NPEPL1 (aminopeptidase like 1) - Rat Genome Database

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Gene: NPEPL1 (aminopeptidase like 1) Homo sapiens
Analyze
Symbol: NPEPL1
Name: aminopeptidase like 1
RGD ID: 1322762
Description:
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aminopeptidase-like 1; bA261P9.2; FLJ11583; FLJ42065; probable aminopeptidase NPEPL1; uncharacterized protein LOC124904942
RGD Orthologs
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,717,595 - 58,719,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,689,131 - 58,719,238 (+)EnsemblGRCh38hg38GRCh38
GRCh372057,264,187 - 57,290,900 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,701,268 - 56,724,307 (+)NCBINCBI36Build 36hg18NCBI36
Build 342056,701,301 - 56,724,306NCBI
Celera2054,008,342 - 54,031,376 (+)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,048,960 - 54,077,009 (+)NCBIHuRef
CHM1_12057,165,703 - 57,192,579 (+)NCBICHM1_1
T2T-CHM13v2.02060,500,200 - 60,501,836 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
NPEPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,717,595 - 58,719,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,689,131 - 58,719,238 (+)EnsemblGRCh38hg38GRCh38
GRCh372057,264,187 - 57,290,900 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,701,268 - 56,724,307 (+)NCBINCBI36Build 36hg18NCBI36
Build 342056,701,301 - 56,724,306NCBI
Celera2054,008,342 - 54,031,376 (+)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,048,960 - 54,077,009 (+)NCBIHuRef
CHM1_12057,165,703 - 57,192,579 (+)NCBICHM1_1
T2T-CHM13v2.02060,500,200 - 60,501,836 (+)NCBIT2T-CHM13v2.0
Npepl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955445859,188 - 874,313 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955445859,404 - 874,004 (-)NCBIChiLan1.0ChiLan1.0
NPEPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,462,862 - 43,479,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,462,792 - 43,478,746 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,709,596 - 42,726,742 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,329,102 - 44,346,243 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,329,129 - 44,346,240 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,433,447 - 43,450,563 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,551,501 - 43,568,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,211,520 - 44,228,689 (+)NCBIUU_Cfam_GSD_1.0
NPEPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1758,873,191 - 58,891,249 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11758,874,499 - 58,891,249 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,140,894 - 66,157,631 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPEPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,427,650 - 5,450,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,427,482 - 5,448,858 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605053,480,147 - 53,501,514 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npepl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474124,986,620 - 25,001,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474124,986,672 - 25,001,764 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000020.10:g.(?_56993257)_(57967907_?)dup duplication Amyotrophic lateral sclerosis type 8 [RCV001324796] Chr20:56993257..57967907 [GRCh37]
Chr20:20q13.32		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2651
Count of miRNA genes:815
Interacting mature miRNAs:947
Transcripts:ENST00000356091, ENST00000525068, ENST00000525817, ENST00000525967, ENST00000527081, ENST00000527587, ENST00000529976, ENST00000532531, ENST00000533788
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH91972  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372057,290,623 - 57,290,747UniSTSGRCh37
Build 362056,724,030 - 56,724,154RGDNCBI36
Celera2054,031,099 - 54,031,223RGD
Cytogenetic Map20q13.32UniSTS
HuRef2054,076,732 - 54,076,856UniSTS
GeneMap99-GB4 RH Map20343.6UniSTS
SHGC-80926  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372057,290,947 - 57,291,286UniSTSGRCh37
Build 362056,724,354 - 56,724,693RGDNCBI36
Celera2054,031,423 - 54,031,762RGD
Cytogenetic Map20q13.32UniSTS
HuRef2054,077,056 - 54,077,395UniSTS
TNG Radiation Hybrid Map2026406.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2236 2873 1430 395 1266 233 4080 2072 3449 170 1235 1276 164 1204 2787
Low 195 114 291 224 662 228 271 121 261 248 212 333 8 1 1 4
Below cutoff 3 4 3 21 4 5 2 10 1 10 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000356091   ⟹   ENSP00000348395
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,692,800 - 58,715,844 (+)Ensembl
RefSeq Acc Id: ENST00000525068
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,713,731 - 58,714,964 (+)Ensembl
RefSeq Acc Id: ENST00000525817   ⟹   ENSP00000437112
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,689,135 - 58,715,550 (+)Ensembl
RefSeq Acc Id: ENST00000525967   ⟹   ENSP00000434810
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,689,131 - 58,715,633 (+)Ensembl
RefSeq Acc Id: ENST00000527081
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,712,821 - 58,715,844 (+)Ensembl
RefSeq Acc Id: ENST00000527587
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,693,179 - 58,719,238 (+)Ensembl
RefSeq Acc Id: ENST00000529976
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,693,169 - 58,715,844 (+)Ensembl
RefSeq Acc Id: ENST00000532531
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,717,364 - 58,719,231 (+)Ensembl
RefSeq Acc Id: ENST00000533788   ⟹   ENSP00000436265
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,694,421 - 58,713,580 (+)Ensembl
RefSeq Acc Id: XM_047440632   ⟹   XP_047296588
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382058,717,595 - 58,719,231 (+)NCBI
RefSeq Acc Id: XM_047446960   ⟹   XP_047302916
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02060,500,200 - 60,501,836 (+)NCBI
Protein Sequences
Protein RefSeqs XP_047296588 (Get FASTA)   NCBI Sequence Viewer  
  XP_047302916 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSP00000436265   ⟸   ENST00000533788
RefSeq Acc Id: ENSP00000434810   ⟸   ENST00000525967
RefSeq Acc Id: ENSP00000437112   ⟸   ENST00000525817
RefSeq Acc Id: ENSP00000348395   ⟸   ENST00000356091
RefSeq Acc Id: XP_047296588   ⟸   XM_047440632
RefSeq Acc Id: XP_047302916   ⟸   XM_047446960

Promoters
RGD ID:6798758
Promoter ID:HG_KWN:39980
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:ENST00000356091,   ENST00000371131,   NM_024663,   UC002XZO.1,   UC002XZP.2
Position:
Human AssemblyChrPosition (strand)Source
Build 362056,700,976 - 56,702,077 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16244 AgrOrtholog
COSMIC NPEPL1 COSMIC
Ensembl Genes ENSG00000215440 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000532531 ENTREZGENE
GTEx ENSG00000215440 GTEx
Human Proteome Map NPEPL1 Human Proteome Map
NCBI Gene LOC124904942 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 NPEPL1  aminopeptidase like 1    aminopeptidase-like 1  Symbol and/or name change 5135510 APPROVED