6JYJ9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFEL
VFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESS
KIRAPTTMKKFEDSEKAKKPVRSMIETRGEKTKEKAKNNKKKGSKKEGSDGPLATSKTAPAEKS
GLPVGPENGELSKEELIRRKREEFIQKHGKGLDKSSKSTKSDIPKEKGKKAPRVWELGGCANKE
VLDYSTPTTNGTPEAALSEDINLIRGTGPGGQLQDLDCSSSDDEGATQNTKPSATKGTLGGMFG
MLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVK
QALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVL
IAACDTFRAGAVEQLRTHTRRLTALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGF
DVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQT
PRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA

hide sequence

Ensembl Acc Id:

ENSRNOP00000015177 ⟸ ENSRNOT00000015177

Ensembl Acc Id:

ENSRNOP00000087621 ⟸ ENSRNOT00000113037

Protein Domains

SRP54-type proteins GTP-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3KRC3-F1-model_v2	AlphaFold	Q3KRC3	1-636	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695836

Promoter ID:

EPDNEW_R6361

Type:

initiation region

Name:

Srpra_1

Description:

SRP receptor alpha subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	36,410,708 - 36,410,768	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311504	AgrOrtholog
BioCyc Gene	G2FUF-31178	BioCyc
Ensembl Genes	ENSRNOG00000010543	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015177	ENTREZGENE
	ENSRNOT00000015177.8	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.140	UniProtKB/TrEMBL
	3.30.450.60	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599400	IMAGE-MGC_LOAD
InterPro	ATPase_AAA+_core	UniProtKB/TrEMBL
	Longin-like	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Sig_recog_particle_rcpt_asu_N	UniProtKB/TrEMBL
	Signal_recog_part_SRP54_GTPase	UniProtKB/TrEMBL
	Signal_recog_particl_SRP54_hlx	UniProtKB/TrEMBL
	SRP/SRP_N_dom	UniProtKB/TrEMBL
	SRP54_N_sf	UniProtKB/TrEMBL
KEGG Report	rno:315548	UniProtKB/TrEMBL
MGC_CLONE	MGC:124867	IMAGE-MGC_LOAD
NCBI Gene	315548	ENTREZGENE
PANTHER	SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA	UniProtKB/TrEMBL
	SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA	UniProtKB/TrEMBL
Pfam	SRP-alpha_N	UniProtKB/TrEMBL
	SRP54	UniProtKB/TrEMBL
	SRP54_N	UniProtKB/TrEMBL
PhenoGen	Srpra	PhenoGen
PROSITE	SRP54	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010543	RatGTEx
SMART	AAA	UniProtKB/TrEMBL
	SRP54	UniProtKB/TrEMBL
	SRP54_N	UniProtKB/TrEMBL
Superfamily-SCOP	Longin_like	UniProtKB/TrEMBL
	SRP54	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A6JYJ9	ENTREZGENE, UniProtKB/TrEMBL
	Q3KRC3	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F7F875	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-04	Srpra	SRP receptor subunit alpha	Srpra	SRP receptor alpha subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-25	Srpra	SRP receptor alpha subunit	Srpr	signal recognition particle receptor ('docking protein')	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Srpr	signal recognition particle receptor ('docking protein')	Srpr_predicted	signal recognition particle receptor ('docking protein') (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Srpr_predicted	signal recognition particle receptor ('docking protein') (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar