Sntg2 (syntrophin, gamma 2) - Rat Genome Database

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Gene: Sntg2 (syntrophin, gamma 2) Rattus norvegicus
Analyze
Symbol: Sntg2
Name: syntrophin, gamma 2
RGD ID: 1311276
Description: Predicted to enable PDZ domain binding activity and neuroligin family protein binding activity. Predicted to be located in several cellular components, including cytoskeleton; nucleoplasm; and plasma membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Orthologous to human SNTG2 (syntrophin gamma 2); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gamma-2-syntrophin; LOC298936
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8652,529,481 - 52,730,972 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl652,529,481 - 52,730,972 (-)EnsemblGRCr8
mRatBN7.2646,801,893 - 47,003,390 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl646,801,377 - 47,003,372 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx647,106,309 - 47,309,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0647,421,180 - 47,624,149 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0646,856,453 - 47,059,438 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0649,123,084 - 49,324,530 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,123,084 - 49,324,450 (-)Ensemblrn6Rnor6.0
Rnor_5.0657,803,704 - 58,004,714 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4648,059,246 - 48,263,991 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera646,005,091 - 46,207,417 (-)NCBICelera
RGSC_v3.1648,062,892 - 48,267,135 (-)NCBI
Cytogenetic Map6q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17292328  


Genomics

Comparative Map Data
Sntg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8652,529,481 - 52,730,972 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl652,529,481 - 52,730,972 (-)EnsemblGRCr8
mRatBN7.2646,801,893 - 47,003,390 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl646,801,377 - 47,003,372 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx647,106,309 - 47,309,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0647,421,180 - 47,624,149 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0646,856,453 - 47,059,438 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0649,123,084 - 49,324,530 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,123,084 - 49,324,450 (-)Ensemblrn6Rnor6.0
Rnor_5.0657,803,704 - 58,004,714 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4648,059,246 - 48,263,991 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera646,005,091 - 46,207,417 (-)NCBICelera
RGSC_v3.1648,062,892 - 48,267,135 (-)NCBI
Cytogenetic Map6q16NCBI
SNTG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382950,849 - 1,367,613 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2950,849 - 1,367,613 (+)Ensemblhg38GRCh38
GRCh372946,535 - 1,371,385 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362936,555 - 1,253,924 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3421,291,271 - 1,350,389NCBI
Celera21,012,573 - 1,421,170 (+)NCBICelera
Cytogenetic Map2p25.3NCBI
HuRef2947,238 - 1,264,560 (+)NCBIHuRef
HuRef21,304,887 - 1,362,945 (+)NCBIHuRef
CHM1_12944,386 - 1,363,779 (+)NCBICHM1_1
T2T-CHM13v2.02950,782 - 1,369,232 (+)NCBIT2T-CHM13v2.0
Sntg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391230,224,481 - 30,423,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1230,224,481 - 30,423,374 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381230,174,482 - 30,373,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1230,174,482 - 30,373,375 (-)Ensemblmm10GRCm38
MGSCv371230,859,422 - 31,058,240 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361230,761,046 - 30,959,380 (-)NCBIMGSCv36mm8
Celera1231,631,444 - 31,829,368 (-)NCBICelera
Cytogenetic Map12A2NCBI
cM Map1213.0NCBI
Sntg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487533,711 - 639,074 (-)Ensembl
ChiLan1.0NW_004955487533,719 - 639,056 (-)NCBIChiLan1.0ChiLan1.0
SNTG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212125,219,585 - 125,628,480 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A125,223,558 - 125,632,457 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A911,002 - 1,317,058 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A1,020,294 - 1,288,408 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A1,020,261 - 1,288,425 (+)EnsemblpanPan2panpan1.1
SNTG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.117682,332 - 764,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl17684,358 - 764,467 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha17666,433 - 752,017 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.017736,579 - 822,178 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl17695,307 - 822,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.117660,741 - 746,303 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.017680,837 - 766,292 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.017680,879 - 766,396 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SNTG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114106,304,115 - 106,703,772 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660455,295,384 - 5,689,797 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sntg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248461,966,584 - 2,051,834 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248461,966,577 - 2,051,953 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sntg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1743,591,052 - 43,793,776 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sntg2
2362 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:86
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000066904
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)64005241156848866Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat

Markers in Region
D6Rat136  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8652,625,268 - 52,625,500 (+)Marker Load Pipeline
Rnor_6.0649,218,700 - 49,218,931NCBIRnor6.0
Rnor_5.0657,898,943 - 57,899,174UniSTSRnor5.0
RGSC_v3.4648,155,752 - 48,155,984RGDRGSC3.4
RGSC_v3.4648,155,753 - 48,155,984UniSTSRGSC3.4
Celera646,101,723 - 46,101,952UniSTS
RGSC_v3.1648,158,878 - 48,159,110RGD
SHRSP x BN Map634.1598RGD
SHRSP x BN Map634.1598UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 10 64 142 47 46 19 33 19 6 228 123 8 123 63 92 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066904   ⟹   ENSRNOP00000060286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl652,529,481 - 52,730,972 (-)Ensembl
mRatBN7.2 Ensembl646,801,377 - 47,003,372 (-)Ensembl
Rnor_6.0 Ensembl649,123,084 - 49,324,450 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097206   ⟹   ENSRNOP00000085255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl652,529,481 - 52,730,972 (-)Ensembl
mRatBN7.2 Ensembl646,801,377 - 47,003,372 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152265   ⟹   ENSRNOP00000100220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl652,529,481 - 52,729,851 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160396   ⟹   ENSRNOP00000101160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl652,529,481 - 52,730,972 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172283   ⟹   ENSRNOP00000105115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl652,529,481 - 52,656,540 (-)Ensembl
RefSeq Acc Id: NM_001106720   ⟹   NP_001100190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8652,529,481 - 52,730,972 (-)NCBI
mRatBN7.2646,801,893 - 47,003,390 (-)NCBI
Rnor_6.0649,123,084 - 49,324,450 (-)NCBI
Rnor_5.0657,803,704 - 58,004,714 (-)NCBI
RGSC_v3.4648,059,246 - 48,263,991 (-)RGD
Celera646,005,091 - 46,207,417 (-)RGD
Sequence:
RefSeq Acc Id: NM_001414914   ⟹   NP_001401843
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8652,529,481 - 52,730,972 (-)NCBI
mRatBN7.2646,801,893 - 47,003,390 (-)NCBI
RefSeq Acc Id: NM_001414915   ⟹   NP_001401844
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8652,529,481 - 52,730,972 (-)NCBI
mRatBN7.2646,801,893 - 47,003,390 (-)NCBI
RefSeq Acc Id: XM_039111960   ⟹   XP_038967888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8652,529,481 - 52,615,037 (-)NCBI
mRatBN7.2646,801,893 - 46,887,447 (-)NCBI
RefSeq Acc Id: NP_001100190   ⟸   NM_001106720
- Peptide Label: isoform 3
- UniProtKB: D3ZR12 (UniProtKB/TrEMBL),   A6HB30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060286   ⟸   ENSRNOT00000066904
RefSeq Acc Id: XP_038967888   ⟸   XM_039111960
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000085255   ⟸   ENSRNOT00000097206
RefSeq Acc Id: NP_001401844   ⟸   NM_001414915
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001401843   ⟸   NM_001414914
- Peptide Label: isoform 1
- UniProtKB: A0A8I6A197 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105115   ⟸   ENSRNOT00000172283
Ensembl Acc Id: ENSRNOP00000101160   ⟸   ENSRNOT00000160396
Ensembl Acc Id: ENSRNOP00000100220   ⟸   ENSRNOT00000152265
Protein Domains
PDZ   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZR12-F1-model_v2 AlphaFold D3ZR12 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311276 AgrOrtholog
BioCyc Gene G2FUF-37936 BioCyc
Ensembl Genes ENSRNOG00000004928 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066904 ENTREZGENE
  ENSRNOT00000066904.3 UniProtKB/TrEMBL
  ENSRNOT00000097206 ENTREZGENE
  ENSRNOT00000097206.2 UniProtKB/TrEMBL
  ENSRNOT00000152265.1 UniProtKB/TrEMBL
  ENSRNOT00000160396.1 UniProtKB/TrEMBL
  ENSRNOT00000172283 ENTREZGENE
  ENSRNOT00000172283.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Syntrophin UniProtKB/TrEMBL
  Syntrophin_4th UniProtKB/TrEMBL
KEGG Report rno:298936 UniProtKB/TrEMBL
NCBI Gene 298936 ENTREZGENE
PANTHER GAMMA-2-SYNTROPHIN UniProtKB/TrEMBL
  Syntrophin UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  Syntrophin_4th UniProtKB/TrEMBL
PhenoGen Sntg2 PhenoGen
PROSITE PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004928 RatGTEx
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A8I6A197 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L765_RAT UniProtKB/TrEMBL
  A0ABK0L877_RAT UniProtKB/TrEMBL
  A0ABK0LJP5_RAT UniProtKB/TrEMBL
  A6HB30 ENTREZGENE, UniProtKB/TrEMBL
  D3ZR12 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sntg2  syntrophin, gamma 2   Sntg2_predicted  syntrophin, gamma 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sntg2_predicted  syntrophin, gamma 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED