Ipo11 (importin 11) - Rat Genome Database

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Gene: Ipo11 (importin 11) Rattus norvegicus
Analyze
Symbol: Ipo11
Name: importin 11
RGD ID: 1311133
Description: Predicted to enable small GTPase binding activity. Predicted to be involved in intracellular protein transport. Predicted to be located in cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: importin-11; LOC310056; similar to importin 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ipo11-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8239,903,316 - 40,076,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,852,646 - 128,855,832 (+)EnsemblGRCr8
mRatBN7.2238,169,688 - 38,342,929 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.0237,952,982 - 38,120,451 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl237,954,161 - 38,110,567 (-)Ensemblrn6Rnor6.0
Rnor_5.0257,049,753 - 57,215,181 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4238,006,409 - 38,054,430 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera234,041,416 - 34,210,706 (-)NCBICelera
RGSC_v3.1237,926,777 - 37,974,871 (-)NCBI
Cytogenetic Map2q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)
nuclear envelope  (IBA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11809816   PMID:12477932  


Genomics

Comparative Map Data
Ipo11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8239,903,316 - 40,076,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,852,646 - 128,855,832 (+)EnsemblGRCr8
mRatBN7.2238,169,688 - 38,342,929 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.0237,952,982 - 38,120,451 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl237,954,161 - 38,110,567 (-)Ensemblrn6Rnor6.0
Rnor_5.0257,049,753 - 57,215,181 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4238,006,409 - 38,054,430 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera234,041,416 - 34,210,706 (-)NCBICelera
RGSC_v3.1237,926,777 - 37,974,871 (-)NCBI
Cytogenetic Map2q13NCBI
IPO11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38562,578,735 - 62,628,589 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl562,403,972 - 62,628,582 (+)Ensemblhg38GRCh38
GRCh37561,874,562 - 61,924,416 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36561,744,351 - 61,960,165 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34561,744,350 - 61,960,164NCBI
Celera558,704,531 - 58,921,350 (+)NCBICelera
Cytogenetic Map5q12.1NCBI
HuRef558,830,947 - 58,880,547 (+)NCBIHuRef
CHM1_1561,874,345 - 61,924,070 (+)NCBICHM1_1
T2T-CHM13v2.0563,398,374 - 63,448,302 (+)NCBIT2T-CHM13v2.0
Ipo11-lrrc70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913106,930,947 - 106,972,810 (-)NCBIGRCm39GRCm39mm39
GRCm3813106,794,439 - 106,836,302 (-)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map13D1NCBI
Ipo11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554466,034,277 - 6,225,640 (-)Ensembl
ChiLan1.0NW_0049554466,034,277 - 6,225,627 (-)NCBIChiLan1.0ChiLan1.0
IPO11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2451,287,365 - 51,499,916 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1549,440,997 - 49,653,546 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0551,370,503 - 51,584,256 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1553,013,430 - 53,226,598 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl553,013,430 - 53,226,598 (-)EnsemblpanPan2panpan1.1
Ipo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213197,168,763 - 197,374,904 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364806,104,333 - 6,304,413 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364806,105,237 - 6,311,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IPO11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1458,602,143 - 58,827,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660497,121,956 - 7,352,145 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ipo11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248157,254,909 - 7,478,569 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248157,255,803 - 7,492,289 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ipo11
1495 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000060904, ENSRNOT00000072212, ENSRNOT00000074971
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
RH142483  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2238,300,022 - 38,300,176 (+)MAPPERmRatBN7.2
Rnor_6.0238,077,021 - 38,077,173NCBIRnor6.0
Rnor_5.0257,171,754 - 57,171,906UniSTSRnor5.0
RGSC_v3.4238,011,590 - 38,011,742UniSTSRGSC3.4
Celera234,167,835 - 34,167,987UniSTS
RH 3.4 Map2174.8UniSTS
Cytogenetic Map2q14UniSTS
AA945067  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8239,949,861 - 39,950,069 (+)Marker Load Pipeline
mRatBN7.2238,216,234 - 38,216,442 (+)MAPPERmRatBN7.2
Rnor_6.0237,998,569 - 37,998,776NCBIRnor6.0
Rnor_5.0257,095,340 - 57,095,547UniSTSRnor5.0
Celera234,087,854 - 34,088,061UniSTS
RH 3.4 Map2174.8UniSTS
Cytogenetic Map2q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000072212   ⟹   ENSRNOP00000065744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl237,954,161 - 38,110,567 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086287   ⟹   ENSRNOP00000083112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,852,646 - 128,855,832 (+)Ensembl
RefSeq Acc Id: XM_063282682   ⟹   XP_063138752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282683   ⟹   XP_063138753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282684   ⟹   XP_063138754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282685   ⟹   XP_063138755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282686   ⟹   XP_063138756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,949,640 - 40,076,485 (-)NCBI
Ensembl Acc Id: ENSRNOP00000065744   ⟸   ENSRNOT00000072212
RefSeq Acc Id: XP_063138754   ⟸   XM_063282684
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZYN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138755   ⟸   XM_063282685
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZYN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138753   ⟸   XM_063282683
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZYN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138752   ⟸   XM_063282682
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138756   ⟸   XM_063282686
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZYN9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083112   ⟸   ENSRNOT00000086287
Protein Domains
Importin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8E8-F1-model_v2 AlphaFold M0R8E8 1-976 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311133 AgrOrtholog
BioCyc Gene G2FUF-54527 BioCyc
Ensembl Genes ENSRNOG00000039717 Ensembl
  ENSRNOG00000055661 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000062438 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086287.3 UniProtKB/TrEMBL
  ENSRNOT00000094263 ENTREZGENE
  ENSRNOT00000094263.2 UniProtKB/TrEMBL
  ENSRNOT00000167605 ENTREZGENE
  ENSRNOT00000167605.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7316678 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/TrEMBL
MGC_CLONE MGC:109371 IMAGE-MGC_LOAD
NCBI Gene 310056 ENTREZGENE
PANTHER IMPORTIN-11 UniProtKB/TrEMBL
  IMPORTIN-7, 8, 11 UniProtKB/TrEMBL
Pfam IBN_N UniProtKB/TrEMBL
  TPR_IPO11 UniProtKB/TrEMBL
PhenoGen Ipo11 PhenoGen
PROSITE IMPORTIN_B_NT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039717 RatGTEx
  ENSRNOG00000055661 RatGTEx
  ENSRNOG00000062438 RatGTEx
SMART IBN_N UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A8I5ZYN9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APG6_RAT UniProtKB/TrEMBL
  A0ABK0LEZ4_RAT UniProtKB/TrEMBL
  Q562A4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Ipo11  importin 11  LOC683676  similar to importin 11  Data merged from RGD:1584477 1643240 APPROVED
2008-04-30 Ipo11  importin 11   Ipo11_predicted  importin 11 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC683676  similar to importin 11      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ipo11_predicted  importin 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED