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Gene: Npepl1 (aminopeptidase-like 1) Rattus norvegicus

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Symbol:

Npepl1

Name:

aminopeptidase-like 1

RGD ID:

1311351

Description:

Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Orthologous to human NPEPL1 (aminopeptidase like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC311671; probable aminopeptidase NPEPL1

RGD Orthologs

Human

Mouse

Black Rat

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NPEPL1 (aminopeptidase like 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Npepl1 (aminopeptidase-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Npepl1 (aminopeptidase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NPEPL1 (aminopeptidase like 1)	HGNC	EggNOG
Alliance orthologs ³
Homo sapiens (human):	NPEPL1 (aminopeptidase like 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Npepl1 (aminopeptidase-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Npepl1 (aminopeptidase-like 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npepl1 (aminopeptidase like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npepl1 (aminopeptidase like 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lap-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lap-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	grsm	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	grsm	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	npepl1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	183,312,185 - 183,324,744 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	183,312,185 - 183,324,744 (+)	Ensembl				GRCr8
mRatBN7.2	3	162,893,932 - 162,906,491 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	162,893,943 - 162,906,492 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	166,692,981 - 166,705,540 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	175,190,900 - 175,203,415 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	172,933,822 - 172,946,381 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	172,195,115 - 172,207,685 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	172,195,844 - 172,207,685 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	178,246,844 - 178,259,415 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	165,035,886 - 165,047,727 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	162,070,042 - 162,081,886 (+)	NCBI		Celera
RGSC_v3.1	3	164,941,225 - 164,953,762 (+)	NCBI
Cytogenetic Map	3	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

actinomycin D (ISO)

Aflatoxin B2 alpha (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

avobenzone (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

dibutyl phthalate (EXP)

disulfiram (ISO)

elemental selenium (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

hexane (EXP)

ivermectin (ISO)

lead diacetate (ISO)

lithium chloride (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

nefazodone (EXP)

nimesulide (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

ozone (ISO)

perfluorooctane-1-sulfonic acid (ISO)

picoxystrobin (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

Soman (EXP)

temozolomide (ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

uranium atom (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IBA,IEA)

Cellular Component

cytoplasm (IBA,IEA)

Molecular Function

aminopeptidase activity (IEA)

hydrolase activity (IEA)

manganese ion binding (IEA)

metal ion binding (IEA)

metalloaminopeptidase activity (IEA)

peptidase activity (IBA,IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:21630459	PMID:23106098

Genomics

Comparative Map Data

Npepl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	183,312,185 - 183,324,744 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	183,312,185 - 183,324,744 (+)	Ensembl				GRCr8
mRatBN7.2	3	162,893,932 - 162,906,491 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	162,893,943 - 162,906,492 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	166,692,981 - 166,705,540 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	175,190,900 - 175,203,415 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	172,933,822 - 172,946,381 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	172,195,115 - 172,207,685 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	172,195,844 - 172,207,685 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	178,246,844 - 178,259,415 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	165,035,886 - 165,047,727 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	162,070,042 - 162,081,886 (+)	NCBI		Celera
RGSC_v3.1	3	164,941,225 - 164,953,762 (+)	NCBI
Cytogenetic Map	3	q43	NCBI

NPEPL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	58,689,131 - 58,715,844 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	58,689,131 - 58,719,238 (+)	Ensembl			hg38	GRCh38
GRCh37	20	57,264,187 - 57,290,900 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	20	q13.32	NCBI
HuRef	20	54,048,960 - 54,077,009 (+)	NCBI		HuRef
CHM1_1	20	57,165,703 - 57,192,579 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	60,471,191 - 60,498,449 (+)	NCBI		T2T-CHM13v2.0

Npepl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	173,951,904 - 173,964,495 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	173,952,142 - 173,964,863 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	174,110,338 - 174,122,702 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	174,110,349 - 174,123,070 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	173,935,852 - 173,948,203 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	173,753,304 - 173,765,641 (+)	NCBI		MGSCv36	mm8
Celera	2	180,074,886 - 180,087,187 (+)	NCBI		Celera
Cytogenetic Map	2	H4	NCBI
cM Map	2	97.87	NCBI

Npepl1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	143,860,975 - 143,873,341 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	67
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000034915
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161492708	189428310	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1300161	Rf10	Renal function QTL 10	3.57		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	3	181611379	189428310	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	166376089	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	161799270	187311134	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	166376089	189428310	Rat

Markers in Region

C85514

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	162,906,262 - 162,906,466 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	172,207,456 - 172,207,659	NCBI	Rnor6.0
Rnor_5.0	3	178,259,186 - 178,259,389	UniSTS	Rnor5.0
RGSC_v3.4	3	165,047,498 - 165,047,701	UniSTS	RGSC3.4
Celera	3	162,081,657 - 162,081,860	UniSTS
Cytogenetic Map	3	q42	UniSTS

RH129102

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	162,906,291 - 162,906,486 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	172,207,485 - 172,207,679	NCBI	Rnor6.0
Rnor_5.0	3	178,259,215 - 178,259,409	UniSTS	Rnor5.0
RGSC_v3.4	3	165,047,527 - 165,047,721	UniSTS	RGSC3.4
Celera	3	162,081,686 - 162,081,880	UniSTS
RH 3.4 Map	3	1495.5	UniSTS
Cytogenetic Map	3	q42	UniSTS

BE099214

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	162,901,084 - 162,901,258 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	172,202,278 - 172,202,451	NCBI	Rnor6.0
Rnor_5.0	3	178,254,008 - 178,254,181	UniSTS	Rnor5.0
RGSC_v3.4	3	165,042,320 - 165,042,493	UniSTS	RGSC3.4
Celera	3	162,076,479 - 162,076,652	UniSTS
RH 3.4 Map	3	1495.5	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	92	59	6	356	192	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000034915 ⟹ ENSRNOP00000035430

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	183,312,185 - 183,324,744 (+)	Ensembl
mRatBN7.2 Ensembl	3	162,893,943 - 162,906,489 (+)	Ensembl
Rnor_6.0 Ensembl	3	172,195,844 - 172,207,685 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098913 ⟹ ENSRNOP00000077489

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	183,312,185 - 183,324,744 (+)	Ensembl
mRatBN7.2 Ensembl	3	162,895,007 - 162,906,492 (+)	Ensembl

RefSeq Acc Id:

NM_001107806 ⟹ NP_001101276

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	183,312,185 - 183,324,744 (+)	NCBI
mRatBN7.2	3	162,893,932 - 162,906,491 (+)	NCBI
Rnor_6.0	3	172,195,844 - 172,207,685 (+)	NCBI
Rnor_5.0	3	178,246,844 - 178,259,415 (+)	NCBI
RGSC_v3.4	3	165,035,886 - 165,047,727 (+)	RGD
Celera	3	162,070,042 - 162,081,886 (+)	RGD

Sequence:

show sequence

CTAGCTCTGGCAGGCAGCTCTGGCCACGCTCAACCCCAACCCCACAGACAGCTGTCCCCTCTAC
CTGAACTGCGCCACAGTGGCAGCTCTGCCGTCCAGGGTGAGCCGGCATAACAGCCCTTCCGCCG
CCCACTTCATCACCAGGCTTGTGAGAACCTGCCTGCCTCCTGGAACCCACCGGTGCATCCTGAT
GGTCTGCGAGCAGCCTGAGGTTTTTGCCTCTGCCTGTGCCCTGGCAAGGGCCTTCCCACTCTTC
ACACACCGCTCAGGGGCATCCAGGCGTACAGAAAAGAGGACGGTCATGGTGGAGTTCTTCCTGG
TGGGACAAGACAATGGCCCCGTGGAAGTGTCCACCTTGCAATGTTTAACCAATGCCACGGAAGG
CGTCCGGCTAGCCGCACGCATTGTGGACACGCCATGCAGTGAGATGAACACAGACATCTTCCTT
GAGGAGATTAGCCAAGTTGGAAGGGAGCTGGGGATCACCCCCACCATCATCCGTGATGAACAGC
TAAAGACCAAAGGATTCGGAGGAATCTACGGGGTTGGCAAAGCTGCCCTCCACCCACCTGCGCT
GGCCGTCCTCAGCCACACCCCTGATGGGGCCACGCAGACCATTGCCTGGGTGGGCAAGGGCATT
GTCTATGACACTGGTGGCCTCAGCATCAAAGGGAAGACCACCATGCCAGGGATGAAGCGGGACT
GTGGGGGTGCTGCAGCCATCCTGGGAGCCTTCAGAGCCGCCATCAAGCAGGGTTTCAAAGATAA
CCTGCACGCTGTGTTCTGCTTGGCTGAGAATGCAGTGGGACCCAATGCCACTAGGCCGGATGAC
ATTCACCTTTTGTATTCAGGAAAGACGGTAGAGATCAACAACACGGACGCTGAGGGCAGGCTGG
TGCTGGCAGACGGGGTGTCTTATGCTTGCAAAGACCTGGGTGCTGACATCATTGTGGACATGGC
CACCCTGACAGGGGCACAGGGCATTGCCACAGGGAAATACCATGCAGCCGTGCTCACCAACAGC
GCCGAGTGGGAGGCGGCCTGTGTGAAGGCTGGGCAGAAGTGCGGGGACCTGGTCCACCCGCTGG
TCTACTGCCCTGAGCTGCACTTCAGCGAGTTCACCTCAGCTGTGGCTGACATGAAGAACTCAGT
GGCGGACCGAGACAACAGCCCCAGCTCCTGTGCCGGCCTCTTCATCGCCTCACACATTGGATTT
GACTGGCCTGGAGTCTGGGTCCACCTGGACATTGCCGCCCCAGTGCATGCTGGTGAGCGAGCCA
CAGGCTTCGGGGTGGCTCTCCTCCTGGCCCTATTTGGCCGTGCCTCCGAGGACCCGCTGCTGAA
CCTGGTGTCCCCGTTGGACTGTGAGGTGGATGCCCAGGAAGACGACAGCGTGGGGCGTGACTCC
AAGAGACGGAGGCTCGTGTGAGCGCTACTTCCCAGCTGGTGACACAGGGTTCCTTACCTCACTT
TGCACTGACTGAGTTCAAGCAATTGAAAGATAACTCTTATGACGAGTTTGGCTTCTCCTTCTGT
ACTCAGTGGTTATGGGAGTGAGCCATTCTTTTCTTAGCAGCGGCTTAGGGGTTTGGTGGGGTCT
GGAGAGAATTGTCACAGATCCCATAGGCCTGCCTTTGCCTGCTCTGTCCCTTGTCCTCCACCCT
GGTCCTTAGAACCACCTCAGGTCACCCTCTGTGGTGAGCGCACTTCCTATATAGGTCCTAGCTC
TGGCCTCTGCTTCCTGAGGTGTCCAGCCAGCCCATGCCAGGGTACGTGTGGTGACTGGCTGTTA
GGGACCCATTCTGTGAAGCAGGAAGAGCCTTGTAGCCCACCCCCAACCCCCAGTTCACTTGAAG
TTGAATTAAATATGGCCACAACATAC

hide sequence

RefSeq Acc Id:

XM_039105147 ⟹ XP_038961075

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	183,313,541 - 183,324,744 (+)	NCBI
mRatBN7.2	3	162,895,277 - 162,906,491 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101276	(Get FASTA)	NCBI Sequence Viewer
	XP_038961075	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL85096	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035430
	ENSRNOP00000035430.7
	ENSRNOP00000077489.2

RefSeq Acc Id:

NP_001101276 ⟸ NM_001107806

- UniProtKB:

D4A3E2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVCEQPEVFASACALARAFPLFTHRSGASRRTEKRTVMVEFFLVGQDNGPVEVSTLQCLTNATE
GVRLAARIVDTPCSEMNTDIFLEEISQVGRELGITPTIIRDEQLKTKGFGGIYGVGKAALHPPA
LAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAILGAFRAAIKQGFKD
NLHAVFCLAENAVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIIVDM
ATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGQKCGDLVHPLVYCPELHFSEFTSAVADMKNS
VADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLL
NLVSPLDCEVDAQEDDSVGRDSKRRRLV

hide sequence

Ensembl Acc Id:

ENSRNOP00000035430 ⟸ ENSRNOT00000034915

RefSeq Acc Id:	XP_038961075 ⟸ XM_039105147
- Peptide Label:	isoform X1
- UniProtKB:	A6KL20 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000077489 ⟸ ENSRNOT00000098913

Protein Domains

Cytosol aminopeptidase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3E2-F1-model_v2	AlphaFold	D4A3E2	1-412	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311351	AgrOrtholog
BioCyc Gene	G2FUF-46479	BioCyc
Ensembl Genes	ENSRNOG00000028384	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000034915	ENTREZGENE
	ENSRNOT00000034915.7	UniProtKB/TrEMBL
	ENSRNOT00000098913.2	UniProtKB/TrEMBL
Gene3D-CATH	Zn peptidases	UniProtKB/TrEMBL
	Zn-dependent exopeptidases	UniProtKB/TrEMBL
InterPro	NPEPL1_N	UniProtKB/TrEMBL
	Peptidase_M17	UniProtKB/TrEMBL
	Peptidase_M17_C	UniProtKB/TrEMBL
KEGG Report	rno:311671	UniProtKB/TrEMBL
NCBI Gene	311671	ENTREZGENE
PANTHER	AMINOPEPTIDASE NPEPL1-RELATED	UniProtKB/TrEMBL
	PTHR11963	UniProtKB/TrEMBL
Pfam	Pdase_M17_N2	UniProtKB/TrEMBL
	Peptidase_M17	UniProtKB/TrEMBL
PhenoGen	Npepl1	PhenoGen
PRINTS	LAMNOPPTDASE	UniProtKB/TrEMBL
PROSITE	CYTOSOL_AP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028384	RatGTEx
Superfamily-SCOP	Zn-dependent exopeptidases	UniProtKB/TrEMBL
UniProt	A0A8I5Y6D5_RAT	UniProtKB/TrEMBL
	A6KL20	ENTREZGENE, UniProtKB/TrEMBL
	D4A3E2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Npepl1	aminopeptidase-like 1	Npepl1_predicted	aminopeptidase-like 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Npepl1_predicted	aminopeptidase-like 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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