Ppcs (phosphopantothenoylcysteine synthetase) - Rat Genome Database

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Gene: Ppcs (phosphopantothenoylcysteine synthetase) Rattus norvegicus
Analyze
Symbol: Ppcs
Name: phosphopantothenoylcysteine synthetase
RGD ID: 1311399
Description: Predicted to enable phosphopantothenate--cysteine ligase activity and protein homodimerization activity. Predicted to be involved in acetyl-CoA biosynthetic process; coenzyme A biosynthetic process; and heart process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2C. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase); PARTICIPATES IN pantothenic acid metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC298490; MGC116383; phosphopantothenate--cysteine ligase; RGD1311399; similar to RIKEN cDNA 6330579B17 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,308,394 - 138,312,047 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5138,308,397 - 138,312,012 (-)EnsemblGRCr8
mRatBN7.25133,023,077 - 133,026,899 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,023,121 - 133,026,933 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5135,751,606 - 135,755,020 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,508,062 - 137,511,476 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,528,672 - 137,532,086 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,466,298 - 138,470,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,466,293 - 138,470,096 (-)Ensemblrn6Rnor6.0
Rnor_5.05142,276,595 - 142,279,846 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45140,008,434 - 140,012,295 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5131,547,070 - 131,550,484 (-)NCBICelera
RGSC_v3.15140,013,626 - 140,017,910 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
endosulfan  (EXP)
fenofibrate  (EXP)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
Muraglitazar  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phorone  (EXP)
pirinixic acid  (EXP,ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:11923312   PMID:12477932   PMID:23376485   PMID:29754768  


Genomics

Comparative Map Data
Ppcs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,308,394 - 138,312,047 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5138,308,397 - 138,312,012 (-)EnsemblGRCr8
mRatBN7.25133,023,077 - 133,026,899 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,023,121 - 133,026,933 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5135,751,606 - 135,755,020 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,508,062 - 137,511,476 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,528,672 - 137,532,086 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,466,298 - 138,470,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,466,293 - 138,470,096 (-)Ensemblrn6Rnor6.0
Rnor_5.05142,276,595 - 142,279,846 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45140,008,434 - 140,012,295 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5131,547,070 - 131,550,484 (-)NCBICelera
RGSC_v3.15140,013,626 - 140,017,910 (-)NCBI
Cytogenetic Map5q36NCBI
PPCS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,456,341 - 42,473,417 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,456,117 - 42,473,385 (+)Ensemblhg38GRCh38
GRCh37142,922,012 - 42,939,088 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,694,760 - 42,698,673 (+)NCBIBuild 36Build 36hg18NCBI36
Celera141,204,112 - 41,208,024 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,042,280 - 41,046,192 (+)NCBIHuRef
CHM1_1143,039,012 - 43,042,924 (+)NCBICHM1_1
T2T-CHM13v2.0142,326,703 - 42,343,779 (+)NCBIT2T-CHM13v2.0
Ppcs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,275,724 - 119,279,673 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,275,727 - 119,279,617 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384119,418,527 - 119,422,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,418,530 - 119,422,420 (-)Ensemblmm10GRCm38
MGSCv374119,091,138 - 119,095,025 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364118,916,465 - 118,920,352 (-)NCBIMGSCv36mm8
Celera4118,149,698 - 118,153,626 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.38NCBI
Ppcs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,080,865 - 2,085,003 (+)Ensembl
ChiLan1.0NW_0049555372,080,865 - 2,084,199 (+)NCBIChiLan1.0ChiLan1.0
PPCS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,338,463 - 184,355,237 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,480,108 - 183,497,012 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,756,403 - 41,773,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,136,337 - 43,153,583 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,136,720 - 43,140,620 (+)EnsemblpanPan2panpan1.1
PPCS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115813,435 - 817,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15813,870 - 816,825 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha151,068,253 - 1,071,661 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.015895,016 - 898,424 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15895,030 - 898,423 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115804,254 - 807,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015865,779 - 869,187 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015880,894 - 884,302 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppcs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,042,297 - 58,046,179 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,867,347 - 23,871,223 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,867,117 - 23,870,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPCS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6168,870,869 - 168,876,779 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16168,833,945 - 168,876,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26156,392,581 - 156,397,630 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPCS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2090,467,656 - 90,473,704 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603326,435,491 - 26,452,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppcs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248921,791,255 - 1,795,250 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248921,791,254 - 1,794,866 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppcs
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1137,539,810 - 37,543,724 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppcs
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:183
Interacting mature miRNAs:212
Transcripts:ENSRNOT00000011392
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH128446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25133,023,188 - 133,023,403 (+)MAPPERmRatBN7.2
Rnor_6.05138,466,380 - 138,466,594NCBIRnor6.0
Rnor_5.05142,276,672 - 142,276,886UniSTSRnor5.0
RGSC_v3.45140,008,513 - 140,008,727UniSTSRGSC3.4
Celera5131,547,147 - 131,547,361UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011392   ⟹   ENSRNOP00000011392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5138,308,397 - 138,312,012 (-)Ensembl
mRatBN7.2 Ensembl5133,023,121 - 133,026,933 (-)Ensembl
Rnor_6.0 Ensembl5138,466,293 - 138,470,096 (-)Ensembl
RefSeq Acc Id: NM_001039010   ⟹   NP_001034099
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85138,308,397 - 138,311,813 (-)NCBI
mRatBN7.25133,023,112 - 133,026,528 (-)NCBI
Rnor_6.05138,466,303 - 138,469,734 (-)NCBI
Rnor_5.05142,276,595 - 142,279,846 (-)NCBI
RGSC_v3.45140,008,434 - 140,012,295 (-)RGD
Celera5131,547,070 - 131,550,484 (-)RGD
Sequence:
RefSeq Acc Id: XM_008763998   ⟹   XP_008762220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85138,308,394 - 138,312,047 (-)NCBI
mRatBN7.25133,023,109 - 133,026,899 (-)NCBI
Rnor_6.05138,466,298 - 138,470,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763999   ⟹   XP_008762221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85138,308,394 - 138,311,881 (-)NCBI
mRatBN7.25133,023,077 - 133,026,597 (-)NCBI
Rnor_6.05138,466,298 - 138,469,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063287431   ⟹   XP_063143501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85138,308,394 - 138,311,143 (-)NCBI
RefSeq Acc Id: NP_001034099   ⟸   NM_001039010
- UniProtKB: D4A6X7 (UniProtKB/TrEMBL),   A6JZP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762220   ⟸   XM_008763998
- Peptide Label: isoform X1
- UniProtKB: A6JZP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762221   ⟸   XM_008763999
- Peptide Label: isoform X1
- UniProtKB: A6JZP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011392   ⟸   ENSRNOT00000011392
RefSeq Acc Id: XP_063143501   ⟸   XM_063287431
- Peptide Label: isoform X2
Protein Domains
DNA/pantothenate metabolism flavoprotein C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6X7-F1-model_v2 AlphaFold D4A6X7 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693981
Promoter ID:EPDNEW_R4506
Type:single initiation site
Name:Ppcs_1
Description:phosphopantothenoylcysteine synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05138,470,099 - 138,470,159EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311399 AgrOrtholog
BioCyc Gene G2FUF-40087 BioCyc
BioCyc Pathway PWY-7850 [taurine biosynthesis II] BioCyc
  PWY-7851 [coenzyme A biosynthesis II (eukaryotic)] BioCyc
BioCyc Pathway Image PWY-7850 BioCyc
  PWY-7851 BioCyc
Ensembl Genes ENSRNOG00000008572 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011392 ENTREZGENE
  ENSRNOT00000011392.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384489 IMAGE-MGC_LOAD
InterPro CoaB-like_sf UniProtKB/TrEMBL
  DNA/pantothenate-metab_flavo_C UniProtKB/TrEMBL
KEGG Report rno:298490 UniProtKB/TrEMBL
MGC_CLONE MGC:116383 IMAGE-MGC_LOAD
NCBI Gene 298490 ENTREZGENE
PANTHER CORNICHON-RELATED UniProtKB/TrEMBL
Pfam DFP UniProtKB/TrEMBL
PhenoGen Ppcs PhenoGen
RatGTEx ENSRNOG00000008572 RatGTEx
Superfamily-SCOP DNA/pantothenate-metab_flavo_C UniProtKB/TrEMBL
UniProt A6JZP0 ENTREZGENE, UniProtKB/TrEMBL
  A6JZP1 ENTREZGENE, UniProtKB/TrEMBL
  D4A6X7 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLH2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ppcs  phosphopantothenoylcysteine synthetase  RGD1311399  similar to RIKEN cDNA 6330579B17 gene  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1311399  similar to RIKEN cDNA 6330579B17 gene  RGD1311399_predicted  similar to RIKEN cDNA 6330579B17 gene (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311399_predicted  similar to RIKEN cDNA 6330579B17 gene (predicted)  LOC298490_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC298490_predicted  similar to RIKEN cDNA 6330579B17 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL