KCNK7 (potassium two pore domain channel subfamily K member 7) - Rat Genome Database

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Gene: KCNK7 (potassium two pore domain channel subfamily K member 7) Homo sapiens
Analyze
Symbol: KCNK7
Name: potassium two pore domain channel subfamily K member 7
RGD ID: 1604643
HGNC Page HGNC:6282
Description: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: K2p7.1; MGC118782; MGC118784; potassium channel subfamily K member 7; potassium channel, subfamily K, member 7; potassium channel, subfamily K, member 7, isoform B; potassium channel, two pore domain subfamily K, member 7; TWIK3; two pore domain K+ channel
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,592,836 - 65,595,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,592,836 - 65,595,996 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,360,307 - 65,363,271 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,116,902 - 65,120,043 (-)NCBINCBI36Build 36hg18NCBI36
Celera1162,687,036 - 62,690,177 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,687,292 - 61,690,433 (-)NCBIHuRef
CHM1_11165,244,223 - 65,247,364 (-)NCBICHM1_1
T2T-CHM13v2.01165,587,069 - 65,590,033 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10206991   PMID:11165377   PMID:11256078   PMID:12477932   PMID:16382106   PMID:21873635   PMID:24927181   PMID:29507755   PMID:32296183   PMID:33961781  


Genomics

Comparative Map Data
KCNK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,592,836 - 65,595,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,592,836 - 65,595,996 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,360,307 - 65,363,271 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,116,902 - 65,120,043 (-)NCBINCBI36Build 36hg18NCBI36
Celera1162,687,036 - 62,690,177 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,687,292 - 61,690,433 (-)NCBIHuRef
CHM1_11165,244,223 - 65,247,364 (-)NCBICHM1_1
T2T-CHM13v2.01165,587,069 - 65,590,033 (-)NCBIT2T-CHM13v2.0
Kcnk7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,754,471 - 5,757,956 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,754,395 - 5,757,137 (+)EnsemblGRCm39 Ensembl
GRCm38195,704,471 - 5,707,984 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,704,367 - 5,707,109 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,704,476 - 5,707,101 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,704,476 - 5,707,101 (+)NCBIMGSCv36mm8
Celera195,574,527 - 5,577,151 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Kcnk7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,419,555 - 212,422,173 (+)NCBIGRCr8
mRatBN7.21202,988,801 - 202,992,842 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,990,198 - 202,992,872 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01221,056,477 - 221,060,607 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,057,713 - 221,060,747 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,991,803 - 227,995,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,327,893 - 208,330,476 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1200,524,457 - 200,528,587 (+)NCBICelera
Cytogenetic Map1q43NCBI
Kcnk7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,666,974 - 19,670,449 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,666,974 - 19,670,449 (+)NCBIChiLan1.0ChiLan1.0
KCNK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,822,501 - 66,827,369 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,865,262 - 67,870,121 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,951,961 - 60,955,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,286,502 - 64,289,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,286,502 - 64,289,662 (-)Ensemblpanpan1.1panPan2
KCNK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,609,373 - 51,613,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,610,746 - 51,613,675 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,217,779 - 50,222,188 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,646,545 - 52,650,954 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,647,896 - 52,650,826 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,746,437 - 51,750,846 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,320,479 - 51,324,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,110,874 - 52,115,286 (+)NCBIUU_Cfam_GSD_1.0
Kcnk7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,421,720 - 7,424,649 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,864,097 - 3,866,994 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,864,110 - 3,866,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,659,054 - 6,662,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,657,841 - 6,662,445 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,881,587 - 5,887,312 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,644,038 - 8,648,132 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,645,231 - 8,647,963 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,938,769 - 105,942,856 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,796,809 - 20,799,915 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,796,733 - 20,799,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNK7
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002419.3(MAP3K11):c.2047C>T (p.Pro683Ser) single nucleotide variant Malignant melanoma [RCV000062327] Chr11:65599553 [GRCh38]
Chr11:65367024 [GRCh37]
Chr11:65123600 [NCBI36]
Chr11:11q13.1		 not provided
GRCh38/hg38 11q13.1(chr11:65520831-65695349)x3 copy number gain See cases [RCV000141174] Chr11:65520831..65695349 [GRCh38]
Chr11:65288302..65462820 [GRCh37]
Chr11:65044878..65219396 [NCBI36]
Chr11:11q13.1		 uncertain significance
GRCh38/hg38 11q13.1(chr11:65327786-65626431)x3 copy number gain See cases [RCV000141334] Chr11:65327786..65626431 [GRCh38]
Chr11:65095257..65393902 [GRCh37]
Chr11:64851833..65150478 [NCBI36]
Chr11:11q13.1		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:65138976-67574402) copy number gain not provided [RCV000767601] Chr11:65138976..67574402 [GRCh37]
Chr11:11q13.1-13.2		 pathogenic
NM_033347.2(KCNK7):c.359C>T (p.Ala120Val) single nucleotide variant Inborn genetic diseases [RCV003261192] Chr11:65593835 [GRCh38]
Chr11:65361306 [GRCh37]
Chr11:11q13.1		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.1(chr11:65348529-65361309)x3 copy number gain not provided [RCV000737553] Chr11:65348529..65361309 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65349504-65363063)x1 copy number loss not provided [RCV000737554] Chr11:65349504..65363063 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65351019-65362975)x4 copy number gain not provided [RCV000737555] Chr11:65351019..65362975 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65351159-65361309)x4 copy number gain not provided [RCV000737556] Chr11:65351159..65361309 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65351159-65362975)x4 copy number gain not provided [RCV000737557] Chr11:65351159..65362975 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65351779-65361309)x4 copy number gain not provided [RCV000737558] Chr11:65351779..65361309 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65144318-65373538)x3 copy number gain not provided [RCV000750081] Chr11:65144318..65373538 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65338400-65361765)x3 copy number gain not provided [RCV000750083] Chr11:65338400..65361765 [GRCh37]
Chr11:11q13.1		 benign
GRCh37/hg19 11q13.1(chr11:65347930-65421892)x3 copy number gain not provided [RCV000750084] Chr11:65347930..65421892 [GRCh37]
Chr11:11q13.1		 benign
NM_033347.2(KCNK7):c.356A>G (p.Lys119Arg) single nucleotide variant not provided [RCV000947354] Chr11:65593838 [GRCh38]
Chr11:65361309 [GRCh37]
Chr11:11q13.1		 benign
NM_033347.2(KCNK7):c.327C>T (p.Gly109=) single nucleotide variant not provided [RCV000947355] Chr11:65593867 [GRCh38]
Chr11:65361338 [GRCh37]
Chr11:11q13.1		 benign
dup(11)(q13.1q13.1) duplication Ependymoma [RCV000785872] Chr11:63533279..65429676 [GRCh37]
Chr11:11q13.1		 likely pathogenic
NC_000011.9:g.(?_64973914)_(70052579_?)dup duplication Aicardi-Goutieres syndrome 3 [RCV003113322]|FADD-related immunodeficiency [RCV003107753] Chr11:64973914..70052579 [GRCh37]
Chr11:11q13.1-13.3		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
NC_000011.9:g.(?_64522783)_(66283694_?)del deletion Bardet-Biedl syndrome [RCV002014493]|Glycogen storage disease, type V [RCV002004587] Chr11:64522783..66283694 [GRCh37]
Chr11:11q13.1-13.2		 pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:64935724-66405514) copy number loss not specified [RCV002052930] Chr11:64935724..66405514 [GRCh37]
Chr11:11q13.1-13.2		 uncertain significance
NC_000011.9:g.(?_65325080)_(65639825_?)del deletion Aicardi-Goutieres syndrome 3 [RCV003119977]|not provided [RCV003109848] Chr11:65325080..65639825 [GRCh37]
Chr11:11q13.1		 pathogenic|uncertain significance|no classifications from unflagged records
NM_033347.2(KCNK7):c.764C>T (p.Thr255Ile) single nucleotide variant Inborn genetic diseases [RCV002821361] Chr11:65593165 [GRCh38]
Chr11:65360636 [GRCh37]
Chr11:11q13.1		 uncertain significance
NM_033347.2(KCNK7):c.794T>A (p.Met265Lys) single nucleotide variant Inborn genetic diseases [RCV002981478] Chr11:65593135 [GRCh38]
Chr11:65360606 [GRCh37]
Chr11:11q13.1		 uncertain significance
NM_033347.2(KCNK7):c.455G>A (p.Arg152His) single nucleotide variant Inborn genetic diseases [RCV002661401] Chr11:65593739 [GRCh38]
Chr11:65361210 [GRCh37]
Chr11:11q13.1		 uncertain significance
NM_033347.2(KCNK7):c.709G>T (p.Ala237Ser) single nucleotide variant Inborn genetic diseases [RCV002665980] Chr11:65593485 [GRCh38]
Chr11:65360956 [GRCh37]
Chr11:11q13.1		 uncertain significance
NM_033347.2(KCNK7):c.349G>A (p.Gly117Ser) single nucleotide variant Inborn genetic diseases [RCV002855532] Chr11:65593845 [GRCh38]
Chr11:65361316 [GRCh37]
Chr11:11q13.1		 uncertain significance
NM_033347.2(KCNK7):c.664C>T (p.Arg222Cys) single nucleotide variant Inborn genetic diseases [RCV003357672] Chr11:65593530 [GRCh38]
Chr11:65361001 [GRCh37]
Chr11:11q13.1		 uncertain significance
NM_033347.2(KCNK7):c.143C>A (p.Ala48Glu) single nucleotide variant Inborn genetic diseases [RCV003347409] Chr11:65595630 [GRCh38]
Chr11:65363101 [GRCh37]
Chr11:11q13.1		 uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3 copy number gain not specified [RCV003986944] Chr11:56895955..69295402 [GRCh37]
Chr11:11q12.1-13.3		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2097
Count of miRNA genes:559
Interacting mature miRNAs:645
Transcripts:ENST00000340313, ENST00000342202, ENST00000394216, ENST00000394217, ENST00000525254, ENST00000530380
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-R80779  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,365,235 - 65,365,374UniSTSGRCh37
Build 361165,121,811 - 65,121,950RGDNCBI36
Celera1162,691,951 - 62,692,090RGD
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q13.1-q13.3UniSTS
HuRef1161,692,207 - 61,692,346UniSTS
GeneMap99-GB4 RH Map11239.7UniSTS
KCNK7_346  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,360,097 - 65,360,955UniSTSGRCh37
Build 361165,116,673 - 65,117,531RGDNCBI36
Celera1162,686,807 - 62,687,665RGD
HuRef1161,687,063 - 61,687,921UniSTS
D17S2241  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371775,027,322 - 75,027,579UniSTSGRCh37
Build 361772,538,917 - 72,539,174RGDNCBI36
Celera1771,621,659 - 71,621,924RGD
Cytogenetic Map11q13UniSTS
HuRef1161,690,384 - 61,691,829UniSTS
HuRef1770,454,876 - 70,455,141UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 3 25 9 27 1300 1 4 2 78 3 9 2 692
Low 2171 2465 1063 208 1451 126 2842 1824 3486 193 1297 1364 97 1184 2013 4
Below cutoff 255 491 649 395 323 329 208 366 223 209 71 236 66 18 83 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000340313   ⟹   ENSP00000344820
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,592,836 - 65,595,800 (-)Ensembl
RefSeq Acc Id: ENST00000342202   ⟹   ENSP00000343923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,592,855 - 65,595,808 (-)Ensembl
RefSeq Acc Id: ENST00000394216   ⟹   ENSP00000377764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,592,855 - 65,595,996 (-)Ensembl
RefSeq Acc Id: ENST00000394217   ⟹   ENSP00000377765
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,592,855 - 65,595,996 (-)Ensembl
RefSeq Acc Id: ENST00000525254   ⟹   ENSP00000435449
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,592,869 - 65,593,519 (-)Ensembl
RefSeq Acc Id: ENST00000530380   ⟹   ENSP00000431950
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1165,592,866 - 65,593,501 (-)Ensembl
RefSeq Acc Id: NM_005714   ⟹   NP_005705
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,592,836 - 65,595,800 (-)NCBI
GRCh371165,360,326 - 65,363,467 (-)RGD
Build 361165,116,902 - 65,120,043 (-)NCBI Archive
Celera1162,687,036 - 62,690,177 (-)RGD
HuRef1161,687,292 - 61,690,433 (-)ENTREZGENE
CHM1_11165,244,223 - 65,247,364 (-)NCBI
T2T-CHM13v2.01165,587,069 - 65,590,033 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033347   ⟹   NP_203133
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,592,836 - 65,595,800 (-)NCBI
GRCh371165,360,326 - 65,363,467 (-)RGD
Build 361165,116,902 - 65,120,043 (-)NCBI Archive
Celera1162,687,036 - 62,690,177 (-)RGD
HuRef1161,687,292 - 61,690,433 (-)ENTREZGENE
CHM1_11165,244,223 - 65,247,364 (-)NCBI
T2T-CHM13v2.01165,587,069 - 65,590,033 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033348   ⟹   NP_203134
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,592,836 - 65,595,800 (-)NCBI
GRCh371165,360,326 - 65,363,467 (-)RGD
Build 361165,116,902 - 65,120,043 (-)NCBI Archive
Celera1162,687,036 - 62,690,177 (-)RGD
HuRef1161,687,292 - 61,690,433 (-)ENTREZGENE
CHM1_11165,244,223 - 65,247,364 (-)NCBI
T2T-CHM13v2.01165,587,069 - 65,590,033 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033455   ⟹   NP_258416
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,592,836 - 65,595,800 (-)NCBI
GRCh371165,360,326 - 65,363,467 (-)RGD
Build 361165,116,902 - 65,120,043 (-)NCBI Archive
Celera1162,687,036 - 62,690,177 (-)RGD
HuRef1161,687,292 - 61,690,433 (-)ENTREZGENE
CHM1_11165,244,223 - 65,247,364 (-)NCBI
T2T-CHM13v2.01165,587,069 - 65,590,033 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_203133   ⟸   NM_033347
- Peptide Label: isoform A precursor
- UniProtKB: Q9Y2U3 (UniProtKB/Swiss-Prot),   Q3SYI2 (UniProtKB/Swiss-Prot),   Q9Y2U4 (UniProtKB/Swiss-Prot),   Q9Y2U2 (UniProtKB/Swiss-Prot),   Q3MI97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_203134   ⟸   NM_033348
- Peptide Label: isoform B precursor
- UniProtKB: Q3SYI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_258416   ⟸   NM_033455
- Peptide Label: isoform B precursor
- UniProtKB: Q3SYI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_005705   ⟸   NM_005714
- Peptide Label: isoform C precursor
- UniProtKB: Q3SYI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000431950   ⟸   ENST00000530380
RefSeq Acc Id: ENSP00000435449   ⟸   ENST00000525254
RefSeq Acc Id: ENSP00000344820   ⟸   ENST00000340313
RefSeq Acc Id: ENSP00000377765   ⟸   ENST00000394217
RefSeq Acc Id: ENSP00000377764   ⟸   ENST00000394216
RefSeq Acc Id: ENSP00000343923   ⟸   ENST00000342202
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y2U2-F1-model_v2 AlphaFold Q9Y2U2 1-307 view protein structure

Promoters
RGD ID:6810031
Promoter ID:HG_ACW:12649
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:KCNK7.FAPR07,   KCNK7.GAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,117,701 - 65,118,201 (-)MPROMDB
RGD ID:6789029
Promoter ID:HG_KWN:13342
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:NM_005714,   NM_033347,   NM_033348,   NM_033455
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,119,521 - 65,120,867 (-)MPROMDB
RGD ID:7221031
Promoter ID:EPDNEW_H16262
Type:initiation region
Name:KCNK7_2
Description:potassium two pore domain channel subfamily K member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16263  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,595,799 - 65,595,859EPDNEW
RGD ID:7221037
Promoter ID:EPDNEW_H16263
Type:single initiation site
Name:KCNK7_1
Description:potassium two pore domain channel subfamily K member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16262  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,596,143 - 65,596,203EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6282 AgrOrtholog
COSMIC KCNK7 COSMIC
Ensembl Genes ENSG00000173338 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000340313 ENTREZGENE
  ENST00000340313.5 UniProtKB/Swiss-Prot
  ENST00000342202 ENTREZGENE
  ENST00000342202.8 UniProtKB/Swiss-Prot
  ENST00000394216 ENTREZGENE
  ENST00000394216.6 UniProtKB/Swiss-Prot
  ENST00000394217 ENTREZGENE
  ENST00000394217.6 UniProtKB/Swiss-Prot
  ENST00000525254.1 UniProtKB/TrEMBL
  ENST00000530380.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000173338 GTEx
HGNC ID HGNC:6282 ENTREZGENE
Human Proteome Map KCNK7 Human Proteome Map
InterPro 2pore_dom_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2pore_dom_K_chnl_TWIK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10089 UniProtKB/Swiss-Prot
NCBI Gene 10089 ENTREZGENE
OMIM 603940 OMIM
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30064 PharmGKB
PIRSF K_channel_subfamily_K_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TWIKCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H0YCM4_HUMAN UniProtKB/TrEMBL
  H0YEB9_HUMAN UniProtKB/TrEMBL
  KCNK7_HUMAN UniProtKB/Swiss-Prot
  Q3MI97 ENTREZGENE, UniProtKB/TrEMBL
  Q3SYI1 ENTREZGENE, UniProtKB/TrEMBL
  Q3SYI2 ENTREZGENE
  Q9Y2U2 ENTREZGENE
  Q9Y2U3 ENTREZGENE
  Q9Y2U4 ENTREZGENE
UniProt Secondary Q3SYI2 UniProtKB/Swiss-Prot
  Q9Y2U3 UniProtKB/Swiss-Prot
  Q9Y2U4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 KCNK7  potassium two pore domain channel subfamily K member 7  KCNK7  potassium channel, two pore domain subfamily K, member 7  Symbol and/or name change 5135510 APPROVED
2015-01-20 KCNK7  potassium channel, two pore domain subfamily K, member 7  KCNK7  potassium channel, subfamily K, member 7  Symbol and/or name change 5135510 APPROVED